Published in J Am Chem Soc on June 27, 2011
From the regulation of peptidoglycan synthesis to bacterial growth and morphology. Nat Rev Microbiol (2011) 4.98
In Situ probing of newly synthesized peptidoglycan in live bacteria with fluorescent D-amino acids. Angew Chem Int Ed Engl (2012) 2.27
(D)-Amino acid chemical reporters reveal peptidoglycan dynamics of an intracellular pathogen. ACS Chem Biol (2013) 1.29
Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division. Science (2017) 1.19
Forming cross-linked peptidoglycan from synthetic gram-negative Lipid II. J Am Chem Soc (2013) 1.18
D-amino acids indirectly inhibit biofilm formation in Bacillus subtilis by interfering with protein synthesis. J Bacteriol (2013) 1.15
D-amino acids modulate the cellular response of enzymatic-instructed supramolecular nanofibers of small peptides. Biomacromolecules (2014) 1.14
Synthesis of fluorescent D-amino acids and their use for probing peptidoglycan synthesis and bacterial growth in situ. Nat Protoc (2014) 1.12
Lipoprotein activators stimulate Escherichia coli penicillin-binding proteins by different mechanisms. J Am Chem Soc (2013) 1.10
Reconstitution of peptidoglycan cross-linking leads to improved fluorescent probes of cell wall synthesis. J Am Chem Soc (2014) 1.00
Detection of lipid-linked peptidoglycan precursors by exploiting an unexpected transpeptidase reaction. J Am Chem Soc (2014) 0.97
Modes of cell wall growth differentiation in rod-shaped bacteria. Curr Opin Microbiol (2013) 0.90
Modular synthesis of diphospholipid oligosaccharide fragments of the bacterial cell wall and their use to study the mechanism of moenomycin and other antibiotics. Tetrahedron (2011) 0.86
Metabolic footprint analysis uncovers strain specific overflow metabolism and D-isoleucine production of Staphylococcus aureus COL and HG001. PLoS One (2013) 0.85
Minimal Peptidoglycan (PG) Turnover in Wild-Type and PG Hydrolase and Cell Division Mutants of Streptococcus pneumoniae D39 Growing Planktonically and in Host-Relevant Biofilms. J Bacteriol (2015) 0.84
Illumination of growth, division and secretion by metabolic labeling of the bacterial cell surface. FEMS Microbiol Rev (2015) 0.83
Enzymatic strategies and biocatalysts for amide bond formation: tricks of the trade outside of the ribosome. Mol Biosyst (2014) 0.81
Identification and characterization of mutations conferring resistance to D-amino acids in Bacillus subtilis. J Bacteriol (2015) 0.80
Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials. Antibiotics (Basel) (2016) 0.77
d-Amino Acid Probes for Penicillin Binding Protein-based Bacterial Surface Labeling. J Biol Chem (2015) 0.77
Dipeptide-Based Metabolic Labeling of Bacterial Cells for Endogenous Antibody Recruitment. ACS Infect Dis (2016) 0.76
Biosynthesis: imaging cell-wall biosynthesis live. Nat Chem (2013) 0.75
Role of D-amino acid oxidase in the production of kynurenine pathway metabolites from D-tryptophan in mice. J Neurochem (2015) 0.75
Eradication of Enterococcus faecalis Biofilms on Human Dentin. Front Microbiol (2016) 0.75
Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams. Nat Chem Biol (2017) 0.75
Full color palette of fluorescent d-amino acids for in situ labeling of bacterial cell walls. Chem Sci (2017) 0.75
Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine. Proc Natl Acad Sci U S A (1965) 10.20
LIPID-PHOSPHOACETYLMURAMYL-PENTAPEPTIDE AND LIPID-PHOSPHODISACCHARIDE-PENTAPEPTIDE: PRESUMED MEMBRANE TRANSPORT INTERMEDIATES IN CELL WALL SYNTHESIS. Proc Natl Acad Sci U S A (1965) 6.85
Peptidoglycan structure and architecture. FEMS Microbiol Rev (2008) 6.69
Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics. Annu Rev Biochem (1983) 6.24
The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis. FEMS Microbiol Rev (2008) 4.83
Glycopeptide transpeptidase and D-alanine carboxypeptidase: penicillin-sensitive enzymatic reactions. Proc Natl Acad Sci U S A (1966) 4.59
Bacterial cell wall synthesis: new insights from localization studies. Microbiol Mol Biol Rev (2005) 3.72
D-amino acids trigger biofilm disassembly. Science (2010) 3.60
D-amino acids govern stationary phase cell wall remodeling in bacteria. Science (2009) 3.55
Penicillin-binding proteins and the future of beta-lactam antibiotics. The Seventh Fleming Lecture. J Gen Microbiol (1983) 3.41
Murein (peptidoglycan) structure, architecture and biosynthesis in Escherichia coli. Biochim Biophys Acta (2007) 2.72
Transpeptidase activity of Streptomyces D-alanyl-D carboxypeptidases. Proc Natl Acad Sci U S A (1972) 2.30
Better substrates for bacterial transglycosylases. J Am Chem Soc (2001) 2.22
Vancomycin analogues active against vanA-resistant strains inhibit bacterial transglycosylase without binding substrate. Proc Natl Acad Sci U S A (2003) 1.96
Effect of D-amino acids on structure and synthesis of peptidoglycan in Escherichia coli. J Bacteriol (1992) 1.96
Biochemistry and comparative genomics of SxxK superfamily acyltransferases offer a clue to the mycobacterial paradox: presence of penicillin-susceptible target proteins versus lack of efficiency of penicillin as therapeutic agent. Microbiol Mol Biol Rev (2002) 1.91
Beta-lactam antibiotic resistance: a current structural perspective. Curr Opin Microbiol (2005) 1.89
Daughter cell separation is controlled by cytokinetic ring-activated cell wall hydrolysis. EMBO J (2010) 1.88
Architecture of peptidoglycan: more data and more models. Trends Microbiol (2010) 1.77
Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proc Natl Acad Sci U S A (2007) 1.68
Use of model enzymes in the determination of the mode of action of penicillins and delta 3-cephalosporins. Annu Rev Biochem (1979) 1.64
Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with beta-lactams. Biochem J (1993) 1.58
FURTHER STUDIES ON THE INCORPORATION OF D-METHIONINE INTO THE BACTERIAL CELL WALL; ITS INCORPORATION INTO THE R-LAYER AND THE STRUCTURAL CONSEQUENCES. Biochim Biophys Acta (1963) 1.58
Acyltransferase activities of the high-molecular-mass essential penicillin-binding proteins. Biochem J (1991) 1.57
In vitro murein peptidoglycan synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli. J Biol Chem (2005) 1.48
Lipid II: total synthesis of the bacterial cell wall precursor and utilization as a substrate for glycosyltransfer and transpeptidation by penicillin binding protein (PBP) 1b of Escherichia coli. J Am Chem Soc (2001) 1.45
Intrinsic lipid preferences and kinetic mechanism of Escherichia coli MurG. Biochemistry (2002) 1.44
Kinetic characterization of the glycosyltransferase module of Staphylococcus aureus PBP2. J Bacteriol (2005) 1.41
Emerging knowledge of regulatory roles of D-amino acids in bacteria. Cell Mol Life Sci (2010) 1.39
Analysis of glycan polymers produced by peptidoglycan glycosyltransferases. J Biol Chem (2007) 1.36
In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli. J Biol Chem (2006) 1.34
Synthetic peptidoglycan substrates for penicillin-binding protein 5 of Gram-negative bacteria. J Org Chem (2004) 1.33
The direction of glycan chain elongation by peptidoglycan glycosyltransferases. J Am Chem Soc (2007) 1.28
Expression and characterization of the isolated glycosyltransferase module of Escherichia coli PBP1b. Biochemistry (2004) 1.17
Site-directed mutagenesis of proposed active-site residues of penicillin-binding protein 5 from Escherichia coli. Biochem J (1994) 1.11
Isolated peptidoglycan glycosyltransferases from different organisms produce different glycan chain lengths. J Am Chem Soc (2008) 1.09
Second lytic target of beta-lactam compounds that have a terminal D-amino acid residue. Eur J Biochem (1985) 1.08
Penicillin-insensitive incorporation of D-amino acids into cell wall peptidoglycan influences the amount of bound lipoprotein in Escherichia coli. J Bacteriol (1984) 1.06
Catalytic mechanism of penicillin-binding protein 5 of Escherichia coli. Biochemistry (2007) 1.02
Site-directed mutants of a soluble form of penicillin-binding protein 5 from Escherichia coli and their catalytic properties. J Biol Chem (1988) 1.01
Effect of D-amino acids on Escherichia coli strains with impaired penicillin-binding proteins. Res Microbiol (1991) 0.97
A computational evaluation of the mechanism of penicillin-binding protein-catalyzed cross-linking of the bacterial cell wall. J Am Chem Soc (2011) 0.96
A mechanism-based inhibitor targeting the DD-transpeptidase activity of bacterial penicillin-binding proteins. J Am Chem Soc (2003) 0.92
Studying a cell division amidase using defined peptidoglycan substrates. J Am Chem Soc (2009) 0.91
Linear, uncross-linked peptidoglycan secreted by penicillin-treated Bacillus subtilis. Isolation and characterization as a substrate for penicillin-sensitive D-alanine carboxypeptidases. J Biol Chem (1980) 0.90
Transpeptidation reactions of a specific substrate catalyzed by the streptomyces R61 DD-peptidase: characterization of a chromogenic substrate and acyl acceptor design. Biochemistry (2005) 0.87
Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli. Cell (2005) 8.22
The bacterial cell envelope. Cold Spring Harb Perspect Biol (2010) 5.14
Structure and function of an essential component of the outer membrane protein assembly machine. Science (2007) 3.85
Reconstitution of outer membrane protein assembly from purified components. Science (2010) 3.30
Defining the roles of the periplasmic chaperones SurA, Skp, and DegP in Escherichia coli. Genes Dev (2007) 3.24
Advances in understanding bacterial outer-membrane biogenesis. Nat Rev Microbiol (2006) 3.23
Chemical conditionality: a genetic strategy to probe organelle assembly. Cell (2005) 3.12
Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli. Proc Natl Acad Sci U S A (2007) 3.09
Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli. Proc Natl Acad Sci U S A (2006) 2.87
YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli. Mol Microbiol (2006) 2.84
β-Barrel membrane protein assembly by the Bam complex. Annu Rev Biochem (2011) 2.55
Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases. Cell (2010) 2.53
Imaging peptidoglycan biosynthesis in Bacillus subtilis with fluorescent antibiotics. Proc Natl Acad Sci U S A (2006) 2.53
Discovery of O-GlcNAc transferase inhibitors. J Am Chem Soc (2005) 2.27
Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes. J Biol Chem (2003) 2.26
Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature (2011) 2.24
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli. Proc Natl Acad Sci U S A (2008) 2.21
Wall teichoic acid function, biosynthesis, and inhibition. Chembiochem (2010) 2.15
Transport of lipopolysaccharide across the cell envelope: the long road of discovery. Nat Rev Microbiol (2009) 2.07
Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases. Proc Natl Acad Sci U S A (2003) 2.02
Vancomycin analogues active against vanA-resistant strains inhibit bacterial transglycosylase without binding substrate. Proc Natl Acad Sci U S A (2003) 1.96
Regulation of cell size in response to nutrient availability by fatty acid biosynthesis in Escherichia coli. Proc Natl Acad Sci U S A (2012) 1.91
Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides. Chem Biol (2002) 1.90
In vitro reconstitution of two essential steps in wall teichoic acid biosynthesis. ACS Chem Biol (2006) 1.89
Probing the barrier function of the outer membrane with chemical conditionality. ACS Chem Biol (2006) 1.86
Characterization of the two-protein complex in Escherichia coli responsible for lipopolysaccharide assembly at the outer membrane. Proc Natl Acad Sci U S A (2010) 1.85
Wall teichoic acids of gram-positive bacteria. Annu Rev Microbiol (2013) 1.77
Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proc Natl Acad Sci U S A (2007) 1.68
The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel. Proc Natl Acad Sci U S A (2011) 1.68
Synthetic lethal compound combinations reveal a fundamental connection between wall teichoic acid and peptidoglycan biosyntheses in Staphylococcus aureus. ACS Chem Biol (2010) 1.64
Remarkable structural similarities between diverse glycosyltransferases. Chem Biol (2002) 1.56
Proteins required for lipopolysaccharide assembly in Escherichia coli form a transenvelope complex. Biochemistry (2010) 1.54
A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps. Chem Biol (2008) 1.52
Bacterial transglycosylase inhibitors. Curr Opin Chem Biol (2005) 1.51
Nonconsecutive disulfide bond formation in an essential integral outer membrane protein. Proc Natl Acad Sci U S A (2010) 1.48
A streamlined metabolic pathway for the biosynthesis of moenomycin A. Chem Biol (2007) 1.47
Intrinsic lipid preferences and kinetic mechanism of Escherichia coli MurG. Biochemistry (2002) 1.44
Lipoprotein LptE is required for the assembly of LptD by the beta-barrel assembly machine in the outer membrane of Escherichia coli. Proc Natl Acad Sci U S A (2011) 1.41
Kinetic characterization of the glycosyltransferase module of Staphylococcus aureus PBP2. J Bacteriol (2005) 1.41
Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids. Proc Natl Acad Sci U S A (2012) 1.39
Distinct single-cell morphological dynamics under beta-lactam antibiotics. Mol Cell (2012) 1.39
Cytoplasmic ATP hydrolysis powers transport of lipopolysaccharide across the periplasm in E. coli. Science (2012) 1.37
Discovery of a small molecule that blocks wall teichoic acid biosynthesis in Staphylococcus aureus. ACS Chem Biol (2009) 1.37
Analysis of glycan polymers produced by peptidoglycan glycosyltransferases. J Biol Chem (2007) 1.36
Synthesis of heptaprenyl-lipid IV to analyze peptidoglycan glycosyltransferases. J Am Chem Soc (2007) 1.35
Regulated assembly of the transenvelope protein complex required for lipopolysaccharide export. Biochemistry (2012) 1.35
Cutaneous metastases in breast cancer. Clin J Oncol Nurs (2011) 1.30
Rapid beta-lactam-induced lysis requires successful assembly of the cell division machinery. Proc Natl Acad Sci U S A (2009) 1.29
The direction of glycan chain elongation by peptidoglycan glycosyltransferases. J Am Chem Soc (2007) 1.28
Ramoplanin inhibits bacterial transglycosylases by binding as a dimer to lipid II. J Am Chem Soc (2003) 1.24
Differential inhibition of Staphylococcus aureus PBP2 by glycopeptide antibiotics. J Am Chem Soc (2005) 1.23
Late-stage polyribitol phosphate wall teichoic acid biosynthesis in Staphylococcus aureus. J Bacteriol (2008) 1.22
HCF-1 is cleaved in the active site of O-GlcNAc transferase. Science (2013) 1.21
The mechanism of action of ramoplanin and enduracidin. Mol Biosyst (2005) 1.21
Identification of active-site inhibitors of MurG using a generalizable, high-throughput glycosyltransferase screen. J Am Chem Soc (2003) 1.20
Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nat Chem Biol (2012) 1.20
Complete characterization of the seventeen step moenomycin biosynthetic pathway. Biochemistry (2009) 1.19
Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design. ACS Chem Biol (2008) 1.19
Forming cross-linked peptidoglycan from synthetic gram-negative Lipid II. J Am Chem Soc (2013) 1.18
AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A. Chem Biol (2005) 1.18
Expression and characterization of the isolated glycosyltransferase module of Escherichia coli PBP1b. Biochemistry (2004) 1.17
The reconstituted Escherichia coli Bam complex catalyzes multiple rounds of β-barrel assembly. Biochemistry (2011) 1.17
The structural basis for induction of VanB resistance. J Am Chem Soc (2002) 1.15
D-amino acids indirectly inhibit biofilm formation in Bacillus subtilis by interfering with protein synthesis. J Bacteriol (2013) 1.15
Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity. Nat Prod Rep (2010) 1.15
In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides. J Am Chem Soc (2005) 1.13
Activation of the Escherichia coli β-barrel assembly machine (Bam) is required for essential components to interact properly with substrate. Proc Natl Acad Sci U S A (2012) 1.12
Disulfide rearrangement triggered by translocon assembly controls lipopolysaccharide export. Science (2012) 1.11
The role of the substrate lipid in processive glycan polymerization by the peptidoglycan glycosyltransferases. J Am Chem Soc (2010) 1.11
Lipoprotein activators stimulate Escherichia coli penicillin-binding proteins by different mechanisms. J Am Chem Soc (2013) 1.10
Isolated peptidoglycan glycosyltransferases from different organisms produce different glycan chain lengths. J Am Chem Soc (2008) 1.09
The Escherichia coli Lpt transenvelope protein complex for lipopolysaccharide export is assembled via conserved structurally homologous domains. J Bacteriol (2013) 1.08
Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents. Chem Biol (2013) 1.07
Acceptor substrate selectivity and kinetic mechanism of Bacillus subtilis TagA. Biochemistry (2006) 1.06
A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases. J Am Chem Soc (2005) 1.05
Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn. Cancer Immunol Immunother (2004) 1.05
Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136. FEMS Microbiol Lett (2008) 1.05
On the essentiality of lipopolysaccharide to Gram-negative bacteria. Curr Opin Microbiol (2013) 1.04
Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics. J Am Chem Soc (2011) 1.04
O-linked N-acetylglucosaminyltransferase inhibition prevents G2/M transition in Xenopus laevis oocytes. J Biol Chem (2007) 1.04