Aire and T cell development.

Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. Immunity (2014) 2.33

Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4+ T cells in acute GVHD. Blood (2015) 1.43

Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci U S A (2012) 1.41

T-cell tolerance: central and peripheral. Cold Spring Harb Perspect Biol (2012) 1.28

Beyond DNA repair: DNA-PK function in cancer. Cancer Discov (2014) 1.16

PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity. J Allergy Clin Immunol (2015) 1.07

Ubiquitin in the immune system. EMBO Rep (2013) 1.06

Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus. J Clin Invest (2013) 1.05

Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens. Front Immunol (2012) 1.03

Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes. Mol Cell Biol (2012) 0.95

Thymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation. J Immunol (2015) 0.93

T cells in the control of organ-specific autoimmunity. J Clin Invest (2015) 0.93

Restoring the balance: immunotherapeutic combinations for autoimmune disease. Dis Model Mech (2014) 0.92

Mechanistic basis of immunotherapies for type 1 diabetes mellitus. Transl Res (2013) 0.84

Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses. J Immunol (2014) 0.84

Homeostatic properties and phenotypic maturation of murine CD4+ pre-thymic emigrants in the thymus. PLoS One (2013) 0.83

From pre-DP, post-DP, SP4, and SP8 Thymocyte Cell Counts to a Dynamical Model of Cortical and Medullary Selection. Front Immunol (2014) 0.83

T Cells: Soldiers and Spies-The Surveillance and Control of Effector T Cells by Regulatory T Cells. Clin J Am Soc Nephrol (2015) 0.82

Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression. J Biol Chem (2012) 0.82

Rag defects and thymic stroma: lessons from animal models. Front Immunol (2014) 0.81

Age-Related Disruption of Steady-State Thymic Medulla Provokes Autoimmune Phenotype via Perturbing Negative Selection. Aging Dis (2012) 0.80

Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator. Nat Commun (2016) 0.80

Anti-CD3ε mAb improves thymic architecture and prevents autoimmune manifestations in a mouse model of Omenn syndrome: therapeutic implications. Blood (2012) 0.80

B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells. Int Immunol (2013) 0.80

The heart of the matter: protection of the myocardium from T cells. J Autoimmun (2013) 0.79

Normal T cell selection occurs in CD205-deficient thymic microenvironments. PLoS One (2012) 0.79

LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity. J Clin Invest (2016) 0.79

Breaking through the central tolerance ceiling to unleash anticancer immune responses. Oncoimmunology (2014) 0.78

Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers. PLoS One (2012) 0.78

Solving the puzzle of autoimmunity: critical questions. F1000Prime Rep (2015) 0.77

Thymic regulatory T cell development: role of signalling pathways and transcription factors. Clin Dev Immunol (2013) 0.77

Paracoccidioides brasiliensis infection promotes thymic disarrangement and premature egress of mature lymphocytes expressing prohibitive TCRs. BMC Infect Dis (2016) 0.77

Newly recognized Mendelian disorders with rheumatic manifestations. Curr Opin Rheumatol (2015) 0.76

Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. PLoS One (2016) 0.76

Development of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigen. Immunol Rev (2016) 0.76

Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells. Front Immunol (2016) 0.75

The dual role of autoimmune regulator in maintaining normal expression level of tissue-restricted autoantigen in the thymus: A modeling investigation. Math Biosci (2016) 0.75

NFKB2 mutation in common variable immunodeficiency and isolated adrenocorticotropic hormone deficiency: A case report and review of literature. Medicine (Baltimore) (2016) 0.75

Treatment of Pediatric Acute Graft-versus-Host Disease-Lessons from Primary Immunodeficiency? Front Immunol (2017) 0.75

Thymic and Postthymic Regulation of Naïve CD4(+) T-Cell Lineage Fates in Humans and Mice Models. Mediators Inflamm (2016) 0.75

Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol (2001) 7.30

Aire regulates negative selection of organ-specific T cells. Nat Immunol (2003) 5.85

Positional cloning of the APECED gene. Nat Genet (1997) 5.47

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet (1997) 4.75

The cellular mechanism of Aire control of T cell tolerance. Immunity (2005) 4.74

Aire. Annu Rev Immunol (2009) 4.43

Deletional tolerance mediated by extrathymic Aire-expressing cells. Science (2008) 4.10

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med (2005) 4.06

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet (1997) 3.70

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet (1997) 3.62

Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med (2004) 3.30

Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med (2006) 3.20

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature (2008) 3.09

RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med (2007) 2.91

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet (2002) 2.91

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med (2007) 2.84

The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity (2008) 2.81

Aire's partners in the molecular control of immunological tolerance. Cell (2010) 2.68

The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity (2008) 2.57

CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med (2004) 2.52

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J Exp Med (2004) 2.43

Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J Exp Med (2004) 2.23

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression. EMBO Rep (2008) 2.22

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab (2006) 2.21

Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity (2008) 2.07

Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nat Rev Immunol (2008) 1.99

Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance. Nat Immunol (2010) 1.89

Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol (2005) 1.88

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer. J Exp Med (2009) 1.87

Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci U S A (2008) 1.83

Lymphotoxin pathway directs thymic Aire expression. Nat Immunol (2003) 1.79

Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity. J Exp Med (2009) 1.71

Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo. J Immunol (2009) 1.69

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J Exp Med (2008) 1.63

Autoimmune polyglandular syndromes. Nat Rev Endocrinol (2010) 1.60

Chromosomal clustering of genes controlled by the aire transcription factor. Proc Natl Acad Sci U S A (2005) 1.49

Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation. J Immunol (2007) 1.46

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature (2007) 1.46

The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Res (2009) 1.46

Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. J Clin Invest (2008) 1.43

Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proc Natl Acad Sci U S A (2008) 1.41

A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Immunol (2007) 1.41

Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). J Immunol (2000) 1.38

Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator. Structure (2009) 1.35

The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription. Proc Natl Acad Sci U S A (2008) 1.33

Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells. Eur J Immunol (2007) 1.31

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Proc Natl Acad Sci U S A (2007) 1.31

NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway. J Clin Invest (2006) 1.29

Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J Exp Med (2010) 1.27

Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation. J Immunol (2008) 1.20

Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells. J Immunol (2010) 1.20

Localization of the APECED protein in distinct nuclear structures. Hum Mol Genet (1999) 1.19

Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. Proc Natl Acad Sci U S A (2010) 1.17

AIRE in the thymus and beyond. Curr Opin Immunol (2009) 1.16

APECED-causing mutations in AIRE reveal the functional domains of the protein. Hum Mutat (2004) 1.16

Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance. Sci Transl Med (2009) 1.15

Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected. J Immunol (2007) 1.15

Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J Immunol (2009) 1.13

Transcriptional impact of Aire varies with cell type. Proc Natl Acad Sci U S A (2008) 1.12

DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity. Biochim Biophys Acta (2007) 1.10

Developmental pathway of CD4+CD8- medullary thymocytes during mouse ontogeny and its defect in Aire-/- mice. Proc Natl Acad Sci U S A (2007) 1.08

The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells. J Immunol (2008) 1.05

Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input. Eur J Immunol (2008) 1.02

An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans. J Clin Invest (2009) 1.01

The autoimmune regulator AIRE in thymoma biology: autoimmunity and beyond. J Thorac Oncol (2010) 1.01

Diversity of TCRs on natural Foxp3+ T cells in mice lacking Aire expression. J Immunol (2010) 0.97

Ltbetar signaling does not regulate Aire-dependent transcripts in medullary thymic epithelial cells. J Immunol (2008) 0.92

PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus. Epigenetics (2008) 0.91

Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population. J Autoimmun (2010) 0.86

CD4+CD25+ T-regulatory cells are decreased in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. J Allergy Clin Immunol (2005) 0.86

Ultrastructure of medullary thymic epithelial cells of autoimmune regulator (Aire)-deficient mice. Immunol Cell Biol (2009) 0.84

Flow cytometry study of blood cell subtypes reflects autoimmune and inflammatory processes in autoimmune polyendocrine syndrome type I. Scand J Immunol (2010) 0.83

Both polymorphic variable number of tandem repeats and autoimmune regulator modulate differential expression of insulin in human thymic epithelial cells. Diabetes (2010) 0.82

Reduced thymic Aire expression and abnormal NF-kappa B2 signaling in a model of systemic autoimmunity. J Immunol (2009) 0.81

Acquired autoimmune polyglandular syndrome, thymoma, and an AIRE defect. N Engl J Med (2010) 0.81

Diversity and clonotypic composition of influenza-specific CD8+ TCR repertoires remain unaltered in the absence of Aire. Eur J Immunol (2010) 0.78

Deletional tolerance mediated by extrathymic Aire-expressing cells. Science (2008) 4.10

An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity (2011) 3.11

Patients with antineutrophil cytoplasmic antibody-associated vasculitis have defective Treg cell function exacerbated by the presence of a suppression-resistant effector cell population. Arthritis Rheum (2013) 1.70

Aire deficiency promotes TRP-1-specific immune rejection of melanoma. Cancer Res (2013) 1.06

Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance. J Exp Med (2014) 1.01

A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy. J Exp Med (2009) 0.99

BAFF-ling autoantibodies. J Clin Invest (2013) 0.82

Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency. J Immunol (2013) 0.79

Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection. J Immunol (2013) 0.79

Reply: To PMID 23553415. Arthritis Rheum (2013) 0.75

Estrogen turns down "the AIRE". J Clin Invest (2016) 0.75