Published in Acta Crystallogr Sect F Struct Biol Cryst Commun on July 27, 2010
Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance. Mol Neurobiol (2015) 0.78
Production of Human Cu,Zn SOD with Higher Activity and Lower Toxicity in E. coli via Mutation of Free Cysteine Residues. Biomed Res Int (2017) 0.75
Immunogenicity and functional characterization of Leishmania-derived hepatitis C virus envelope glycoprotein complex. Sci Rep (2016) 0.75
Immunogenicity of Leishmania-derived hepatitis B small surface antigen particles exposing highly conserved E2 epitope of hepatitis C virus. Microb Cell Fact (2016) 0.75
Effect of Oxidative Damage on the Stability and Dimerization of Superoxide Dismutase 1. Biophys J (2016) 0.75
Enhancement of Solubility and Specific Activity of a Cu/Zn Superoxide Dismutase by Co-expression with a Copper Chaperone in Escherichia coli. Iran J Biotechnol (2016) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
The Protein Data Bank. Nucleic Acids Res (2000) 187.10
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
XDS. Acta Crystallogr D Biol Crystallogr (2010) 67.46
Molecular replacement with MOLREP. Acta Crystallogr D Biol Crystallogr (2009) 26.26
Improved R-factors for diffraction data analysis in macromolecular crystallography. Nat Struct Biol (1997) 25.74
Use of TLS parameters to model anisotropic displacements in macromolecular refinement. Acta Crystallogr D Biol Crystallogr (2001) 21.01
BALBES: a molecular-replacement pipeline. Acta Crystallogr D Biol Crystallogr (2007) 9.29
Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase. Proc Natl Acad Sci U S A (1992) 2.02
Structural genomics. Tapping DNA for structures produces a trickle. Science (2002) 1.99
ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization. J Mol Biol (2003) 1.82
Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants. Proc Natl Acad Sci U S A (2004) 1.76
The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis. J Mol Biol (2003) 1.68
Modifications of superoxide dismutase (SOD1) in human erythrocytes: a possible role in amyotrophic lateral sclerosis. J Biol Chem (2009) 1.46
Non-pathogenic trypanosomatid protozoa as a platform for protein research and production. Protein Expr Purif (2002) 1.33
The coupling between disulphide status, metallation and dimer interface strength in Cu/Zn superoxide dismutase. J Mol Biol (2006) 1.28
Genetic manipulation of kinetoplastida. Parasitol Today (1999) 1.22
Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase. J Mol Biol (2002) 1.20
The expression of biologically active human p53 in Leishmania cells: a novel eukaryotic system to produce recombinant proteins. Nucleic Acids Res (1995) 1.15
Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A. Arch Biochem Biophys (2009) 1.09
Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu-Zn superoxide dismutase. Proc Natl Acad Sci U S A (2007) 1.00
Development of an inducible protein expression system based on the protozoan host Leishmania tarentolae. Protein Expr Purif (2005) 0.98
Recombinant protein expression in Leishmania tarentolae. Mol Biotechnol (2009) 0.93
Development of a defined medium for heterologous expression in Leishmania tarentolae. J Basic Microbiol (2008) 0.90
Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase. Proteins (1997) 0.88
A cost-effective amino-acid-type selective isotope labeling of proteins expressed in Leishmania tarentolae. J Biomol Struct Dyn (2009) 0.81
Isotopic labeling of recombinant proteins expressed in the protozoan host Leishmania tarentolae. Protein Expr Purif (2006) 0.80
Comparison of properties between human recombinant and placental copper-zinc SOD. J Biochem (1988) 0.78
The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Science (2010) 2.73
A common red algal origin of the apicomplexan, dinoflagellate, and heterokont plastids. Proc Natl Acad Sci U S A (2010) 2.41
Phenazine compounds in fluorescent Pseudomonas spp. biosynthesis and regulation. Annu Rev Phytopathol (2006) 2.31
Structures of the dual bromodomains of the P-TEFb-activating protein Brd4 at atomic resolution. J Biol Chem (2009) 1.96
RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity. Mol Cell (2009) 1.94
Cell biology. Irremediable complexity? Science (2010) 1.85
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science (2003) 1.80
The evolution and diversity of kinetoplastid flagellates. Trends Parasitol (2006) 1.79
Novel correlations between the genotype and the phenotype of hypertrophic and dilated cardiomyopathy: results from the German Competence Network Heart Failure. Eur J Heart Fail (2011) 1.70
Towards multilocus sequence typing of the Leishmania donovani complex: resolving genotypes and haplotypes for five polymorphic metabolic enzymes (ASAT, GPI, NH1, NH2, PGD). Int J Parasitol (2006) 1.67
Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism. Cell (2006) 1.67
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. Cell (2004) 1.62
Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein. EMBO J (2003) 1.58
RNA interference analyses suggest a transcript-specific regulatory role for mitochondrial RNA-binding proteins MRP1 and MRP2 in RNA editing and other RNA processing in Trypanosoma brucei. J Biol Chem (2004) 1.58
Diversity and evolution of the phenazine biosynthesis pathway. Appl Environ Microbiol (2009) 1.51
Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei. Proc Natl Acad Sci U S A (2008) 1.51
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nat Chem Biol (2009) 1.50
TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex. RNA (2008) 1.47
Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice. J Clin Invest (2011) 1.39
Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4. EMBO J (2006) 1.39
The phylogeny of Goussia and Choleoeimeria (Apicomplexa; Eimeriorina) and the evolution of excystation structures in coccidia. Protist (2002) 1.38
Kinetoplastid guide RNA biogenesis is dependent on subunits of the mitochondrial RNA binding complex 1 and mitochondrial RNA polymerase. RNA (2009) 1.37
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Mol Cell (2003) 1.37
Non-pathogenic trypanosomatid protozoa as a platform for protein research and production. Protein Expr Purif (2002) 1.33
Structural and thermodynamic analysis of the GFP:GFP-nanobody complex. Protein Sci (2010) 1.28
Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators. Proc Natl Acad Sci U S A (2007) 1.26
Of two make one: the biosynthesis of phenazines. Chembiochem (2009) 1.24
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes. Nat Chem Biol (2010) 1.24
Species-independent translational leaders facilitate cell-free expression. Nat Biotechnol (2009) 1.22
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J Am Chem Soc (2006) 1.15
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization. Chembiochem (2007) 1.15
Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene. PLoS One (2007) 1.15
High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA. EMBO Rep (2010) 1.14
Unique mitochondrial genome structure in diplonemids, the sister group of kinetoplastids. Eukaryot Cell (2005) 1.14
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. EMBO J (2011) 1.14
Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. EMBO J (2006) 1.14
The evolutionary history of kinetoplastids and their kinetoplasts. Mol Biol Evol (2002) 1.13
Structure and function of the native and recombinant mitochondrial MRP1/MRP2 complex from Trypanosoma brucei. Int J Parasitol (2008) 1.13
A model for taxonomic work on homoxenous coccidia: redescription, host specificity, and molecular phylogeny of Eimeria ranae Dobell, 1909, with a review of anuran-host Eimeria (Apicomplexa: Eimeriorina). J Eukaryot Microbiol (2009) 1.12
Evolution of the haem synthetic pathway in kinetoplastid flagellates: an essential pathway that is not essential after all? Int J Parasitol (2009) 1.11
Genetic polymorphism within the leishmania donovani complex: correlation with geographic origin. Am J Trop Med Hyg (2004) 1.11
Diels-Alder ligation and surface immobilization of proteins. Angew Chem Int Ed Engl (2005) 1.10
Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration. Breast Cancer Res (2010) 1.10
Architecture of the trypanosome RNA editing accessory complex, MRB1. Nucleic Acids Res (2012) 1.10
Adenylylation: renaissance of a forgotten post-translational modification. Trends Biochem Sci (2011) 1.09
A putative novel nuclear-encoded subunit of the cytochrome c oxidase complex in trypanosomatids. Mol Biochem Parasitol (2002) 1.08
The Leishmania donovani complex: genotypes of five metabolic enzymes (ICD, ME, MPI, G6PDH, and FH), new targets for multilocus sequence typing. Int J Parasitol (2006) 1.08
Downregulation of the nuclear-encoded subunits of the complexes III and IV disrupts their respective complexes but not complex I in procyclic Trypanosoma brucei. Mol Microbiol (2005) 1.07
Evolution of the apicoplast and its hosts: from heterotrophy to autotrophy and back again. Int J Parasitol (2008) 1.06
Re-evaluating the green versus red signal in eukaryotes with secondary plastid of red algal origin. Genome Biol Evol (2012) 1.05
Knock-downs of iron-sulfur cluster assembly proteins IscS and IscU down-regulate the active mitochondrion of procyclic Trypanosoma brucei. J Biol Chem (2006) 1.05
Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei. Mol Microbiol (2008) 1.05
Biophysical analysis of the interaction of Rab6a GTPase with its effector domains. J Biol Chem (2008) 1.05
SmD1 is required for spliced leader RNA biogenesis. Eukaryot Cell (2004) 1.04
PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis. J Am Chem Soc (2008) 1.04
Guide to the nomenclature of kinetoplastid RNA editing: a proposal. Protist (2009) 1.03
Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases. Org Biomol Chem (2005) 1.02
MRB3010 is a core component of the MRB1 complex that facilitates an early step of the kinetoplastid RNA editing process. RNA (2011) 1.01
Development of a direct species-specific PCR assay for differential diagnosis of Leishmania tropica. Diagn Microbiol Infect Dis (2006) 1.01
Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae. Elife (2013) 1.01
Systematically fragmented genes in a multipartite mitochondrial genome. Nucleic Acids Res (2010) 1.01
Site-selective protein immobilization by Staudinger ligation. Angew Chem Int Ed Engl (2006) 1.00
Oriented immobilization of farnesylated proteins by the thiol-ene reaction. Angew Chem Int Ed Engl (2010) 1.00
Understanding and exploiting protein prenyltransferases. Chembiochem (2010) 0.99
Lipidated ras and rab peptides and proteins--synthesis, structure, and function. Angew Chem Int Ed Engl (2006) 0.99
Trypanosoma brucei: two steps to spread out from Africa. Trends Parasitol (2010) 0.99
Development of an inducible protein expression system based on the protozoan host Leishmania tarentolae. Protein Expr Purif (2005) 0.98
Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens. J Biol Chem (2014) 0.97
Evolutionary relationships of Spirurina (Nematoda: Chromadorea: Rhabditida) with special emphasis on dracunculoid nematodes inferred from SSU rRNA gene sequences. Int J Parasitol (2006) 0.97
Unusual polypeptide synthesis in the kinetoplast-mitochondria from Leishmania tarentolae. Identification of individual de novo translation products. J Biol Chem (2001) 0.97
Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma brucei. RNA (2012) 0.97
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. EMBO J (2008) 0.97
Thiolation controls cytoplasmic tRNA stability and acts as a negative determinant for tRNA editing in mitochondria. J Biol Chem (2009) 0.97
Mitochondrial tRNA import in Trypanosoma brucei is independent of thiolation and the Rieske protein. RNA (2009) 0.95
Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution. J Struct Biol (2005) 0.95
Crystal structures of chloroperoxidase with its bound substrates and complexed with formate, acetate, and nitrate. J Biol Chem (2006) 0.94
Diversity of insect trypanosomatids assessed from the spliced leader RNA and 5S rRNA genes and intergenic regions. J Eukaryot Microbiol (2004) 0.94
The Fe/S cluster assembly protein Isd11 is essential for tRNA thiolation in Trypanosoma brucei. J Biol Chem (2010) 0.94
Three novel mutations in the ACTA2 gene in German patients with thoracic aortic aneurysms and dissections. Eur J Hum Genet (2011) 0.94
Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. PLoS One (2011) 0.94
A protein fluorescence amplifier: continuous fluorometric assay for rab geranylgeranyltransferase. Chembiochem (2006) 0.93
The effect of down-regulation of mitochondrial RNA-binding proteins MRP1 and MRP2 on respiratory complexes in procyclic Trypanosoma brucei. Mol Biochem Parasitol (2006) 0.93
Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein. Biochemistry (2009) 0.93
Split photosystem protein, linear-mapping topology, and growth of structural complexity in the plastid genome of Chromera velia. Mol Biol Evol (2013) 0.92
Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei. Proc Natl Acad Sci U S A (2008) 0.92
The 2'-O-ribose methyltransferase for cap 1 of spliced leader RNA and U1 small nuclear RNA in Trypanosoma brucei. Mol Cell Biol (2007) 0.92
Evolutionary relationships among cyst-forming coccidia Sarcocystis spp. (Alveolata: Apicomplexa: Coccidea) in endemic African tree vipers and perspective for evolution of heteroxenous life cycle. Mol Phylogenet Evol (2003) 0.92
Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates. Biochemistry (2002) 0.91
Characterization of the growth behavior of Leishmania tarentolae: a new expression system for recombinant proteins. J Basic Microbiol (2007) 0.91
Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis. J Biol Chem (2009) 0.90
Leishmania cell-free protein expression system. Methods (2011) 0.90
Ancestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes. Mol Microbiol (2008) 0.90
The Trypanosoma brucei La protein is a candidate poly(U) shield that impacts spliced leader RNA maturation and tRNA intron removal. Int J Parasitol (2005) 0.90
Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases. Structure (2002) 0.90
Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc (2012) 0.90