PubRank

Yasuo Ihara

Author PubWeight™ 54.80‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. J Neurosci 2009 2.49
2 Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J Neurosci 2005 2.48
3 Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes Cells 2005 1.86
4 Potent amyloidogenicity and pathogenicity of Aβ43. Nat Neurosci 2011 1.76
5 Active gamma-secretase complexes contain only one of each component. J Biol Chem 2007 1.69
6 Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. J Biol Chem 2006 1.66
7 Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. J Biol Chem 2003 1.49
8 Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42. Biochemistry 2004 1.32
9 Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. Hum Mol Genet 2006 1.27
10 SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS One 2013 1.23
11 Emergence of cooperation in public goods games. Proc Biol Sci 2009 1.20
12 γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43. Cell Rep 2013 1.20
13 Genetic association of CTNNA3 with late-onset Alzheimer's disease in females. Hum Mol Genet 2007 1.15
14 Gamma-secretase activity is present in rafts but is not cholesterol-dependent. Biochemistry 2003 1.15
15 Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics 2009 1.12
16 DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase. Biochemistry 2006 1.12
17 Alzheimer's disease: beta-Amyloid protein and tau. J Neurosci Res 2002 1.06
18 Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states. J Biol Chem 2008 1.04
19 Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells. Biochemistry 2003 1.02
20 Progressive neurodegeneration in C. elegans model of tauopathy. Neurobiol Dis 2005 1.00
21 Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction. Genes Cells 2011 0.99
22 Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains. J Biol Chem 2007 0.97
23 Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease. EMBO Mol Med 2012 0.96
24 Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. J Biol Chem 2005 0.96
25 Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau. J Biol Chem 2004 0.95
26 Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity. Cell Signal 2009 0.94
27 γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment. J Biol Chem 2013 0.92
28 Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction. J Biol Chem 2001 0.90
29 Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. FASEB J 2004 0.90
30 Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein. FEBS Lett 2005 0.90
31 Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta. J Biol Chem 2008 0.88
32 Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads. J Neuropathol Exp Neurol 2005 0.87
33 A theoretical study on the evolution of male parental care and female multiple mating: effects of female mate choice and male care bias. J Theor Biol 2007 0.86
34 GAB2 is not associated with late-onset Alzheimer's disease in Japanese. Eur J Hum Genet 2008 0.85
35 Molecular aging of tau: disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo. J Neurochem 2004 0.85
36 Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase. Nat Commun 2013 0.84
37 SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease. J Alzheimers Dis 2013 0.82
38 The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel. Psychogeriatrics 2010 0.81
39 Immunostaining of oxidized DJ-1 in human and mouse brains. J Neuropathol Exp Neurol 2014 0.80
40 Dissociation of β-amyloid from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates β-amyloid-42 assembly. J Neurosci Res 2011 0.79
41 Suspected limited efficacy of γ-secretase modulators. Neurobiol Aging 2012 0.79
42 Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. EMBO J 2003 0.79
43 [A proposal for diagnostic and clinical assessment criteria for Alzheimer's disease]. Rinsho Shinkeigaku 2005 0.78
44 Human homogamy in facial characteristics: does a sexual-imprinting-like mechanism play a role? Hum Nat 2012 0.78
45 Replicator-dynamics models of sexual conflict. J Theor Biol 2009 0.77
46 Evolution of male parental care and female multiple mating: game-theoretical and two-locus diploid models. Am Nat 2005 0.77
47 Estrous asynchrony causes low birth rates in wild female chimpanzees. Am J Primatol 2010 0.77
48 Evolution of social behavior in finite populations: a payoff transformation in general n-player games and its implications. Theor Popul Biol 2012 0.77
49 Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3. J Biol Chem 2013 0.77
50 Effects of human apolipoprotein E isoforms on the amyloid beta-protein concentration and lipid composition in brain low-density membrane domains. J Neurochem 2007 0.76
51 Classes of communication and the conditions for their evolution. Theor Popul Biol 2011 0.76
52 Homogamy and imprinting-like effect on mate choice preference for body height in the current Japanese population. Ann Hum Biol 2011 0.76
53 Generous cooperators can outperform non-generous cooperators when replacing a population of defectors. Theor Popul Biol 2010 0.75
54 [Amyloid beta protein of CSF]. Nihon Rinsho 2011 0.75
55 Alzheimer disease research in Japan: public funding. Nat Med 2006 0.75