Published in Nat Med on May 18, 2003
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest (2006) 9.49
The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev (2006) 6.80
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest (2005) 4.55
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med (2010) 2.76
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A (2004) 2.57
Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. Diabetes (2008) 2.33
AMPK: Lessons from transgenic and knockout animals. Front Biosci (Landmark Ed) (2009) 2.09
AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol (2006) 2.06
Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest (2007) 2.03
Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. J Clin Invest (2006) 1.94
Hypothalamic malonyl-CoA as a mediator of feeding behavior. Proc Natl Acad Sci U S A (2003) 1.82
The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Proc Natl Acad Sci U S A (2006) 1.77
Critical role of STAT3 in leptin's metabolic actions. Cell Metab (2006) 1.70
Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain. J Physiol (2006) 1.67
Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance. Cell Metab (2012) 1.66
Role of carnitine in disease. Nutr Metab (Lond) (2010) 1.63
Neuronal regulation of homeostasis by nutrient sensing. Nat Med (2010) 1.61
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci U S A (2007) 1.61
The Genetic Basis of Type 2 Diabetes. Cellscience (2006) 1.58
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. J Clin Invest (2008) 1.53
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes (2009) 1.46
Targeting the CNS to treat type 2 diabetes. Nat Rev Drug Discov (2009) 1.45
Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency. Cell Metab (2010) 1.42
Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. Cell Mol Life Sci (2010) 1.27
Regulation of hypothalamic malonyl-CoA by central glucose and leptin. Proc Natl Acad Sci U S A (2007) 1.26
Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity. Cell Metab (2011) 1.25
Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing. Am J Physiol Regul Integr Comp Physiol (2009) 1.21
Activation of K(ATP) channels suppresses glucose production in humans. J Clin Invest (2011) 1.11
Nesfatin-1 action in the brain increases insulin sensitivity through Akt/AMPK/TORC2 pathway in diet-induced insulin resistance. Diabetes (2012) 1.08
Altered hypothalamic function in diet-induced obesity. Int J Obes (Lond) (2011) 1.08
Transcriptomes of parents identify parenting strategies and sexual conflict in a subsocial beetle. Nat Commun (2015) 1.06
Implications of crosstalk between leptin and insulin signaling during the development of diet-induced obesity. Biochim Biophys Acta (2008) 1.04
Why does brain metabolism not favor burning of fatty acids to provide energy? Reflections on disadvantages of the use of free fatty acids as fuel for brain. J Cereb Blood Flow Metab (2013) 1.03
Hypothalamic AMP-activated protein kinase regulates glucose production. Diabetes (2010) 1.02
Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity. Mol Cell Biol (2013) 1.02
Plasticity of central autonomic neural circuits in diabetes. Biochim Biophys Acta (2008) 1.01
Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production. Am J Physiol Endocrinol Metab (2010) 1.00
Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding. Proc Natl Acad Sci U S A (2011) 1.00
Activation of N-methyl-D-aspartate (NMDA) receptors in the dorsal vagal complex lowers glucose production. J Biol Chem (2010) 0.99
A treasure trove of hypothalamic neurocircuitries governing body weight homeostasis. Endocrinology (2010) 0.98
Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats. Diabetes (2011) 0.98
Oleic acid directly regulates POMC neuron excitability in the hypothalamus. J Neurophysiol (2009) 0.98
Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents. PLoS One (2009) 0.97
The role of the vgf gene and VGF-derived peptides in nutrition and metabolism. Genes Nutr (2007) 0.96
Rethinking the central causes of diabetes. Nat Med (2003) 0.94
Selective reversible inhibition of liver carnitine palmitoyl-transferase 1 by teglicar reduces gluconeogenesis and improves glucose homeostasis. Diabetes (2011) 0.92
Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling. Biochim Biophys Acta (2009) 0.92
Cyanidin-3-O-β-glucoside regulates fatty acid metabolism via an AMP-activated protein kinase-dependent signaling pathway in human HepG2 cells. Lipids Health Dis (2012) 0.91
Regulation of hypothalamic neuronal sensing and food intake by ketone bodies and fatty acids. Diabetes (2013) 0.91
Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation. J Lipid Res (2008) 0.90
Hypothalamic malonyl-coenzyme A and the control of energy balance. Mol Endocrinol (2008) 0.90
Abnormally low serum acylcarnitine levels in narcolepsy patients. Sleep (2011) 0.90
The Effect of High-Fat Diet-Induced Pathophysiological Changes in the Gut on Obesity: What Should be the Ideal Treatment? Clin Transl Gastroenterol (2013) 0.90
Role of AMP-activated protein kinase in the control of appetite. J Neuroendocrinol (2008) 0.89
Ketosis, ketogenic diet and food intake control: a complex relationship. Front Psychol (2015) 0.89
Mitochondrial fatty acid oxidation in obesity. Antioxid Redox Signal (2012) 0.88
Impact of nutrients on circadian rhythmicity. Am J Physiol Regul Integr Comp Physiol (2014) 0.87
Cisplatin-induced downregulation of OCTN2 affects carnitine wasting. Clin Cancer Res (2010) 0.87
Expression of the diabetes-associated gene TCF7L2 in adult mouse brain. J Comp Neurol (2009) 0.86
Hypothalamic malonyl-CoA and the control of food intake. Physiol Behav (2013) 0.86
CNS control of glucose metabolism: response to environmental challenges. Front Neurosci (2013) 0.85
Evidence for central regulation of glucose metabolism. J Biol Chem (2013) 0.85
Sphingolipid metabolism and obesity-induced inflammation. Front Endocrinol (Lausanne) (2013) 0.84
Hypothalamic sensing of circulating lactate regulates glucose production. J Cell Mol Med (2010) 0.84
QTLs associated with dry matter intake, metabolic mid-test weight, growth and feed efficiency have little overlap across 4 beef cattle studies. BMC Genomics (2014) 0.83
The multiple roles of fatty acid handling proteins in brain. Front Physiol (2012) 0.82
Effects of the increase in neuronal fatty acids availability on food intake and satiety in mice. Psychopharmacology (Berl) (2010) 0.82
Genome-wide association studies for feed intake and efficiency in two laying periods of chickens. Genet Sel Evol (2015) 0.81
Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats. Am J Physiol Regul Integr Comp Physiol (2008) 0.80
The CPT1C 5'UTR contains a repressing upstream open reading frame that is regulated by cellular energy availability and AMPK. PLoS One (2011) 0.80
Central but not systemic lipid infusion augments the counterregulatory response to hypoglycemia. Am J Physiol Endocrinol Metab (2009) 0.80
Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism. Exp Mol Med (2016) 0.80
Hypothalamic inhibition of acetyl-CoA carboxylase stimulates hepatic counter-regulatory response independent of AMPK activation in rats. PLoS One (2013) 0.79
Regulation of peripheral metabolism by substrate partitioning in the brain. Endocrinol Metab Clin North Am (2013) 0.79
The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing. Nat Rev Endocrinol (2016) 0.78
Effect of 24 h Fasting on Gene Expression of AMPK, Appetite Regulation Peptides and Lipometabolism Related Factors in the Hypothalamus of Broiler Chicks. Asian-Australas J Anim Sci (2012) 0.78
Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profile. PLoS One (2014) 0.78
Fatty acid transporter CD36 mediates hypothalamic effect of fatty acids on food intake in rats. PLoS One (2013) 0.78
Post-weaning blood transcriptomic differences between Yorkshire pigs divergently selected for residual feed intake. BMC Genomics (2016) 0.78
Central control of glucose homeostasis. Rev Diabet Stud (2006) 0.78
Upregulated expression of brain enzymatic markers of arachidonic and docosahexaenoic acid metabolism in a rat model of the metabolic syndrome. BMC Neurosci (2012) 0.77
Estradiol impairs hypothalamic molecular responses to hypoglycemia. Brain Res (2009) 0.77
Effect of a 3-day high-fat feeding period on carbohydrate balance and ad libitum energy intake in humans. Int J Obes (Lond) (2010) 0.77
Effects of atypical antipsychotics and haloperidol on PC12 cells: only aripiprazole phosphorylates AMP-activated protein kinase. J Neural Transm (Vienna) (2010) 0.77
Hypothalamic AMPK as a Regulator of Energy Homeostasis. Neural Plast (2016) 0.76
The Role of Circulating Amino Acids in the Hypothalamic Regulation of Liver Glucose Metabolism. Adv Nutr (2016) 0.76
Metabolic mystery: aging, obesity, diabetes, and the ventromedial hypothalamus. Trends Endocrinol Metab (2013) 0.76
Fatty acid-induced astrocyte ketone production and the control of food intake. Am J Physiol Regul Integr Comp Physiol (2016) 0.76
Omental transplantation for neuroendocrinological disorders. Am J Neurodegener Dis (2015) 0.75
Role of Hypothalamic Creb-Binding Protein in Obesity and Molecular Reprogramming of Metabolic Substrates. PLoS One (2016) 0.75
Oleate induces KATP channel-dependent hyperpolarisation in mouse hypothalamic glucose-excited neurones without altering cellular energy charge. Neuroscience (2017) 0.75
Glucagon and lipid signaling in the hypothalamus. Mamm Genome (2014) 0.75
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature (2006) 11.90
H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell (2008) 5.23
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A (2010) 4.99
SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab (2007) 4.74
Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med (2002) 4.69
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell (2011) 4.56
Hypothalamic K(ATP) channels control hepatic glucose production. Nature (2005) 4.56
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science (2010) 4.37
Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem (2005) 4.32
p53 regulates maternal reproduction through LIF. Nature (2007) 4.12
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci (2002) 3.64
Regulation of fasted blood glucose by resistin. Science (2004) 3.54
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med (2006) 3.24
Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. J Clin Invest (2003) 3.11
A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology (2003) 3.04
Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest (2003) 2.95
Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat Med (2008) 2.91
Central administration of oleic acid inhibits glucose production and food intake. Diabetes (2002) 2.91
Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes (2002) 2.90
Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML. Cell Stem Cell (2012) 2.89
A brain-liver circuit regulates glucose homeostasis. Cell Metab (2005) 2.83
Hypothalamic sensing of fatty acids. Nat Neurosci (2005) 2.67
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med (2005) 2.66
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev (2006) 2.66
Regulation of blood glucose by hypothalamic pyruvate metabolism. Science (2005) 2.28
Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J Clin Invest (2006) 2.13
Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. J Clin Invest (2006) 1.94
Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell (2010) 1.92
Molecular disruption of hypothalamic nutrient sensing induces obesity. Nat Neurosci (2006) 1.87
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A (2011) 1.87
Role of resistin in diet-induced hepatic insulin resistance. J Clin Invest (2004) 1.83
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci U S A (2009) 1.79
Disulfide-dependent multimeric assembly of resistin family hormones. Science (2004) 1.76
Critical role of STAT3 in leptin's metabolic actions. Cell Metab (2006) 1.70
The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Mol Cell Biol (2009) 1.69
Central leptin acutely reverses diet-induced hepatic insulin resistance. Diabetes (2005) 1.69
A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells. Cancer Res (2007) 1.67
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Mol Cell Biol (2004) 1.63
Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. J Clin Invest (2005) 1.55
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. J Clin Invest (2008) 1.53
Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins. Nat Med (2007) 1.51
Minireview: nutrient sensing and the regulation of insulin action and energy balance. Endocrinology (2003) 1.47
Effect of L-carnitine administration on erythrocyte survival in haemodialysis patients. Nephrol Dial Transplant (2006) 1.46
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes (2009) 1.46
L-carnitine is an osmotic agent suitable for peritoneal dialysis. Kidney Int (2011) 1.45
Hypothalamic responses to long-chain fatty acids are nutritionally regulated. J Biol Chem (2004) 1.44
The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis (2002) 1.43
Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice. Diabetes (2007) 1.42
Abnormal glucose homeostasis due to chronic hyperresistinemia. Diabetes (2004) 1.39
Carnitine, mitochondrial function and therapy. Adv Drug Deliv Rev (2009) 1.38
Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway. Genes Cancer (2010) 1.38
Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice. J Clin Invest (2005) 1.35
Melanocortin-independent effects of leptin on hepatic glucose fluxes. J Biol Chem (2004) 1.35
Identification of a biochemical link between energy intake and energy expenditure. J Clin Invest (2002) 1.29
p53: a new player in reproduction. Cell Cycle (2008) 1.20
Fructose improves the ability of hyperglycemia per se to regulate glucose production in type 2 diabetes. Diabetes (2002) 1.13
p63 regulates glutaminase 2 expression. Cell Cycle (2013) 1.12
Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors. Mol Cell Neurosci (2007) 1.12
Leptin resistance during aging is independent of fat mass. Diabetes (2002) 1.12
Hypothalamic resistin induces hepatic insulin resistance. J Clin Invest (2007) 1.10
LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway. Oncotarget (2014) 1.08
Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2. FASEB J (2008) 1.08
Hypothalamic protein kinase C regulates glucose production. Diabetes (2008) 1.07
The Regulation of Multiple p53 Stress Responses is Mediated through MDM2. Genes Cancer (2012) 1.06
Gut microbiota metabolism of L-carnitine and cardiovascular risk. Atherosclerosis (2013) 1.02
Role of transcription factor NFAT in glucose and insulin homeostasis. Mol Cell Biol (2006) 1.02
Glycemic control determines hepatic and peripheral glucose effectiveness in type 2 diabetic subjects. Diabetes (2002) 0.98
Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats. Diabetes (2011) 0.98
DNA damage, repair, and mutation induction by (+)-Syn and (-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxides in mouse cells. Cancer Res (2004) 0.98
Acrolein induced DNA damage, mutagenicity and effect on DNA repair. Mol Nutr Food Res (2011) 0.97
Intracerebroventricular leptin regulates hepatic cholesterol metabolism. Biochem J (2004) 0.96
Reconstructing signal transduction pathways: challenges and opportunities. Ann N Y Acad Sci (2007) 0.92
Selective reversible inhibition of liver carnitine palmitoyl-transferase 1 by teglicar reduces gluconeogenesis and improves glucose homeostasis. Diabetes (2011) 0.92
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. J Med Chem (2011) 0.91
Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma. Oncotarget (2014) 0.91
Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway. Atherosclerosis (2002) 0.91
The regulation of human reproduction by p53 and its pathway. Cell Cycle (2009) 0.90
Tumor suppressor p53 and its gain-of-function mutants in cancer. Acta Biochim Biophys Sin (Shanghai) (2013) 0.89
Gene expression profiling of leukemia stem cells. Methods Mol Biol (2009) 0.89
Toward personalized hemodialysis by low molecular weight amino-containing compounds: future perspective of patient metabolic fingerprint. Blood Transfus (2012) 0.88
Nickel (II) enhances benzo[a]pyrene diol epoxide-induced mutagenesis through inhibition of nucleotide excision repair in human cells: a possible mechanism for nickel (II)-induced carcinogenesis. Carcinogenesis (2003) 0.87
Transcription-coupled and transcription-independent repair of cyclobutane pyrimidine dimers in the dihydrofolate reductase gene. J Biol Chem (2002) 0.87
Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells. Mol Carcinog (2004) 0.87
Pharmacological use of L-carnitine in uremic anemia: has its full potential been exploited? Pharmacol Res (2010) 0.87
Fructose amplifies counterregulatory responses to hypoglycemia in humans. Diabetes (2002) 0.86
Propionyl-L-carnitine prevents renal function deterioration due to ischemia/reperfusion. Kidney Int (2002) 0.86
Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms. Biochemistry (2003) 0.86
The AMPK-malonyl-CoA-CPT1 axis in the control of hypothalamic neuronal function. Cell Metab (2008) 0.84
Hypothalamic sensing of circulating lactate regulates glucose production. J Cell Mol Med (2010) 0.84
Transformation from committed progenitor to leukemia stem cells. Ann N Y Acad Sci (2009) 0.83
Effects of fasting and glucocorticoids on hepatic gluconeogenesis assessed using two independent methods in vivo. Am J Physiol Endocrinol Metab (2002) 0.83
Gene expression of primary human bronchial epithelial cells in response to coal dusts with different prevalence of coal workers' pneumoconiosis. J Toxicol Environ Health A (2003) 0.82
Effects of the increase in neuronal fatty acids availability on food intake and satiety in mice. Psychopharmacology (Berl) (2010) 0.82
TAp63γ enhances nucleotide excision repair through transcriptional regulation of DNA repair genes. DNA Repair (Amst) (2011) 0.81