Published in Proc Natl Acad Sci U S A on July 18, 2003
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23
Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites. Nucleic Acids Res (2009) 2.22
Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue. Proc Natl Acad Sci U S A (2011) 2.15
Redox sensor CtBP mediates hypoxia-induced tumor cell migration. Proc Natl Acad Sci U S A (2006) 1.67
Hairy transcriptional repression targets and cofactor recruitment in Drosophila. PLoS Biol (2004) 1.63
Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab (2015) 1.38
Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis. Proc Natl Acad Sci U S A (2005) 1.35
Mineralocorticoid receptors: distribution and activation. Heart Fail Rev (2005) 1.28
Transcriptional regulation of BRCA1 expression by a metabolic switch. Nat Struct Mol Biol (2010) 1.25
Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype. Mol Cancer (2009) 1.20
NADP regulates the yeast GAL induction system. Science (2008) 1.15
Therapeutic targeting of C-terminal binding protein in human cancer. Cell Cycle (2010) 1.12
NAD+ as a signaling molecule modulating metabolism. Cold Spring Harb Symp Quant Biol (2012) 1.12
NAD captureSeq indicates NAD as a bacterial cap for a subset of regulatory RNAs. Nature (2014) 1.08
Label-free separation of human embryonic stem cells and their differentiating progenies by phasor fluorescence lifetime microscopy. J Biomed Opt (2012) 1.08
P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1. Proc Natl Acad Sci U S A (2003) 1.06
NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise. Am J Physiol Endocrinol Metab (2012) 1.05
RIBEYE recruits Munc119, a mammalian ortholog of the Caenorhabditis elegans protein unc119, to synaptic ribbons of photoreceptor synapses. J Biol Chem (2008) 1.04
NADH distribution in live progenitor stem cells by phasor-fluorescence lifetime image microscopy. Biophys J (2012) 1.04
Expression of CtBP family protein isoforms in breast cancer and their role in chemoresistance. Biol Cell (2010) 1.03
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol (2011) 1.03
The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets. EMBO J (2011) 1.02
Fluorescence lifetime endoscopy using TCSPC for the measurement of FRET in live cells. Opt Express (2010) 1.01
Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2. J Biol Chem (2008) 0.98
The potential of dual camera systems for multimodal imaging of cardiac electrophysiology and metabolism. Exp Biol Med (Maywood) (2009) 0.98
Serum or target deprivation-induced neuronal death causes oxidative neuronal accumulation of Zn2+ and loss of NAD+. Eur J Neurosci (2010) 0.96
Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1. Oncogene (2010) 0.96
CtBP contributes quantitatively to Knirps repression activity in an NAD binding-dependent manner. Mol Cell Biol (2004) 0.93
Metabolic mechanisms of epigenetic regulation. ACS Chem Biol (2013) 0.92
The C-terminal domain of the transcriptional corepressor CtBP is intrinsically unstructured. Protein Sci (2006) 0.92
CtBP2 Promotes Human Cancer Cell Migration by Transcriptional Activation of Tiam1. Genes Cancer (2012) 0.92
Nicotinamide adenine dinucleotide-dependent binding of the neuronal Ca2+ sensor protein GCAP2 to photoreceptor synaptic ribbons. J Neurosci (2010) 0.91
NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association. Oncogene (2009) 0.89
Metabolic regulation of histone post-translational modifications. ACS Chem Biol (2015) 0.87
Fluorescence lifetime imaging unravels C. trachomatis metabolism and its crosstalk with the host cell. PLoS Pathog (2011) 0.86
Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene. Mol Cell Biol (2007) 0.86
Phasor-FLIM analysis of NADH distribution and localization in the nucleus of live progenitor myoblast cells. Microsc Res Tech (2012) 0.85
Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression. J Biomol Screen (2014) 0.85
Lactate shuttling and lactate use as fuel after traumatic brain injury: metabolic considerations. J Cereb Blood Flow Metab (2014) 0.85
C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer. Int J Cell Biol (2013) 0.84
Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons. Aging Cell (2014) 0.84
Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design. FEBS Lett (2014) 0.84
Mineralocorticoid receptor antagonists: emerging roles in cardiovascular medicine. Integr Blood Press Control (2013) 0.84
GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis. J Biol Chem (2010) 0.83
Fluxes of lactate into, from, and among gap junction-coupled astrocytes and their interaction with noradrenaline. Front Neurosci (2014) 0.83
The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases. Protein Sci (2010) 0.82
A renaissance of metabolite sensing and signaling: from modular domains to riboswitches. Plant Cell (2004) 0.82
Components of the CtBP1/BARS-dependent fission machinery. Histochem Cell Biol (2013) 0.82
Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development. Mol Cell Biol (2010) 0.81
Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells. Endocrinology (2009) 0.80
A link between hinge-bending domain motions and the temperature dependence of catalysis in 3-isopropylmalate dehydrogenase. Biophys J (2009) 0.80
NADH binds and stabilizes the 26S proteasomes independent of ATP. J Biol Chem (2014) 0.79
CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4. Cell Death Dis (2015) 0.78
Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP). Bioorg Med Chem (2016) 0.78
Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1. Circulation (2016) 0.77
Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders. Clin Transl Med (2016) 0.77
CtBP1 associates metabolic syndrome and breast carcinogenesis targeting multiple miRNAs. Oncotarget (2016) 0.77
Structure-guided design of a high affinity inhibitor to human CtBP. ACS Chem Biol (2015) 0.77
Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone. J Transl Med (2011) 0.77
Nicotinamide adenine dinucleotide-induced multimerization of the co-repressor CtBP1 relies on a switching tryptophan. J Biol Chem (2013) 0.77
Evaluation of NAD(H) analogues as selective inhibitors for Trypanosoma cruzi S-adenosylhomocysteine hydrolase. Nucleosides Nucleotides Nucleic Acids (2009) 0.76
Endogenous fluorescence signatures in living pluripotent stem cells change with loss of potency. PLoS One (2012) 0.76
Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3). J Biol Chem (2016) 0.76
Oligomeric form of CtBP coactivates NeuroD1-mediated transcription. FEBS Lett (2016) 0.75
Evidence of Kinetic Cooperativity in Dimeric Ketopantoate Reductase from Staphylococcus aureus. Biochemistry (2015) 0.75
C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis. Mol Cell Neurosci (2013) 0.75
Hyperpolarized 13C NMR observation of lactate kinetics in skeletal muscle. J Exp Biol (2015) 0.75
ANGUSTIFOLIA, a Plant Homolog of CtBP/BARS Localizes to Stress Granules and Regulates Their Formation. Front Plant Sci (2017) 0.75
Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP. Nat Commun (2017) 0.75
Metabolic control by sirtuins and other enzymes that sense NAD(+), NADH, or their ratio. Biochim Biophys Acta (2017) 0.75
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (2000) 12.98
The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem J (1967) 12.40
Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev (2000) 9.36
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A (2000) 7.92
Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature (2003) 6.48
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science (2001) 5.03
Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc Natl Acad Sci U S A (2000) 3.94
The polycomb protein Pc2 is a SUMO E3. Cell (2003) 3.91
Regulation of corepressor function by nuclear NADH. Science (2002) 3.83
Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase. Mol Cell (2002) 3.28
Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc Natl Acad Sci U S A (1995) 3.28
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol Cell Biol (2002) 3.13
Interaction of short-range repressors with Drosophila CtBP in the embryo. Science (1998) 2.61
Long-range nonradiative transfer of electronic excitation energy in proteins and polypeptides. Annu Rev Biochem (1971) 2.46
C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs. Proc Natl Acad Sci U S A (2003) 2.25
Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases. Trends Biochem Sci (2003) 2.03
Class II histone deacetylases: structure, function, and regulation. Biochem Cell Biol (2001) 2.00
CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission. EMBO J (2003) 1.86
A dynamic role for HDAC7 in MEF2-mediated muscle differentiation. J Biol Chem (2001) 1.68
The development of gluconeogenesis in rat liver: experiments in vivo. Biochem J (1969) 1.39
Nicotinamide adenine dinucleotide stimulates oligomerization, interaction with adenovirus E1A and an intrinsic dehydrogenase activity of CtBP. FEBS Lett (2003) 1.38
Control of the redox state of the nicotinamide-adenine dinucleotide couple in rat liver cytoplasm. Biochem J (1972) 1.31
Association of class I histone deacetylases with transcriptional corepressor CtBP. FEBS Lett (2003) 1.16
Chromatin remodeling: nucleosomes bulging at the seams. Curr Biol (2002) 1.15
On the enzymatic activation of NADH. J Biol Chem (2000) 1.11
The mechanism of end product inhibition of serine biosynthesis. II. Optical studies of phosphoglycerate dehydrogenase. J Biol Chem (1968) 1.10
Cofactor binding to Escherichia coli D-3-phosphoglycerate dehydrogenase induces multiple conformations which alter effector binding. J Biol Chem (2002) 1.00
Deoxyhypusine synthase generates and uses bound NADH in a transient hydride transfer mechanism. J Biol Chem (2000) 0.95
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci U S A (2005) 6.61
Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell (2004) 6.08
Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature (2009) 4.18
An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci U S A (2008) 3.98
Regulation of corepressor function by nuclear NADH. Science (2002) 3.83
Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat Neurosci (2007) 3.81
A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions. J Neurosci (2007) 2.45
Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV. Neuron (2002) 2.45
Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell (2003) 2.42
microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus. Proc Natl Acad Sci U S A (2010) 2.28
An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling. Mol Cell Neurosci (2009) 2.28
C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs. Proc Natl Acad Sci U S A (2003) 2.25
Retracted Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Proc Natl Acad Sci U S A (2007) 2.09
Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells. Proc Natl Acad Sci U S A (2007) 1.89
Redox sensor CtBP mediates hypoxia-induced tumor cell migration. Proc Natl Acad Sci U S A (2006) 1.67
Cell-type-specific binding of the transcription factor CREB to the cAMP-response element. Proc Natl Acad Sci U S A (2004) 1.49
Deacetylase activity is required for cAMP activation of a subset of CREB target genes. J Biol Chem (2003) 1.48
A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression. Mol Cell Biol (2008) 1.42
A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers. Proc Natl Acad Sci U S A (2009) 1.37
Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis. Proc Natl Acad Sci U S A (2005) 1.35
Epigenetic mechanisms and gene networks in the nervous system. J Neurosci (2005) 1.33
Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J Biol Chem (2007) 1.21
An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4. J Biol Chem (2006) 1.21
Affinity purification of microRNA-133a with the cardiac transcription factor, Hand2. Proc Natl Acad Sci U S A (2010) 1.14
The acetyltransferase activity of CBP is required for wingless activation and H4 acetylation in Drosophila melanogaster. Mol Cell Biol (2002) 1.08
Role reversal: the regulation of neuronal gene expression by microRNAs. Curr Opin Neurobiol (2005) 1.06
MicroRNA pathways in neural development and plasticity. Curr Opin Neurobiol (2010) 1.04
Capturing microRNA targets using an RNA-induced silencing complex (RISC)-trap approach. Proc Natl Acad Sci U S A (2012) 0.96
Buprenorphine is a weak partial agonist that inhibits opioid receptor desensitization. J Neurosci (2009) 0.93
Regulation of microRNA-375 by cAMP in pancreatic β-cells. Mol Endocrinol (2012) 0.92
Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. Neoplasia (2007) 0.89
The interaction between the coactivator dCBP and Modulo, a chromatin-associated factor, affects segmentation and melanotic tumor formation in Drosophila. Proc Natl Acad Sci U S A (2002) 0.88
Calmodulin-dependent protein kinase IV mediated antagonism of BMP signaling regulates lineage and survival of hematopoietic progenitors. Development (2002) 0.87
MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9. Proc Natl Acad Sci U S A (2013) 0.80
Corrigendum: miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3. Nat Commun (2015) 0.76
Retraction for Zhang et al., Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Proc Natl Acad Sci U S A (2015) 0.75