Published in Proc Natl Acad Sci U S A on July 01, 1990
A cytochrome b5 is required for full activity of flavonoid 3', 5'-hydroxylase, a cytochrome P450 involved in the formation of blue flower colors. Proc Natl Acad Sci U S A (1999) 1.54
Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome. Proc Natl Acad Sci U S A (1995) 1.44
Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3. Biochem J (2007) 1.17
The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b(5). Arch Biochem Biophys (2010) 1.16
Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5. J Biol Chem (2008) 1.09
Cloning of human very-long-chain acyl-coenzyme A dehydrogenase and molecular characterization of its deficiency in two patients. Am J Hum Genet (1995) 1.04
Molecular characterization of mitochondrial trifunctional protein deficiency: formation of the enzyme complex is important for stabilization of both alpha- and beta-subunits. Am J Hum Genet (1996) 1.01
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE. J Biol Chem (1964) 24.57
Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques. Mol Cell Biol (1985) 13.99
General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes. J Virol (1984) 10.98
Oxygen activation by cytochrome P-450. Annu Rev Biochem (1980) 3.44
A form of cytochrome b5 that contains an additional hydrophobic sequence of 40 amino acid residues. Proc Natl Acad Sci U S A (1971) 3.28
Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography. J Biol Chem (1976) 2.63
An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Pharmacol Exp Ther (1978) 2.40
Evidence for the participation of cytochrome b 5 in hepatic microsomal mixed-function oxidation reactions. Arch Biochem Biophys (1971) 1.63
Cytochrome P-450 isozyme/isozyme functional interactions and NADPH-cytochrome P-450 reductase concentrations as factors in microsomal metabolism of warfarin. Eur J Biochem (1985) 1.11
Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes. J Biol Chem (1983) 1.06
Human NADPH-P450 oxidoreductase: complementary DNA cloning, sequence and vaccinia virus-mediated expression and localization of the CYPOR gene to chromosome 7. Mol Pharmacol (1989) 1.04
Purification and characterization of hepatic microsomal cytochrome P-450. Pharmacol Ther (1990) 0.99
Rat liver microsomal elongation of fatty acids. Possible involvement of cytochrome b5. J Biol Chem (1979) 0.96
Oxygen reduction by the P450 monoxygenase systems. Adv Enzymol Relat Areas Mol Biol (1978) 0.96
Effects of conditions for reconstitution with cytochrome b5 on the formation of products in cytochrome P-450-catalyzed reactions. Drug Metab Dispos (1986) 0.95
Acetone-inducible cytochrome P-450: purification, catalytic activity, and interaction with cytochrome b5. Arch Biochem Biophys (1986) 0.91
Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase. J Biol Chem (1981) 0.90
Cytochrome b5 as electron donor to rabbit liver cytochrome P-450LM2 in reconstituted phospholipid vesicles. Biochem Biophys Res Commun (1980) 0.88
Liver microsomal electron transport systems. III. The involvement of cytochrome b5 in the NADPH-supported cytochrome P-450-dependent hydroxylation of chlorobenzene. Biochem Biophys Res Commun (1974) 0.87
On the mechanism of action of cytochrome P-450. Oxidation and reduction of the ferrous dioxygen complex of liver microsomal cytochrome P-450 by cytochrome b5. J Biol Chem (1984) 0.86
Cytochrome b5 as electron donor for oxy-cytochrome P-450. Eur J Biochem (1981) 0.84
The possible involvement of cytochrome b5 in the oxidation of lauric acid by microsomes from kidney cortex and liver of rats. Life Sci (1974) 0.83
The roles of cytochrome b5 in reconstituted monooxygenase systems containing various forms of hepatic microsomal cytochrome P-450. J Biochem (1981) 0.82
Evidence against participation of cytochrome b5 in the hepatic microsomal mixed-function oxidase reaction. Mol Pharmacol (1973) 0.81
The interaction of cytochrome b5 with four cytochrome P-450 enzymes from the untreated rat. Drug Metab Dispos (1985) 0.81
Selective potent restriction of P450b- but not P450e-dependent 7,12-dimethylbenz[a]anthracene metabolism by the microsomal environment. Arch Biochem Biophys (1989) 0.79
Immunochemical study on the route of electron transfer from NADH and NADPH to cytochrome P-450 of liver microsomes. J Biochem (1980) 0.78
The effect of extra bound cytochrome b-5 on cytochrome P-450-dependent enzyme activities in liver microsomes. Biochem Biophys Res Commun (1974) 0.77
Influence of cytochrome b5 on the stoichiometry of the different oxidative reactions catalyzed by liver microsomal cytochrome P-450. Drug Metab Dispos (1987) 0.77
Modulation of the reductive metabolism of halothane by microsomal cytochrome b5 in rat liver. Biochim Biophys Acta (1987) 0.77
Characterization of halothane oxidation by hepatic microsomes and purified cytochromes P-450 using a gas chromatographic mass spectrometric assay. J Pharmacol Exp Ther (1988) 0.77
NADH-dependent O-deethylation of p-nitrophenetole with rabbit liver microsomes. Arch Biochem Biophys (1976) 0.77
Isolation and characterization of human liver cytochrome b5 cDNA. Pharmacol Res (1990) 0.77
Methoxyflurane acts at the substrate binding site of cytochrome P450 LM2 to induce a dependence on cytochrome b5. Arch Biochem Biophys (1989) 0.76
Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci U S A (1981) 11.92
Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature (1981) 9.25
Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol (2001) 8.95
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature (1998) 7.30
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol (1995) 7.12
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest (1999) 6.99
P450 genes: structure, evolution, and regulation. Annu Rev Biochem (1987) 6.72
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell (2000) 6.71
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science (1995) 6.03
The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev (1996) 5.71
Specific binding of a cellular DNA replication protein to the origin of replication of adenovirus DNA. Proc Natl Acad Sci U S A (1983) 5.21
The PPARalpha-leukotriene B4 pathway to inflammation control. Nature (1996) 5.14
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol (1993) 4.92
Adenovirus DNA replication in vitro: identification of a host factor that stimulates synthesis of the preterminal protein-dCMP complex. Proc Natl Acad Sci U S A (1982) 4.72
Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J Biol Chem (2000) 4.15
Mitochondrial DNA polymorphism in Japanese. II. Analysis with restriction enzymes of four or five base pair recognition. Hum Genet (1986) 3.93
Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). J Biol Chem (1998) 3.78
Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme. J Biol Chem (1968) 3.74
The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol (1991) 3.73
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature (1988) 3.69
Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. J Biol Chem (1999) 3.57
Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. Physiol Rev (1980) 3.40
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme. J Biol Chem (1986) 3.39
Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Mol Cell Biol (2000) 3.37
Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med (2001) 3.23
RNA polymerase of influenza virus: role of NP in RNA chain elongation. J Biochem (1988) 3.23
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest (2000) 3.17
Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation. J Biol Chem (2000) 3.15
The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. DNA (1989) 3.03
Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicol Appl Pharmacol (1996) 3.01
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem (2000) 2.99
A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation. EMBO Rep (2001) 2.96
The P450 gene superfamily: recommended nomenclature. DNA (1987) 2.95
The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am J Hum Genet (1989) 2.90
Spred is a Sprouty-related suppressor of Ras signalling. Nature (2001) 2.87
Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS-M. Nat Genet (1996) 2.77
Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet (2001) 2.73
Interobserver and intraobserver reliability of the japanese orthopaedic association scoring system for evaluation of cervical compression myelopathy. Spine (Phila Pa 1976) (2001) 2.60
Adenovirus DNA replication in vitro: synthesis of full-length DNA with purified proteins. Proc Natl Acad Sci U S A (1983) 2.58
Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9. Pharmacogenetics (1994) 2.55
Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. Carcinogenesis (1997) 2.46
A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice. J Clin Invest (1998) 2.42
Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions. Chem Res Toxicol (1992) 2.41
Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J Cell Biol (2001) 2.41
Cellular splicing factor RAF-2p48/NPI-5/BAT1/UAP56 interacts with the influenza virus nucleoprotein and enhances viral RNA synthesis. J Virol (2001) 2.33
Reproducible establishment of hemopoietic supportive stromal cell lines from murine bone marrow. Exp Hematol (1989) 2.31
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J Biol Chem (2001) 2.29
Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem (1996) 2.25
Lung-specific inactivation of CCAAT/enhancer binding protein alpha causes a pathological pattern characteristic of COPD. Eur Respir J (2009) 2.24
Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis. J Cell Biol (2000) 2.24
Site-specific DNA binding of nuclear factor I: analyses of cellular binding sites. Mol Cell Biol (1985) 2.19
Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice. J Biol Chem (1997) 2.18
Mitochondrial DNA polymorphism in Japanese. I. Analysis with restriction enzymes of six base pair recognition. Hum Genet (1984) 2.17
Monoclonal antibody defining a molecule possibly identical to the p75 subunit of interleukin 2 receptor. J Exp Med (1989) 2.15
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J Clin Invest (2001) 2.15
Endotoxin-induced serum factor that stimulates gamma interferon production. Infect Immun (1989) 2.13
Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence. Science (1985) 2.11
Long term freeze storage of Campylobacter pyloridis. J Clin Pathol (1987) 2.08
DNA sequences required for the in vitro replication of adenovirus DNA. Proc Natl Acad Sci U S A (1984) 2.07
cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry (1993) 2.03
In vivo analysis of the promoter structure of the influenza virus RNA genome using a transfection system with an engineered RNA. Proc Natl Acad Sci U S A (1991) 2.03
Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J Clin Invest (1996) 2.02
Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J Biol Chem (1998) 2.00
Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8. Cancer Res (1994) 1.99
A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock. Infect Immun (1995) 1.99
CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. Eur J Immunol (2000) 1.96
HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Mol Cell Biol (1997) 1.96
Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity. J Biol Chem (1998) 1.94
Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites. Biochemistry (1998) 1.93
Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Mol Endocrinol (2000) 1.93
Nomenclature for human CYP2D6 alleles. Pharmacogenetics (1996) 1.91
Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone. FEBS Lett (2001) 1.90
Reconstitution of influenza virus RNA-nucleoprotein complexes structurally resembling native viral ribonucleoprotein cores. J Biol Chem (1990) 1.89
A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction. Proc Natl Acad Sci U S A (2001) 1.88
Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4. Mol Pharmacol (1989) 1.87
Lesions of aryl-hydrocarbon receptor-deficient mice. Vet Pathol (1997) 1.85
A microsome-dependent binding of benzo[a]pyrene to DNA. Cancer Res (1969) 1.85
Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs. Proc Natl Acad Sci U S A (1988) 1.82
Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F. Leukemia (2007) 1.81
Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Mol Cell Biol (1998) 1.81
Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation. Mol Psychiatry (2010) 1.80
Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes. J Biol Chem (1985) 1.79
Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease. Gut (2006) 1.77
L-arginine-induced hypotension. Lancet (1990) 1.77
Viral RNA polymerases. CRC Crit Rev Biochem (1988) 1.76
Transcription of a recombinant influenza virus RNA in cells that can express the influenza virus RNA polymerase and nucleoprotein genes. J Gen Virol (1992) 1.75
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22. Genomics (1988) 1.75
The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences. J Biol Chem (1984) 1.75
Cell surface receptors for extracellular matrix components. Biochim Biophys Acta (1990) 1.73
Identification of the RNA polymerase-binding site on genome RNA of influenza virus. J Biochem (1987) 1.73
Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity. J Biol Chem (2000) 1.73
Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas. Proc Natl Acad Sci U S A (1999) 1.73
Hypoxia inducible factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis. Allergy (2011) 1.73
A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. EMBO J (1998) 1.72
Disruption of the c/ebp alpha gene in adult mouse liver. Mol Cell Biol (1997) 1.72
Holoprosencephaly in human embryos: epidemiologic studies of 150 cases. Teratology (1977) 1.70