Published in Diabetes on August 03, 2010
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Hypothalamic nutrient sensing activates a forebrain-hindbrain neuronal circuit to regulate glucose production in vivo. Diabetes (2010) 0.94
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Glucose transporter-1 in the hypothalamic glial cells mediates glucose sensing to regulate glucose production in vivo. Diabetes (2011) 0.93
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Hypothalamic glucagon signals through the KATP channels to regulate glucose production. Mol Metab (2013) 0.83
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Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes. J Biol Chem (2013) 0.81
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Targeted inactivation of GPR26 leads to hyperphagia and adiposity by activating AMPK in the hypothalamus. PLoS One (2012) 0.77
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Central nervous system control of food intake and body weight. Nature (2006) 11.89
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature (2004) 7.64
A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell (2001) 5.57
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes (2002) 5.21
AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem (2004) 3.84
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab (2007) 3.43
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest (2007) 3.32
Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med (2003) 3.21
Central administration of oleic acid inhibits glucose production and food intake. Diabetes (2002) 2.91
Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med (2004) 2.80
Hypothalamic sensing of fatty acids. Nat Neurosci (2005) 2.67
Regulation of blood glucose by hypothalamic pyruvate metabolism. Science (2005) 2.28
Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology (2009) 1.92
Molecular disruption of hypothalamic nutrient sensing induces obesity. Nat Neurosci (2006) 1.87
Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. J Biol Chem (2005) 1.83
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J (2003) 1.77
Neuronal regulation of homeostasis by nutrient sensing. Nat Med (2010) 1.61
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci U S A (2007) 1.61
Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. Proc Natl Acad Sci U S A (2000) 1.46
Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia. Diabetes (2007) 1.42
A role for hypothalamic malonyl-CoA in the control of food intake. J Biol Chem (2005) 1.28
Nutritional status, cognition, and survival: a new role for leptin and AMP kinase. J Biol Chem (2005) 1.14
A balance of lipid-sensing mechanisms in the brain and liver. Cell Metab (2007) 1.11
Hypoglycaemic effect of AICAriboside in mice. Diabetologia (1996) 1.08
Hypothalamic protein kinase C regulates glucose production. Diabetes (2008) 1.07
CNS regulation of glucose homeostasis. Physiology (Bethesda) (2009) 1.06
Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proc Natl Acad Sci U S A (2008) 1.02
Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake. Diabetes (2009) 0.96
Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance. Mol Cell Biol (2010) 0.90
Hypothalamic K(ATP) channels control hepatic glucose production. Nature (2005) 4.56
The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem (2004) 3.31
Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production. Nature (2008) 3.31
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci (2008) 2.99
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes (2009) 2.92
Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes. Nat Med (2012) 2.48
Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis. Nat Methods (2009) 2.23
Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells. Diabetes (2005) 2.20
MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines. J Biol Chem (2007) 2.15
Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem J (2003) 2.02
Multiple forms of "kiss-and-run" exocytosis revealed by evanescent wave microscopy. Curr Biol (2003) 1.98
Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing. Biochem J (2004) 1.97
Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. J Clin Invest (2006) 1.94
Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1. J Cell Sci (2004) 1.92
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. Diabetes (2009) 1.90
Molecular disruption of hypothalamic nutrient sensing induces obesity. Nat Neurosci (2006) 1.87
Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K(+) channels. J Physiol (2002) 1.80
Loss of brain volume in endogenous Cushing's syndrome and its reversibility after correction of hypercortisolism. J Clin Endocrinol Metab (2002) 1.79
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J (2003) 1.77
Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells. Mol Biol Cell (2005) 1.69
Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells. Am J Hum Genet (2007) 1.62
Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6). J Biol Chem (2003) 1.59
Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells. Biochem J (2003) 1.58
miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1). Mol Cell Biol (2011) 1.55
Mechanisms of dense core vesicle recapture following "kiss and run" ("cavicapture") exocytosis in insulin-secreting cells. J Biol Chem (2004) 1.48
Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM. J Clin Invest (2004) 1.44
Intestinal cholecystokinin controls glucose production through a neuronal network. Cell Metab (2009) 1.37
ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells. J Lipid Res (2006) 1.34
Expanding role of AMPK in endocrinology. Trends Endocrinol Metab (2006) 1.29
Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver. Mol Pharmacol (2006) 1.29
Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. Proc Natl Acad Sci U S A (2004) 1.27
Lipotoxicity disrupts incretin-regulated human β cell connectivity. J Clin Invest (2013) 1.27
Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells. Biochim Biophys Acta (2009) 1.27
Glucose-stimulated oscillations in free cytosolic ATP concentration imaged in single islet beta-cells: evidence for a Ca2+-dependent mechanism. Diabetes (2002) 1.26
N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress. Am J Physiol Endocrinol Metab (2003) 1.25
Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab (2004) 1.23
Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress. Hum Mol Genet (2007) 1.23
5'-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics. J Biol Chem (2003) 1.22
Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure. Am J Physiol Endocrinol Metab (2006) 1.21
LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo. Am J Physiol Endocrinol Metab (2010) 1.21
Involvement of conventional kinesin in glucose-stimulated secretory granule movements and exocytosis in clonal pancreatic beta-cells. J Cell Sci (2002) 1.20
Identification of genes selectively disallowed in the pancreatic islet. Islets (2010) 1.20
Dynamics of glucose-induced membrane recruitment of protein kinase C beta II in living pancreatic islet beta-cells. J Biol Chem (2002) 1.19
The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells. PLoS One (2012) 1.18
ATP regulation in adult rat cardiomyocytes: time-resolved decoding of rapid mitochondrial calcium spiking imaged with targeted photoproteins. J Biol Chem (2006) 1.14
Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention. Diabetes (2009) 1.14
Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells. Diabetes (2007) 1.13
Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations. EMBO J (2004) 1.12
Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells. Diabetes (2009) 1.12
A balance of lipid-sensing mechanisms in the brain and liver. Cell Metab (2007) 1.11
Hypothalamic glucagon signaling inhibits hepatic glucose production. Nat Med (2013) 1.11
TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells. Biochem Soc Trans (2008) 1.11
Hypothalamic resistin induces hepatic insulin resistance. J Clin Invest (2007) 1.10
A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults. Diabetes (2008) 1.10
Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. J Biol Chem (2010) 1.08
Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR). Proc Natl Acad Sci U S A (2011) 1.08
Activation of central lactate metabolism lowers glucose production in uncontrolled diabetes and diet-induced insulin resistance. Diabetes (2008) 1.07
Regulation of ATP production by mitochondrial Ca(2+). Cell Calcium (2012) 1.07
Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis. J Biol Chem (2005) 1.07
Hypothalamic protein kinase C regulates glucose production. Diabetes (2008) 1.07
CNS regulation of glucose homeostasis. Physiology (Bethesda) (2009) 1.06
Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cells. J Biol Chem (2011) 1.06
Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism. Diabetes (2005) 1.05
Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology (2010) 1.04
A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation. EMBO Rep (2009) 1.04
Kinesin I and cytoplasmic dynein orchestrate glucose-stimulated insulin-containing vesicle movements in clonal MIN6 beta-cells. Biochem Biophys Res Commun (2003) 1.04
Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing. Diabetes (2004) 1.03
Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysis. Am J Physiol Endocrinol Metab (2006) 1.03
The AMP-regulated kinase family: enigmatic targets for diabetes therapy. Mol Cell Endocrinol (2008) 1.03
Mitochondrial localization as a determinant of capacitative Ca2+ entry in HeLa cells. Cell Calcium (2004) 1.03
Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic beta-cells. Diabetes (2006) 1.01
Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency. J Biol Chem (2004) 1.01
Animal models of GWAS-identified type 2 diabetes genes. J Diabetes Res (2013) 1.01
Glucose is necessary for embryonic pancreatic endocrine cell differentiation. J Biol Chem (2007) 1.01
Mitochondrial and ER-targeted eCALWY probes reveal high levels of free Zn2+. ACS Chem Biol (2014) 1.01
Ambulatory percutaneous nephrolithotomy: what is the rate of readmission? J Endourol (2014) 1.01
Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms? Exp Physiol (2006) 1.01