The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo.

PubWeight™: 1.48‹?› | Rank: Top 4%

🔗 View Article (PMC 3202469)

Published in J Pharmacol Exp Ther on August 19, 2010

Authors

Camilo Rojas1, Ying Li, Jie Zhang, Marigo Stathis, Jesse Alt, Ajit G Thomas, Sergio Cantoreggi, Silvia Sebastiani, Claudio Pietra, Barbara S Slusher

Author Affiliations

1: The Brain Science Institute, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Suite 270, Baltimore, MD 21205, USA.

Articles citing this

Netupitant PET imaging and ADME studies in humans. J Clin Pharmacol (2013) 1.10

Palonosetron in the prevention of chemotherapy-induced nausea and vomiting: an evidence-based review of safety, efficacy, and place in therapy. Core Evid (2015) 0.96

Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting. Eur J Pharmacol (2013) 0.95

Comparison of palonosetron with ondansetron in prevention of postoperative nausea and vomiting in patients receiving intravenous patient-controlled analgesia after gynecological laparoscopic surgery. Korean J Anesthesiol (2013) 0.95

The comparative study to evaluate the effect of palonosetron monotherapy versus palonosetron with dexamethasone combination therapy for prevention of postoperative nausea and vomiting. Korean J Anesthesiol (2012) 0.95

Prolonged inhibition of 5-HT₃ receptors by palonosetron results from surface receptor inhibition rather than inducing receptor internalization. Br J Pharmacol (2013) 0.93

Current pharmacotherapy for chemotherapy-induced nausea and vomiting in cancer patients. Expert Opin Pharmacother (2013) 0.90

Impact of 5-HT3 receptor antagonists on chemotherapy-induced nausea and vomiting: a retrospective cohort study. BMC Health Serv Res (2012) 0.89

Pilot study on the efficacy of an ondansetron- versus palonosetron-containing antiemetic regimen prior to highly emetogenic chemotherapy. Support Care Cancer (2013) 0.88

Comparison of an extended-release formulation of granisetron (APF530) versus palonosetron for the prevention of chemotherapy-induced nausea and vomiting associated with moderately or highly emetogenic chemotherapy: results of a prospective, randomized, double-blind, noninferiority phase 3 trial. Support Care Cancer (2014) 0.87

Open-label, randomized, comparative, phase III study on effects of reducing steroid use in combination with Palonosetron. Cancer Sci (2015) 0.86

The efficacy of triplet antiemetic therapy with 0.75 mg of palonosetron for chemotherapy-induced nausea and vomiting in lung cancer patients receiving highly emetogenic chemotherapy. Support Care Cancer (2013) 0.86

Netupitant and palonosetron trigger NK1 receptor internalization in NG108-15 cells. Exp Brain Res (2014) 0.86

Effect of netupitant, a highly selective NK₁ receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives. Support Care Cancer (2013) 0.86

Update on the management of chemotherapy-induced nausea and vomiting - focus on palonosetron. Ther Clin Risk Manag (2015) 0.81

Agonists and antagonists induce different palonosetron dissociation rates in 5-HT₃A and 5-HT₃AB receptors. Neuropharmacology (2013) 0.81

Palonosetron in the management of chemotherapy-induced nausea and vomiting in patients receiving multiple-day chemotherapy. Cancer Manag Res (2014) 0.81

Measuring the nausea-to-emesis continuum in non-human animals: refocusing on gastrointestinal vagal signaling. Exp Brain Res (2014) 0.80

Treatment of Nausea and Vomiting During Chemotherapy. US Oncol Hematol (2011) 0.80

Comparison between the antiemetic effects of palonosetron and granisetron in breast cancer patients treated with anthracycline-based regimens. Oncol Lett (2014) 0.79

Efficacy and safety of aprepitant in the prevention of chemotherapy-induced nausea and vomiting: a pooled analysis. Support Care Cancer (2011) 0.79

Efficacy and safety of oral palonosetron compared with IV palonosetron administered with dexamethasone for the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients with solid tumors receiving cisplatin-based highly emetogenic chemotherapy (HEC). Support Care Cancer (2015) 0.79

Efficacy of palonosetron and 1-day dexamethasone in moderately emetogenic chemotherapy compared with fosaprepitant, granisetron, and dexamethasone: a prospective randomized crossover study. Int J Clin Oncol (2015) 0.78

Palonosetron and dexamethasone for the prevention of nausea and vomiting in patients receiving allogeneic hematopoietic stem cell transplantation. Support Care Cancer (2013) 0.78

A Phase II single-arm trial of palonosetron for the prevention of acute and delayed chemotherapy-induced nausea and vomiting in malignant glioma patients receiving multidose irinotecan in combination with bevacizumab. Ther Clin Risk Manag (2016) 0.78

The Impact of 5-HT3RA Use on Cost and Utilization in Patients with Chemotherapy-Induced Nausea and Vomiting: Systematic Review of the Literature. Am Health Drug Benefits (2014) 0.76

A randomized, double-blind trial evaluating the efficacy of palonosetron with total intravenous anesthesia using propofol and remifentanil for the prevention of postoperative nausea and vomiting after gynecologic surgery. J Anesth (2016) 0.76

Profile of Antiemetic Activity of Netupitant Alone or in Combination with Palonosetron and Dexamethasone in Ferrets and Suncus murinus (House Musk Shrew). Front Pharmacol (2016) 0.76

Drug-drug interaction profile of components of a fixed combination of netupitant and palonosetron: Review of clinical data. J Oncol Pharm Pract (2015) 0.76

Management of acute and delayed chemotherapy-induced nausea and vomiting: role of netupitant-palonosetron combination. Ther Clin Risk Manag (2016) 0.75

Efficacy of Palonosetron vs. Ramosetron for the Prevention of Postoperative Nausea and Vomiting: A Meta-Analysis of Randomized Controlled Trials. Yonsei Med J (2017) 0.75

Palonosetron versus older 5-HT3 receptor antagonists for nausea prevention in patients receiving chemotherapy: a multistudy analysis. J Community Support Oncol (2014) 0.75

Evaluating the various phases of cisplatin-induced emesis in rats. Oncol Lett (2014) 0.75

A prospective, randomized, double-blind, multicenter trial to evaluate the therapeutic efficacy and safety of palonosetron in the treatment of postoperative nausea and vomiting over a 72-h period. J Anesth (2014) 0.75

Articles cited by this

Chemotherapy-induced nausea and vomiting. N Engl J Med (2008) 4.00

Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial. Lancet Oncol (2009) 3.69

Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist: results of a phase III, single-dose trial versus dolasetron. Cancer (2003) 2.88

A phase III, double-blind, randomized trial of palonosetron compared with ondansetron in preventing chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy. Ann Oncol (2006) 2.84

Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor. Anesth Analg (2008) 2.79

Palonosetron triggers 5-HT(3) receptor internalization and causes prolonged inhibition of receptor function. Eur J Pharmacol (2009) 1.81

The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro. Br J Pharmacol (1995) 1.57

Differential involvement of neurotransmitters through the time course of cisplatin-induced emesis as revealed by therapy with specific receptor antagonists. Eur J Cancer (2003) 1.48

Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors. Mol Pharmacol (1996) 1.26

Pharmacological characterization of RS 25259-197, a novel and selective 5-HT3 receptor antagonist, in vivo. Br J Pharmacol (1995) 1.04

An interaction of ondansetron and dexamethasone antagonizing cisplatin-induced acute and delayed emesis in the ferret. Br J Pharmacol (1996) 0.99

Effects of CP-99, 994, a tachykinin NK(1) receptor antagonist, on abdominal afferent vagal activity in ferrets: evidence for involvement of NK(1) and 5-HT(3) receptors. Eur J Pharmacol (2001) 0.97

Differential action of ondansetron and dexamethasone to modify cisplatin-induced acute and delayed kaolin consumption ("pica") in rats. Eur J Pharmacol (2002) 0.96

Characteristics of [14C]guanidinium accumulation in NG 108-15 cells exposed to serotonin 5-HT3 receptor ligands and substance P. J Neurochem (1993) 0.95

Substance P and serotonin act synergistically to activate a cation permeability in a neuronal cell line. Brain Res (1989) 0.92

Dose-independent pharmacokinetics of ondansetron in rats: contribution of hepatic and intestinal first-pass effects to low bioavailability. Biopharm Drug Dispos (2008) 0.92

Substance P potentiates 5-HT3 receptor-mediated current in rat trigeminal ganglion neurons. Neurosci Lett (2004) 0.86

Effects of various 5-HT3 receptor antagonists, granisetron, ondansetron, ramosetron and azasetron on serotonin (5-HT) release from the ferret isolated ileum. Res Commun Mol Pathol Pharmacol (1999) 0.85

Pharmacokinetics of granisetron in rat blood and brain by microdialysis. Life Sci (1999) 0.84

Articles by these authors

A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81

Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med (2007) 9.83

Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Proc Natl Acad Sci U S A (2003) 8.21

The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19

Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol (2006) 8.05

Genome sequence and analysis of the tuber crop potato. Nature (2011) 7.77

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity (2008) 7.60

Negative Staining and Image Classification - Powerful Tools in Modern Electron Microscopy. Biol Proced Online (2004) 6.14

Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol (2011) 5.98

Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell (2009) 5.74

Incorporating structure to predict microRNA targets. Proc Natl Acad Sci U S A (2005) 5.68

DNA helicase Srs2 disrupts the Rad51 presynaptic filament. Nature (2003) 5.66

Analyses of pig genomes provide insight into porcine demography and evolution. Nature (2012) 5.58

Validation of the ITS2 region as a novel DNA barcode for identifying medicinal plant species. PLoS One (2010) 5.39

Aptamers evolved from live cells as effective molecular probes for cancer study. Proc Natl Acad Sci U S A (2006) 5.35

Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell (2005) 5.10

Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature (2009) 4.98

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A (2010) 4.95

Lanthanide-transition-metal sandwich framework comprising {Cu3} cluster pillars and layered networks of {Er36} wheels. Angew Chem Int Ed Engl (2005) 4.93

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab (2012) 4.80

Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J Exp Med (2003) 4.64

Unsupervised learning of an atlas from unlabeled point-sets. IEEE Trans Pattern Anal Mach Intell (2004) 4.63

Sequence and analysis of rice chromosome 4. Nature (2002) 4.39

Cross-leg flaps: our preferred alternative to free flaps in the treatment of complex traumatic lower extremity wounds. J Am Coll Surg (2013) 4.30

ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell (2011) 4.26

Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature (2007) 4.12

A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the treatment of Early Aggressive Rheumatoid Arthritis Trial. Arthritis Rheum (2012) 4.01

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med (2009) 3.97

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature (2013) 3.93

Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature (2003) 3.72

Recognizing names in biomedical texts: a machine learning approach. Bioinformatics (2004) 3.70

Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res (2008) 3.54

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J Immunol (2007) 3.47

Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars. Nat Genet (2013) 3.41

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature (2012) 3.38

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res (2010) 3.30

Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist. Science (2006) 3.26

The phosphothreonine lyase activity of a bacterial type III effector family. Science (2007) 3.18

Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR. J Virol (2003) 3.10

The Selaginella genome identifies genetic changes associated with the evolution of vascular plants. Science (2011) 3.10

Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. Proc Natl Acad Sci U S A (2007) 3.06

Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1. J Neurophysiol (2008) 2.99

Estrogen receptor (ER) mRNA and ER-related gene expression in breast cancers that are 1% to 10% ER-positive by immunohistochemistry. J Clin Oncol (2012) 2.98

Use of ITS2 region as the universal DNA barcode for plants and animals. PLoS One (2010) 2.92

Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr Biol (2007) 2.84

Porous lanthanide-organic open frameworks with helical tubes constructed from interweaving triple-helical and double-helical chains. Angew Chem Int Ed Engl (2005) 2.83

Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor. Anesth Analg (2008) 2.79

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nat Neurosci (2013) 2.71

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell (2011) 2.58

Selection of aptamers for molecular recognition and characterization of cancer cells. Anal Chem (2007) 2.57

Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort. Arthritis Rheum (2009) 2.50

Cell-specific aptamer probes for membrane protein elucidation in cancer cells. J Proteome Res (2008) 2.44

Recognition of protein/gene names from text using an ensemble of classifiers. BMC Bioinformatics (2005) 2.42

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med (2009) 2.41

De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis. BMC Genomics (2010) 2.41

Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell (2006) 2.40

Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant (2004) 2.35

Gene set enrichment in eQTL data identifies novel annotations and pathway regulators. PLoS Genet (2008) 2.32

Association of EGFR mutation or ALK rearrangement with expression of DNA repair and synthesis genes in never-smoker women with pulmonary adenocarcinoma. Cancer (2012) 2.24

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity (2009) 2.21

The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development (2005) 2.19

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet (2012) 2.17

Barriers to accessing TB diagnosis for rural-to-urban migrants with chronic cough in Chongqing, China: a mixed methods study. BMC Health Serv Res (2008) 2.17

Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks. Nat Genet (2010) 2.16

Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction. Circ Res (2012) 2.16

Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. Obesity (Silver Spring) (2010) 2.15

Actin homolog MreBH governs cell morphogenesis by localization of the cell wall hydrolase LytE. Dev Cell (2006) 2.14

Modulation of cardiac gap junction expression and arrhythmic susceptibility. Circ Res (2004) 2.11

Long-term calcium supplementation may have adverse effects on serum cholesterol and carotid intima-media thickness in postmenopausal women: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr (2013) 2.11

Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes. Heart Rhythm (2011) 2.10

Functional regeneration of supraspinal connections in a patient with transected spinal cord following transplantation of bulbar olfactory ensheathing cells with peripheral nerve bridging. Cell Transplant (2014) 2.09

Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem (2004) 2.08

Diverse CD81 proteins support hepatitis C virus infection. J Virol (2006) 2.07

Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis. J Cell Biol (2007) 2.07

Pharmacological mechanisms of 5-HT₃ and tachykinin NK₁ receptor antagonism to prevent chemotherapy-induced nausea and vomiting. Eur J Pharmacol (2012) 2.07

Superfamily phenomena and motifs of networks induced from time series. Proc Natl Acad Sci U S A (2008) 2.06

Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages. Ann Neurol (2007) 2.05

The growth inhibitory effect of mesenchymal stem cells on tumor cells in vitro and in vivo. Cancer Biol Ther (2007) 2.05

Effect of thimerosal on the neurodevelopment of premature rats. World J Pediatr (2013) 2.04

A series of luminescent lanthanide-cadmium-organic frameworks with helical channels and tubes. Chem Commun (Camb) (2006) 2.01

Biodistribution, tumor detection, and radiation dosimetry of 18F-DCFBC, a low-molecular-weight inhibitor of prostate-specific membrane antigen, in patients with metastatic prostate cancer. J Nucl Med (2012) 2.00

Multitarget therapy for induction treatment of lupus nephritis: a randomized trial. Ann Intern Med (2015) 1.99

Utility of N-terminal pro B-type natriuretic peptide and mean platelet volume in differentiating congestive heart failure from chronic obstructive pulmonary disease. Int J Cardiol (2013) 1.99

The crystal structure of the bifunctional primase-helicase of bacteriophage T7. Mol Cell (2003) 1.99

Jamming by shear. Nature (2011) 1.98

High-affinity near-infrared fluorescent small-molecule contrast agents for in vivo imaging of prostate-specific membrane antigen. Mol Imaging (2005) 1.97

Age-related differences in unruptured intracranial aneurysms: 1-year outcomes. J Neurosurg (2014) 1.96

Expression of stimulated by retinoic acid gene 8 (Stra8) and maturation of murine gonocytes and spermatogonia induced by retinoic acid in vitro. Biol Reprod (2007) 1.94

Flagellin induces innate immunity in nonhost interactions that is suppressed by Pseudomonas syringae effectors. Proc Natl Acad Sci U S A (2005) 1.94

A germanate framework containing 24-ring channels, Ni--Ge bonds, and chiral [Ni@Ge14O24(OH)3] cluster motifs transferred from chiral metal complexes. Angew Chem Int Ed Engl (2005) 1.94

High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Res (2005) 1.94

Trends in the use of biologic agents among rheumatoid arthritis patients enrolled in the US medicare program. Arthritis Care Res (Hoboken) (2013) 1.92

Exome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome. Am J Hum Genet (2012) 1.91