PubRank

Yoshinori Ohsumi

Author PubWeight™ 294.75‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The role of autophagy during the early neonatal starvation period. Nature 2004 22.40
2 Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005 18.60
3 In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2003 17.55
4 Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003 16.67
5 Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 2009 9.32
6 LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci 2004 9.20
7 A unified nomenclature for yeast autophagy-related genes. Dev Cell 2003 9.18
8 The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol 2011 8.18
9 Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell 2007 7.11
10 Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci 2003 6.50
11 The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem 2007 6.28
12 Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells 2007 6.14
13 Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell 2009 5.85
14 Autophagosome formation in mammalian cells. Cell Struct Funct 2002 5.58
15 Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem 2002 4.27
16 Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Mol Biol Cell 2005 4.02
17 Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae. FEBS Lett 2007 3.65
18 Leaf senescence and starvation-induced chlorosis are accelerated by the disruption of an Arabidopsis autophagy gene. Plant Physiol 2002 3.47
19 Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells 2008 3.23
20 Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy. Plant Cell 2004 3.17
21 Tor directly controls the Atg1 kinase complex to regulate autophagy. Mol Cell Biol 2009 2.86
22 Atg8-family interacting motif crucial for selective autophagy. FEBS Lett 2010 2.83
23 Yeast autophagosomes: de novo formation of a membrane structure. Trends Cell Biol 2002 2.69
24 Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem 2005 2.64
25 Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae. Mol Biol Cell 2006 2.63
26 Organization of the pre-autophagosomal structure responsible for autophagosome formation. Mol Biol Cell 2008 2.49
27 Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Mol Cell Biol 2005 2.44
28 Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis. Plant Cell 2009 2.32
29 The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J 2009 2.25
30 In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy. J Biol Chem 2004 2.21
31 Structure of Atg5.Atg16, a complex essential for autophagy. J Biol Chem 2006 2.18
32 Atg9 vesicles are an important membrane source during early steps of autophagosome formation. J Cell Biol 2012 2.12
33 AtATG genes, homologs of yeast autophagy genes, are involved in constitutive autophagy in Arabidopsis root tip cells. Plant Cell Physiol 2006 2.06
34 The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8. Genes Cells 2004 1.98
35 Autophagy in development and stress responses of plants. Autophagy 2006 1.93
36 Mobilization of rubisco and stroma-localized fluorescent proteins of chloroplasts to the vacuole by an ATG gene-dependent autophagic process. Plant Physiol 2008 1.91
37 The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function. J Biol Chem 2008 1.89
38 Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae. Biochem Biophys Res Commun 2007 1.87
39 The early secretory pathway contributes to autophagy in yeast. Cell Struct Funct 2003 1.83
40 Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae. Genes Cells 2008 1.74
41 Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Biochem Biophys Res Commun 2005 1.73
42 Current knowledge of the pre-autophagosomal structure (PAS). FEBS Lett 2010 1.72
43 Autophagy plays a role in chloroplast degradation during senescence in individually darkened leaves. Plant Physiol 2008 1.72
44 Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy. EMBO Rep 2006 1.72
45 Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy. J Biol Chem 2005 1.70
46 Studies of cargo delivery to the vacuole mediated by autophagosomes in Saccharomyces cerevisiae. Dev Cell 2002 1.68
47 The crystal structure of plant ATG12 and its biological implication in autophagy. Autophagy 2005 1.63
48 Starvation triggers the delivery of the endoplasmic reticulum to the vacuole via autophagy in yeast. Traffic 2005 1.62
49 Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae. J Biol Chem 2004 1.60
50 SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation. Cell Struct Funct 2002 1.58
51 The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation. J Biol Chem 2007 1.55
52 Characterization of a novel autophagy-specific gene, ATG29. Biochem Biophys Res Commun 2005 1.54
53 Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis. Autophagy 2012 1.52
54 Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction. PLoS One 2011 1.51
55 Atg17 recruits Atg9 to organize the pre-autophagosomal structure. Genes Cells 2009 1.50
56 PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans. J Clin Invest 2008 1.45
57 An Arabidopsis homolog of yeast ATG6/VPS30 is essential for pollen germination. Plant Physiol 2007 1.44
58 Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae. Biochem Biophys Res Commun 2009 1.44
59 In vitro reconstitution of plant Atg8 and Atg12 conjugation systems essential for autophagy. J Biol Chem 2007 1.43
60 Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae. J Cell Sci 2013 1.42
61 Structural basis of Atg8 activation by a homodimeric E1, Atg7. Mol Cell 2011 1.38
62 Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, Atg34p. J Biol Chem 2010 1.34
63 Structure-function relationship of Atg12, a ubiquitin-like modifier essential for autophagy. Autophagy 2005 1.32
64 Interrelationships among Atg proteins during autophagy in Saccharomyces cerevisiae. Yeast 2004 1.28
65 A sorting nexin PpAtg24 regulates vacuolar membrane dynamics during pexophagy via binding to phosphatidylinositol-3-phosphate. Mol Biol Cell 2004 1.26
66 The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy. J Biochem 2002 1.24
67 Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method. FEBS Lett 2002 1.22
68 Autophagy-related protein 8 (Atg8) family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm-to-vacuole targeting pathway. J Biol Chem 2010 1.20
69 Modification of a ubiquitin-like protein Paz2 conducted micropexophagy through formation of a novel membrane structure. Mol Biol Cell 2003 1.20
70 Highly oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis. Plant Cell 2013 1.18
71 Dimeric coiled-coil structure of Saccharomyces cerevisiae Atg16 and its functional significance in autophagy. J Biol Chem 2009 1.17
72 Role of the Apg12 conjugation system in mammalian autophagy. Int J Biochem Cell Biol 2003 1.15
73 Structure-based analyses reveal distinct binding sites for Atg2 and phosphoinositides in Atg18. J Biol Chem 2012 1.13
74 Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site. Nat Struct Mol Biol 2013 1.11
75 PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast. J Lipids 2011 1.11
76 Lap3 is a selective target of autophagy in yeast, Saccharomyces cerevisiae. Biochem Biophys Res Commun 2008 1.10
77 Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy. J Biol Chem 2012 1.09
78 ATG systems from the protein structural point of view. Chem Rev 2009 1.09
79 Structure of the Atg12-Atg5 conjugate reveals a platform for stimulating Atg8-PE conjugation. EMBO Rep 2012 1.07
80 Atg9 vesicles recruit vesicle-tethering proteins Trs85 and Ypt1 to the autophagosome formation site. J Biol Chem 2012 1.07
81 The yeast Tor signaling pathway is involved in G2/M transition via polo-kinase. PLoS One 2008 1.06
82 Atg14: a key player in orchestrating autophagy. Int J Cell Biol 2011 1.05
83 Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. J Cell Biol 2013 1.04
84 A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. J Biol Chem 2004 1.02
85 Organ-specific quality control of plant peroxisomes is mediated by autophagy. J Cell Sci 2014 1.01
86 Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34. J Biol Chem 2010 1.01
87 Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy. J Biol Chem 2012 1.00
88 Structural insights into Atg10-mediated formation of the autophagy-essential Atg12-Atg5 conjugate. Structure 2012 1.00
89 Physiological pH and acidic phospholipids contribute to substrate specificity in lipidation of Atg8. J Biol Chem 2008 0.99
90 Dynamics and function of PtdIns(3)P in autophagy. Autophagy 2008 0.98
91 Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7. Nat Struct Mol Biol 2012 0.96
92 A landmark protein essential for mitophagy: Atg32 recruits the autophagic machinery to mitochondria. Autophagy 2009 0.96
93 The NMR structure of the autophagy-related protein Atg8. J Biomol NMR 2010 0.96
94 Selective autophagy regulates insertional mutagenesis by the Ty1 retrotransposon in Saccharomyces cerevisiae. Dev Cell 2011 0.94
95 Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast. Biochemistry 2004 0.92
96 OsATG10b, an autophagosome component, is needed for cell survival against oxidative stresses in rice. Mol Cells 2009 0.91
97 The amino-terminal region of Atg3 is essential for association with phosphatidylethanolamine in Atg8 lipidation. FEBS Lett 2009 0.90
98 The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation. J Biol Chem 2012 0.90
99 Novel families of vacuolar amino acid transporters. IUBMB Life 2008 0.90
100 SDS-PAGE techniques to study ubiquitin-like conjugation systems in yeast autophagy. Methods Mol Biol 2012 0.87
101 Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS-targeted Atg2. FEBS Lett 2012 0.83
102 Crystallization and preliminary crystallographic analysis of human Atg4B-LC3 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 0.83
103 Lipidation of Atg8: how is substrate specificity determined without a canonical E3 enzyme? Autophagy 2008 0.82
104 Crystallization of the Atg12-Atg5 conjugate bound to Atg16 by the free-interface diffusion method. J Synchrotron Radiat 2008 0.81
105 Crystallization of Saccharomyces cerevisiae aminopeptidase 1, the major cargo protein of the Cvt pathway. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 0.81
106 Crystallization of Saccharomyces cerevisiae alpha-mannosidase, a cargo protein of the Cvt pathway. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 0.80
107 Starved cells eat ribosomes. Nat Cell Biol 2008 0.79
108 Crystallization of the coiled-coil domain of Atg16 essential for autophagy. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 0.79
109 Crystallization and preliminary X-ray analysis of LC3-I. Acta Crystallogr D Biol Crystallogr 2003 0.78
110 Crystallization and preliminary X-ray analysis of Atg3. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 0.77
111 [Key questions about membrane dynamics during autophagy]. Seikagaku 2008 0.77
112 Expression, purification and crystallization of the Atg5-Atg16 complex essential for autophagy. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 0.76
113 Crystallization and preliminary X-ray analysis of Atg10. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 0.76
114 Two-colored fluorescence correlation spectroscopy screening for LC3-P62 interaction inhibitors. J Biomol Screen 2013 0.76
115 [The pre-autophagosomal structure (PAS), required for the formation of autophagosome membrane]. Seikagaku 2003 0.76
116 [Involvement of the secretory pathway in the autophagosome formation]. Tanpakushitsu Kakusan Koso 2006 0.76
117 apg15-1, a UGA mutant allele in the Saccharomyces cerevisiae APG16 gene, and its suppression by a cytoplasmic factor. Biosci Biotechnol Biochem 2004 0.75
118 Yoshinori Ohsumi: autophagy from beginning to end. Interview by Caitlin Sedwick. J Cell Biol 2012 0.75
119 [Physiological role of autophagy for starvation-adaptation in yeast]. Tanpakushitsu Kakusan Koso 2006 0.75
120 [Molecular mechanisms of autophagy in yeast]. Tanpakushitsu Kakusan Koso 2008 0.75