Published in Mol Cell Biol on October 08, 2007
Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol Cell (2010) 2.60
Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol (2012) 2.26
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity (2008) 2.04
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med (2009) 1.86
Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression. Genes Dev (2008) 1.79
The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J Exp Med (2011) 1.60
Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus. Immunity (2013) 1.33
Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. Immunity (2010) 1.17
Regulation of the Ifng locus in the context of T-lineage specification and plasticity. Immunol Rev (2010) 1.12
Molecular mechanisms by which T-bet regulates T-helper cell commitment. Immunol Rev (2010) 1.07
Ash2l interacts with Tbx1 and is required during early embryogenesis. Exp Biol Med (Maywood) (2010) 1.06
Transcriptional mechanisms that regulate T helper 1 cell differentiation. Curr Opin Immunol (2012) 1.03
Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice. J Immunol (2014) 1.02
Common themes emerge in the transcriptional control of T helper and developmental cell fate decisions regulated by the T-box, GATA and ROR families. Immunology (2009) 0.97
Impaired CD4+ T-cell proliferation and effector function correlates with repressive histone methylation events in a mouse model of severe sepsis. Eur J Immunol (2010) 0.96
Transcription factor-dependent chromatin remodeling of Il18r1 during Th1 and Th2 differentiation. J Immunol (2008) 0.94
The retinoblastoma protein modulates Tbx2 functional specificity. Mol Biol Cell (2010) 0.92
T cell immunity as a tool for studying epigenetic regulation of cellular differentiation. Front Genet (2013) 0.89
T-bet employs diverse regulatory mechanisms to repress transcription. Trends Immunol (2011) 0.88
Regulators of chromatin state and transcription in CD4 T-cell polarization. Immunology (2013) 0.87
IL-2-inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4+ T cells. J Allergy Clin Immunol (2013) 0.86
Inflammation programs self-reactive CD8+ T cells to acquire T-box-mediated effector function but does not prevent deletional tolerance. J Leukoc Biol (2014) 0.82
The interface between transcriptional and epigenetic control of effector and memory CD8⁺ T-cell differentiation. Immunol Rev (2014) 0.82
Histone methyltransferase and histone methylation in inflammatory T-cell responses. Immunotherapy (2013) 0.81
T-bet-dependent regulation of CD8+ T-cell expansion during experimental Trypanosoma cruzi infection. Immunology (2009) 0.77
Correlation Network Analysis Reveals Relationships between MicroRNAs, Transcription Factor T-bet, and Deregulated Cytokine/Chemokine-Receptor Network in Pulmonary Sarcoidosis. Mediators Inflamm (2015) 0.77
Epigenome-modifying tools in asthma. Epigenomics (2015) 0.76
Changes in histone acetylation and methylation that are important for persistent but not transient expression of CCR4 in human CD4+ T cells. Eur J Immunol (2010) 0.75
A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell (2000) 17.61
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell (2007) 9.73
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol (2005) 8.27
Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science (2003) 7.75
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells. Nat Immunol (2002) 7.28
Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev (2002) 6.74
Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol (2006) 6.10
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science (2001) 5.58
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity (1998) 5.38
Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol (2006) 4.81
T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol (2002) 4.38
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science (2005) 3.65
Eomesodermin is required for mouse trophoblast development and mesoderm formation. Nature (2000) 3.53
A distal conserved sequence element controls Ifng gene expression by T cells and NK cells. Immunity (2006) 3.16
Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation. J Immunol (2002) 3.04
T-box genes in vertebrate development. Annu Rev Genet (2005) 3.00
T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood (2005) 2.95
Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction. Nat Immunol (2002) 2.87
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J Exp Med (2006) 2.70
A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J Biol Chem (2003) 2.59
T-box genes in early embryogenesis. Dev Dyn (2004) 2.45
Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature (1998) 2.37
T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects. J Biol Chem (2006) 2.24
Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells. Proc Natl Acad Sci U S A (2004) 2.21
Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis. Nat Genet (2007) 2.03
Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity (2004) 1.98
T-box genes in human disorders. Hum Mol Genet (2003) 1.79
The T-box family. Genome Biol (2002) 1.69
IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. J Exp Med (2005) 1.64
Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus. J Biol Chem (2002) 1.62
TBX5 mutations and congenital heart disease: Holt-Oram syndrome revealed. Curr Opin Cardiol (2004) 1.52
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc Natl Acad Sci U S A (2005) 1.45
Temporal dissection of T-bet functions. J Immunol (2007) 1.43
Identification of cooperative monomeric Brachyury sites conferring T-bet responsiveness to the proximal IFN-gamma promoter. Int Immunol (2003) 1.29
An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm. Proc Natl Acad Sci U S A (2003) 1.28
Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes. Proc Natl Acad Sci U S A (2006) 1.26
T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site. Proc Natl Acad Sci U S A (2005) 1.22
A cell autonomous function of Brachyury in T/T embryonic stem cell chimaeras. Nature (1991) 1.14
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity (2004) 6.43
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nat Immunol (2011) 2.76
Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol Cell (2010) 2.60
Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol (2012) 2.26
CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. Immunity (2009) 2.24
T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects. J Biol Chem (2006) 2.24
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med (2009) 1.86
Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression. Genes Dev (2008) 1.79
The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J Exp Med (2011) 1.60
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc Natl Acad Sci U S A (2005) 1.45
Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat Rev Immunol (2012) 1.36
Nitric oxide binding to prokaryotic homologs of the soluble guanylate cyclase beta1 H-NOX domain. J Biol Chem (2006) 1.13
Molecular mechanisms by which T-bet regulates T-helper cell commitment. Immunol Rev (2010) 1.07
Transcriptional mechanisms that regulate T helper 1 cell differentiation. Curr Opin Immunol (2012) 1.03
Suicide, guns, and public policy. Am J Public Health (2012) 0.98
Common themes emerge in the transcriptional control of T helper and developmental cell fate decisions regulated by the T-box, GATA and ROR families. Immunology (2009) 0.97
Apoptosis and antigen receptor function in T and B cells following exposure to herpes simplex virus. Virology (2006) 0.93
Restricted MHC-peptide repertoire predisposes to autoimmunity. J Exp Med (2005) 0.93
T-bet employs diverse regulatory mechanisms to repress transcription. Trends Immunol (2011) 0.88
Cell type-specific induction and inhibition of apoptosis by Herpes Simplex virus type 2 ICP10. J Virol (2008) 0.87
Encoding stability versus flexibility: lessons learned from examining epigenetics in T helper cell differentiation. Curr Top Microbiol Immunol (2012) 0.84
Ikaros changes the face of NuRD remodeling. Nat Immunol (2011) 0.78
Multiple mutant T alleles cause haploinsufficiency of Brachyury and short tails in Manx cats. Mamm Genome (2013) 0.78
An essential interaction between T-box proteins and histone-modifying enzymes. Epigenetics (2009) 0.77
Isolation and structure determination of an antimicrobial ester from a marine sediment-derived bacterium. J Nat Prod (2003) 0.76
Suicide affects all of us. Lancet (2012) 0.75
A piece of my mind. Time to reconsider. JAMA (2011) 0.75