Published in Nat Struct Mol Biol on September 06, 2009
The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. Nature (2010) 2.49
A long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophy. Cell (2012) 2.29
The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing. Genes Dev (2009) 1.82
Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness. Nat Struct Mol Biol (2012) 1.67
Every amino acid matters: essential contributions of histone variants to mammalian development and disease. Nat Rev Genet (2014) 1.62
Histone variant macroH2A confers resistance to nuclear reprogramming. EMBO J (2011) 1.57
MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation. Nat Struct Mol Biol (2014) 1.52
Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo. Cancer Cell (2015) 1.47
Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases. Nat Struct Mol Biol (2013) 1.47
Histone variants in metazoan development. Dev Cell (2010) 1.42
The roles of PARP1 in gene control and cell differentiation. Curr Opin Genet Dev (2010) 1.40
MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency. Nat Commun (2013) 1.39
QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferation. Mol Cell Biol (2011) 1.38
Histone H2A variants in nucleosomes and chromatin: more or less stable? Nucleic Acids Res (2012) 1.33
NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism. Cancer Discov (2014) 1.27
Histone variants: dynamic punctuation in transcription. Genes Dev (2014) 1.22
Histone variants: emerging players in cancer biology. Cell Mol Life Sci (2013) 1.17
Genome-wide distribution of macroH2A1 histone variants in mouse liver chromatin. Mol Cell Biol (2010) 1.15
A dynamic alternative splicing program regulates gene expression during terminal erythropoiesis. Nucleic Acids Res (2014) 1.13
MacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells. Mol Cell Biol (2012) 1.11
Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency. J Cell Sci (2012) 1.10
ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression. Genes Dev (2012) 1.10
Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells. Mol Cell (2012) 1.05
Histone variant macroH2A1 deletion in mice causes female-specific steatosis. Epigenetics Chromatin (2010) 1.03
X chromosome inactivation and differentiation occur readily in ES cells doubly-deficient for macroH2A1 and macroH2A2. PLoS One (2011) 1.00
A repetitive elements perspective in Polycomb epigenetics. Front Genet (2012) 0.97
Do different neurons age differently? Direct genome-wide analysis of aging in single identified cholinergic neurons. Front Aging Neurosci (2010) 0.96
Synergism between DNA methylation and macroH2A1 occupancy in epigenetic silencing of the tumor suppressor gene p16(CDKN2A). Nucleic Acids Res (2010) 0.96
E-box-independent regulation of transcription and differentiation by MYC. Nat Cell Biol (2011) 0.95
Expression and functionality of histone H2A variants in cancer. Oncotarget (2014) 0.95
macroH2A1 histone variant represses rDNA transcription. Nucleic Acids Res (2013) 0.94
DPY30 regulates pathways in cellular senescence through ID protein expression. EMBO J (2013) 0.92
Epo-induced erythroid maturation is dependent on Plcγ1 signaling. Cell Death Differ (2014) 0.90
A Cbx8-containing polycomb complex facilitates the transition to gene activation during ES cell differentiation. PLoS Genet (2014) 0.86
Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma brucei. PLoS Genet (2016) 0.85
The histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1. Mol Cell Biol (2014) 0.85
Macro histone variants are critical for the differentiation of human pluripotent cells. J Biol Chem (2013) 0.85
Variants of core histones and their roles in cell fate decisions, development and cancer. Nat Rev Mol Cell Biol (2017) 0.84
The basic linker of macroH2A stabilizes DNA at the entry/exit site of the nucleosome. Nucleic Acids Res (2012) 0.84
Distinct distribution of ectopically expressed histone variants H2A.Bbd and MacroH2A in open and closed chromatin domains. PLoS One (2012) 0.83
The histone variant MacroH2A regulates Ca(2+) influx through TRPC3 and TRPC6 channels. Oncogenesis (2013) 0.83
The histone variant H2A.Bbd is enriched at sites of DNA synthesis. Nucleic Acids Res (2014) 0.82
Mice without macroH2A histone variants. Mol Cell Biol (2014) 0.82
Genome-wide analysis of the chromatin composition of histone H2A and H3 variants in mouse embryonic stem cells. PLoS One (2014) 0.81
Expanding the Circuitry of Pluripotency by Selective Isolation of Chromatin-Associated Proteins. Mol Cell (2016) 0.81
MacroH2A subtypes contribute antagonistically to the transcriptional regulation of the ribosomal cistron during seasonal acclimatization of the carp fish. Epigenetics Chromatin (2010) 0.80
Comparative transcriptome analysis of obligately asexual and cyclically sexual rotifers reveals genes with putative functions in sexual reproduction, dormancy, and asexual egg production. BMC Genomics (2013) 0.79
The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation. Genes Dev (2012) 0.79
Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich's Ataxia. Front Neurol (2015) 0.79
Histone variants as emerging regulators of embryonic stem cell identity. Epigenetics (2015) 0.79
Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins. J Zhejiang Univ Sci B (2014) 0.78
Effects of MacroH2A and H2A.Z on Nucleosome Dynamics as Elucidated by Molecular Dynamics Simulations. Biophys J (2016) 0.78
Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis. Semin Cancer Biol (2015) 0.78
First Barcelona Conference on Epigenetics and Cancer. Epigenetics (2014) 0.78
Molecular turnover, the H3.3 dilemma and organismal aging (hypothesis). Aging Cell (2015) 0.77
The histone H2A variant macroH2A1 does not localize to the centrosome. PLoS One (2011) 0.77
Histone variants and cellular plasticity. Trends Genet (2015) 0.77
MacroH2A1 associates with nuclear lamina and maintains chromatin architecture in mouse liver cells. Sci Rep (2015) 0.76
German-Catalan workshop on epigenetics and cancer. Epigenetics (2013) 0.75
Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation. Sci Rep (2016) 0.75
The characterization of macroH2A beyond vertebrates supports an ancestral origin and conserved role for histone variants in chromatin. Epigenetics (2016) 0.75
The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1. Cell Rep (2016) 0.75
Loss of histone variant macroH2A2 expression associates with progression of anal neoplasm. J Clin Pathol (2015) 0.75
Study of methylation of histone H3 lysine 9 and H3 lysine 27 during X chromosome inactivation in three types of cells. Chromosome Res (2012) 0.75
The histone variant macroH2A confers functional robustness to the intestinal stem cell compartment. PLoS One (2017) 0.75
DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol (2003) 84.79
Chromatin modifications and their function. Cell (2007) 55.98
Stages of embryonic development of the zebrafish. Dev Dyn (1995) 42.72
Identifying biological themes within lists of genes with EASE. Genome Biol (2003) 31.72
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08
Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett (2004) 11.00
Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell (2003) 10.42
High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat Protoc (2008) 10.25
Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell (2004) 10.16
A comparison of background correction methods for two-colour microarrays. Bioinformatics (2007) 8.59
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J (2004) 7.32
Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res (2006) 6.75
RankProd: a bioconductor package for detecting differentially expressed genes in meta-analysis. Bioinformatics (2006) 6.50
Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev (2001) 6.36
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev (2004) 6.19
Epigenetics: regulation through repression. Science (1999) 4.57
The macro domain is an ADP-ribose binding module. EMBO J (2005) 4.07
Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals. Nature (1998) 3.93
Splicing regulates NAD metabolite binding to histone macroH2A. Nat Struct Mol Biol (2005) 3.40
Comparison of sample preparation methods for ChIP-chip assays. Biotechniques (2006) 2.89
MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundary. Nat Neurosci (2008) 2.65
Histone variants meet their match. Nat Rev Mol Cell Biol (2005) 2.47
The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling. Mol Cell (2003) 2.29
The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity. Genes Dev (2006) 1.95
Structural characterization of the histone variant macroH2A. Mol Cell Biol (2005) 1.85
Developmental changes in histone macroH2A1-mediated gene regulation. Mol Cell Biol (2007) 1.77
Mechanism of polymerase II transcription repression by the histone variant macroH2A. Mol Cell Biol (2006) 1.75
Epigenetic determination of a cell-specific gene expression program by ATF-2 and the histone variant macroH2A. EMBO J (2006) 1.54
DNA instructed displacement of histones H2A and H2B at an inducible promoter. Mol Cell (2004) 1.53
Poly(ADP-ribose) polymerase 1 is inhibited by a histone H2A variant, MacroH2A, and contributes to silencing of the inactive X chromosome. J Biol Chem (2007) 1.53
The role of HOX genes in malignant myeloid disease. Curr Opin Hematol (2007) 1.39
Stem cells primed for action: polycomb repressive complexes restrain the expression of lineage-specific regulators in embryonic stem cells. Cell Cycle (2006) 1.32
macroH2A1 histone variants are depleted on active genes but concentrated on the inactive X chromosome. Mol Cell Biol (2006) 1.28
Expression profiling of lineage differentiation in pluripotential human embryonal carcinoma cells. Cell Growth Differ (2002) 1.22
The methyl-CpG binding protein MBD1 is required for PML-RARalpha function. Proc Natl Acad Sci U S A (2006) 1.17
Abl-kinase-sensitive levels of ERK5 and its intrinsic basal activity contribute to leukaemia cell survival. EMBO Rep (2005) 0.95
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
International network of cancer genome projects. Nature (2010) 20.35
Landscape of transcription in human cells. Nature (2012) 20.18
GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res (2012) 19.19
The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res (2012) 15.41
The Polycomb group protein EZH2 directly controls DNA methylation. Nature (2005) 13.67
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18
Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype. Nature (2004) 11.03
Characterization of mammalian selenoproteomes. Science (2003) 9.07
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41
Nucleosome positioning as a determinant of exon recognition. Nat Struct Mol Biol (2009) 5.14
Modelling and simulating generic RNA-Seq experiments with the flux simulator. Nucleic Acids Res (2012) 4.81
Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Genome Res (2007) 4.33
Comparative gene prediction in human and mouse. Genome Res (2003) 4.13
The GEM mapper: fast, accurate and versatile alignment by filtration. Nat Methods (2012) 3.89
Tandem chimerism as a means to increase protein complexity in the human genome. Genome Res (2005) 3.89
Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAs. Genome Res (2012) 3.83
Pseudogenes in the ENCODE regions: consensus annotation, analysis of transcription, and evolution. Genome Res (2007) 3.82
Functional classification of proteins for the prediction of cellular function from a protein-protein interaction network. Genome Biol (2003) 3.80
A combinatorial code for CPE-mediated translational control. Cell (2008) 3.23
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell (2007) 3.16
Sequence and analysis of chromosome 2 of Dictyostelium discoideum. Nature (2002) 3.01
Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition. Mol Cell (2005) 2.99
Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J (2004) 2.94
Systematic evaluation of spliced alignment programs for RNA-seq data. Nat Methods (2013) 2.92
Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci (2003) 2.87
Modeling gene expression using chromatin features in various cellular contexts. Genome Biol (2012) 2.76
Fast computation and applications of genome mappability. PLoS One (2012) 2.73
ASTD: The Alternative Splicing and Transcript Diversity database. Genomics (2008) 2.72
Improving gene annotation using peptide mass spectrometry. Genome Res (2006) 2.69
Structured RNAs in the ENCODE selected regions of the human genome. Genome Res (2007) 2.69
Are splicing mutations the most frequent cause of hereditary disease? FEBS Lett (2005) 2.68
Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice. J Clin Invest (2004) 2.67
Evaluation of annotation strategies using an entire genome sequence. Bioinformatics (2003) 2.66
Understanding transcriptional regulation by integrative analysis of transcription factor binding data. Genome Res (2012) 2.66
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol Cell Biol (2008) 2.57
Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories. Nat Biotechnol (2013) 2.53
Context-based tourism information filtering with a semantic rule engine. Sensors (Basel) (2012) 2.51
Intussusception risk after rotavirus vaccination in U.S. infants. N Engl J Med (2014) 2.41
The circadian molecular clock creates epidermal stem cell heterogeneity. Nature (2011) 2.34
Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus). Proc Natl Acad Sci U S A (2010) 2.30
The genome of melon (Cucumis melo L.). Proc Natl Acad Sci U S A (2012) 2.24
Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells. Cardiovasc Res (2008) 2.23
Penile length alterations following penile prosthesis surgery. Eur Urol (2006) 2.20
A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci (2004) 2.14
Overall quality of outcomes framework scores lower in practices in deprived areas. Br J Gen Pract (2006) 2.14
Combining RT-PCR-seq and RNA-seq to catalog all genic elements encoded in the human genome. Genome Res (2012) 2.13
Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells. Cell Stem Cell (2012) 2.11
Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution. PLoS Genet (2009) 2.07
Using geneid to identify genes. Curr Protoc Bioinformatics (2007) 2.04
RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells. Cell Rep (2012) 2.03
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. Proc Natl Acad Sci U S A (2013) 2.00
Low rates of testing and diagnostic codes usage in a commercial clinical laboratory: evidence for lack of physician awareness of chronic kidney disease. J Am Soc Nephrol (2005) 1.98
Ablation for longstanding permanent atrial fibrillation: results from a randomized study comparing three different strategies. Heart Rhythm (2008) 1.96
MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer. Gastroenterology (2005) 1.94
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun (2008) 1.92
Recent advances in gene structure prediction. Curr Opin Struct Biol (2004) 1.90
Distance, rurality and the need for care: access to health services in South West England. Int J Health Geogr (2004) 1.90
A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila. Dev Cell (2003) 1.88
Localized cell death focuses mechanical forces during 3D patterning in a biofilm. Proc Natl Acad Sci U S A (2012) 1.82
Comparative analysis of amino acid repeats in rodents and humans. Genome Res (2004) 1.78
1,25-Dihydroxyvitamin D3 but not cinacalcet HCl (Sensipar/Mimpara) treatment mediates aortic calcification in a rat model of secondary hyperparathyroidism. Nephrol Dial Transplant (2005) 1.76
SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane. J Cell Biol (2004) 1.75
Retracted Lysyl oxidase-like 2 deaminates lysine 4 in histone H3. Mol Cell (2012) 1.74
Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10. Eur J Neurosci (2005) 1.73
A general definition and nomenclature for alternative splicing events. PLoS Comput Biol (2008) 1.72
Molecular biology of mosquito vitellogenesis: from basic studies to genetic engineering of antipathogen immunity. Insect Biochem Mol Biol (2002) 1.72
Genome-wide identification of in vivo Drosophila Engrailed-binding DNA fragments and related target genes. Development (2003) 1.70
Electrical isolation of the superior vena cava: an adjunctive strategy to pulmonary vein antrum isolation improving the outcome of AF ablation. J Cardiovasc Electrophysiol (2007) 1.68
Polycomb complexes in stem cells and embryonic development. Development (2013) 1.67
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun (2006) 1.67
Efficient targeted transcript discovery via array-based normalization of RACE libraries. Nat Methods (2008) 1.66
Immune globulins and thrombotic adverse events as recorded in a large administrative database in 2008 through 2010. Transfusion (2012) 1.66
A phase III equivalence trial of azithromycin versus benzathine penicillin for treatment of early syphilis. J Infect Dis (2010) 1.64
Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. J Pharmacol Exp Ther (2003) 1.63
Can calcimimetics inhibit parathyroid hyperplasia? Evidence from preclinical studies. Nephrol Dial Transplant (2007) 1.63
Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer. Cancer Cell (2013) 1.61
Calcimimetic inhibits late-stage cyst growth in ADPKD. J Am Soc Nephrol (2009) 1.58
Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. EMBO Rep (2004) 1.58
Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver. Mol Cell Biol (2009) 1.58
The DART classification of unannotated transcription within the ENCODE regions: associating transcription with known and novel loci. Genome Res (2007) 1.56
High-resolution whole-genome sequencing reveals that specific chromatin domains from most human chromosomes associate with nucleoli. Mol Biol Cell (2010) 1.56
Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia. Genome Res (2013) 1.51
Role of the human immunodeficiency virus type 1 envelope gene in viral fitness. J Virol (2003) 1.51
Pulmonary vein antrum isolation for treatment of atrial fibrillation in patients with valvular heart disease or prior open heart surgery. Heart Rhythm (2004) 1.51
Autologous intervertebral disc cell implantation: a model using Psammomys obesus, the sand rat. Spine (Phila Pa 1976) (2002) 1.50
Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia. Blood (2007) 1.48
Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction. Proc Natl Acad Sci U S A (2006) 1.48
The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains. EMBO J (2011) 1.48
Transthoracic echocardiographic predictors of left atrial appendage thrombus. Am J Cardiol (2005) 1.46
Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4. Cell Stem Cell (2011) 1.45