Modes of p53 regulation.

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet (2012) 5.28

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96

Signaling to p53: ribosomal proteins find their way. Cancer Cell (2009) 3.84

The nucleolus under stress. Mol Cell (2010) 3.63

Self-consumption: the interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol (2014) 3.38

Transcriptional regulation by p53. Cold Spring Harb Perspect Biol (2010) 3.16

The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol (2010) 3.08

Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol (2010) 2.87

MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat Rev Cancer (2012) 2.78

AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75

Intrinsically disordered proteins in cellular signalling and regulation. Nat Rev Mol Cell Biol (2015) 2.69

p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54

Depletion of ribosomal protein L37 occurs in response to DNA damage and activates p53 through the L11/MDM2 pathway. Cell Cycle (2010) 2.41

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40

Posttranslational modification of p53: cooperative integrators of function. Cold Spring Harb Perspect Biol (2009) 2.34

The origin of allosteric functional modulation: multiple pre-existing pathways. Structure (2009) 2.33

Downmodulation of tumor suppressor p53 by T cell receptor signaling is critical for antigen-specific CD4(+) T cell responses. Immunity (2014) 2.27

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor. Genes Dev (2010) 2.27

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. EMBO J (2010) 2.25

Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science (2015) 2.20

Tumor suppressive functions of p53. Cold Spring Harb Perspect Biol (2009) 2.10

The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury. Physiol Genomics (2012) 2.08

Ferroptosis as a p53-mediated activity during tumour suppression. Nature (2015) 2.06

Distinct p53 genomic binding patterns in normal and cancer-derived human cells. Cell Cycle (2011) 2.01

Metabolic regulation by p53 family members. Cell Metab (2013) 2.00

Cancer as a metabolic disease. Nutr Metab (Lond) (2010) 1.98

Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells. Mol Cell (2012) 1.94

p53 at a glance. J Cell Sci (2010) 1.88

Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87

The multiple levels of regulation by p53 ubiquitination. Cell Death Differ (2010) 1.87

Gene copy-number alterations: a cost-benefit analysis. Cell (2013) 1.79

Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene (2010) 1.78

When ribosomes go bad: diseases of ribosome biogenesis. Mol Biosyst (2010) 1.76

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature (2010) 1.71

Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis. J Clin Invest (2013) 1.68

The impact of acetylation and deacetylation on the p53 pathway. Protein Cell (2011) 1.66

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo. Proc Natl Acad Sci U S A (2011) 1.66

The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage. Cell Res (2012) 1.66

Emerging roles for chromatin as a signal integration and storage platform. Nat Rev Mol Cell Biol (2013) 1.65

The ubiquitin proteasome system in neuropathology. Acta Neuropathol (2009) 1.65

Two-phase dynamics of p53 in the DNA damage response. Proc Natl Acad Sci U S A (2011) 1.65

The tumor suppressor p53: from structures to drug discovery. Cold Spring Harb Perspect Biol (2010) 1.64

Arabidopsis PHYTOCHROME INTERACTING FACTOR proteins promote phytochrome B polyubiquitination by COP1 E3 ligase in the nucleus. Plant Cell (2010) 1.59

Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry. Genes Dev (2013) 1.57

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature (2016) 1.56

Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol (2014) 1.54

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52

p53 regulation by ubiquitin. FEBS Lett (2011) 1.51

Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activity. J Biol Chem (2012) 1.45

53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms. Mol Cell (2016) 1.44

Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice. J Clin Invest (2011) 1.42

Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol (2010) 1.41

A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.41

ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. Mol Cell (2012) 1.40

Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci U S A (2010) 1.39

SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell (2013) 1.38

Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas. Genes Dev (2011) 1.37

Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3'-end processing and function during DNA damage. Genes Dev (2011) 1.37

p53 ancestry: gazing through an evolutionary lens. Nat Rev Cancer (2009) 1.37

Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Sci Transl Med (2010) 1.35

Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy. Cell Cycle (2012) 1.32

Oxidative stress and pulmonary fibrosis. Biochim Biophys Acta (2012) 1.31

Oncogenes and tumor suppressor genes. Cold Spring Harb Perspect Biol (2010) 1.31

A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes Dev (2014) 1.31

SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J Biol Chem (2010) 1.30

Push back to respond better: regulatory inhibition of the DNA double-strand break response. Nat Rev Mol Cell Biol (2013) 1.29

WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte death. Cell Signal (2010) 1.28

The p53 pathway as a target in cancer therapeutics: obstacles and promise. Sci Transl Med (2011) 1.28

Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J Clin Invest (2010) 1.27

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination. J Biol Chem (2011) 1.27

The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes. Nat Rev Cancer (2012) 1.27

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Mol Cell (2011) 1.27

Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia. Blood (2010) 1.27

USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. EMBO J (2011) 1.26

Regulation of cell differentiation by the DNA damage response. Trends Cell Biol (2011) 1.25

Surf the post-translational modification network of p53 regulation. Int J Biol Sci (2012) 1.25

Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury. J Am Soc Nephrol (2014) 1.24

Regulation of p53: a collaboration between Mdm2 and Mdmx. Oncotarget (2012) 1.24

Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity. Nat Commun (2012) 1.24

The regulation of the p53-mediated stress response by MDM2 and MDM4. Cold Spring Harb Perspect Biol (2010) 1.23

Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network. PLoS One (2013) 1.22

GSK-3β: A Bifunctional Role in Cell Death Pathways. Int J Cell Biol (2012) 1.21

p53-mediated apoptosis requires inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A (2010) 1.20

Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis. Biochim Biophys Acta (2013) 1.20

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53. Nucleic Acids Res (2010) 1.20

Ribosomal protein S14 unties the MDM2-p53 loop upon ribosomal stress. Oncogene (2012) 1.19

S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. EMBO J (2010) 1.18

Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. J Biol Chem (2010) 1.18

A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO Mol Med (2012) 1.18

EDD inhibits ATM-mediated phosphorylation of p53. J Biol Chem (2011) 1.17

Role of the lncRNA-p53 regulatory network in cancer. J Mol Cell Biol (2014) 1.16

Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion. Oncogene (2012) 1.16

Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration. Proc Natl Acad Sci U S A (2011) 1.16

Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA. J Biol Chem (2011) 1.13

SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage. EMBO J (2012) 1.12

Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation. Mol Cell Biol (2009) 1.12

High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assays. PLoS One (2011) 1.11

RNA content in the nucleolus alters p53 acetylation via MYBBP1A. EMBO J (2011) 1.11

A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. Proc Natl Acad Sci U S A (2010) 1.11

The functional diversity of protein lysine methylation. Mol Syst Biol (2014) 1.11

Translating the histone code. Science (2001) 56.77

Surfing the p53 network. Nature (2000) 35.36

p53, the cellular gatekeeper for growth and division. Cell (1997) 31.04

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science (2004) 24.42

Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26

A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65

Regulation of p53 stability by Mdm2. Nature (1997) 18.20

T antigen is bound to a host protein in SV40-transformed cells. Nature (1979) 17.78

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell (1997) 16.79

Cancer. p53, guardian of the genome. Nature (1992) 16.36

Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell (2004) 16.15

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97

Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05

Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell (1979) 14.05

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science (1994) 13.51

Definition of a consensus binding site for p53. Nat Genet (1992) 12.76

The p53 proto-oncogene can act as a suppressor of transformation. Cell (1989) 11.67

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53

p53 in health and disease. Nat Rev Mol Cell Biol (2007) 11.33

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett (1997) 11.19

CBP/p300 in cell growth, transformation, and development. Genes Dev (2000) 10.76

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell (1997) 10.52

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature (1995) 10.18

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science (2004) 9.52

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14

p53 has a direct apoptogenic role at the mitochondria. Mol Cell (2003) 8.98

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer (2006) 8.83

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (1995) 8.68

A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature (2004) 8.67

Tumor suppression by Ink4a-Arf: progress and puzzles. Curr Opin Genet Dev (2003) 8.00

DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev (1998) 7.78

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc Natl Acad Sci U S A (1979) 6.93

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem (2000) 6.92

Identification of p53 as a sequence-specific DNA-binding protein. Science (1991) 6.60

Regulation of the specific DNA binding function of p53. Cell (1992) 6.16

Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97

Regulation of p53 activity through lysine methylation. Nature (2004) 5.78

Nucleolar Arf sequesters Mdm2 and activates p53. Nat Cell Biol (1999) 5.78

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev (2000) 5.72

Acetylation is indispensable for p53 activation. Cell (2008) 5.70

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64

p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol (2004) 5.56

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol (2003) 5.46

Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell (2003) 5.44

Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem (2001) 5.43

Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40

Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell (2004) 5.30

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23

Divorcing ARF and p53: an unsettled case. Nat Rev Cancer (2006) 5.17

The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature (2004) 5.05

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell (2003) 4.96

Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature (2000) 4.93

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature (2000) 4.90

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol (1999) 4.88

p53 and human cancer: the first ten thousand mutations. Adv Cancer Res (2000) 4.71

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J (1999) 4.69

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A (2006) 4.68

DBC1 is a negative regulator of SIRT1. Nature (2008) 4.66

Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol (2003) 4.61

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60

p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53

Repression of p53 activity by Smyd2-mediated methylation. Nature (2006) 4.51

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell (2004) 4.46

The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol (2003) 4.46

ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell (2001) 4.38

Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet (2001) 4.23

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol (2004) 4.08

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci U S A (2008) 4.07

A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Science (1995) 3.74

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol Cell (2001) 3.74

Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell (2007) 3.68

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell (1991) 3.59

hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell (2007) 3.56

Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ (2006) 3.53

Latent and active p53 are identical in conformation. Nat Struct Biol (2001) 3.47

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Annu Rev Pharmacol Toxicol (2009) 3.47

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell (2008) 3.38

Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J (2001) 3.37

Two cellular proteins that bind to wild-type but not mutant p53. Proc Natl Acad Sci U S A (1994) 3.30

Regulation of p53 function and stability by phosphorylation. Mol Cell Biol (1999) 3.24

Yin Yang 1 is a negative regulator of p53. Cell (2004) 3.24

Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell (2007) 3.20

p300/CBP and cancer. Oncogene (2004) 3.13

Stress signals utilize multiple pathways to stabilize p53. Mol Cell Biol (2000) 3.12

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J (2004) 3.10

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol (2002) 3.10

Critical role for Daxx in regulating Mdm2. Nat Cell Biol (2006) 2.96

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ (2006) 2.95

Arginine methylation regulates the p53 response. Nat Cell Biol (2008) 2.94

Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc Natl Acad Sci U S A (2001) 2.92

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors. Nat Chem Biol (2006) 2.91

Tumour suppression: disruption of HAUSP gene stabilizes p53. Nature (2004) 2.83

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proc Natl Acad Sci U S A (2003) 2.73

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72

A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol Cell (1999) 2.71

Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71

Acetylation is indispensable for p53 activation. Cell (2008) 5.70

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64

p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol (2003) 5.46

SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96

SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60

Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33

Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14

A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05

Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37

How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17

Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11

Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06

Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06

Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72

A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59

p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35

Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood (2006) 2.06

Microfluidics for flow cytometric analysis of cells and particles. Physiol Meas (2005) 2.00

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92

Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91

Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82

SnapShot: p53 posttranslational modifications. Cell (2008) 1.75

Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell (2009) 1.72

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature (2010) 1.71

Improving genome assemblies by sequencing PCR products with PacBio. Biotechniques (2012) 1.70

Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Anal Chem (2005) 1.70

Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression. Mol Cell (2013) 1.67

The impact of acetylation and deacetylation on the p53 pathway. Protein Cell (2011) 1.66

Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54

α-adducin Gly460Trp polymorphism and essential hypertension risk in Chinese: a meta-analysis. Hypertens Res (2011) 1.51

p53 regulation by ubiquitin. FEBS Lett (2011) 1.51

p53-Dependent and p53-independent activation of autophagy by ARF. Cancer Res (2008) 1.50

Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation. Genes Dev (2008) 1.50

Clinical relevance of the TLR4 11367 polymorphism in patients with major trauma. Arch Surg (2009) 1.42

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol (2013) 1.36

ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription. Mol Cell Biol (2007) 1.35

Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33

Dynamics in the p53-Mdm2 ubiquitination pathway. Cell Cycle (2004) 1.33

Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys. J Pharmacol Exp Ther (2009) 1.29

Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem (2008) 1.27

FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J Biol Chem (2006) 1.26

Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell Metab (2011) 1.23

MSL2 promotes Mdm2-independent cytoplasmic localization of p53. J Biol Chem (2008) 1.21

Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. Biochem Biophys Res Commun (2004) 1.18

Mechanism of fast peptide recognition by SH3 domains. Angew Chem Int Ed Engl (2008) 1.17

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17

Artificial polyploidy improves bacterial single cell genome recovery. PLoS One (2012) 1.10

Cyclophilin A binds to linear peptide motifs containing a consensus that is present in many human proteins. J Biol Chem (2005) 1.09

Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells. Am J Pathol (2010) 1.08

Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. World J Gastroenterol (2007) 1.08

New insights into p53 activation. Cell Res (2010) 1.06

Identification and comparative analysis of the Eriocheir sinensis microRNA transcriptome response to Spiroplasma eriocheiris infection using a deep sequencing approach. Fish Shellfish Immunol (2011) 1.06

Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A (2011) 1.04

Potential roles of N-glycosylation in cell adhesion. Glycoconj J (2012) 1.04

Draft Genome Sequence of Methylomicrobium buryatense Strain 5G, a Haloalkaline-Tolerant Methanotrophic Bacterium. Genome Announc (2013) 1.04

[Epidemiological survey of mental illnesses in the people aged 15 and older in Zhejiang Province, China]. Zhonghua Yu Fang Yi Xue Za Zhi (2005) 1.04

Handheld recirculation system and customized media for microfluidic cell culture. Lab Chip (2005) 1.03

Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor. Mol Biol Cell (2008) 1.03

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. J Virol (2009) 1.03

Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor β1 (TGF-β1) in epithelial cell lines. J Biol Chem (2012) 1.03

Monoubiquitination: the signal for p53 nuclear export? Cell Cycle (2004) 1.02

SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol (2011) 1.02

SIRT1: Regulator of p53 Deacetylation. Genes Cancer (2013) 1.01

To be, or not to be: functional dilemma of p53 metabolic regulation. Curr Opin Oncol (2014) 1.00

Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J Biol Chem (2011) 1.00

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