Published in J Innate Immun on June 29, 2013
The bicomponent pore-forming leucocidins of Staphylococcus aureus. Microbiol Mol Biol Rev (2014) 1.32
The extracytoplasmic linker peptide of the sensor protein SaeS tunes the kinase activity required for staphylococcal virulence in response to host signals. PLoS Pathog (2015) 0.83
Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections. PLoS Pathog (2015) 0.83
Staphylococcus aureus Inhibits Neutrophil-derived IL-8 to Promote Cell Death. J Infect Dis (2015) 0.79
The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response. Microbiol Spectr (2016) 0.79
Staphylococcus aureus SaeR/S-regulated factors reduce human neutrophil reactive oxygen species production. J Leukoc Biol (2016) 0.78
Staphylococcus aureus Coordinates Leukocidin Expression and Pathogenesis by Sensing Metabolic Fluxes via RpiRc. MBio (2016) 0.78
Using Quantitative Spectrometry to Understand the Influence of Genetics and Nutritional Perturbations On the Virulence Potential of Staphylococcus aureus. Mol Cell Proteomics (2017) 0.78
Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors. Nat Rev Microbiol (2017) 0.78
Proteomic Identification of saeRS-Dependent Targets Critical for Protective Humoral Immunity against Staphylococcus aureus Skin Infection. Infect Immun (2015) 0.77
The SaeRS Two-Component System of Staphylococcus aureus. Genes (Basel) (2016) 0.75
Epic Immune Battles of History: Neutrophils vs. Staphylococcus aureus. Front Cell Infect Microbiol (2017) 0.75
Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J (1993) 11.30
Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis (2006) 8.17
Staphylococcus aureus endocarditis: a consequence of medical progress. JAMA (2005) 7.41
Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils. J Immunol (2005) 5.18
Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model. J Infect Dis (2010) 4.19
Global regulation of Staphylococcus aureus genes by Rot. J Bacteriol (2003) 3.02
Global changes in Staphylococcus aureus gene expression in human blood. PLoS One (2011) 2.61
Staphylococcus aureus-associated skin and soft tissue infections in ambulatory care. Emerg Infect Dis (2006) 2.43
Transient interference with staphylococcal quorum sensing blocks abscess formation. Proc Natl Acad Sci U S A (2005) 2.30
Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J Infect Dis (2011) 2.19
Mouse neutrophils lack defensins. Infect Immun (1992) 2.01
The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing. Microbiology (2003) 1.98
Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus. J Immunol (2008) 1.97
Staphylococcus aureus susceptibility to innate antimicrobial peptides, beta-defensins and CAP18, expressed by human keratinocytes. Infect Immun (2003) 1.90
Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics. PLoS One (2010) 1.89
agr-Dependent interactions of Staphylococcus aureus USA300 with human polymorphonuclear neutrophils. J Innate Immun (2010) 1.77
SaeR binds a consensus sequence within virulence gene promoters to advance USA300 pathogenesis. J Infect Dis (2010) 1.76
The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus. J Infect Dis (2009) 1.74
Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis. Mol Microbiol (2010) 1.71
Importance of the global regulators Agr and SaeRS in the pathogenesis of CA-MRSA USA300 infection. PLoS One (2010) 1.64
The virulence regulator Sae of Staphylococcus aureus: promoter activities and response to phagocytosis-related signals. J Bacteriol (2008) 1.58
Transcription of inflammatory genes in the lung after infection with community-associated methicillin-resistant Staphylococcus aureus: a role for panton-valentine leukocidin? Infect Immun (2009) 1.52
Differential target gene activation by the Staphylococcus aureus two-component system saeRS. J Bacteriol (2009) 1.49
Neutrophil isolation from nonhuman species. Methods Mol Biol (2007) 1.36
In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS. J Bacteriol (2010) 1.35
Staphylococcus aureus leukotoxin GH promotes inflammation. J Infect Dis (2012) 1.30
Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection. PLoS One (2012) 1.18
The Sbi protein is a multifunctional immune evasion factor of Staphylococcus aureus. Infect Immun (2011) 1.16
The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory response. Infect Immun (2012) 1.09
The SaeR/S gene regulatory system induces a pro-inflammatory cytokine response during Staphylococcus aureus infection. PLoS One (2011) 1.05
RNase Y of Staphylococcus aureus and its role in the activation of virulence genes. Mol Microbiol (2012) 1.05
The auxiliary protein complex SaePQ activates the phosphatase activity of sensor kinase SaeS in the SaeRS two-component system of Staphylococcus aureus. Mol Microbiol (2012) 1.00
Organizational requirements of the SaeR binding sites for a functional P1 promoter of the sae operon in Staphylococcus aureus. J Bacteriol (2012) 0.86
Analysis of Staphylococcus aureus gene expression during PMN phagocytosis. Methods Mol Biol (2008) 0.84
STAT3 mutations in the hyper-IgE syndrome. N Engl J Med (2007) 8.99
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Metal chelation and inhibition of bacterial growth in tissue abscesses. Science (2008) 4.55
Agr-mediated dispersal of Staphylococcus aureus biofilms. PLoS Pathog (2008) 3.91
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med (2010) 3.36
Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system. Cell Microbiol (2004) 3.26
A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence. J Biol Chem (2004) 3.05
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature (2012) 2.94
Modulation of eDNA release and degradation affects Staphylococcus aureus biofilm maturation. PLoS One (2009) 2.84
Bacteria activate sensory neurons that modulate pain and inflammation. Nature (2013) 2.56
Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils. Proc Natl Acad Sci U S A (2003) 2.54
Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps. J Innate Immun (2010) 2.34
Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain. J Infect Dis (2004) 2.29
Identification of genes involved in polysaccharide-independent Staphylococcus aureus biofilm formation. PLoS One (2010) 2.27
Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo. J Immunol (2011) 2.16
Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection. Cell Host Microbe (2013) 1.99
The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A. Biochemistry (2003) 1.97
Peptide signaling in the staphylococci. Chem Rev (2010) 1.89
Interconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturation. Infect Immun (2009) 1.86
CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. Nature (2012) 1.85
Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: cell fate is regulated at the level of gene expression. Proc Natl Acad Sci U S A (2002) 1.85
Biofilm dispersal of community-associated methicillin-resistant Staphylococcus aureus on orthopedic implant material. J Orthop Res (2010) 1.81
Staphylococcus aureus redirects central metabolism to increase iron availability. PLoS Pathog (2006) 1.81
Identification and characterization of a novel heme-associated cell surface protein made by Streptococcus pyogenes. Infect Immun (2002) 1.79
Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion. Proc Natl Acad Sci U S A (2004) 1.77
agr-Dependent interactions of Staphylococcus aureus USA300 with human polymorphonuclear neutrophils. J Innate Immun (2010) 1.77
SaeR binds a consensus sequence within virulence gene promoters to advance USA300 pathogenesis. J Infect Dis (2010) 1.76
The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus. J Infect Dis (2009) 1.74
Intracellular metalloporphyrin metabolism in Staphylococcus aureus. Biometals (2007) 1.71
Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis. Mol Microbiol (2010) 1.71
Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. PLoS One (2011) 1.71
Identification and characterization of HtsA, a second heme-binding protein made by Streptococcus pyogenes. Infect Immun (2003) 1.68
Specificity for human hemoglobin enhances Staphylococcus aureus infection. Cell Host Microbe (2010) 1.66
An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammation. J Leukoc Biol (2003) 1.66
Fluorescent reporters for Staphylococcus aureus. J Microbiol Methods (2009) 1.65
An in vitro biofilm model to examine the effect of antibiotic ointments on biofilms produced by burn wound bacterial isolates. Burns (2010) 1.64
Staphylococcus aureus leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo. Mol Microbiol (2011) 1.64
Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis. J Clin Invest (2005) 1.64
Gene expression profiling provides insight into the pathophysiology of chronic granulomatous disease. J Immunol (2004) 1.63
Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation. PLoS One (2010) 1.60
New approaches for treating staphylococcal biofilm infections. Ann N Y Acad Sci (2011) 1.56
Insights into pathogen immune evasion mechanisms: Anaplasma phagocytophilum fails to induce an apoptosis differentiation program in human neutrophils. J Immunol (2005) 1.53
Low levels of β-lactam antibiotics induce extracellular DNA release and biofilm formation in Staphylococcus aureus. MBio (2012) 1.51
Staphylococcal and streptococcal superantigen exotoxins. Clin Microbiol Rev (2013) 1.48
Staphylococcus aureus LukAB cytotoxin kills human neutrophils by targeting the CD11b subunit of the integrin Mac-1. Proc Natl Acad Sci U S A (2013) 1.45
Staphylococcal biofilm disassembly. Trends Microbiol (2011) 1.44
Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells. Proc Natl Acad Sci U S A (2002) 1.42
Neutrophils in the innate immune response. Arch Immunol Ther Exp (Warsz) (2006) 1.42
Regulation of Helicobacter pylori cagA expression in response to salt. Cancer Res (2007) 1.38
Staphylococcus aureus elaborates leukocidin AB to mediate escape from within human neutrophils. Infect Immun (2013) 1.37
A role for type I signal peptidase in Staphylococcus aureus quorum sensing. Mol Microbiol (2007) 1.35
Signaling and DNA-binding activities of the Staphylococcus aureus HssR-HssS two-component system required for heme sensing. J Biol Chem (2007) 1.34
A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis. Cell Host Microbe (2013) 1.31
Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factor. J Leukoc Biol (2005) 1.28
Down-regulation of proinflammatory capacity during apoptosis in human polymorphonuclear leukocytes. J Immunol (2003) 1.24
Proteolytic cleavage inactivates the Staphylococcus aureus lipoteichoic acid synthase. J Bacteriol (2011) 1.22
Pentaerythritol propoxylate: a new crystallization agent and cryoprotectant induces crystal growth of 2-methylcitrate dehydratase. Acta Crystallogr D Biol Crystallogr (2002) 1.20
Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion. J Immunol (2011) 1.20
Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury. MBio (2013) 1.19
Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection. PLoS One (2012) 1.18
Opsonophagocytosis-inhibiting mac protein of group a streptococcus: identification and characteristics of two genetic complexes. Infect Immun (2002) 1.16
Postgenomic analysis of four novel antigens of group a streptococcus: growth phase-dependent gene transcription and human serologic response. J Bacteriol (2002) 1.14
Protein-protein interactions among Helicobacter pylori cag proteins. J Bacteriol (2006) 1.14
Staphylococcus aureus HrtA is an ATPase required for protection against heme toxicity and prevention of a transcriptional heme stress response. J Bacteriol (2008) 1.13
Extracellular proteases are key mediators of Staphylococcus aureus virulence via the global modulation of virulence-determinant stability. Microbiologyopen (2012) 1.13
Structural basis for ligand recognition and discrimination of a quorum-quenching antibody. J Biol Chem (2011) 1.13
Bacterial survival amidst an immune onslaught: the contribution of the Staphylococcus aureus leukotoxins. PLoS Pathog (2013) 1.12
Biosynthesis of peptide signals in gram-positive bacteria. Adv Appl Microbiol (2010) 1.10
Proinflammatory exoprotein characterization of toxic shock syndrome Staphylococcus aureus. Biochemistry (2011) 1.10
Biosynthesis of Staphylococcus aureus autoinducing peptides by using the synechocystis DnaB mini-intein. Appl Environ Microbiol (2007) 1.08
The effects of Staphylococcus aureus leukotoxins on the host: cell lysis and beyond. Curr Opin Microbiol (2013) 1.08
Regulation of the neutrophil-mediated inflammatory response to infection. Microbes Infect (2003) 1.08
Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. J Biol Chem (2012) 1.08
sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates. Mol Microbiol (2012) 1.08
FamClash: a method for ranking the activity of engineered enzymes. Proc Natl Acad Sci U S A (2004) 1.06
Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis. EMBO J (2012) 1.06
Rot and SaeRS cooperate to activate expression of the staphylococcal superantigen-like exoproteins. J Bacteriol (2012) 1.06
Identification of Staphylococcus aureus AgrD residues required for autoinducing peptide biosynthesis. J Biol Chem (2009) 1.06
The SaeR/S gene regulatory system induces a pro-inflammatory cytokine response during Staphylococcus aureus infection. PLoS One (2011) 1.05
Characterization of an extracellular virulence factor made by group A Streptococcus with homology to the Listeria monocytogenes internalin family of proteins. Infect Immun (2003) 1.05
Membrane damage elicits an immunomodulatory program in Staphylococcus aureus. PLoS Pathog (2010) 1.05
Reduced vancomycin susceptibility in an in vitro catheter-related biofilm model correlates with poor therapeutic outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2013) 1.02
The Tricarballylate utilization (tcuRABC) genes of Salmonella enterica serovar Typhimurium LT2. J Bacteriol (2004) 1.02
Evolution of hypervirulence by a MRSA clone through acquisition of a transposable element. Mol Microbiol (2014) 1.01
Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry. J Nat Prod (2014) 1.01
Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor. Infect Immun (2013) 1.01