Published in Proc Natl Acad Sci U S A on April 26, 2010
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet (2013) 3.17
Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths. Nat Protoc (2010) 2.88
TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. Gut (2011) 2.75
Healthy aging and disease: role for telomere biology? Clin Sci (Lond) (2011) 2.10
Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither? Epidemiol Rev (2013) 2.05
Effect of telomere length on survival in patients with idiopathic pulmonary fibrosis: an observational cohort study with independent validation. Lancet Respir Med (2014) 1.91
A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. Cancer Prev Res (Phila) (2011) 1.86
Evolution of CST function in telomere maintenance. Cell Cycle (2010) 1.81
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet (2012) 1.77
Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet (2013) 1.72
Leukocyte telomere length and the father's age enigma: implications for population health and for life course. Int J Epidemiol (2013) 1.66
Synchrony of telomere length among hematopoietic cells. Exp Hematol (2010) 1.63
The association of telomere length and genetic variation in telomere biology genes. Hum Mutat (2010) 1.53
A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet (2013) 1.52
Leukocyte telomere length in healthy Caucasian and African-American adolescents: relationships with race, sex, adiposity, adipokines, and physical activity. J Pediatr (2010) 1.50
The roles of senescence and telomere shortening in cardiovascular disease. Nat Rev Cardiol (2013) 1.48
Genetics of leukocyte telomere length and its role in atherosclerosis. Mutat Res (2011) 1.44
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways. Age (Dordr) (2011) 1.26
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Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in. Cell Res (2012) 1.20
Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length. Am J Obstet Gynecol (2012) 1.16
Genome-wide association study of relative telomere length. PLoS One (2011) 1.16
Telomere length and the risk of cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations. PLoS One (2013) 1.07
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Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. Oncotarget (2015) 1.03
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A prospective study of leukocyte telomere length and risk of type 2 diabetes in postmenopausal women. Diabetes (2012) 0.98
Human TEN1 maintains telomere integrity and functions in genome-wide replication restart. J Biol Chem (2013) 0.95
Connecting complex disorders through biology. Nat Genet (2012) 0.95
Common variants near TERC are associated with leukocyte telomere length in the Chinese Han population. Eur J Hum Genet (2011) 0.95
Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci. Sci Rep (2014) 0.94
Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer. Br J Cancer (2015) 0.93
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Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. Front Genet (2014) 0.93
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Telomere-associated polymorphisms correlate with cardiovascular disease mortality in Caucasian women: the Cardiovascular Health Study. Mech Ageing Dev (2012) 0.92
Effects of brood size manipulation and common origin on phenotype and telomere length in nestling collared flycatchers. BMC Ecol (2012) 0.92
Telomeres, atherosclerosis, and the hemothelium: the longer view. Annu Rev Med (2011) 0.91
Functional haplotypes of the hTERT gene, leukocyte telomere length shortening, and the risk of peripheral arterial disease. PLoS One (2012) 0.91
Prenatal stress, development, health and disease risk: A psychobiological perspective-2015 Curt Richter Award Paper. Psychoneuroendocrinology (2015) 0.91
Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease. PLoS One (2013) 0.90
DCAF4, a novel gene associated with leucocyte telomere length. J Med Genet (2015) 0.90
QTL mapping of leukocyte telomere length in American Indians: the Strong Heart Family Study. Aging (Albany NY) (2013) 0.89
The heritability of leucocyte telomere length dynamics. J Med Genet (2015) 0.87
Telomere length and common disease: study design and analytical challenges. Hum Genet (2015) 0.87
Evaluation of the gene-age interactions in HDL cholesterol, LDL cholesterol, and triglyceride levels: the impact of the SORT1 polymorphism on LDL cholesterol levels is age dependent. Atherosclerosis (2011) 0.87
Race, Ethnicity, Psychosocial Factors, and Telomere Length in a Multicenter Setting. PLoS One (2016) 0.87
Sex- and age-interacting eQTLs in human complex diseases. Hum Mol Genet (2013) 0.86
No association between mean telomere length and life stress observed in a 30 year birth cohort. PLoS One (2014) 0.85
A genome-wide association study identifies a locus on TERT for mean telomere length in Han Chinese. PLoS One (2014) 0.84
Racial and Socioeconomic Variation in Genetic Markers of Telomere Length: A Cross-Sectional Study of U.S. Older Adults. EBioMedicine (2016) 0.84
Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease. Public Health Genomics (2014) 0.84
Telomere structure and maintenance gene variants and risk of five cancer types. Int J Cancer (2016) 0.83
Genetic architecture of natural variation of telomere length in Arabidopsis thaliana. Genetics (2014) 0.82
Cdk1 regulates the temporal recruitment of telomerase and Cdc13-Stn1-Ten1 complex for telomere replication. Mol Cell Biol (2013) 0.82
Telomere replication: poised but puzzling. J Cell Mol Med (2011) 0.82
Absence of association of a single-nucleotide polymorphism in the TERT-CLPTM1L locus with age-related phenotypes in a large multicohort study: the HALCyon programme. Aging Cell (2011) 0.82
Shortened leukocyte telomere length in type 2 diabetes mellitus: genetic polymorphisms in mitochondrial uncoupling proteins and telomeric pathways. Clin Transl Med (2016) 0.81
Telomere length, genetic variants and risk of squamous cell carcinoma of the head and neck in Southeast Chinese. Sci Rep (2016) 0.81
Leukocyte telomere length-related rs621559 and rs398652 genetic variants influence risk of HBV-related hepatocellular carcinoma. PLoS One (2014) 0.81
The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length. Genetics (2016) 0.81
Nuclear and mitochondrial DNA repair in selected eukaryotic aging model systems. Oxid Med Cell Longev (2012) 0.81
Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Med Genet (2015) 0.81
Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort. Circ Cardiovasc Genet (2014) 0.81
Stn1 is critical for telomere maintenance and long-term viability of somatic human cells. Aging Cell (2015) 0.80
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers. Carcinogenesis (2016) 0.80
Telomere length in the two extremes of abnormal fetal growth and the programming effect of maternal arterial hypertension. Sci Rep (2015) 0.80
Association between genetic variants in DNA and histone methylation and telomere length. PLoS One (2012) 0.80
Genetic susceptibility and pulmonary fibrosis. Curr Opin Pulm Med (2014) 0.78
Surprises from the chromosome front: lessons from Arabidopsis on telomeres and telomerase. Cold Spring Harb Symp Quant Biol (2013) 0.78
Telomere Length and the Cancer-Atherosclerosis Trade-Off. PLoS Genet (2016) 0.78
Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer. Oncotarget (2016) 0.77
Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population. Korean J Intern Med (2015) 0.77
Shorter telomere length in Europeans than in Africans due to polygenetic adaptation. Hum Mol Genet (2016) 0.77
Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol. Atherosclerosis (2012) 0.77
Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Nat Commun (2016) 0.75
Genome maintenance and human longevity. Curr Opin Genet Dev (2014) 0.75
Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals. Environ Res (2014) 0.75
A genome-wide association study yields five novel thyroid cancer risk loci. Nat Commun (2017) 0.75
Telomerase activity and the risk of lung cancer. J Korean Med Sci (2012) 0.75
Estimating Telomere Length Heritability in an Unrelated Sample of Adults: Is Heritability of Telomere Length Modified by Life Course Socioeconomic Status? Biodemography Soc Biol (2016) 0.75
Association between Genetic Variations Affecting Mean Telomere Length and the Prevalence of Hypertension and Coronary Heart Disease in Koreans. Clin Nutr Res (2016) 0.75
The known genetic loci for telomere length may be involved in the modification of telomeres length after birth. Sci Rep (2016) 0.75
Basic Biology of Oxidative Stress and the Cardiovascular System: Part 1 of a 3-Part Series. J Am Coll Cardiol (2017) 0.75
Preterm infants have significantly longer telomeres than their term born counterparts. PLoS One (2017) 0.75
Relationship between the TERT, TNIP1 and OBFC1 genetic polymorphisms and susceptibility to colorectal cancer in Chinese Han population. Oncotarget (2017) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
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SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics (2008) 15.77
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
How shelterin protects mammalian telomeres. Annu Rev Genet (2008) 11.20
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Obesity, cigarette smoking, and telomere length in women. Lancet (2005) 8.59
Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med (2007) 8.23
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Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med (2005) 7.09
Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet (1994) 7.04
The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell (2006) 6.80
Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A (2007) 5.95
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med (2007) 5.28
Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension (2001) 4.07
The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med (2008) 3.68
Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci U S A (2007) 3.67
Telomere length and possible link to X chromosome. Lancet (2004) 3.36
Mapping of a major locus that determines telomere length in humans. Am J Hum Genet (2004) 3.33
Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension (2000) 3.32
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Rise in insulin resistance is associated with escalated telomere attrition. Circulation (2005) 3.27
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Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Genet (2006) 3.25
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Telomere length predicts survival independent of genetic influences. Aging Cell (2007) 3.01
Common variants near TERC are associated with mean telomere length. Nat Genet (2010) 2.98
RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Mol Cell (2009) 2.93
Telomere length and mortality: a study of leukocytes in elderly Danish twins. Am J Epidemiol (2008) 2.85
Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. Aging Cell (2007) 2.62
Chemokines in atherosclerosis: an update. Arterioscler Thromb Vasc Biol (2008) 2.42
Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet (2006) 2.36
Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart Study. Circulation (2008) 2.22
The epidemiology of human telomeres: faults and promises. J Gerontol A Biol Sci Med Sci (2008) 2.11
Neutrophil mobilization and clearance in the bone marrow. Immunology (2008) 1.87
CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. Blood (2009) 1.83
Telomeres and human somatic fitness. J Gerontol A Biol Sci Med Sci (2006) 1.82
Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genet (2008) 1.80
Dyskeratosis congenita -- a disease of dysfunctional telomere maintenance. Curr Mol Med (2005) 1.78
Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell (2009) 1.72
Paternal age is positively linked to telomere length of children. Aging Cell (2005) 1.69
Telomere length in small-for-gestational-age babies. BJOG (2006) 1.66
Leukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth. Exp Hematol (2009) 1.66
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. BMC Med Genet (2007) 1.65
Biological ageing and cardiovascular disease. Heart (2008) 1.64
Paternal age at birth is an important determinant of offspring telomere length. Hum Mol Genet (2007) 1.58
Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition. EMBO J (2008) 1.56
OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. J Biol Chem (2009) 1.53
A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length. J Med Genet (2009) 1.51
A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans. Hum Mol Genet (2008) 1.43
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med (2008) 57.29
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol (2002) 35.63
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation (2008) 26.42
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study of global gene expression. Nat Genet (2007) 22.98
Global quantification of mammalian gene expression control. Nature (2011) 22.36
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46
Vitamin D deficiency and risk of cardiovascular disease. Circulation (2008) 13.39
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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
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Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Metabolite profiles and the risk of developing diabetes. Nat Med (2011) 12.22
Human genetic variation and its contribution to complex traits. Nat Rev Genet (2009) 12.11
Opioid prescriptions for chronic pain and overdose: a cohort study. Ann Intern Med (2010) 11.99
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
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