Published in J Biol Chem on April 14, 2011
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HPV E6, E6AP and cervical cancer. BMC Biochem (2008) 1.08
E6AP mediates regulated proteasomal degradation of the nuclear receptor coactivator amplified in breast cancer 1 in immortalized cells. Cancer Res (2006) 1.08
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The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein. J Neurochem (2009) 1.01
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IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Am J Physiol Gastrointest Liver Physiol (2006) 3.72
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The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell (2005) 2.85
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Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell (2011) 2.16
The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation. J Biol Chem (2005) 2.01
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Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature (2002) 1.80
Caspase activation inhibits proteasome function during apoptosis. Mol Cell (2004) 1.78
siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells. Oncogene (2003) 1.78
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Involvement of the DNA repair protein hHR23 in p53 degradation. Mol Cell Biol (2003) 1.38
A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1. Biochem Biophys Res Commun (2003) 1.37
Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity (2005) 1.33
Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. Mol Cell Biol (2006) 1.31
Ubiquitin as a central cellular regulator. Cell (2004) 1.30
The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation. Mol Cell (2012) 1.30
Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system. Circ Res (2006) 1.27
UBE1L2, a novel E1 enzyme specific for ubiquitin. J Biol Chem (2007) 1.25
Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-kappaB precursor. Mol Cell (2009) 1.23
The role of the ubiquitin ligase E6-AP in human papillomavirus E6-mediated degradation of PDZ domain-containing proteins. J Biol Chem (2006) 1.23
Degradation of ubiquitin: the fate of the cellular reaper. Cell Cycle (2010) 1.22
Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family. Eur J Hum Genet (2002) 1.21
Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. Cancer Res (2009) 1.12
The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105. J Biol Chem (2002) 1.11
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Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. J Biol Chem (2007) 1.08
Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology. Proc Natl Acad Sci U S A (2013) 1.07
Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome. Proc Natl Acad Sci U S A (2010) 1.07
Determinants of nuclear and cytoplasmic ubiquitin-mediated degradation of MyoD. J Biol Chem (2002) 1.06
Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation. Proc Natl Acad Sci U S A (2009) 1.06
Ubiquitin-proteasome-mediated degradation of keratin intermediate filaments in mechanically stimulated A549 cells. J Biol Chem (2008) 1.05
Ubiquitin-proteasome-mediated degradation, intracellular localization, and protein synthesis of MyoD and Id1 during muscle differentiation. J Biol Chem (2005) 1.03
Regulation of the Polycomb protein RING1B ubiquitination by USP7. Biochem Biophys Res Commun (2010) 1.02
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Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite. J Biol Chem (2010) 0.99
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Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc. Proc Natl Acad Sci U S A (2013) 0.99
Phosphorylation and ubiquitination are necessary for Na,K-ATPase endocytosis during hypoxia. Cell Signal (2007) 0.98
Mutation of HERC2 causes developmental delay with Angelman-like features. J Med Genet (2012) 0.98
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Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system. Mol Cell Proteomics (2012) 0.93
FAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination. Mol Biol Cell (2011) 0.92
Mutations in gasdermin 3 cause aberrant differentiation of the hair follicle and sebaceous gland. J Invest Dermatol (2005) 0.92
ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor. Biochem Biophys Res Commun (2009) 0.92
Nonenzymatic polyubiquitination of expressed proteins. J Am Chem Soc (2014) 0.92
PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins. Biochem Biophys Res Commun (2011) 0.91
The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis. J Exp Med (2010) 0.91
Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53. J Virol (2005) 0.91
Personalized medicine: the road ahead. Am J Respir Crit Care Med (2012) 0.90
Ubiquitin ligase E6-AP and its role in human disease. Biochem Soc Trans (2008) 0.90
Oxidative stress-related increase in ubiquitination in early coronary atherogenesis. FASEB J (2003) 0.90
Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD. J Biol Chem (2004) 0.89
Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation. J Biol Chem (2005) 0.89
Ubiquitination participates in the lysosomal degradation of Na,K-ATPase in steady-state conditions. Am J Respir Cell Mol Biol (2009) 0.89
HUWE1 ubiquitinates MyoD and targets it for proteasomal degradation. Biochem Biophys Res Commun (2012) 0.88
Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases. Mol Cell (2013) 0.88
The ubiquitin-protein ligase activity of Hdm2 is inhibited by nucleic acids. FEBS Lett (2003) 0.88
Generation of a mono-ubiquitinated PCNA mimic by click chemistry. Chembiochem (2011) 0.88
Increased ubiquitin immunoreactivity in unstable atherosclerotic plaques associated with acute coronary syndromes. J Am Coll Cardiol (2002) 0.88
Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. J Gen Virol (2007) 0.87
The N-terminal domain of MyoD is necessary and sufficient for its nuclear localization-dependent degradation by the ubiquitin system. Proc Natl Acad Sci U S A (2008) 0.87
Turning the RING domain protein MdmX into an active ubiquitin-protein ligase. J Biol Chem (2010) 0.86
Two distinct ubiquitin-dependent mechanisms are involved in NF-kappaB p105 proteolysis. Biochem Biophys Res Commun (2006) 0.86
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