Published in J Exp Med on May 01, 1989
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J Exp Med (1991) 4.98
Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. J Exp Med (1990) 1.91
Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles. J Exp Med (1991) 1.46
An idiotypic marker associated with a germ-line encoded kappa light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b polysaccharide. J Clin Invest (1991) 1.24
Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations. J Clin Invest (1992) 1.21
Assembly and analysis of the mouse immunoglobulin kappa gene sequence. Immunogenetics (2004) 1.19
Early rearrangements of genes encoding murine immunoglobulin kappa chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus. Proc Natl Acad Sci U S A (1989) 1.14
Deletions of immunoglobulin C kappa region characterized by the circular excision products in mouse splenocytes. J Exp Med (1991) 1.02
Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing. J Immunol (2012) 0.98
Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells. Proc Natl Acad Sci U S A (1990) 0.94
Preferential rearrangement of V kappa 4 gene segments in pre-B cell lines. J Exp Med (1990) 0.93
Selection of antigen-specific, idiotype-positive B cells in transgenic mice expressing a rearranged M167-mu heavy chain gene. J Exp Med (1991) 0.90
A single pre-B cell can give rise to antigen-specific B cells that utilize distinct immunoglobulin gene rearrangements. J Exp Med (1990) 0.88
Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinations. J Exp Med (1993) 0.78
Analysis of the expression immunoglobulin gene repertoire by screening libraries derived from PCR-amplified cDNA. Nucleic Acids Res (1991) 0.76
Multiple factors influence the contribution of individual immunoglobulin light chain genes to the naïve antibody repertoire. BMC Immunol (2014) 0.76
A murine Ig light chain transgene reveals IGKV3 gene contributions to anti-collagen types IV and II specificities. Mol Immunol (2017) 0.75
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature (1984) 5.75
The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes. Eur J Immunol (1984) 5.33
Development of the primary antibody repertoire. Science (1987) 4.19
Developmentally controlled expression of immunoglobulin VH genes. Science (1985) 2.96
Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B cells. J Exp Med (1986) 2.04
VH-gene expression in murine lipopolysaccharide blasts distributes over the nine known VH-gene groups and may be random. Eur J Immunol (1985) 2.03
Sets of immunoglobulin V kappa genes homologous to ten cloned V kappa sequences: implications for the number of germline V kappa genes. J Mol Appl Genet (1981) 1.93
Classification of mouse VK groups based on the partial amino acid sequence to the first invariant tryptophan: impact of 14 new sequences from IgG myeloma proteins. Mol Immunol (1982) 1.93
Developmentally regulated and strain-specific expression of murine VH gene families. J Exp Med (1988) 1.85
Molecular cloning of seven mouse immunoglobulin kappa chain messenger ribonucleic acids. Biochemistry (1980) 1.82
Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes. EMBO J (1985) 1.75
How immunoglobulin V kappa genes rearrange. J Immunol (1987) 1.68
Influence of clonal selection on the expression of immunoglobulin variable region genes. Science (1984) 1.57
Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice. J Exp Med (1987) 1.49
A member of a new VH gene family encodes antibromelinized mouse red blood cell autoantibodies. Eur J Immunol (1988) 1.28
Determinants of the hierarchy of humoral immune responsiveness during ontogeny. J Immunol (1975) 1.08
The Ig kappa L chain allelic groups among the Ig kappa haplotypes and Ig kappa crossover populations suggest a gene order. J Immunol (1988) 1.07
Strain-dependent expression of VH gene families. J Immunol (1988) 1.07
A new murine Ig VH gene family. J Immunol (1988) 1.06
Evidence for 65 electrophoretically distinct groups of light chains in BALB/c and NZB myelomas. Mol Immunol (1984) 0.96
Biased usage of certain Vk gene families by autoantibodies and their polymorphism in autoimmune mice. Mol Immunol (1988) 0.91
Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper disks: phenotypic and genotypic analysis of B cell colonies. Methods Enzymol (1987) 0.91
Intraclonal generation of antibody mutants in germinal centres. Nature (1991) 7.39
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J Exp Med (1991) 4.98
Oligomeric structure of gp41, the transmembrane protein of human immunodeficiency virus type 1. J Virol (1989) 4.07
Defining criteria for autoimmune diseases (Witebsky's postulates revisited) Immunol Today (1993) 3.81
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J Exp Med (1992) 3.13
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J Exp Med (1993) 3.13
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J Exp Med (1998) 3.04
Cell cycle regulation of mouse H3 histone mRNA metabolism. Mol Cell Biol (1984) 2.97
Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J Immunol (1995) 2.72
V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science (1997) 2.58
Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype. J Exp Med (1979) 2.53
Regulation of the B cell response to T-dependent antigens by classical pathway complement. J Immunol (1996) 2.51
Spontaneous H-2 mutants provide evidence that a copy mechanism analogous to gene conversion generates polymorphism in the major histocompatibility complex. Proc Natl Acad Sci U S A (1983) 2.51
Mitogenic effect of bacterial peptidoglycans possessing adjuvant activity. J Immunol (1975) 2.15
Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science (1996) 2.03
Immunosenescence and germinal center reaction. Immunol Rev (1997) 2.00
Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule. Science (1993) 1.96
Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb gene shows a cluster of seven nucleotide differences. Proc Natl Acad Sci U S A (1983) 1.92
Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers. J Immunol (1998) 1.89
Influenza A virus transfectants with chimeric hemagglutinins containing epitopes from different subtypes. J Virol (1992) 1.88
CD28 is required for germinal center formation. J Immunol (1996) 1.78
Cellular basis of regulation of expression of idiotype. II. Immunity to anti-MOPC-460 idiotype antibodies increases the level of anti-trinitrophenyl antibodies bearing 460 idiotypes. J Exp Med (1979) 1.76
Chimeric influenza virus induces neutralizing antibodies and cytotoxic T cells against human immunodeficiency virus type 1. J Virol (1993) 1.70
RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity (1999) 1.66
Spontaneous formation of germinal centers in autoimmune mice. J Leukoc Biol (2001) 1.62
Blastic transformtion of mouse spleen lymphocytes by a water-soluble mitogen extracted from Nocardia. Proc Natl Acad Sci U S A (1974) 1.62
Dependence of germinal center B cells on expression of CD21/CD35 for survival. Science (1998) 1.59
Immune response to levan. I. Kinetics and ontogeny of anti-levan and anti-inulin antibody response and of expression of cross-reactive idiotype. J Immunol (1978) 1.57
Proteases as mitogens. The Effect of trypsin and pronase on mouse and human lymphocytes. Exp Cell Res (1974) 1.56
Control idiotope expression by monoclonal anti-idiotope antibodies. Immunol Rev (1980) 1.56
Isolation of mitogenic and adjuvant active fractions from various species of Nocardiae. Infect Immun (1975) 1.54
Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J Exp Med (1996) 1.52
Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. J Exp Med (2000) 1.51
Interaction between Kb and Q4 gene sequences generates the Kbm6 mutation. Mol Cell Biol (1986) 1.50
Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice. J Exp Med (1987) 1.49
Identification of the cloned gene for the murine transplantation antigen H-2Kb by hybridization with synthetic oligonucleotides. Mol Cell Biol (1983) 1.48
Identification of a new V kappa gene family that is highly expressed in hybridomas from an autoimmune mouse strain. J Immunol (1990) 1.46
Conditions that induce tolerance in mature CD4+ T cells. J Exp Med (1997) 1.45
Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice. J Exp Med (1999) 1.44
Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. J Exp Med (1996) 1.42
Mitogenic effect of a water-soluble extract of Nocardia opaca: a comparative study with some bacterial adjuvants on spleen and peripheral lymphocytes of four mammalian species. J Immunol (1974) 1.40
Target cells for the activity of a synthetic adjuvant: muramyl dipeptide. Cell Immunol (1977) 1.36
Immune response to levan. III. The capacity to produce anti-inulin antibodies and cross-reactive idiotypes appears late in ontogeny. J Immunol (1979) 1.34
Alternative pathways for the selection of antigen-specific peripheral T cells. Nature (1996) 1.33
A human T-independent B lymphocyte mitogen extracted from Nocardia opaca. J Immunol (1976) 1.33
Idiotypic regulation by isologous monoclonal anti-idiotope antibodies. Nature (1981) 1.31
Locus-specific somatic hypermutation in germinal centre T cells. Nature (1994) 1.28
Blast transformation of rabbit B-derived lymphocytes by a mitogen extracted from Nocardia. J Immunol (1975) 1.25
Mutually exclusive and cassette exons underlie alternatively spliced isoforms of the Na/Ca exchanger. J Biol Chem (1994) 1.25
Neonatal treatment with low doses of anti-idiotypic antibody leads to the expression of a silent clone. J Exp Med (1981) 1.24
[Serological evolution of infection by Plasmodium malariae: variations of fluorescent antibody titre after radical treatment]. Bull World Health Organ (1969) 1.22
Ig VH hypermutation is absent in the germinal centers of aged mice. J Immunol (1995) 1.22
Novel subunit composition of a renal epithelial KATP channel. J Biol Chem (1998) 1.22
Polyclonal activation of human B lymphocytes by Nocardia water soluble mitogen (NWSM). Immunol Rev (1979) 1.19
Repertoire diversity of antibody response to bacterial antigens in aged mice. II. Phosphorylcholine-antibody in young and aged mice differ in both VH/VL gene repertoire and in specificity. J Immunol (1991) 1.18
Cell suppression in PPD-induced blast specific response of human peripheral blood lymphocytes. Clin Exp Immunol (1976) 1.18
Reciprocal expansions of idiotypic and anti-idiotypic clones following antigen stimulation. Nature (1979) 1.18
Presence and subcellular localization of two distinct mitogenic fractions in the cells of Nocardia rubra and Nocardia opaca: preparation of soluble mitogenic peptidoglycan fractions. Infect Immun (1976) 1.18
The fluorescent antibody technique in the estimation of immunity in patients infected with Plasmodium malariae. Trans R Soc Trop Med Hyg (1966) 1.17
[The value of the immunofluorescent reaction in the detection of asymptomatic parasitemia due to Plasmodium malariae]. Bull World Health Organ (1967) 1.17
Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes. J Exp Med (1995) 1.14
Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence. J Immunol (2000) 1.14
Distinctive characteristics of germinal center B cells. Semin Immunol (1997) 1.14
Regulation of the anti-inulin antibody response by a nonallotype-linked gene. J Exp Med (1980) 1.14
T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1. J Exp Med (1996) 1.13
Mitogenic analysis of murine B-cell heterogeneity. J Exp Med (1978) 1.13
Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes. J Invest Dermatol (2001) 1.13
Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody. Eur J Immunol (1981) 1.11
Genetic and cellular regulation of the expression of specific antibody idiotypes in the anti-polyfructosan immune response. Ann Immunol (Paris) (1979) 1.10
Transfer of antigenic macromolecules from macrophages to lymphocytes. I. Autoradiographic and quantitative study of ( 14 C)endotoxin and ( 125 I)haemocyanin transfer. Immunology (1972) 1.09
Anti-immunoglobulin antibodies. I. Expression of cross-reactive idiotypes and Ir gene control of the response to IgG2a of the b allotype. J Exp Med (1980) 1.08
Thymic requirement for cyclical idiotypic and reciprocal anti-idiotypic immune responses to a T-independent antigen. J Exp Med (1980) 1.06
DNA sequence comparison among closely related Drosophila species in the mulleri complex. Genetics (1986) 1.06
Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. Curr Biol (1996) 1.05
Idiotypic determinants of rabbit B- and T-derived lymphocytes. Immunol Rev (1977) 1.04
Cellular mechanisms involved in protection against influenza virus infection in transgenic mice expressing a TCR receptor specific for class II hemagglutinin peptide in CD4+ and CD8+ T cells. J Immunol (1998) 1.03
Immune response to levan. II. T independence of suppression of cross-reactive idiotypes by anti-idiotype antibodies. J Immunol (1979) 1.02
Enhanced protection against influenza virus of mice immunized as newborns with a mixture of plasmids expressing hemagglutinin and nucleoprotein. Vaccine (1998) 1.01
DNA immunization of newborn mice with a plasmid-expressing nucleoprotein of influenza virus. Viral Immunol (1996) 0.99
Idiotype vaccines. Ann Inst Pasteur Immunol (1985) 0.98
Direct and indirect suppression induced by anti-idiotype antibody in the inulin-bacterial levan antigenic system. Mol Immunol (1979) 0.98
Predicted and inferred waiting times for key mutations in the germinal centre reaction: evidence for stochasticity in selection. Immunol Cell Biol (1998) 0.97
Highly reduced protection against Streptococcus pneumoniae after deletion of a single heavy chain gene in mouse. Proc Natl Acad Sci U S A (2000) 0.97
Functional differences between cardiac and renal isoforms of the rat Na+-Ca2+ exchanger NCX1 expressed in Xenopus oocytes. J Physiol (2000) 0.97
IgM anti-Fc gamma R autoantibodies trigger neutrophil degranulation. J Exp Med (1991) 0.96
Cells expressing an H chain Ig gene carrying a viral T cell epitope are lysed by specific cytolytic T cells. J Immunol (1992) 0.96
Synergistic genetic defect in B-lymphocyte function. I. Defective responses to B-cell stimulants and their genetic basis. J Exp Med (1980) 0.96
High frequency of autoantibodies bearing cross-reactive idiotopes among hybridomas using VH7183 genes prepared from normal and autoimmune murine strains. J Clin Invest (1987) 0.95
Pinocytosis of some exotoxins by leucocytes. Pinocytosis of diphtheria toxin and of dick erythrotoxin. Exp Cell Res (1966) 0.94
Stimulation of lymphocytes by purified protein derivative: suppression by cells from human vaccinated with Bacille Calmette-Guérin. J Infect Dis (1976) 0.94
Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells. Proc Natl Acad Sci U S A (1990) 0.94
Histochemical and cytoenzymological studies in myositis ossificans. Acta Histochem (1967) 0.93
Transfer of antigen from macrophages to lymphocytes. II. Immunological significance of the transfer of lipopolysaccharide. Immunology (1973) 0.93
Induction of antihemagglutinin antibodies by polyclonal antiidiotype antibodies. Viral Immunol (1993) 0.92
[Ultrastructure of guinea pig macrophages]. Ann Inst Pasteur (Paris) (1971) 0.92
Lymphocyte development and selection in germinal centers. Curr Top Microbiol Immunol (1998) 0.92