Published in Crit Care Med on March 01, 2014
Microparticles: markers and mediators of sepsis-induced microvascular dysfunction, immunosuppression, and AKI. Kidney Int (2015) 1.09
Propofol increases morbidity and mortality in a rat model of sepsis. Crit Care (2015) 0.87
Killing without collateral damage: new hope for sepsis therapy. Immunol Cell Biol (2014) 0.77
Insights and limits of translational research in critical care medicine. Ann Intensive Care (2015) 0.76
Kidney-specific Sonoporation-mediated Gene Transfer. Mol Ther (2015) 0.75
Tumor necrosis factor inhibition in severe sepsis: a promise not fulfilled*. Crit Care Med (2014) 0.75
Perspective on optimizing clinical trials in critical care: how to puzzle out recurrent failures. J Intensive Care (2016) 0.75
An Enrichment Strategy For Sepsis Clinical Trials. Shock (2016) 0.75
Man is the new mouse: Elective surgery as a key translational model for multi-organ dysfunction and sepsis. J Intensive Care Soc (2015) 0.75
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med (2004) 24.47
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med (2013) 17.37
Hydrocortisone therapy for patients with septic shock. N Engl J Med (2008) 15.85
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39
High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med (2015) 10.15
Mortality after surgery in Europe: a 7 day cohort study. Lancet (2012) 9.96
Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med (2010) 8.58
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
High versus low blood-pressure target in patients with septic shock. N Engl J Med (2014) 7.37
Intravascular Complications of Central Venous Catheterization by Insertion Site. N Engl J Med (2015) 7.02
Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med (2011) 6.79
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69
Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA (2008) 6.29
Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med (2004) 5.90
Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med (2002) 5.84
Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA (2010) 5.80
Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med (2014) 5.70
Transfusion requirements in surgical oncology patients: a prospective, randomized controlled trial. Anesthesiology (2015) 5.52
Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department. Chest (2006) 5.31
The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. Crit Care Med (2004) 5.23
Circulatory shock. N Engl J Med (2013) 4.95
Sepsis biomarkers: a review. Crit Care (2010) 4.76
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med (2004) 4.56
Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit. Crit Care Med (2007) 4.54
Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis. Crit Care Med (2014) 4.11
Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial. JAMA (2002) 4.09
Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis (2012) 4.07
Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis. Crit Care Med (2003) 4.04
Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med (2005) 3.97
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Pulse pressure variations to predict fluid responsiveness: influence of tidal volume. Intensive Care Med (2005) 3.81
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78
Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care (2013) 3.65
High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest (2005) 3.58
Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med (2015) 3.55
The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med (2006) 3.53
Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr (2003) 3.38
Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med (2006) 3.36
Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Crit Care Med (2011) 3.34
The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med (2009) 3.30
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17
Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Lancet (2010) 3.15
Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome. N Engl J Med (2004) 3.14
Management of bleeding following major trauma: an updated European guideline. Crit Care (2010) 3.09
Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005-2006). Crit Care Med (2009) 3.07
Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial. JAMA (2004) 3.07
Microvascular response to red blood cell transfusion in patients with severe sepsis. Crit Care Med (2007) 3.06
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev (2007) 2.96
C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest (2003) 2.95
A multibiomarker-based outcome risk stratification model for adult septic shock*. Crit Care Med (2014) 2.94
Immediate percutaneous coronary intervention is associated with better survival after out-of-hospital cardiac arrest: insights from the PROCAT (Parisian Region Out of hospital Cardiac ArresT) registry. Circ Cardiovasc Interv (2010) 2.91
Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest (2008) 2.90
Rationing critical care beds: a systematic review. Crit Care Med (2004) 2.86
Let us use the pulmonary artery catheter correctly and only when we need it. Crit Care Med (2005) 2.83
Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma (2010) 2.82
Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Crit Care Med (2015) 2.81
Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study. Crit Care Med (2006) 2.74
Do all nonsurvivors of cardiogenic shock die with a low cardiac index? Chest (2003) 2.73
Has mortality from acute renal failure decreased? A systematic review of the literature. Am J Med (2005) 2.73
Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome. Crit Care Med (2013) 2.72
Short- and long-term outcome in elderly patients after out-of-hospital cardiac arrest: a cohort study. Crit Care Med (2014) 2.70
Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit Care Med (2009) 2.68
Critical care medicine training and certification for emergency physicians. Ann Emerg Med (2005) 2.67
Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation (2011) 2.65
The circumplex model of affect: an integrative approach to affective neuroscience, cognitive development, and psychopathology. Dev Psychopathol (2005) 2.64
Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med (2008) 2.64
End-of-life care for the critically ill: A national intensive care unit survey. Crit Care Med (2006) 2.61
Abandon the mouse research ship? Not just yet! Shock (2014) 2.60
Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis. Thromb Haemost (2003) 2.59
Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock (2009) 2.59
Beneficial effects of short-term vasopressin infusion during severe septic shock. Anesthesiology (2002) 2.59
Point: Are the best patient outcomes achieved when ICU bundles are rigorously adhered to? Yes. Chest (2013) 2.59
Early antibiotic treatment for severe acute necrotizing pancreatitis: a randomized, double-blind, placebo-controlled study. Ann Surg (2007) 2.55
Influence of overweight on ICU mortality: a prospective study. Chest (2004) 2.54