Published in Proc Natl Acad Sci U S A on April 23, 2008
Photoremovable protecting groups in chemistry and biology: reaction mechanisms and efficacy. Chem Rev (2012) 2.49
Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamics. PLoS Comput Biol (2009) 1.67
Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail. Proc Natl Acad Sci U S A (2012) 1.09
Competing pathways in the photo-Favorskii rearrangement and release of esters: studies on fluorinated p-hydroxyphenacyl-caged GABA and glutamate phototriggers. J Org Chem (2009) 1.05
Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations. Proc Natl Acad Sci U S A (2012) 0.99
Structure and function of Vps15 in the endosomal G protein signaling pathway. Biochemistry (2009) 0.96
Unravelling the mechanism of dual-specificity GAPs. EMBO J (2010) 0.96
Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway. Cell Death Dis (2013) 0.90
A novel Golgi retention signal RPWS for tumor suppressor UBIAD1. PLoS One (2013) 0.88
The role of magnesium for geometry and charge in GTP hydrolysis, revealed by quantum mechanics/molecular mechanics simulations. Biophys J (2012) 0.87
Efforts toward the direct experimental characterization of enzyme microenvironments: tyrosine100 in dihydrofolate reductase. Angew Chem Int Ed Engl (2009) 0.85
Phosphate vibrations probe local electric fields and hydration in biomolecules. J Am Chem Soc (2011) 0.84
The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B. Sci Rep (2016) 0.83
Time-resolved Fourier transform infrared spectroscopy of the nucleotide-binding domain from the ATP-binding Cassette transporter MsbA: ATP hydrolysis is the rate-limiting step in the catalytic cycle. J Biol Chem (2012) 0.81
Overview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras. Mol Simul (2014) 0.79
(19) F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP Hydrolysis. Angew Chem Int Ed Engl (2016) 0.79
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. Small GTPases (2013) 0.78
Exceptionally large entropy contributions enable the high rates of GTP hydrolysis on the ribosome. Sci Rep (2015) 0.77
Stereochemically probing the photo-Favorskii rearrangement: a mechanistic investigation. J Org Chem (2012) 0.77
Pressure and Temperature Effects on the Activity and Structure of the Catalytic Domain of Human MT1-MMP. Biophys J (2015) 0.76
The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects. J Biol Chem (2017) 0.75
Surface-attached polyhistidine-tag proteins characterized by FTIR difference spectroscopy. Chemphyschem (2012) 0.75
Photorelease of phosphates: Mild methods for protecting phosphate derivatives. Beilstein J Org Chem (2014) 0.75
Adenylylation of Tyr77 stabilizes Rab1b GTPase in an active state: A molecular dynamics simulation analysis. Sci Rep (2016) 0.75
Mechanism of the intrinsic arginine finger in heterotrimeric G proteins. Proc Natl Acad Sci U S A (2016) 0.75
Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer (2003) 15.17
Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer (2007) 10.27
The guanine nucleotide-binding switch in three dimensions. Science (2001) 9.34
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science (1997) 9.21
RAS oncogenes: the first 30 years. Nat Rev Cancer (2003) 8.61
GEFs and GAPs: critical elements in the control of small G proteins. Cell (2007) 7.32
Electrostatic basis for enzyme catalysis. Chem Rev (2006) 4.35
What vibrations tell us about proteins. Q Rev Biophys (2002) 4.17
Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue. Nature (1997) 3.55
Substrate twinning activates the signal recognition particle and its receptor. Nature (2004) 2.91
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The entropic cost of bound water in crystals and biomolecules. Science (1994) 2.53
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nat Struct Biol (1997) 2.43
Simultaneous monitoring of light-induced changes in protein side-group protonation, chromophore isomerization, and backbone motion of bacteriorhodopsin by time-resolved Fourier-transform infrared spectroscopy. Proc Natl Acad Sci U S A (1990) 2.38
Heterodimeric GTPase core of the SRP targeting complex. Science (2004) 2.36
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Functional waters in intraprotein proton transfer monitored by FTIR difference spectroscopy. Nature (2005) 2.31
New approaches to molecular cancer therapeutics. Nat Chem Biol (2006) 2.28
Ground state structure of F1-ATPase from bovine heart mitochondria at 1.9 A resolution. J Biol Chem (2007) 2.19
Molecular genetic analysis of a plant virus polyprotein cleavage site: a model. Virology (1989) 2.15
Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature (1997) 1.90
Photoremovable protecting groups: reaction mechanisms and applications. Photochem Photobiol Sci (2002) 1.86
A model-independent approach to assigning bacteriorhodopsin's intramolecular reactions to photocycle intermediates. Biophys J (1993) 1.77
Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy. Biochemistry (1997) 1.49
Ras catalyzes GTP hydrolysis by shifting negative charges from gamma- to beta-phosphate as revealed by time-resolved FTIR difference spectroscopy. Biochemistry (2001) 1.12
Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time. Proc Natl Acad Sci U S A (2001) 1.11
A theoretical investigation of p-hydroxyphenacyl caged phototrigger compounds: an examination of the excited state photochemistry of p-hydroxyphenacyl acetate. J Phys Chem A (2006) 1.08
A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein. Proc Natl Acad Sci U S A (2006) 1.06
Time-resolved FTIR studies of the GTPase reaction of H-ras p21 reveal a key role for the beta-phosphate. Biochemistry (1998) 1.05
G proteins. The arginine finger strikes again. Nature (1997) 1.04
Surface change of Ras enabling effector binding monitored in real time at atomic resolution. Chembiochem (2007) 1.01
The mechanism of Ras GTPase activation by neurofibromin. Biochemistry (2003) 0.97
Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations. FEBS Lett (2007) 0.93
Evidence for a perturbation of arginine-82 in the bacteriorhodopsin photocycle from time-resolved infrared spectra. Biochemistry (2000) 0.89
GTPase catalysis by Ras and other G-proteins: insights from Substrate Directed SuperImposition. J Mol Biol (2003) 0.89
Conformational changes during enzyme catalysis: role of water in the transition state. Proc Natl Acad Sci U S A (1980) 0.86
GEFs and GAPs: critical elements in the control of small G proteins. Cell (2007) 7.32
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science (2005) 5.99
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature (2013) 5.04
Structural insight into filament formation by mammalian septins. Nature (2007) 2.90
It takes two to tango: regulation of G proteins by dimerization. Nat Rev Mol Cell Biol (2009) 2.34
Functional waters in intraprotein proton transfer monitored by FTIR difference spectroscopy. Nature (2005) 2.31
The complex of Arl2-GTP and PDE delta: from structure to function. EMBO J (2002) 2.24
Structure and regulation of the cAMP-binding domains of Epac2. Nat Struct Biol (2003) 2.11
The regulation of mDia1 by autoinhibition and its release by Rho*GTP. EMBO J (2005) 2.10
Capturing cyclic nucleotides in action: snapshots from crystallographic studies. Nat Rev Mol Cell Biol (2007) 2.07
The GTPase-activating protein Rap1GAP uses a catalytic asparagine. Nature (2004) 2.06
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat Chem Biol (2011) 2.00
How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. Nature (2006) 1.92
Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state. Nature (2006) 1.88
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins. Nat Cell Biol (2011) 1.87
Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element. EMBO J (2006) 1.75
The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization. Mol Cell (2004) 1.74
A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat Genet (2009) 1.71
Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy. Mol Cell (2007) 1.67
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex. EMBO J (2003) 1.67
The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat Struct Mol Biol (2008) 1.64
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J (2002) 1.64
A new family of RhoGEFs activates the Rop molecular switch in plants. Nature (2005) 1.64
Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO J (2008) 1.62
The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proc Natl Acad Sci U S A (2004) 1.57
Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac. J Biol Chem (2003) 1.53
RanGAP mediates GTP hydrolysis without an arginine finger. Nature (2002) 1.50
Structural insights into HypB, a GTP-binding protein that regulates metal binding. J Biol Chem (2006) 1.47
Dynamics of water molecules in the bacteriorhodopsin trimer in explicit lipid/water environment. Biophys J (2004) 1.41
Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis. EMBO J (2007) 1.38
Proton binding within a membrane protein by a protonated water cluster. Proc Natl Acad Sci U S A (2005) 1.36
Regulation of dynamic polarity switching in bacteria by a Ras-like G-protein and its cognate GAP. EMBO J (2010) 1.35
GTP-induced conformational changes in septins and implications for function. Proc Natl Acad Sci U S A (2009) 1.35
Nucleotide binding and filament assembly of recombinant yeast septin complexes. Biol Chem (2005) 1.34
The structure of the TrmE GTP-binding protein and its implications for tRNA modification. EMBO J (2004) 1.34
Rap-specific GTPase activating protein follows an alternative mechanism. J Biol Chem (2002) 1.28
The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. EMBO J (2008) 1.28
Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins. J Biol Chem (2007) 1.28
Specificity of interactions between mDia isoforms and Rho proteins. J Biol Chem (2008) 1.27
Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes. Angew Chem Int Ed Engl (2010) 1.25
Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. Hum Mutat (2010) 1.24
GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins. J Biol Chem (2006) 1.22
Structural evidence for a common intermediate in small G protein-GEF reactions. Mol Cell (2007) 1.20
Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac. J Biol Chem (2003) 1.18
Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex. FEBS Lett (2008) 1.17
Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity. EMBO J (2011) 1.16
Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. Structure (2006) 1.15
Proton transfer via a transient linear water-molecule chain in a membrane protein. Proc Natl Acad Sci U S A (2011) 1.15
De novo design of conformationally flexible transmembrane peptides driving membrane fusion. Proc Natl Acad Sci U S A (2004) 1.14
Characterization of the GbpD-activated Rap1 pathway regulating adhesion and cell polarity in Dictyostelium discoideum. J Biol Chem (2006) 1.14
Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway. FEBS Lett (2009) 1.13
N-Ras forms dimers at POPC membranes. Biophys J (2012) 1.13
Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. EMBO J (2012) 1.12
Structural basis of slow activation gating in the cardiac I Ks channel complex. Cell Physiol Biochem (2011) 1.11
Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail. Proc Natl Acad Sci U S A (2012) 1.09
Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy. FEBS Lett (2004) 1.08
Synthesis of the Rheb and K-Ras4B GTPases. Angew Chem Int Ed Engl (2010) 1.07
In channelrhodopsin-2 Glu-90 is crucial for ion selectivity and is deprotonated during the photocycle. J Biol Chem (2012) 1.06
A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein. Proc Natl Acad Sci U S A (2006) 1.06
Proteins in action monitored by time-resolved FTIR spectroscopy. Chemphyschem (2005) 1.06
The assignment of the different infrared continuum absorbance changes observed in the 3000-1800-cm(-1) region during the bacteriorhodopsin photocycle. Biophys J (2004) 1.06
Fluorescence methods in the study of small GTP-binding proteins. Methods Mol Biol (2002) 1.05
Coupling of light-induced electron transfer to proton uptake in photosynthesis. Nat Struct Biol (2003) 1.02
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2. Biochim Biophys Acta (2003) 1.02
Theoretical IR spectroscopy based on QM/MM calculations provides changes in charge distribution, bond lengths, and bond angles of the GTP ligand induced by the Ras-protein. Biophys J (2005) 1.02
Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction? Mol Cell Biol (2003) 1.02
Fourier transform infrared spectroscopy on the Rap.RapGAP reaction, GTPase activation without an arginine finger. J Biol Chem (2004) 1.02
The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism. Cell (2010) 1.02
Surface change of Ras enabling effector binding monitored in real time at atomic resolution. Chembiochem (2007) 1.01
Kissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopy. PLoS Biol (2009) 1.01
Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc Natl Acad Sci U S A (2012) 0.99
Lipidated ras and rab peptides and proteins--synthesis, structure, and function. Angew Chem Int Ed Engl (2006) 0.99
Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations. Proc Natl Acad Sci U S A (2012) 0.99
The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo. EMBO Rep (2013) 0.98
Prediction of a ligand-binding niche within a human olfactory receptor by combining site-directed mutagenesis with dynamic homology modeling. Angew Chem Int Ed Engl (2011) 0.98
Rho proteins of plants--functional cycle and regulation of cytoskeletal dynamics. Eur J Cell Biol (2011) 0.98
G-domain dimerization orchestrates the tRNA wobble modification reaction in the MnmE/GidA complex. J Mol Biol (2009) 0.97
A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected]. Mol Biol Cell (2010) 0.96
Structural changes of membrane-anchored native PrP(C). Proc Natl Acad Sci U S A (2008) 0.96
Unravelling the mechanism of dual-specificity GAPs. EMBO J (2010) 0.96
Structure and function of Rho-type molecular switches in plants. Plant Physiol Biochem (2007) 0.95
Directional proton transfer in membrane proteins achieved through protonated protein-bound water molecules: a proton diode. Angew Chem Int Ed Engl (2010) 0.94
Properties of the interaction of Arf-like protein 2 with PDEdelta. J Mol Biol (2005) 0.94
Immunohistochemistry, histopathology and infrared spectral histopathology of colon cancer tissue sections. J Biophotonics (2012) 0.93
Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations. FEBS Lett (2007) 0.93
Conformational states of Ras complexed with the GTP analogue GppNHp or GppCH2p: implications for the interaction with effector proteins. Biochemistry (2005) 0.93
Structural and biochemical properties of Sept7, a unique septin required for filament formation. Biol Chem (2011) 0.92
Light-induced reactions of Escherichia coli DNA photolyase monitored by Fourier transform infrared spectroscopy. FEBS J (2005) 0.92
RPGR and RP2: targets for the treatment of X-linked retinitis pigmentosa? Expert Opin Ther Targets (2009) 0.91
Amino acids of the bacterial toxin SopE involved in G nucleotide exchange on Cdc42. J Biol Chem (2003) 0.91
Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach. J Mol Biol (2006) 0.89
Marker-free automated histopathological annotation of lung tumour subtypes by FTIR imaging. Analyst (2015) 0.89