Published in Biochemistry on March 28, 2006
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Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease. EMBO Rep (2007) 2.85
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Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase. Biochem Biophys Res Commun (2003) 1.58
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. J Biol Chem (2003) 1.49
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Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42. Biochemistry (2004) 1.32
Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. Hum Mol Genet (2006) 1.27
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 1.27
BMP4 induction of trophoblast from mouse embryonic stem cells in defined culture conditions on laminin. In Vitro Cell Dev Biol Anim (2009) 1.25
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Cloning and characterization of a Caenorhabditis elegans D2-like dopamine receptor. J Neurochem (2003) 1.24
The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy. J Biochem (2002) 1.24
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS One (2013) 1.23
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γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43. Cell Rep (2013) 1.20
Molecular links among the causative genes for ocular malformation: Otx2 and Sox2 coregulate Rax expression. Proc Natl Acad Sci U S A (2008) 1.17
ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase. Biochem Biophys Res Commun (2004) 1.16
Genetic association of CTNNA3 with late-onset Alzheimer's disease in females. Hum Mol Genet (2007) 1.15
Gamma-secretase activity is present in rafts but is not cholesterol-dependent. Biochemistry (2003) 1.15
Characterization of a novel D2-like dopamine receptor with a truncated splice variant and a D1-like dopamine receptor unique to invertebrates from Caenorhabditis elegans. J Neurochem (2005) 1.15
MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1. Nucleic Acids Res (2009) 1.13
Intracellular localization of homopolymeric amino acid-containing proteins expressed in mammalian cells. J Biol Chem (2004) 1.12
Quantitative analysis of CUG-BP1 binding to RNA repeats. J Biochem (2007) 1.12
Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics (2009) 1.12
Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion. Biochem Biophys Res Commun (2006) 1.10
Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay. J Biol Chem (2007) 1.09
Alzheimer's disease: beta-Amyloid protein and tau. J Neurosci Res (2002) 1.06
Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states. J Biol Chem (2008) 1.04
Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells. Biochemistry (2003) 1.02
BACE1 interacts with lipid raft proteins. J Neurosci Res (2006) 1.01
Progressive neurodegeneration in C. elegans model of tauopathy. Neurobiol Dis (2005) 1.00
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction. Genes Cells (2011) 0.99
Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations. J Biol Chem (2009) 0.97
Identification of a dopamine receptor from Caenorhabditis elegans. Neurosci Lett (2002) 0.97
Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients. Neurosci Lett (2006) 0.97
Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains. J Biol Chem (2007) 0.97
beta-Secretase inhibitor potency is decreased by aberrant beta-cleavage location of the "Swedish mutant" amyloid precursor protein. J Biol Chem (2009) 0.96
Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease. EMBO Mol Med (2012) 0.96
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. J Biol Chem (2005) 0.96
Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice. Int J Dev Biol (2010) 0.96
Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau. J Biol Chem (2004) 0.95
Expression of MBNL and CELF mRNA transcripts in muscles with myotonic dystrophy. Neuromuscul Disord (2007) 0.94
MBNL1 associates with YB-1 in cytoplasmic stress granules. J Neurosci Res (2008) 0.94
Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity. Cell Signal (2009) 0.94
The (pro)renin receptor is cleaved by ADAM19 in the Golgi leading to its secretion into extracellular space. Hypertens Res (2011) 0.93
γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment. J Biol Chem (2013) 0.92
The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice. J Neurochem (2005) 0.91
BACE1 interacts with nicastrin. Biochem Biophys Res Commun (2002) 0.91
Csk-homologous kinase interacts with SHPS-1 and enhances neurite outgrowth of PC12 cells. J Neurochem (2007) 0.90
Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. FASEB J (2004) 0.90
Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein. FEBS Lett (2005) 0.90
Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction. J Biol Chem (2001) 0.90
Degradation of nicastrin involves both proteasome and lysosome. J Neurochem (2007) 0.90
Comparative analysis of the cytotoxicity of homopolymeric amino acids. Biochim Biophys Acta (2005) 0.90
Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1). J Neurosci Res (2007) 0.90
KMI-008, a novel beta-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: design and synthesis of substrate-based octapeptides. Bioorg Med Chem Lett (2003) 0.88
Dopamine receptors in C. elegans. Eur J Pharmacol (2004) 0.87
Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner. PLoS One (2009) 0.87
Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads. J Neuropathol Exp Neurol (2005) 0.87
Alternative splicing of PDLIM3/ALP, for α-actinin-associated LIM protein 3, is aberrant in persons with myotonic dystrophy. Biochem Biophys Res Commun (2011) 0.87
A theoretical study on the evolution of male parental care and female multiple mating: effects of female mate choice and male care bias. J Theor Biol (2007) 0.86
Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by γ-secretase complex. Biochem Biophys Res Commun (2011) 0.86
Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations. Biochem Biophys Res Commun (2007) 0.86
Identification of an estrogenic hormone receptor in Caenorhabditis elegans. Biochem Biophys Res Commun (2007) 0.86
A secreted form of human ADAM9 has an alpha-secretase activity for APP. Biochem Biophys Res Commun (2002) 0.86
Abnormal morphology of Bacillus subtilis ugtP mutant cells lacking glucolipids. Genes Genet Syst (2011) 0.85
Molecular aging of tau: disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo. J Neurochem (2004) 0.85
GAB2 is not associated with late-onset Alzheimer's disease in Japanese. Eur J Hum Genet (2008) 0.85
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase. Nat Commun (2013) 0.84
Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 1. Genes Cells (2011) 0.84
Interactions between homopolymeric amino acids (HPAAs). Protein Sci (2007) 0.84
Hesr1 knockout mice exhibit behavioral alterations through the dopaminergic nervous system. J Neurosci Res (2006) 0.84
In vitro reconstitution of gamma-secretase activity using yeast microsomes. Biochem Biophys Res Commun (2008) 0.84
Altered expression of CUG binding protein 1 mRNA in myotonic dystrophy 1: possible RNA-RNA interaction. Neurosci Res (2004) 0.83
beta-Secretase inhibitors: modification at the P4 position and improvement of inhibitory activity in cultured cells. Bioorg Med Chem Lett (2006) 0.83
Zygotic VegT is required for Xenopus paraxial mesoderm formation and is regulated by Nodal signaling and Eomesodermin. Int J Dev Biol (2010) 0.83