Role of JNK in mammary gland development and breast cancer.

JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A (2012) 1.88

Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8). PLoS One (2013) 1.33

JNK signalling in cancer: in need of new, smarter therapeutic targets. Br J Pharmacol (2014) 1.11

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling. Elife (2013) 1.02

The 2 Faces of JNK Signaling in Cancer. Genes Cancer (2013) 1.00

c-Jun N-Terminal Kinases Mediate a Wide Range of Targets in the Metastatic Cascade. Genes Cancer (2013) 0.98

Oncogenic suppression of apoptosis uncovers a Rac1/JNK proliferation pathway activated by loss of Par3. Oncogene (2014) 0.94

JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships. Microbiol Mol Biol Rev (2016) 0.81

Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma. Cancer Res (2014) 0.81

Repression of phosphoinositide-dependent protein kinase 1 expression by ciglitazone via Egr-1 represents a new approach for inhibition of lung cancer cell growth. Mol Cancer (2014) 0.79

Stress signaling and the shaping of the mammary tissue in development and cancer. Oncogene (2014) 0.79

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis. Cancer Res (2015) 0.78

The role of MAPK signaling pathway in the Her-2-positive meningiomas. Oncol Rep (2016) 0.78

Proton irradiation augments the suppression of tumor progression observed with advanced age. Radiat Res (2014) 0.77

c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression. Oncotarget (2015) 0.77

Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents. Clin Cancer Res (2015) 0.77

Neddylation controls basal MKK7 kinase activity in breast cancer cells. Oncogene (2015) 0.77

The bioinformatics analysis of miRNAs signatures differentially expressed in HER2(+) versus HER2(-) breast cancers. Cancer Biother Radiopharm (2012) 0.77

G15 sensitizes epithelial breast cancer cells to doxorubicin by preventing epithelial-mesenchymal transition through inhibition of GPR30. Am J Transl Res (2015) 0.76

Black Rice Anthocyanins Suppress Metastasis of Breast Cancer Cells by Targeting RAS/RAF/MAPK Pathway. Biomed Res Int (2015) 0.75

Expression levels of JNK associated with polymorphic lactotransferrin haplotypes in human nasopharyngeal carcinoma. Oncol Lett (2016) 0.75

S100A4 elevation empowers expression of metastasis effector molecules in human breast cancer. Cancer Res (2016) 0.75

JNK pathway inhibition enhances chemotherapeutic sensitivity to Adriamycin in nasopharyngeal carcinoma cells. Oncol Lett (2017) 0.75

c-Jun N-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine. Mucosal Immunol (2017) 0.75

Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41

Signal transduction by the JNK group of MAP kinases. Cell (2000) 18.24

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97

Diverse somatic mutation patterns and pathway alterations in human cancers. Nature (2010) 10.83

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science (2000) 8.56

The specificities of protein kinase inhibitors: an update. Biochem J (2003) 7.76

Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem (2002) 7.74

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development. Curr Opin Cell Biol (1998) 6.28

The JNK signal transduction pathway. Curr Opin Cell Biol (2007) 5.86

Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev (2000) 5.71

The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron (1999) 4.51

Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Dev Cell (2008) 4.18

Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity (1998) 3.70

JNK phosphorylates paxillin and regulates cell migration. Nature (2003) 3.60

Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell (2008) 3.43

A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse. J Neurosci (2003) 3.26

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res (2003) 3.13

Targeting JNK for therapeutic benefit: from junk to gold? Nat Rev Drug Discov (2003) 3.11

Tissue architecture: the ultimate regulator of breast epithelial function. Curr Opin Cell Biol (2003) 2.92

Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development (2005) 2.73

Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol (2003) 2.68

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell (2007) 2.60

Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis. Breast Cancer Res (2005) 2.46

JNK2 is a positive regulator of the cJun transcription factor. Mol Cell (2006) 2.32

Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell (2008) 2.16

Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras. Proc Natl Acad Sci U S A (2008) 2.14

The role of JNK in the development of hepatocellular carcinoma. Genes Dev (2011) 2.07

The control of cell motility and epithelial morphogenesis by Jun kinases. Trends Cell Biol (2004) 1.99

Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. Proc Natl Acad Sci U S A (2007) 1.83

Role of mitogen-activated protein kinase kinase 4 in cancer. Oncogene (2007) 1.79

Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell (2009) 1.79

A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J (2003) 1.72

Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A (2007) 1.67

Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models. Cell Cycle (2007) 1.62

The Drosophila JNK pathway controls the morphogenesis of imaginal discs during metamorphosis. Development (1999) 1.62

Thorax closure in Drosophila: involvement of Fos and the JNK pathway. Development (1999) 1.59

JNK regulates FoxO-dependent autophagy in neurons. Genes Dev (2011) 1.45

Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development. Breast Cancer Res (2009) 1.40

JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure. Genes Dev (2003) 1.27

Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo. Mol Cell Biol (2010) 1.23

JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. Dev Dyn (2006) 1.21

The importance of being a myoepithelial cell. Breast Cancer Res (2002) 1.20

The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis. Proc Natl Acad Sci U S A (2004) 1.19

Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation. Mol Cell Biol (2011) 1.12

Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model. PLoS One (2010) 1.12

Role of JNK in a Trp53-dependent mouse model of breast cancer. PLoS One (2010) 1.05

Functional significance of MMP-9 in tumor necrosis factor-induced proliferation and branching morphogenesis of mammary epithelial cells. Endocrinology (2000) 1.00

The Drosophila JNK pathway controls the morphogenesis of the egg dorsal appendages and micropyle. Dev Biol (2001) 0.97

Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling. J Cell Biol (2004) 0.92

MAP kinases in the immune response. Annu Rev Immunol (2001) 7.62

The JNK signal transduction pathway. Curr Opin Cell Biol (2007) 5.86

Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol (2003) 5.38

A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science (2008) 5.28

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A (2003) 5.01

JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A (2005) 3.68

Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell (2009) 3.37

Mechanism of p38 MAP kinase activation in vivo. Genes Dev (2003) 3.36

The JNK signal transduction pathway. Curr Opin Genet Dev (2002) 3.35

Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell (2006) 3.32

ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell (2010) 3.25

Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol (2006) 3.18

Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol (2005) 3.14

JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (2012) 3.12

Targeting JNK for therapeutic benefit: from junk to gold? Nat Rev Drug Discov (2003) 3.11

The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08

Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J Cell Biol (2005) 2.88

Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem (2005) 2.74

VEGF targets the tumour cell. Nat Rev Cancer (2013) 2.71

Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science (2008) 2.67

Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest (2005) 2.61

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev (2004) 2.51

A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A (2003) 2.47

IAP regulation of metastasis. Cancer Cell (2010) 2.47

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem (2002) 2.45

Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell (2007) 2.43

A semisynthetic epitope for kinase substrates. Nat Methods (2007) 2.40

JunD mediates survival signaling by the JNK signal transduction pathway. Mol Cell (2003) 2.39

Plasma microRNAs as potential biomarkers for non-small-cell lung cancer. Lab Invest (2010) 2.37

A genetically encoded fluorescent sensor of ERK activity. Proc Natl Acad Sci U S A (2008) 2.34

JNK2 is a positive regulator of the cJun transcription factor. Mol Cell (2006) 2.32

ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. Lab Invest (2009) 2.25

Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers. Int J Cancer (2010) 2.20

Prevention of steatosis by hepatic JNK1. Cell Metab (2009) 2.20

Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res (2002) 2.20

De novo analysis of transcriptome dynamics in the migratory locust during the development of phase traits. PLoS One (2010) 2.19

Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell (2008) 2.16

Amplification/overexpression of a mitotic kinase gene in human bladder cancer. J Natl Cancer Inst (2002) 2.16

Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer. Lung Cancer (2009) 2.14

Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol Biol Cell (2003) 2.11

The epithelial-mesenchymal transition (EMT) and colorectal cancer progression. Cancer Biol Ther (2005) 2.10

Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity (2007) 2.07

The role of JNK in the development of hepatocellular carcinoma. Genes Dev (2011) 2.07

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 2.05

C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science (2009) 2.04

Regulation of the immune response by stress-activated protein kinases. Immunol Rev (2009) 2.00

Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature (2004) 1.99

Dicer-2 and R2D2 coordinately bind siRNA to promote assembly of the siRISC complexes. RNA (2006) 1.98

Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol (2005) 1.97

Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. Cancer Res (2003) 1.95

Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. J Neurosci (2004) 1.94

Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor. J Am Coll Cardiol (2006) 1.89

Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. J Exp Med (2006) 1.88

JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A (2012) 1.88

Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer. Cancer Epidemiol Biomarkers Prev (2010) 1.85

Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma. Cancer Res (2004) 1.83

Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. J Biol Chem (2003) 1.83

A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun. EMBO J (2003) 1.83

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. Gut (2006) 1.82

JNK regulates autocrine expression of TGF-beta1. Mol Cell (2004) 1.81

IMP3 is a novel biomarker for triple negative invasive mammary carcinoma associated with a more aggressive phenotype. Hum Pathol (2009) 1.80

Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers. Mod Pathol (2010) 1.80

Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Mol Cell Biol (2005) 1.80

Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell (2009) 1.79

ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation. Cancer Biol Ther (2009) 1.79

Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers. BMC Cancer (2011) 1.74

MicroRNAs as potential biomarkers in human solid tumors. Cancer Lett (2012) 1.73

Role of JNK in tumor development. Cell Cycle (2003) 1.71

Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell (2007) 1.69

Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A (2007) 1.67

Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. J Cell Biol (2002) 1.66

AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol (2010) 1.64

Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin. Cancer Res (2005) 1.61

Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer. Cancer Res (2003) 1.61

Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation. J Exp Med (2002) 1.61

Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1. J Cell Sci (2008) 1.60

Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol (2012) 1.59

Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways. Gastroenterology (2012) 1.58

Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression. Cancer Metastasis Rev (2005) 1.58

c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor. Mol Cell Biol (2003) 1.58

Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer. Clin Cancer Res (2007) 1.57

Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol Cell Biol (2009) 1.56

Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer. Mol Cancer (2010) 1.56

Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol Cell Biol (2005) 1.53

Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem (2002) 1.52

Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS One (2010) 1.52

Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol (2004) 1.52

Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep (2002) 1.52

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth. Cancer Lett (2013) 1.51

Up-regulation of 14-3-3zeta in lung cancer and its implication as prognostic and therapeutic target. Cancer Res (2007) 1.51

Targeting dendritic cell signaling to regulate the response to immunization. Blood (2008) 1.50

Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis. Blood (2011) 1.50

Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. Mol Cell Biol (2002) 1.50

GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. EMBO J (2004) 1.50