Published in Curr Opin Genet Dev on June 28, 2010
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Nat Rev Mol Cell Biol (2012) 3.45
Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol (2012) 3.40
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. Genes Dev (2012) 2.82
Family-wide analysis of poly(ADP-ribose) polymerase activity. Nat Commun (2014) 1.26
Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function. Mol Cell (2015) 1.12
PARP1 represses PAP and inhibits polyadenylation during heat shock. Mol Cell (2012) 1.05
Promoter hypomethylation, especially around the E26 transformation-specific motif, and increased expression of poly (ADP-ribose) polymerase 1 in BRCA-mutated serous ovarian cancer. BMC Cancer (2013) 1.04
Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response. Chromosoma (2013) 0.98
Alternative modes of binding of poly(ADP-ribose) polymerase 1 to free DNA and nucleosomes. J Biol Chem (2012) 0.97
Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli. PLoS Genet (2012) 0.96
Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles. PLoS One (2012) 0.95
Targeting microglial activation in stroke therapy: pharmacological tools and gender effects. Curr Med Chem (2014) 0.93
Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation. Cell Death Differ (2014) 0.92
Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation. Biochim Biophys Acta (2013) 0.90
New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases. Chem Rev (2015) 0.88
Regulation of myofibroblast differentiation by poly(ADP-ribose) polymerase 1. Am J Pathol (2013) 0.86
Post-transcriptional regulation by poly(ADP-ribosyl)ation of the RNA-binding proteins. Int J Mol Sci (2013) 0.85
Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem Biol (2015) 0.84
PARP-1 modulates amyloid beta peptide-induced neuronal damage. PLoS One (2013) 0.83
Doxorubicin enhances Snail/LSD1-mediated PTEN suppression in a PARP1-dependent manner. Cell Cycle (2014) 0.82
Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses. J Virol (2012) 0.81
Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture. Proteome Sci (2014) 0.81
A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development. PLoS One (2011) 0.81
Poly(ADP-ribose) glycohydrolase and poly(ADP-ribose)-interacting protein Hrp38 regulate pattern formation during Drosophila eye development. Gene (2013) 0.80
Poly(ADP-Ribosyl)ation Affects Histone Acetylation and Transcription. PLoS One (2015) 0.79
Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2. Mol Cell Biol (2015) 0.79
SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress. Open Biol (2013) 0.79
Lidocaine induces endoplasmic reticulum stress-associated apoptosis in vitro and in vivo. Int J Mol Sci (2011) 0.79
Association of poly(ADP-ribose) polymerase-1 polymorphism with Tourette syndrome. Neurol Sci (2013) 0.78
Basal activity of a PARP1-NuA4 complex varies dramatically across cancer cell lines. Cell Rep (2014) 0.78
Noncovalent pADPr interaction with proteins and competition with RNA for binding to proteins. Methods Mol Biol (2011) 0.77
Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation. PLoS One (2015) 0.77
Polymorphisms in poly (ADP-ribose) polymerase-1 (PARP1) promoter and 3' untranslated region and their association with PARP1 expression in breast cancer patients. Int J Clin Exp Pathol (2015) 0.77
New ribosomes for new memories? Commun Integr Biol (2015) 0.77
Mitotic bookmarking: maintaining post-mitotic reprogramming of transcription reactivation. Curr Mol Biol Rep (2016) 0.77
New links between mRNA polyadenylation and diverse nuclear pathways. Mol Cells (2014) 0.77
Cytotoxic and apoptotic effects of menadione on rat hepatocellular carcinoma cells. Cytotechnology (2014) 0.77
Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver. Toxicol Appl Pharmacol (2012) 0.76
ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β. Sci Rep (2016) 0.76
Novel insights into the neuroendocrine control of inflammation: the role of GR and PARP1. Endocr Connect (2013) 0.76
HYDAMTIQ, a selective PARP-1 inhibitor, improves bleomycin-induced lung fibrosis by dampening the TGF-β/SMAD signalling pathway. J Cell Mol Med (2016) 0.76
The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. PLoS Genet (2016) 0.75
Charon Mediates Immune Deficiency-Driven PARP-1-Dependent Immune Responses in Drosophila. J Immunol (2016) 0.75
ADP-ribosyltransferases and poly ADP-ribosylation. Curr Protein Pept Sci (2015) 0.75
MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1. J Cell Biol (2017) 0.75
Understanding alternative splicing: towards a cellular code. Nat Rev Mol Cell Biol (2005) 13.21
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J (1999) 9.00
The PARP superfamily. Bioessays (2004) 6.14
FACT facilitates transcription-dependent nucleosome alteration. Science (2003) 5.83
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors. Curr Opin Cell Biol (2005) 5.14
Rapid, transcription-independent loss of nucleosomes over a large chromatin domain at Hsp70 loci. Cell (2008) 4.81
NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1. Cell (2004) 4.21
The macro domain is an ADP-ribose binding module. EMBO J (2005) 4.07
Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science (2003) 3.97
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science (2009) 3.68
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature (2008) 3.67
Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes. Science (2008) 3.45
Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins. J Biol Chem (2000) 3.30
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nat Struct Mol Biol (2009) 3.26
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Proc Natl Acad Sci U S A (2009) 3.02
Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. EMBO J (2003) 2.94
DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation. Mol Cell (2007) 2.48
Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites. Nucleic Acids Res (2009) 2.22
Regulation of alternative splicing by reversible protein phosphorylation. J Biol Chem (2007) 2.07
FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell (2008) 1.99
The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during development. Genes Dev (2002) 1.96
The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity. Genes Dev (2006) 1.95
Structural characterization of the histone variant macroH2A. Mol Cell Biol (2005) 1.85
Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster. Proc Natl Acad Sci U S A (2003) 1.85
ISWI regulates higher-order chromatin structure and histone H1 assembly in vivo. PLoS Biol (2007) 1.82
The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription. Mol Cell Biol (2007) 1.82
Multiple roles for ISWI in transcription, chromosome organization and DNA replication. Biochim Biophys Acta (2004) 1.75
The histone variant macroH2A is an epigenetic regulator of key developmental genes. Nat Struct Mol Biol (2009) 1.75
PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli. J Cell Sci (2005) 1.73
Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length. Nucleic Acids Res (2007) 1.73
Steroid signaling in plants and insects--common themes, different pathways. Genes Dev (2002) 1.68
In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs). BMC Genomics (2005) 1.62
The Drosophila nucleosome remodeling factor NURF is required for Ecdysteroid signaling and metamorphosis. Genes Dev (2005) 1.60
Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications. J Am Chem Soc (2009) 1.59
Poly(ADP-ribose) polymerase 1 is inhibited by a histone H2A variant, MacroH2A, and contributes to silencing of the inactive X chromosome. J Biol Chem (2007) 1.53
Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity. J Biol Chem (2007) 1.50
A proteomic approach to the identification of heterogeneous nuclear ribonucleoproteins as a new family of poly(ADP-ribose)-binding proteins. Biochem J (2003) 1.45
Involvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function. Mol Cell Biol (2003) 1.43
The Drosophila E74 gene is required for metamorphosis and plays a role in the polytene chromosome puffing response to ecdysone. Development (1995) 1.34
Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing. Nucleic Acids Res (2009) 1.30
Modulation of nucleosome-binding activity of FACT by poly(ADP-ribosyl)ation. Nucleic Acids Res (2006) 1.18
The nucleosome-remodeling ATPase ISWI is regulated by poly-ADP-ribosylation. PLoS Biol (2008) 1.17
Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body. PLoS Genet (2009) 1.15
Drosophila poly(ADP-ribose) glycohydrolase mediates chromatin structure and SIR2-dependent silencing. Genetics (2005) 1.13
Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis. Proc Natl Acad Sci U S A (2006) 1.13
Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast. Cancer Res (2001) 1.09
PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation. J Biol Chem (2009) 1.08
Poly(ADP-ribose) binds to the splicing factor ASF/SF2 and regulates its phosphorylation by DNA topoisomerase I. J Biol Chem (2008) 1.08
Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1. Nucleic Acids Res (2008) 1.06
Uncoupling of the transactivation and transrepression functions of PARP1 protein. Proc Natl Acad Sci U S A (2010) 1.03
Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWI. PLoS Genet (2008) 1.03
Hormonal regulation of the E75 gene in Drosophila: identifying functional regulatory elements through computational and biological analysis. J Mol Biol (2009) 0.96
Parp1-deficiency induces differentiation of ES cells into trophoblast derivatives. Dev Biol (2003) 0.95
Ecdysone receptor-dependent gene regulation mediates histone poly(ADP-ribosyl)ation. Biochem Biophys Res Commun (2004) 0.88
Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes. Dev Biol (2009) 0.84
Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA. Genes Dev (2009) 1.82
Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity. J Biol Chem (2007) 1.50
Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing. Nucleic Acids Res (2009) 1.30
Drosophila histone H2A variant (H2Av) controls poly(ADP-ribose) polymerase 1 (PARP1) activation in chromatin. Proc Natl Acad Sci U S A (2011) 1.17
The nucleosome-remodeling ATPase ISWI is regulated by poly-ADP-ribosylation. PLoS Biol (2008) 1.17
Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body. PLoS Genet (2009) 1.15
Poly-ADP-ribose polymerase: machinery for nuclear processes. Mol Aspects Med (2013) 1.06
Uncoupling of the transactivation and transrepression functions of PARP1 protein. Proc Natl Acad Sci U S A (2010) 1.03
Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli. PLoS Genet (2012) 0.96
Poly(ADP-ribose) controls DE-cadherin-dependent stem cell maintenance and oocyte localization. Nat Commun (2012) 0.95
Post-transcriptional regulation by poly(ADP-ribosyl)ation of the RNA-binding proteins. Int J Mol Sci (2013) 0.85
Minor grove binding ligands disrupt PARP-1 activation pathways. Oncotarget (2014) 0.84
Stellate repeats: targets of silencing and modules causing cis-inactivation and trans-activation. Genetica (2003) 0.84
Small-molecule collection and high-throughput colorimetric assay to identify PARP1 inhibitors. Methods Mol Biol (2011) 0.84
Dcas supports cell polarization and cell-cell adhesion complexes in development. PLoS One (2010) 0.83
Poly(ADP-ribose) glycohydrolase and poly(ADP-ribose)-interacting protein Hrp38 regulate pattern formation during Drosophila eye development. Gene (2013) 0.80
PARP1 genomics: chromatin immunoprecipitation approach using anti-PARP1 antibody (ChIP and ChIP-seq). Methods Mol Biol (2011) 0.77
Generating a knockdown transgene against Drosophila heterochromatic Tim17b gene encoding mitochondrial translocase subunit. PLoS One (2011) 0.75