Published in Nat Protoc on September 02, 2010
Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR. Nucleic Acids Res (2011) 2.92
Reproducibility of telomere length assessment: an international collaborative study. Int J Epidemiol (2014) 2.91
Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun (2013) 2.56
Leukocyte telomere length and mortality in the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci (2011) 2.19
Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither? Epidemiol Rev (2013) 2.05
Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients. Clin Cancer Res (2012) 1.90
Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res (2011) 1.79
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet (2012) 1.77
Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule. J Gerontol A Biol Sci Med Sci (2011) 1.72
Telomerase is required for zebrafish lifespan. PLoS Genet (2013) 1.59
Do leukocyte telomere length dynamics depend on baseline telomere length? An analysis that corrects for 'regression to the mean'. Eur J Epidemiol (2013) 1.28
Commentary: The reliability of telomere length measurements. Int J Epidemiol (2015) 1.23
Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis. Aging Cell (2011) 1.20
Energy intake and leukocyte telomere length in young adults. Am J Clin Nutr (2012) 1.18
Tracking and fixed ranking of leukocyte telomere length across the adult life course. Aging Cell (2013) 1.17
Comparison between southern blots and qPCR analysis of leukocyte telomere length in the health ABC study. J Gerontol A Biol Sci Med Sci (2013) 1.15
Soda and cell aging: associations between sugar-sweetened beverage consumption and leukocyte telomere length in healthy adults from the National Health and Nutrition Examination Surveys. Am J Public Health (2014) 1.10
Measuring telomere length and telomere dynamics in evolutionary biology and ecology. Methods Ecol Evol (2014) 1.10
Telomerase promoter mutations in cancer: an emerging molecular biomarker? Virchows Arch (2014) 1.09
Measurement of telomere DNA content by dot blot analysis. Nucleic Acids Res (2011) 1.08
Leukocyte telomere length is associated with noninvasively measured age-related disease: The Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci (2011) 1.08
Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging. Aging Cell (2012) 1.07
TeloTool: a new tool for telomere length measurement from terminal restriction fragment analysis with improved probe intensity correction. Nucleic Acids Res (2013) 1.04
Estimating telomere length from whole genome sequence data. Nucleic Acids Res (2014) 1.00
A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. J Virol (2012) 0.98
TERRA Expression Levels Do Not Correlate with Telomere Length and Radiation Sensitivity in Human Cancer Cell Lines. Front Oncol (2013) 0.98
Improving qPCR telomere length assays: Controlling for well position effects increases statistical power. Am J Hum Biol (2015) 0.96
Telomere dynamics in keloids. Eplasty (2011) 0.95
A model of canine leukocyte telomere dynamics. Aging Cell (2011) 0.94
Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans. Mol Hum Reprod (2012) 0.94
Telomerase protects werner syndrome lineage-specific stem cells from premature aging. Stem Cell Reports (2014) 0.94
Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth. Mech Ageing Dev (2011) 0.94
Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease. Pediatrics (2016) 0.93
Longer leukocyte telomere length in Costa Rica's Nicoya Peninsula: a population-based study. Exp Gerontol (2013) 0.93
Telomere-associated polymorphisms correlate with cardiovascular disease mortality in Caucasian women: the Cardiovascular Health Study. Mech Ageing Dev (2012) 0.92
Leukocyte telomere dynamics in the elderly. Eur J Epidemiol (2013) 0.92
Telomerase and telomere length in pulmonary fibrosis. Am J Respir Cell Mol Biol (2013) 0.92
Telomere dynamics in rhesus monkeys: no apparent effect of caloric restriction. J Gerontol A Biol Sci Med Sci (2011) 0.90
DCAF4, a novel gene associated with leucocyte telomere length. J Med Genet (2015) 0.90
Leukocyte telomere length and physical ability among Danish twins age 70+. Mech Ageing Dev (2011) 0.90
Telomeres and atherosclerosis. Cardiovasc J Afr (2012) 0.89
The heritability of leucocyte telomere length dynamics. J Med Genet (2015) 0.87
Leukocyte telomere length and coronary artery calcium. Am J Cardiol (2015) 0.87
Race, Ethnicity, Psychosocial Factors, and Telomere Length in a Multicenter Setting. PLoS One (2016) 0.87
Telomeres and telomere dynamics: relevance to cancers of the GI tract. Expert Rev Gastroenterol Hepatol (2013) 0.87
Leukocyte telomere length and age at menopause. Epidemiology (2014) 0.87
Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality. J Lipid Res (2012) 0.86
Telomere length: a review of methods for measurement. Nurs Res (2014) 0.86
Prognostic significance of telomere maintenance mechanisms in pediatric high-grade gliomas. J Neurooncol (2014) 0.86
Telomeres and human reproduction. Fertil Steril (2013) 0.86
Premature senescence in primary muscle cultures of myotonic dystrophy type 2 is not associated with p16 induction. Eur J Histochem (2014) 0.85
Measurement of telomere length: a new assay using QuantiGene chemistry on a Luminex platform. Cancer Epidemiol Biomarkers Prev (2014) 0.85
Robust measurement of telomere length in single cells. Proc Natl Acad Sci U S A (2013) 0.85
The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex. Nat Struct Mol Biol (2015) 0.85
Lifelong leukocyte telomere dynamics and survival in a free-living mammal. Aging Cell (2015) 0.84
Toward a molecular classification of colorectal cancer: the role of telomere length. Front Oncol (2014) 0.84
Sex difference in leukocyte telomere length is ablated in opposite-sex co-twins. Int J Epidemiol (2014) 0.84
A nucleolar AAA-NTPase is required for parasite division. Mol Microbiol (2013) 0.83
Leukocyte telomere length dynamics in women and men: menopause vs age effects. Int J Epidemiol (2015) 0.83
Medaka fish exhibits longevity gender gap, a natural drop in estrogen and telomere shortening during aging: a unique model for studying sex-dependent longevity. Front Zool (2013) 0.83
Influence of DNA extraction methods on relative telomere length measurements and its impact on epidemiological studies. Sci Rep (2016) 0.81
Early-Life Telomere Dynamics Differ between the Sexes and Predict Growth in the Barn Swallow (Hirundo rustica). PLoS One (2015) 0.81
DNA methylation changes in response to active smoking exposure are associated with leukocyte telomere length among older adults. Eur J Epidemiol (2016) 0.81
Telomere length is a prognostic biomarker in elderly advanced ovarian cancer patients: a multicenter GINECO study. Aging (Albany NY) (2015) 0.80
Stn1 is critical for telomere maintenance and long-term viability of somatic human cells. Aging Cell (2015) 0.80
Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts. Nat Commun (2015) 0.80
Paternal age and telomere length in twins: the germ stem cell selection paradigm. Aging Cell (2015) 0.80
Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo. Chromosoma (2011) 0.80
Association Between Leukocyte Telomere Length and Plasma Homocysteine in a Singapore Chinese Population. Rejuvenation Res (2015) 0.80
Determination of Arabidopsis thaliana telomere length by PCR. Sci Rep (2014) 0.80
Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells. Nucleic Acids Res (2013) 0.79
Association of leukocyte telomere length with fatigue in nondisabled older adults. J Aging Res (2014) 0.78
Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs. J Math Biol (2013) 0.78
The development of a novel Mycobacterium-Escherichia coli shuttle vector system using pMyong2, a linear plasmid from Mycobacterium yongonense DSM 45126T. PLoS One (2015) 0.78
Increased attrition of leukocyte telomere length in young adults is associated with poorer cognitive function in midlife. Eur J Epidemiol (2015) 0.78
Telomere length and the risk of atrial fibrillation: insights into the role of biological versus chronological aging. Circ Arrhythm Electrophysiol (2014) 0.78
Novel Luminex Assay for Telomere Repeat Mass Does Not Show Well Position Effects Like qPCR. PLoS One (2016) 0.77
Telomere attrition and restoration in the normal teleost Oryzias latipes are linked to growth rate and telomerase activity at each life stage. Aging (Albany NY) (2016) 0.77
Shorter telomere length in Europeans than in Africans due to polygenetic adaptation. Hum Mol Genet (2016) 0.77
Telomere shortening in Down syndrome patients--when does it start? DNA Cell Biol (2015) 0.76
Telomere length and telomerase activity; a Yin and Yang of cell senescence. J Vis Exp (2013) 0.76
Association between the Dietary Inflammatory Index (DII) and telomere length and C-reactive protein from the National Health and Nutrition Examination Survey-1999-2002. Mol Nutr Food Res (2016) 0.76
Maternal pre-pregnancy body mass index and newborn telomere length. BMC Med (2016) 0.76
Expression of human protection of telomere 1 correlates with telomere length and radiosensitivity in the human laryngeal cancer Hep-2 cell line. Oncol Lett (2015) 0.75
Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish. PLoS Genet (2016) 0.75
Associations of Accelerometer-Measured and Self-Reported Sedentary Time With Leukocyte Telomere Length in Older Women. Am J Epidemiol (2017) 0.75
Telomere length assessment in leukocytes presents potential diagnostic value in patients with breast cancer. Oncol Lett (2016) 0.75
Telomere length measurement by a novel Luminex-based assay: a blinded comparison to Southern blot. Int J Mol Epidemiol Genet (2016) 0.75
Integration of Telomere Length Dynamics into Systems Biology Framework: A Review. Gene Regul Syst Bio (2016) 0.75
Sizing femtogram amounts of dsDNA by single-molecule counting. Nucleic Acids Res (2015) 0.75
Biomarkers of Alzheimer's disease risk in peripheral tissues; focus on buccal cells. Curr Alzheimer Res (2014) 0.75
Telomere shortening leads to earlier age of onset in ALS mice. Aging (Albany NY) (2016) 0.75
Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson Gilford Progeria Syndrome. Mol Cell Biol (2017) 0.75
Leukocyte telomere length, T cell composition and DNA methylation age. Aging (Albany NY) (2017) 0.75
Cardiomyocyte-Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans. J Am Heart Assoc (2017) 0.75
Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles. Stem Cell Reports (2017) 0.75
Leisure-time physical activity and leukocyte telomere length among older women. Exp Gerontol (2017) 0.75
The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation. Sci Rep (2017) 0.75
Evaluation of telomere length in human cardiac tissues using cardiac quantitative FISH. Nat Protoc (2017) 0.75
Increased Neutralizing Antibody Production and Interferon-γ Secretion in Response to Porcine Reproductive and Respiratory Syndrome Virus Immunization in Genetically Modified Pigs. Front Immunol (2017) 0.75
Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97
Telomere measurement by quantitative PCR. Nucleic Acids Res (2002) 18.69
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J (1992) 10.97
Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A (1992) 10.19
Obesity, cigarette smoking, and telomere length in women. Lancet (2005) 8.59
Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet (2005) 6.85
Heterogeneity in telomere length of human chromosomes. Hum Mol Genet (1996) 6.55
Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res (2009) 6.42
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Telomere diseases. N Engl J Med (2009) 5.68
Telomere end-replication problem and cell aging. J Mol Biol (1992) 5.37
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Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med (1999) 4.27
Flow cytometry and FISH to measure the average length of telomeres (flow FISH). Nat Protoc (2006) 4.00
Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita. Blood (2007) 3.86
Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet (2003) 3.77
Telomere length and possible link to X chromosome. Lancet (2004) 3.36
Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study. Aging Cell (2008) 3.24
Common variants near TERC are associated with mean telomere length. Nat Genet (2010) 2.98
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A (2010) 2.47
Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart Study. Circulation (2008) 2.22
High-throughput telomere length quantification by FISH and its application to human population studies. Proc Natl Acad Sci U S A (2007) 2.15
Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genet (2008) 1.80
Telomere instability in the male germline. Hum Mol Genet (2005) 1.55
Telomere biology in healthy aging and disease. Pflugers Arch (2009) 1.41
Analysis of telomeres and telomerase. Curr Protoc Cell Biol (2003) 1.35
Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei mice. Free Radic Biol Med (2008) 1.34
The load of short telomeres, estimated by a new method, Universal STELA, correlates with number of senescent cells. Aging Cell (2010) 1.06
Isolation of High-molecular-weight DNA from Mammalian Cells Using Proteinase K and Phenol. CSH Protoc (2006) 0.98
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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Long-term mortality after gastric bypass surgery. N Engl J Med (2007) 10.75
Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol (2006) 5.28
Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet (2004) 4.51
Gene transfer in humans using a conditionally replicating lentiviral vector. Proc Natl Acad Sci U S A (2006) 4.23
The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med (2008) 3.68
Telomere length and possible link to X chromosome. Lancet (2004) 3.36
Rise in insulin resistance is associated with escalated telomere attrition. Circulation (2005) 3.27
Telomere length in the newborn. Pediatr Res (2002) 3.26
Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Genet (2006) 3.25
Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study. Aging Cell (2008) 3.24
Health benefits of gastric bypass surgery after 6 years. JAMA (2012) 3.10
Common variants near TERC are associated with mean telomere length. Nat Genet (2010) 2.98
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR. Nucleic Acids Res (2011) 2.92
Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol (2008) 2.86
Telomere length and mortality: a study of leukocytes in elderly Danish twins. Am J Epidemiol (2008) 2.85
Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun (2013) 2.56
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A (2010) 2.47
Urinary incontinence predictors and life impact in ethnically diverse perimenopausal women. Obstet Gynecol (2002) 2.47
Left ventricular hypertrophy in severe obesity: interactions among blood pressure, nocturnal hypoxemia, and body mass. Hypertension (2006) 2.43
Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension (2004) 2.41
Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood (2003) 2.29
Favorable changes in cardiac geometry and function following gastric bypass surgery: 2-year follow-up in the Utah obesity study. J Am Coll Cardiol (2011) 2.26
Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart Study. Circulation (2008) 2.22
Leukocyte telomere length and mortality in the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci (2011) 2.19
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TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition. Hum Mol Genet (2006) 2.15
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Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load. Mol Ther (2004) 1.80
Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genet (2008) 1.80
Adipocyte iron regulates adiponectin and insulin sensitivity. J Clin Invest (2012) 1.78
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet (2012) 1.77
Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo. Cancer Epidemiol Biomarkers Prev (2007) 1.75
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Leukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth. Exp Hematol (2009) 1.66
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Synchrony of telomere length among hematopoietic cells. Exp Hematol (2010) 1.63
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The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell (2011) 1.55
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Design and rationale of the Utah obesity study. A study to assess morbidity following gastric bypass surgery. Contemp Clin Trials (2005) 1.53
Ethnic differences in past hysterectomy for benign conditions. Womens Health Issues (2005) 1.52
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Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr (2007) 1.47
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Preservation of myocardial microcirculation during mechanical reperfusion for myocardial ischemia with either abciximab or eptifibatide. J Invasive Cardiol (2003) 1.39
The telomere lengthening conundrum--artifact or biology? Nucleic Acids Res (2013) 1.38
Hypertension in pregnancy as a risk factor for cardiovascular disease later in life. J Hypertens (2010) 1.36
Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei mice. Free Radic Biol Med (2008) 1.34
Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. J Immunol (2008) 1.34
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Do leukocyte telomere length dynamics depend on baseline telomere length? An analysis that corrects for 'regression to the mean'. Eur J Epidemiol (2013) 1.28
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Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus. Arthritis Rheum (2010) 1.27
An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study. BMC Genet (2007) 1.27
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INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism. Obesity (Silver Spring) (2008) 1.24
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