Published in Mol Cell on June 01, 2003
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Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal (2013) 2.59
Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. Mol Cell Biol (2005) 2.57
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev (2004) 2.51
TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. J Biol Chem (2006) 2.19
Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J Cell Biol (2006) 2.12
The role of JNK in the development of hepatocellular carcinoma. Genes Dev (2011) 2.07
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Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell (2009) 1.79
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Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol Cell Biol (2009) 1.56
Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol Clin Exp Res (2005) 1.49
Transcriptional switch by activating transcription factor 2-derived peptide sensitizes melanoma cells to apoptosis and inhibits their tumorigenicity. Proc Natl Acad Sci U S A (2004) 1.46
JNK regulates FoxO-dependent autophagy in neurons. Genes Dev (2011) 1.45
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A novel vascular disrupting agent plinabulin triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cells. Blood (2011) 0.94
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JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. Mol Cell Biol (2005) 0.92
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Febrile-range hyperthermia augments lipopolysaccharide-induced lung injury by a mechanism of enhanced alveolar epithelial apoptosis. J Immunol (2010) 0.90
An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan. Aging Cell (2012) 0.90
Control of oncogenesis and cancer therapy resistance. Br J Cancer (2004) 0.88
USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics. Cell Death Differ (2015) 0.87
Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity. Expert Opin Drug Metab Toxicol (2015) 0.87
Expression of signal transduction genes differs after hypoxic or isoflurane preconditioning of rat hippocampal slice cultures. Anesthesiology (2009) 0.86
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JNK1 is required for lentivirus entry and gene transfer. J Virol (2010) 0.83
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JunD/AP-1-mediated gene expression promotes lymphocyte growth dependent on interleukin-7 signal transduction. PLoS One (2012) 0.81
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Prologation of c-Jun N-terminal kinase is associated with cell death induced by tumor necrosis factor alpha in human chondrocytes. J Korean Med Sci (2004) 0.77
An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response. J Cell Sci (2016) 0.77
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Protocatechuic Acid Prevents oxLDL-Induced Apoptosis by Activating JNK/Nrf2 Survival Signals in Macrophages. Oxid Med Cell Longev (2015) 0.76
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c-Jun N-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine. Mucosal Immunol (2017) 0.75
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Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A (2004) 9.00
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A (2006) 8.27
MAP kinases in the immune response. Annu Rev Immunol (2001) 7.62
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med (2004) 7.49
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IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79
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Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature (2007) 6.58
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science (2006) 6.55
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol (2007) 6.20
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The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A (2008) 5.59
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell (2004) 5.50
Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol (2003) 5.38
Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature (2005) 5.32
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science (2008) 5.28
A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol (2009) 5.26
A toll-like receptor that prevents infection by uropathogenic bacteria. Science (2004) 5.26
Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science (2009) 5.24
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest (2009) 5.09
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A (2003) 5.01
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med (2007) 4.95
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T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med (2005) 4.28
Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med (2006) 4.28
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol (2003) 4.15
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15
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JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A (2005) 3.68
Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. Cell Host Microbe (2007) 3.52
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46
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Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity (2011) 3.38
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Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell (2006) 3.32
Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. Immunity (2008) 3.26
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A (2004) 3.26
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Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
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Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol (2005) 3.14
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (2012) 3.12
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The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation. J Immunol (2002) 3.04
Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat Immunol (2005) 2.96
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci U S A (2003) 2.94
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Regulation of the Th2 cytokine locus by a locus control region. Immunity (2003) 2.84
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Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell (2008) 2.68
Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science (2008) 2.67