Published in Aging Cell on February 01, 2011
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Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degeneration. Aging Cell (2013) 1.05
Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies. Organogenesis (2014) 0.87
"Ins" and "Outs" of mesenchymal stem cell osteogenesis in regenerative medicine. World J Stem Cells (2014) 0.81
Probing the depths of cellular senescence. J Cell Biol (2013) 0.81
Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells. Age (Dordr) (2012) 0.79
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Evolution of Microbial Quorum Sensing to Human Global Quorum Sensing: An Insight into How Gap Junctional Intercellular Communication Might Be Linked to the Global Metabolic Disease Crisis. Biology (Basel) (2016) 0.75
Phenyl 2-pyridyl ketoxime induces cellular senescence-like alterations via nitric oxide production in human diploid fibroblasts. Aging Cell (2015) 0.75
Chitosan Treatment Delays the Induction of Senescence in Human Foreskin Fibroblast Strains. PLoS One (2015) 0.75
Analysis of Gene Expression in Human Dermal Fibroblasts Treated with Senescence-Modulating COX Inhibitors. Genomics Inform (2017) 0.75
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature (2002) 8.45
Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev (2006) 6.62
mTOR is a key modulator of ageing and age-related disease. Nature (2013) 5.40
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011) 4.48
Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell (2008) 3.58
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science (2013) 3.41
A molecular mechanism of chronological aging in yeast. Cell Cycle (2009) 3.12
Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell (2006) 2.95
The TOR pathway comes of age. Biochim Biophys Acta (2009) 2.83
Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science (2009) 2.62
Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab (2012) 2.56
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res (2008) 2.32
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell (2008) 2.32
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci Transl Med (2012) 1.98
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A (2009) 1.96
Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A (2008) 1.80
A method for high-throughput quantitative analysis of yeast chronological life span. J Gerontol A Biol Sci Med Sci (2008) 1.76
Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet (2008) 1.76
Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC Dev Biol (2008) 1.75
Measuring replicative life span in the budding yeast. J Vis Exp (2009) 1.68
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Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT. Genes Dev (2005) 1.52
Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. PLoS Genet (2011) 1.52
Genome instability and aging. Annu Rev Physiol (2013) 1.46
Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. PLoS One (2008) 1.45
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A haplotype-based molecular analysis of CFTR mutations associated with respiratory and pancreatic diseases. Hum Mol Genet (2003) 1.40
Measuring Caenorhabditis elegans life span on solid media. J Vis Exp (2009) 1.39
The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics (2006) 1.36
HIF-1 modulates longevity and healthspan in a temperature-dependent manner. Aging Cell (2011) 1.35
Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. Aging Cell (2006) 1.32
Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell (2013) 1.31
Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Exp Gerontol (2007) 1.31
Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding. Mol Endocrinol (2004) 1.30
A comparative analysis of the cell biology of senescence and aging. Cell Mol Life Sci (2009) 1.26
Ageing: A midlife longevity drug? Nature (2009) 1.25
Hot topics in aging research: protein translation, 2009. Aging Cell (2009) 1.24
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Mol Biol Cell (2002) 1.24
MRP2 haplotypes confer differential susceptibility to toxic liver injury. Pharmacogenet Genomics (2007) 1.23
Hypertrophy and senescence factors in yeast aging. A reply to Bilinski et al. FEMS Yeast Res (2012) 1.23
Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae. Genetics (2012) 1.23
A genomic analysis of chronological longevity factors in budding yeast. Cell Cycle (2011) 1.22
Autophagy impairment induces premature senescence in primary human fibroblasts. PLoS One (2011) 1.22
Distributions of ACE and APOE polymorphisms and their relations with dementia status in Korean centenarians. J Gerontol A Biol Sci Med Sci (2003) 1.21
pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast. Cell Cycle (2012) 1.21
Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice. PLoS Genet (2006) 1.19
Aging alters the apoptotic response to genotoxic stress. Nat Med (2002) 1.18
Senescent phenotype can be reversed by reduction of caveolin status. J Biol Chem (2003) 1.18
Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. Cell Metab (2012) 1.18
Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast. PLoS One (2011) 1.16
Single-stranded DNA binding factor AtWHY1 modulates telomere length homeostasis in Arabidopsis. Plant J (2007) 1.15
Morphological adjustment of senescent cells by modulating caveolin-1 status. J Biol Chem (2004) 1.14
Quantifying yeast chronological life span by outgrowth of aged cells. J Vis Exp (2009) 1.14
Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: implication to age-associated bone diseases and defects. Mech Ageing Dev (2012) 1.13
Genome-wide identification of conserved longevity genes in yeast and worms. Mech Ageing Dev (2006) 1.13
Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. Cell Cycle (2011) 1.13
Genetic studies reveal the role of the endocrine and metabolic systems in aging. J Clin Endocrinol Metab (2010) 1.13
The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging. Biol Chem (2010) 1.12
Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice. Cancer Res (2005) 1.12
MicroRNA in Aging: From Discovery to Biology. Curr Genomics (2012) 1.08
Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation. J Biol Chem (2012) 1.08
Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles. Aging Cell (2011) 1.05
Spermidine surprise for a long life. Nat Cell Biol (2009) 1.03
Suppression of RICE TELOMERE BINDING PROTEIN 1 results in severe and gradual developmental defects accompanied by genome instability in rice. Plant Cell (2007) 1.03
YODA: software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast. BMC Bioinformatics (2010) 1.03
The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1. PLoS Genet (2013) 1.02
Endoscopic resection of duodenal neoplasms: a single-center study. Surg Endosc (2010) 1.02
A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS Genet (2013) 1.02
Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1. J Gerontol A Biol Sci Med Sci (2013) 1.01
Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation. J Cell Sci (2012) 1.01
Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell (2011) 1.01
Midlife gene expressions identify modulators of aging through dietary interventions. Proc Natl Acad Sci U S A (2012) 1.00
Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities. Bioorg Med Chem Lett (2003) 1.00
Regulation of mRNA translation as a conserved mechanism of longevity control. Adv Exp Med Biol (2010) 0.99
A genomic approach to yeast chronological aging. Methods Mol Biol (2009) 0.99
Up-regulation of cytoskeletal-associated protein 2 in primary human gastric adenocarcinomas. J Cancer Res Clin Oncol (2003) 0.99
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC Genomics (2012) 0.99
The enigmatic role of Sir2 in aging. Cell (2005) 0.99
Increased caveolin-1, a cause for the declined adipogenic potential of senescent human mesenchymal stem cells. Mech Ageing Dev (2005) 0.98
Interaction of an Arabidopsis RNA-binding protein with plant single-stranded telomeric DNA modulates telomerase activity. J Biol Chem (2003) 0.98
WormFarm: a quantitative control and measurement device toward automated Caenorhabditis elegans aging analysis. Aging Cell (2013) 0.98
Fermented garlic protects diabetic, obese mice when fed a high-fat diet by antioxidant effects. Nutr Res (2011) 0.97
Preserving youth: does rapamycin deliver? Sci Transl Med (2013) 0.97
Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma. Cancer Res (2004) 0.97
Discovery of functional gene variants associated with human longevity: opportunities and challenges. J Gerontol A Biol Sci Med Sci (2011) 0.96
Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1. J Biol Chem (2009) 0.96
Induction of senescence-like state and suppression of telomerase activity through inhibition of HPV E6/E7 gene expression in cells immortalized by HPV16 DNA. Exp Cell Res (2002) 0.96
Yeast replicative aging: a paradigm for defining conserved longevity interventions. FEMS Yeast Res (2013) 0.94
Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell (2012) 0.94
Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes. Aging (Albany NY) (2013) 0.94
DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase. J Biol Chem (2004) 0.93
Regulation of telomeric repeat binding factor 1 binding to telomeres by casein kinase 2-mediated phosphorylation. J Biol Chem (2008) 0.93
Caveolin-1 as a prime modulator of aging: a new modality for phenotypic restoration? Mech Ageing Dev (2005) 0.93
CHIP promotes human telomerase reverse transcriptase degradation and negatively regulates telomerase activity. J Biol Chem (2010) 0.93
Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans. Curr Genomics (2012) 0.93
Potent inhibition of human telomerase by nitrostyrene derivatives. Mol Pharmacol (2003) 0.92