Published in J Allergy Clin Immunol on March 12, 2011
Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med (2012) 4.85
Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med (2011) 1.76
Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma. Clin Exp Allergy (2012) 1.50
Vitamin D and asthma. Am J Respir Crit Care Med (2011) 1.44
Genome-wide interrogation of longitudinal FEV1 in children with asthma. Am J Respir Crit Care Med (2014) 1.44
Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility. PLoS One (2012) 1.23
Genome-wide association study of lung function decline in adults with and without asthma. J Allergy Clin Immunol (2012) 1.20
Asthma genetics and personalised medicine. Lancet Respir Med (2014) 1.17
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol (2013) 1.15
Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol (2012) 1.11
Sonic hedgehog signaling in the lung. From development to disease. Am J Respir Cell Mol Biol (2015) 1.02
Self-reported race/ethnicity in the age of genomic research: its potential impact on understanding health disparities. Hum Genomics (2015) 0.98
The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma. J Allergy Clin Immunol (2012) 0.98
A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2. J Assoc Res Otolaryngol (2013) 0.97
Large-scale RNA-Seq Transcriptome Analysis of 4043 Cancers and 548 Normal Tissue Controls across 12 TCGA Cancer Types. Sci Rep (2015) 0.95
Tissue-derived hedgehog proteins modulate Th differentiation and disease. J Immunol (2013) 0.89
Genes and chronic obstructive pulmonary disease. Med Clin North Am (2012) 0.88
Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma. J Allergy Clin Immunol (2014) 0.87
Deletion of 4q28.3-31.23 in the background of multiple malformations with pulmonary hypertension. Mol Cytogenet (2014) 0.86
Regulation of nuclear-cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt. Mol Biol Cell (2015) 0.84
Association of lung function genes with chronic obstructive pulmonary disease. Lung (2014) 0.82
Polycyclic aromatic hydrocarbons reciprocally regulate IL-22 and IL-17 cytokines in peripheral blood mononuclear cells from both healthy and asthmatic subjects. PLoS One (2015) 0.82
The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients. J Allergy Clin Immunol (2011) 0.81
Severe asthma in children. J Allergy Clin Immunol Pract (2014) 0.80
iGWAS: Integrative Genome-Wide Association Studies of Genetic and Genomic Data for Disease Susceptibility Using Mediation Analysis. Genet Epidemiol (2015) 0.80
GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma. J Allergy Clin Immunol (2013) 0.79
Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function. J Cell Biol (2015) 0.79
Sonic Hedgehog Signaling Regulates Myofibroblast Function During Alveolar Septum Formation in Murine Postnatal Lung. Am J Respir Cell Mol Biol (2017) 0.78
Association of IREB2 Gene rs2568494 Polymorphism with Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis. Med Sci Monit (2016) 0.78
Genetics of asthma susceptibility and severity. Clin Chest Med (2012) 0.78
Sonic Hedgehog Signaling: Evidence for Its Protective Role in Endotoxin Induced Acute Lung Injury in Mouse Model. PLoS One (2015) 0.78
Severe Asthma in Children: Lessons Learned and Future Directions. J Allergy Clin Immunol Pract (2016) 0.77
An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma. PLoS One (2016) 0.76
Combining genomewide association study and lung eQTL analysis provides evidence for novel genes associated with asthma. Allergy (2016) 0.76
Frontline Science: Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma. J Leukoc Biol (2017) 0.76
Asthma pharmacogenetics and the development of genetic profiles for personalized medicine. Pharmgenomics Pers Med (2015) 0.75
A Genome-Wide Association Study of Post-bronchodilator Lung Function in Children with Asthma. Am J Respir Crit Care Med (2015) 0.75
An Adaptive Fisher's Combination Method for Joint Analysis of Multiple Phenotypes in Association Studies. Sci Rep (2016) 0.75
Implications of population structure and ancestry on asthma genetic studies. Curr Opin Allergy Clin Immunol (2014) 0.75
Predictors of emergency department use in children with persistent asthma in metropolitan Atlanta, Georgia. Ann Allergy Asthma Immunol (2017) 0.75
The role of heterogeneity in asthma: a structure-to-function perspective. Clin Transl Med (2017) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
The structure of haplotype blocks in the human genome. Science (2002) 50.88
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
Many sequence variants affecting diversity of adult human height. Nat Genet (2008) 12.80
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature (2002) 8.28
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med (2009) 7.17
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol (2007) 6.33
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56
Variants of DENND1B associated with asthma in children. N Engl J Med (2009) 4.18
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature (1999) 3.87
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol (2008) 3.59
Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol (2009) 2.53
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol (2010) 2.51
Design and baseline characteristics of the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol (2004) 2.22
Molecular mechanisms of early lung specification and branching morphogenesis. Pediatr Res (2005) 1.97
Ethnic differences in asthma and associated phenotypes: collaborative study on the genetics of asthma. J Allergy Clin Immunol (2001) 1.89
Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn (2004) 1.75
Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development (2004) 1.72
Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma. Am J Hum Genet (2001) 1.50
Severity assessment in asthma: An evolving concept. J Allergy Clin Immunol (2005) 1.42
Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo. Nature (1993) 1.35
Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers. Respir Res (2009) 1.25
Lung function and airway diseases. Nat Genet (2010) 1.15
Recent advances in hedgehog signalling. Trends Cell Biol (1997) 1.08
Cumulative association of five genetic variants with prostate cancer. N Engl J Med (2008) 15.34
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med (2009) 9.38
The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest (2006) 8.43
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J (2013) 8.39
Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med (2004) 8.39
Daily versus as-needed corticosteroids for mild persistent asthma. N Engl J Med (2005) 7.61
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med (2009) 7.17
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol (2007) 6.33
Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med (2010) 6.19
Efficacy of esomeprazole for treatment of poorly controlled asthma. N Engl J Med (2009) 5.90
Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet (2012) 5.82
An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med (2011) 5.53
Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet (2003) 5.10
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med (2014) 4.95
Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP. J Natl Cancer Inst (2007) 4.85
Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med (2009) 4.83
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat Med (2008) 4.70
Active albuterol or placebo, sham acupuncture, or no intervention in asthma. N Engl J Med (2011) 4.68
Respiratory effects of exposure to diesel traffic in persons with asthma. N Engl J Med (2007) 4.58
Randomized comparison of strategies for reducing treatment in mild persistent asthma. N Engl J Med (2007) 4.40
Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol (2010) 4.38
Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet (2008) 4.06
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med (2011) 3.80
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. N Engl J Med (2002) 3.68
Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol (2002) 3.66
Lansoprazole for children with poorly controlled asthma: a randomized controlled trial. JAMA (2012) 3.40
Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol (2011) 3.35
Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol (2007) 3.28
Nitric oxide in health and disease of the respiratory system. Physiol Rev (2004) 3.15
Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol (2010) 3.12
A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma. Am J Respir Crit Care Med (2010) 3.11
Detection of lung cancer by sensor array analyses of exhaled breath. Am J Respir Crit Care Med (2005) 2.94
Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol (1985) (2007) 2.83