Published in Nat Rev Genet on October 01, 2006
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The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. BMC Med Genomics (2011) 9.20
Gene--environment-wide association studies: emerging approaches. Nat Rev Genet (2010) 6.10
Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med (2012) 5.98
Instrumenting the health care enterprise for discovery research in the genomic era. Genome Res (2009) 4.13
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Correction of population stratification in large multi-ethnic association studies. PLoS One (2008) 1.59
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Environmental exposure measurement in cancer epidemiology. Mutagenesis (2008) 1.19
A novel statistic for genome-wide interaction analysis. PLoS Genet (2010) 1.19
The success of pharmacogenomics in moving genetic association studies from bench to bedside: study design and implementation of precision medicine in the post-GWAS era. Hum Genet (2012) 1.16
Using lifetime risk estimates in personal genomic profiles: estimation of uncertainty. Am J Hum Genet (2009) 1.14
The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption. Hum Genet (2012) 1.13
The All Our Babies pregnancy cohort: design, methods, and participant characteristics. BMC Pregnancy Childbirth (2013) 1.12
Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing. Pharmacogenomics (2007) 1.12
Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease. Genome Med (2009) 1.12
How can polygenic inheritance be used in population screening for common diseases? Genet Med (2013) 1.10
Survival bias and drug interaction can attenuate cross-sectional case-control comparisons of genes with health outcomes. An example of the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism and coronary heart disease. BMC Med Genet (2011) 1.08
From nature versus nurture, via nature and nurture, to gene x environment interaction in mental disorders. Eur Child Adolesc Psychiatry (2009) 1.02
A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese population. BMC Infect Dis (2008) 1.00
ESR1 and EGF genetic variation in relation to breast cancer risk and survival. Breast Cancer Res (2008) 1.00
Leveraging Epidemiologic and Clinical Collections for Genomic Studies of Complex Traits. Hum Hered (2015) 1.00
Realizing the promise of population biobanks: a new model for translation. Hum Genet (2011) 0.99
Genetic association analysis under complex survey sampling: the Hispanic Community Health Study/Study of Latinos. Am J Hum Genet (2014) 0.98
Genetic architecture of colorectal cancer. Gut (2015) 0.97
Genomic approaches to coronary artery disease. Indian J Med Res (2010) 0.96
Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics. BMJ Open (2015) 0.96
Clinical implications of shared genetics and pathogenesis in autoimmune diseases. Nat Rev Endocrinol (2013) 0.96
Interactions between genetic factors that predict diabetes and dietary factors that ultimately impact on risk of diabetes. Curr Opin Lipidol (2010) 0.94
Nature versus nurture: death of a dogma, and the road ahead. Neuron (2010) 0.93
Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study. Breast Cancer Res (2006) 0.93
Chromosome 9p21.3 polymorphism in a Chinese Han population is associated with angiographic coronary plaque progression in non-diabetic but not in type 2 diabetic patients. Cardiovasc Diabetol (2010) 0.93
Systematic review of birth cohort studies in Africa. J Glob Health (2011) 0.92
Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort. J Invest Dermatol (2009) 0.92
A platform for the remote conduct of gene-environment interaction studies. PLoS One (2013) 0.90
Mutual information for testing gene-environment interaction. PLoS One (2009) 0.89
Bilirubin as a potential causal factor in type 2 diabetes risk: a Mendelian randomization study. Diabetes (2014) 0.89
Asia Cohort Consortium: challenges for collaborative research. J Epidemiol (2012) 0.88
Longitudinal population-based studies of affective disorders: where to from here? BMC Psychiatry (2008) 0.87
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Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study. Cerebrovasc Dis (2008) 0.87
A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. Hum Mol Genet (2013) 0.87
Observational research on NCDs in HIV-positive populations: conceptual and methodological considerations. J Acquir Immune Defic Syndr (2014) 0.87
Design and analysis issues in gene and environment studies. Environ Health (2012) 0.86
Genomics meets proteomics: identifying the culprits in disease. Hum Genet (2013) 0.86
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Diabetes (2012) 0.86
Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility. World J Diabetes (2014) 0.85
Oesophageal squamous cell carcinoma in high-risk Chinese populations: Possible role for vascular epithelial growth factor A. Eur J Cancer (2014) 0.84
Social- and behavioral-specific genetic effects on blood pressure traits: the Strong Heart Family Study. Circ Cardiovasc Genet (2009) 0.84
Design, methods and demographics from phase I of Alberta's Tomorrow Project cohort: a prospective cohort profile. CMAJ Open (2016) 0.83
Curve-based multivariate distance matrix regression analysis: application to genetic association analyses involving repeated measures. Physiol Genomics (2010) 0.83
DRD4 rare variants in Attention-Deficit/Hyperactivity Disorder (ADHD): further evidence from a birth cohort study. PLoS One (2013) 0.82
Statistical Optimization of Pharmacogenomics Association Studies: Key Considerations from Study Design to Analysis. Curr Pharmacogenomics Person Med (2011) 0.82
Integrating genomic and clinical medicine: searching for susceptibility genes in complex lung diseases. Transl Res (2007) 0.82
Review and evaluation of electronic health records-driven phenotype algorithm authoring tools for clinical and translational research. J Am Med Inform Assoc (2015) 0.81
The impact of the catechol-O-methyltransferase Val158Met polymorphism on survival in the general population--the HUNT study. BMC Med Genet (2007) 0.81
Post-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study. Ann Hum Genet (2013) 0.80
Gene-environment interaction and children's health and development. Curr Opin Pediatr (2010) 0.80
Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study. Sci Rep (2016) 0.80
Newspaper coverage of biobanks. PeerJ (2014) 0.80
Gene-environment interactions and obesity: recent developments and future directions. BMC Med Genomics (2015) 0.79
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Enacting the molecular imperative: How gene-environment interaction research links bodies and environments in the post-genomic age. Soc Sci Med (2016) 0.78
Gene-environment interactions in obesity: implication for future applications in preventive medicine. J Hum Genet (2015) 0.78
Associations of Rs3744841 and Rs3744843 Polymorphisms in Endothelial Lipase Gene with Risk of Coronary Artery Disease and Lipid Levels in a Chinese Population. PLoS One (2016) 0.78
The genetics of age-related health outcomes. J Gerontol A Biol Sci Med Sci (2012) 0.77
Longitudinal Intergenerational Birth Cohort Designs: A Systematic Review of Australian and New Zealand Studies. PLoS One (2016) 0.77
Trade-off between toxicity and signal detection orchestrated by frequency- and density-dependent genes. PLoS One (2011) 0.77
Jumping on the Train of Personalized Medicine: A Primer for Non-Geneticist Clinicians: Part 2. Fundamental Concepts in Genetic Epidemiology. Curr Psychiatry Rev (2014) 0.77
Participation bias and its impact on the assembly of a genetic specimen repository for a myocardial infarction cohort. Mayo Clin Proc (2007) 0.76
Recent progress and clinical importance on pharmacogenetics in cancer therapy. Clin Chem Lab Med (2011) 0.76
The expanding role of epigenetics. Glob Cardiol Sci Pract (2012) 0.76
Gene-Environment Interactions in Preventive Medicine: Current Status and Expectations for the Future. Int J Mol Sci (2017) 0.75
Applying data envelopment analysis to preventive medicine: a novel method for constructing a personalized risk model of obesity. PLoS One (2015) 0.75
Levels of evidence in medicine. Int J Sports Phys Ther (2012) 0.75
Coverage of genomic medicine: information gap between lay public and scientists. Risk Manag Healthc Policy (2012) 0.75
Differential Vulnerability to Early-Life Parental Death: The Moderating Effects of Family Suicide History on Risks for Major Depression and Substance Abuse in Later Life. Biodemography Soc Biol (2016) 0.75
Collecting Biospecimens From an Internet-Based Prospective Cohort Study of Inflammatory Bowel Disease (CCFA Partners): A Feasibility Study. JMIR Res Protoc (2016) 0.75
Unravelling the contributions of social, environmental and genetic factors to health differences. CMAJ (2008) 0.75
Approaches for the identification of genetic modifiers of nutrient dependent phenotypes: examples from folate. Front Nutr (2014) 0.75
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A (2002) 20.48
International network of cancer genome projects. Nature (2010) 20.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
A HapMap harvest of insights into the genetics of common disease. J Clin Invest (2008) 18.31
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Replicating genotype-phenotype associations. Nature (2007) 16.11
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Policy: NIH plans to enhance reproducibility. Nature (2014) 15.71
New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature (2003) 12.10
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
The path to personalized medicine. N Engl J Med (2010) 9.87
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res (2004) 9.18
Policy: NIH to balance sex in cell and animal studies. Nature (2014) 9.15
Ethics. Identifiability in genomic research. Science (2007) 9.08
A mouse for all reasons. Cell (2007) 9.01
The family history--more important than ever. N Engl J Med (2004) 8.35
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
The knockout mouse project. Nat Genet (2004) 7.80
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2004) 7.55
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31
NIH Molecular Libraries Initiative. Science (2004) 7.04
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays. Nat Methods (2006) 6.25
Heritable individual-specific and allele-specific chromatin signatures in humans. Science (2010) 5.94
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Systematic comparison of three genomic enrichment methods for massively parallel DNA sequencing. Genome Res (2010) 5.76
Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS). Genome Res (2005) 5.71
Phenotype and course of Hutchinson-Gilford progeria syndrome. N Engl J Med (2008) 5.34
MicroRNA target site polymorphisms and human disease. Trends Genet (2008) 5.32
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci U S A (2004) 4.85
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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Human laminopathies: nuclei gone genetically awry. Nat Rev Genet (2006) 3.89
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci U S A (2006) 3.86
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Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2005) 3.64
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Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51
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Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites. Proc Natl Acad Sci U S A (2004) 3.41
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
The genome gets personal--almost. JAMA (2008) 3.28
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Res (2011) 3.25
Keeping pace with the times--the Genetic Information Nondiscrimination Act of 2008. N Engl J Med (2008) 3.22
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome. Nat Genet (2002) 2.94
Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Proc Natl Acad Sci U S A (2013) 2.93
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop. Genet Med (2009) 2.91
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. Nat Genet (2002) 2.76
Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35. Am J Hum Genet (2004) 2.65
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Sociology. Weaving a richer tapestry in biomedical science. Science (2011) 2.63
Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. PLoS Genet (2006) 2.62
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Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. Nat Genet (2012) 2.55
A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14. Diabetes (2004) 2.46
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44
Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes. Diabetes (2004) 2.43
The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin. PLoS One (2007) 2.41
Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet (2002) 2.39
Welcome to the genomic era. N Engl J Med (2003) 2.38
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet (2013) 2.36
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet (2012) 2.34
Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells. Sci Transl Med (2011) 2.33
Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet (2003) 2.33
High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools. Proc Natl Acad Sci U S A (2002) 2.32
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Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2006) 2.28
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A new partner for the international knockout mouse consortium. Cell (2007) 2.23
The completion of the Mammalian Gene Collection (MGC). Genome Res (2009) 2.21
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes (2011) 2.21