Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells.

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Published in Proc Natl Acad Sci U S A on July 01, 1990

Authors

A Kaushik1, D H Schulze, F A Bonilla, C Bona, G Kelsoe

Author Affiliations

1: Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029.

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Stimulation of lymphocytes by purified protein derivative: suppression by cells from human vaccinated with Bacille Calmette-Guérin. J Infect Dis (1976) 0.94

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Induction of antihemagglutinin antibodies by polyclonal antiidiotype antibodies. Viral Immunol (1993) 0.92

[Ultrastructure of guinea pig macrophages]. Ann Inst Pasteur (Paris) (1971) 0.92