Published in Mol Cell Oncol on December 23, 2014
ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer (2003) 16.06
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
The p53-mdm-2 autoregulatory feedback loop. Genes Dev (1993) 11.19
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett (1997) 11.19
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer (2006) 8.83
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell (1998) 8.33
Modulation of microRNA processing by p53. Nature (2009) 7.88
Protein regulation by monoubiquitin. Nat Rev Mol Cell Biol (2001) 6.96
miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A (2008) 6.24
Acetylation is indispensable for p53 activation. Cell (2008) 5.70
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64
Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell (2003) 5.44
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96
miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol (2008) 4.81
p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53
Repression of p53 activity by Smyd2-mediated methylation. Nature (2006) 4.51
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell (2004) 4.46
MicroRNA-125b is a novel negative regulator of p53. Genes Dev (2009) 4.43
ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell (2001) 4.38
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell (2005) 4.16
A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res (2008) 3.70
Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell (2007) 3.68
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol (2002) 3.55
The MDM2-p53 interaction. Mol Cancer Res (2003) 3.43
Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell (2007) 3.20
USP10 regulates p53 localization and stability by deubiquitinating p53. Cell (2010) 3.17
Transcriptional regulation by p53. Cold Spring Harb Perspect Biol (2010) 3.16
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J (2004) 3.10
ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat Genet (1998) 3.01
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature (2002) 2.94
Arginine methylation regulates the p53 response. Nat Cell Biol (2008) 2.94
Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability. Nat Cell Biol (2006) 2.90
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation. Mol Cell Biol (2000) 2.72
G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64
Negative feedback regulation of wild-type p53 biosynthesis. EMBO J (1995) 2.52
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell (2006) 2.50
Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol Cell (2008) 2.46
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell (2007) 2.32
iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. Nat Genet (2006) 2.20
DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol Cell (2007) 2.18
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP. Nat Struct Mol Biol (2007) 2.13
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J (2007) 2.07
Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell (2008) 1.99
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage. Proc Natl Acad Sci U S A (2005) 1.97
Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell (2010) 1.92
Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene (2010) 1.78
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation. Nat Cell Biol (2007) 1.73
Mapping of phosphomonoester and apparent phosphodiester bonds of the oncogene product p53 from simian virus 40-transformed 3T3 cells. Proc Natl Acad Sci U S A (1986) 1.72
c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif. Cell Growth Differ (1993) 1.72
Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J (2005) 1.67
5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage. Genes Dev (2010) 1.64
Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage. J Biol Chem (2005) 1.50
HDAC5, a key component in temporal regulation of p53-mediated transactivation in response to genotoxic stress. Mol Cell (2013) 1.49
Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol (2006) 1.45
KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat Cell Biol (2009) 1.43
Thymidylate synthase protein and p53 mRNA form an in vivo ribonucleoprotein complex. Mol Cell Biol (1999) 1.40
Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas. Genes Dev (2011) 1.37
Regulation of p53 expression by thymidylate synthase. Proc Natl Acad Sci U S A (1999) 1.37
Participation of the human p53 3'UTR in translational repression and activation following gamma-irradiation. EMBO J (1997) 1.37
SUMO-1 and p53. Cell Cycle (2002) 1.34
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1. Oncogene (2006) 1.29
FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J Biol Chem (2006) 1.26
Regulation of p53 stability and function by the deubiquitinating enzyme USP42. EMBO J (2011) 1.24
MSL2 promotes Mdm2-independent cytoplasmic localization of p53. J Biol Chem (2008) 1.21
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity. Nat Commun (2011) 1.20
Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA. J Biol Chem (2011) 1.13
The role of ubiquitin modification in the regulation of p53. Biochim Biophys Acta (2013) 1.12
Selective killing of lung cancer cells by miRNA-506 molecule through inhibiting NF-κB p65 to evoke reactive oxygen species generation and p53 activation. Oncogene (2014) 1.09
Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. Oncogene (2010) 1.08
The tumor suppressor p53 regulates its own transcription. Mol Cell Biol (1993) 1.08
Stabilization and activation of p53 by the coactivator protein TAFII31. J Biol Chem (2001) 1.06
Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents. J Biol Chem (2000) 1.06
p53-dependent transcription and tumor suppression are not affected in Set7/9-deficient mice. Mol Cell (2011) 1.05
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities. Oncogene (2006) 1.04
MiR-138 promotes induced pluripotent stem cell generation through the regulation of the p53 signaling. Stem Cells (2012) 1.04
Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage. Proc Natl Acad Sci U S A (2008) 1.02
Distinct phosphatases antagonize the p53 response in different phases of the cell cycle. Proc Natl Acad Sci U S A (2014) 1.01
Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis. Cancer Res (2011) 1.00
TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage. Mol Cell Biol (2014) 1.00
SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia. Blood (2014) 0.98
PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53. Mol Cancer Ther (2009) 0.98
SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation. Arch Biochem Biophys (2014) 0.98
The NF-Y/p53 liaison: well beyond repression. Biochim Biophys Acta (2011) 0.97
Posttranslational phosphorylation of mutant p53 protein in tumor development. Med Mol Morphol (2006) 0.96
Nucleotide biosynthetic enzyme GMP synthase is a TRIM21-controlled relay of p53 stabilization. Mol Cell (2014) 0.95
miR-19b promotes tumor growth and metastasis via targeting TP53. RNA (2014) 0.90
Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation. Mol Cell Biol (2011) 0.89
A portrayal of E3 ubiquitin ligases and deubiquitylases in cancer. Int J Cancer (2013) 0.86
p53 is positively regulated by miR-542-3p. Cancer Res (2014) 0.84
Transcriptional regulation of tumor suppressor p53 by cAMP-responsive element-binding protein/AMP-activated protein kinase complex in response to glucose deprivation. Genes Cells (2009) 0.84
Conserved CPEs in the p53 3' untranslated region influence mRNA stability and protein synthesis. Anticancer Res (2008) 0.84
Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. EMBO J (2013) 0.82
VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage. FEBS Lett (2014) 0.81
Acetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitro. PLoS One (2013) 0.79
p53 requires the stress sensor USF1 to direct appropriate cell fate decision. PLoS Genet (2014) 0.79