Published in PLoS One on May 13, 2011
Virulence strategies of the dominant USA300 lineage of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). FEMS Immunol Med Microbiol (2012) 1.19
The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory response. Infect Immun (2012) 1.09
Rot and SaeRS cooperate to activate expression of the staphylococcal superantigen-like exoproteins. J Bacteriol (2012) 1.06
Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor. Infect Immun (2013) 1.01
Epicutaneous model of community-acquired Staphylococcus aureus skin infections. Infect Immun (2013) 0.92
Virus-like particle-induced protection against MRSA pneumonia is dependent on IL-13 and enhancement of phagocyte function. Am J Pathol (2012) 0.90
Differential regulation of staphylococcal virulence by the sensor kinase SaeS in response to neutrophil-derived stimuli. Proc Natl Acad Sci U S A (2014) 0.90
The role of innate immunity in promoting SaeR/S-mediated virulence in Staphylococcus aureus. J Innate Immun (2013) 0.89
The impact of α-toxin on host cell plasma membrane permeability and cytokine expression during human blood infection by CA-MRSA USA300. J Leukoc Biol (2013) 0.88
Efficacy of two novel 2,2'-bifurans to inhibit methicillin-resistant Staphylococcus aureus infection in male mice in comparison to vancomycin. Drug Des Devel Ther (2012) 0.88
Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections. PLoS Pathog (2015) 0.83
The AirSR two-component system contributes to Staphylococcus aureus survival in human blood and transcriptionally regulates sspABC operon. Front Microbiol (2015) 0.80
The Sbi Protein Contributes to Staphylococcus aureus Inflammatory Response during Systemic Infection. PLoS One (2015) 0.79
Staphylococcus aureus Inhibits Neutrophil-derived IL-8 to Promote Cell Death. J Infect Dis (2015) 0.79
Antibacterial activity of THAM Trisphenylguanide against methicillin-resistant Staphylococcus aureus. PLoS One (2014) 0.79
Immunomodulatory effects of recombinant lactoferrin during MRSA infection. Int Immunopharmacol (2014) 0.76
The SaeRS Two-Component System of Staphylococcus aureus. Genes (Basel) (2016) 0.75
Epic Immune Battles of History: Neutrophils vs. Staphylococcus aureus. Front Cell Infect Microbiol (2017) 0.75
Staphylococcus aureus infections. N Engl J Med (1998) 36.39
The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med (2003) 32.30
Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA (2007) 26.98
Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med (2006) 18.83
Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national database. J Clin Microbiol (2003) 16.45
Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. JAMA (1998) 15.66
Genome and virulence determinants of high virulence community-acquired MRSA. Lancet (2002) 14.64
Methicillin-resistant Staphylococcus aureus disease in three communities. N Engl J Med (2005) 12.75
The immunopathogenesis of sepsis. Nature (2002) 11.83
DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol (2006) 10.73
Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol Microbiol (2003) 10.68
Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet (2002) 10.26
Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med (2005) 8.39
Exotoxins of Staphylococcus aureus. Clin Microbiol Rev (2000) 7.35
A clone of methicillin-resistant Staphylococcus aureus among professional football players. N Engl J Med (2005) 6.14
Harmful molecular mechanisms in sepsis. Nat Rev Immunol (2008) 6.03
Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils. J Immunol (2005) 5.18
Epidemiology of methicillin-resistant Staphylococcus aureus. Clin Infect Dis (2008) 4.48
Toxic shock syndrome and bacterial superantigens: an update. Annu Rev Microbiol (2001) 4.48
Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis. J Clin Invest (1994) 4.39
The sepsis seesaw: tilting toward immunosuppression. Nat Med (2009) 3.95
Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus. FEMS Immunol Med Microbiol (2004) 3.88
Neutrophils in development of multiple organ failure in sepsis. Lancet (2006) 3.64
Gram-positive toxic shock syndromes. Lancet Infect Dis (2009) 3.37
Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era. J Clin Invest (2009) 3.24
Regulation of virulence determinants in Staphylococcus aureus: complexity and applications. FEMS Microbiol Rev (2004) 3.01
Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children. N Engl J Med (2005) 2.91
Staphylococcal accessory regulator (sar) in conjunction with agr contributes to Staphylococcus aureus virulence in endophthalmitis. Infect Immun (1997) 2.13
The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing. Microbiology (2003) 1.98
The immunology of sepsis. J Pathol (2008) 1.90
SaeR binds a consensus sequence within virulence gene promoters to advance USA300 pathogenesis. J Infect Dis (2010) 1.76
Influence of the two-component system SaeRS on global gene expression in two different Staphylococcus aureus strains. J Bacteriol (2006) 1.76
The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus. J Infect Dis (2009) 1.74
Regulation of Staphylococcus aureus alpha-toxin gene (hla) expression by agr, sarA, and sae in vitro and in experimental infective endocarditis. J Infect Dis (2006) 1.68
The role of neutrophils in severe sepsis. Shock (2008) 1.64
Inactivation of a two-component signal transduction system, SaeRS, eliminates adherence and attenuates virulence of Staphylococcus aureus. Infect Immun (2006) 1.63
IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection. J Immunol (2008) 1.53
Subinhibitory concentrations of beta-lactam induce haemolytic activity in Staphylococcus aureus through the SaeRS two-component system. FEMS Microbiol Lett (2007) 1.52
Endogenous gamma interferon, tumor necrosis factor, and interleukin-6 in Staphylococcus aureus infection in mice. Infect Immun (1995) 1.44
Secreted virulence factor comparison between methicillin-resistant and methicillin-sensitive Staphylococcus aureus, and its relevance to atopic dermatitis. J Allergy Clin Immunol (2010) 1.42
Staphylococcus aureus agr and sarA functions are required for invasive infection but not inflammatory responses in the lung. Infect Immun (2002) 1.36
The dual role of interferon-gamma in experimental Staphylococcus aureus septicaemia versus arthritis. Immunology (1998) 1.30
The anti-inflammatory activities of Staphylococcus aureus. Trends Immunol (2007) 1.29
sae is essential for expression of the staphylococcal adhesins Eap and Emp. Microbiology (2005) 1.27
Interleukin-4 and interleukin-10 are involved in host resistance to Staphylococcus aureus infection through regulation of gamma interferon. Infect Immun (2000) 1.23
Interferon-gamma, interleukin-1 and tumour necrosis factor-alpha synthesis during experimental murine staphylococcal infection. FEMS Immunol Med Microbiol (1993) 1.15
Phenotypic characterization and virulence of a sae- agr- mutant of Staphylococcus aureus. Can J Microbiol (1996) 1.14
Protective role of nitric oxide in Staphylococcus aureus infection in mice. Infect Immun (1998) 1.10
Staphylococcal strains vary greatly in their ability to induce an inflammatory response in endothelial cells. J Infect Dis (2010) 0.94
Characterization of a Tn925-induced mutant of Staphylococcus aureus altered in exoprotein production. J Basic Microbiol (1994) 0.88
Staphylococcal superantigen-like genes, ssl5 and ssl8, are positively regulated by Sae and negatively by Agr in the Newman strain. FEMS Microbiol Lett (2010) 0.88
STAT3 mutations in the hyper-IgE syndrome. N Engl J Med (2007) 8.99
Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system. Cell Microbiol (2004) 3.26
A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence. J Biol Chem (2004) 3.05
Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils. Proc Natl Acad Sci U S A (2003) 2.54
Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain. J Infect Dis (2004) 2.29
Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: cell fate is regulated at the level of gene expression. Proc Natl Acad Sci U S A (2002) 1.85
Identification and characterization of a novel heme-associated cell surface protein made by Streptococcus pyogenes. Infect Immun (2002) 1.79
SaeR binds a consensus sequence within virulence gene promoters to advance USA300 pathogenesis. J Infect Dis (2010) 1.76
Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis. Mol Microbiol (2010) 1.71
Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. PLoS One (2011) 1.71
Identification and characterization of HtsA, a second heme-binding protein made by Streptococcus pyogenes. Infect Immun (2003) 1.68
An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammation. J Leukoc Biol (2003) 1.66
Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis. J Clin Invest (2005) 1.64
Gene expression profiling provides insight into the pathophysiology of chronic granulomatous disease. J Immunol (2004) 1.63
Insights into pathogen immune evasion mechanisms: Anaplasma phagocytophilum fails to induce an apoptosis differentiation program in human neutrophils. J Immunol (2005) 1.53
Neutrophils in the innate immune response. Arch Immunol Ther Exp (Warsz) (2006) 1.42
Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells. Proc Natl Acad Sci U S A (2002) 1.42
Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factor. J Leukoc Biol (2005) 1.28
Down-regulation of proinflammatory capacity during apoptosis in human polymorphonuclear leukocytes. J Immunol (2003) 1.24
Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection. PLoS One (2012) 1.18
Opsonophagocytosis-inhibiting mac protein of group a streptococcus: identification and characteristics of two genetic complexes. Infect Immun (2002) 1.16
Postgenomic analysis of four novel antigens of group a streptococcus: growth phase-dependent gene transcription and human serologic response. J Bacteriol (2002) 1.14
Regulation of the neutrophil-mediated inflammatory response to infection. Microbes Infect (2003) 1.08
Rot and SaeRS cooperate to activate expression of the staphylococcal superantigen-like exoproteins. J Bacteriol (2012) 1.06
Characterization of an extracellular virulence factor made by group A Streptococcus with homology to the Listeria monocytogenes internalin family of proteins. Infect Immun (2003) 1.05
Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor. Infect Immun (2013) 1.01
Community-associated methicillin-resistant Staphylococcus aureus skin infections: advances toward identifying the key virulence factors. Curr Opin Infect Dis (2008) 1.00
The role of innate immunity in promoting SaeR/S-mediated virulence in Staphylococcus aureus. J Innate Immun (2013) 0.89
The impact of α-toxin on host cell plasma membrane permeability and cytokine expression during human blood infection by CA-MRSA USA300. J Leukoc Biol (2013) 0.88
18β-Glycyrrhetinic acid inhibits methicillin-resistant Staphylococcus aureus survival and attenuates virulence gene expression. Antimicrob Agents Chemother (2012) 0.88
SpyA, a C3-like ADP-ribosyltransferase, contributes to virulence in a mouse subcutaneous model of Streptococcus pyogenes infection. Infect Immun (2011) 0.81
The SaeR/S two-component system induces interferon-gamma production in neutrophils during invasive Staphylococcus aureus infection. Microbes Infect (2013) 0.79