Published in Mol Cell Biol on August 29, 2011
RPA antagonizes microhomology-mediated repair of DNA double-strand breaks. Nat Struct Mol Biol (2014) 1.82
Histone H2A.Z controls a critical chromatin remodeling step required for DNA double-strand break repair. Mol Cell (2012) 1.63
Pathways for genome integrity in G2 phase of the cell cycle. Biomolecules (2012) 1.44
Complex Breakpoints and Template Switching Associated with Non-canonical Termination of Homologous Recombination in Mammalian Cells. PLoS Genet (2016) 1.38
Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair (Amst) (2012) 1.37
DNA double-strand break repair pathway choice and cancer. DNA Repair (Amst) (2014) 1.33
Similarities and differences between "uncapped" telomeres and DNA double-strand breaks. Chromosoma (2011) 1.05
Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias. Oncogene (2012) 1.05
End-resection at DNA double-strand breaks in the three domains of life. Biochem Soc Trans (2013) 0.98
Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break. PLoS Genet (2015) 0.93
Coincident resection at both ends of random, γ-induced double-strand breaks requires MRX (MRN), Sae2 (Ctp1), and Mre11-nuclease. PLoS Genet (2013) 0.92
Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling. Proc Natl Acad Sci U S A (2015) 0.89
Interplay between Ku and Replication Protein A in the Restriction of Exo1-mediated DNA Break End Resection. J Biol Chem (2015) 0.89
Mechanism and regulation of DNA end resection in eukaryotes. Crit Rev Biochem Mol Biol (2016) 0.88
Homologous recombination via synthesis-dependent strand annealing in yeast requires the Irc20 and Srs2 DNA helicases. Genetics (2012) 0.88
Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection. EMBO Rep (2015) 0.88
Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination. Nucleic Acids Res (2012) 0.86
Interdependence of the rad50 hook and globular domain functions. Mol Cell (2015) 0.86
Synthetic viability genomic screening defines Sae2 function in DNA repair. EMBO J (2015) 0.85
Resection activity of the Sgs1 helicase alters the affinity of DNA ends for homologous recombination proteins in Saccharomyces cerevisiae. Genetics (2013) 0.85
Reprogramming homing endonuclease specificity through computational design and directed evolution. Nucleic Acids Res (2013) 0.84
DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA. EMBO J (2014) 0.82
Replication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrity. Bioessays (2014) 0.82
The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks. Cell Rep (2013) 0.82
Processing of DNA double-stranded breaks and intermediates of recombination and repair by Saccharomyces cerevisiae Mre11 and its stimulation by Rad50, Xrs2, and Sae2 proteins. J Biol Chem (2013) 0.82
Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein. PLoS Genet (2015) 0.81
Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks. Nat Commun (2016) 0.80
Cdk1-dependent regulation of the Mre11 complex couples DNA repair pathways to cell cycle progression. Cell Cycle (2014) 0.80
Phenotypic Consequences of a Spontaneous Loss of Heterozygosity in a Common Laboratory Strain of Candida albicans. Genetics (2016) 0.78
Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer. Cell Rep (2016) 0.78
The MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA-Dependent Tel1 Activation. PLoS Genet (2016) 0.77
Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity. PLoS Genet (2015) 0.77
The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair. Nucleic Acids Res (2016) 0.75
HCoDES reveals chromosomal DNA end structures with single-nucleotide resolution. Mol Cell (2014) 0.75
Consider the workhorse: Nonhomologous end-joining in budding yeast. Biochem Cell Biol (2016) 0.75
Genetic separation of Sae2 nuclease activity from Mre11 nuclease functions in budding yeast. Mol Cell Biol (2017) 0.75
The non-homologous end-joining factor Nej1 inhibits resection mediated by Dna2-Sgs1 at DNA double strand breaks. J Biol Chem (2017) 0.75
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast (1998) 48.29
Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell (1997) 10.32
Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer (2006) 9.15
Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell (1998) 8.31
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature (2008) 8.15
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell (2008) 7.63
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol Cell (1998) 6.50
A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell (1995) 6.00
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell (2003) 5.45
A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response. Nature (2005) 5.13
DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev (2008) 5.07
Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae. Genetics (1992) 5.02
Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases. Nat Genet (2000) 4.65
Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. Nature (2005) 4.53
The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol Cell Biol (1999) 4.32
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell (2007) 4.28
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell (2008) 4.26
The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell (2002) 4.23
Mechanism of interaction between Ku protein and DNA. J Biol Chem (1986) 4.22
Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants. Nat Genet (1999) 4.18
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res (1989) 4.01
CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature (2008) 3.96
Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol Cell (2007) 3.86
Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell (1998) 3.80
A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol Cell (2001) 3.65
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J Biol Chem (2003) 3.45
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J Biol Chem (1998) 3.40
DNA end resection: many nucleases make light work. DNA Repair (Amst) (2009) 3.28
Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. Nucleic Acids Res (1998) 3.11
EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. Genes Dev (2002) 3.05
DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2. Nature (2010) 3.04
Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol Cell (2010) 2.91
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae. Nature (2010) 2.79
Antitumour drugs impede DNA uncoiling by topoisomerase I. Nature (2007) 2.77
Analysis of the mechanism of interaction of simian Ku protein with DNA. Nucleic Acids Res (1991) 2.76
Ca2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity. Proc Natl Acad Sci U S A (2004) 2.74
A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae. J Biol Chem (1993) 2.72
Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. Science (2010) 2.67
DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex. J Biol Chem (2001) 2.65
Covalent protein-DNA complexes at the 5' strand termini of meiosis-specific double-strand breaks in yeast. Proc Natl Acad Sci U S A (1995) 2.56
The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.51
Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage. Proc Natl Acad Sci U S A (2002) 2.50
Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism. Genetics (2001) 2.46
The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses. Mol Cell Biol (2007) 2.41
Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres. Mol Cell Biol (2003) 2.33
Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11. Genetics (1998) 2.32
Repair of topoisomerase I-mediated DNA damage. Prog Nucleic Acid Res Mol Biol (2006) 2.16
Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks. Nat Struct Mol Biol (2010) 2.14
Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA. Mol Cell (2009) 2.12
Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks. EMBO J (2010) 2.04
Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1. Proc Natl Acad Sci U S A (2002) 2.00
Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage. EMBO Rep (2003) 1.96
Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2. EMBO J (2010) 1.92
Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination. Nat Struct Mol Biol (2007) 1.87
Multiple endonucleases function to repair covalent topoisomerase I complexes in Saccharomyces cerevisiae. Genetics (2005) 1.84
Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae. DNA Repair (Amst) (2002) 1.77
Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance. DNA Repair (Amst) (2002) 1.57
Ku binds telomeric DNA in vitro. J Biol Chem (1999) 1.55
Links between replication and recombination in Saccharomyces cerevisiae: a hypersensitive requirement for homologous recombination in the absence of Rad27 activity. Proc Natl Acad Sci U S A (2001) 1.54
Ku proteins join DNA fragments as shown by atomic force microscopy. Cancer Res (1997) 1.51
Role of the Saccharomyces cerevisiae Rad51 paralogs in sister chromatid recombination. Genetics (2008) 1.41
Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death. J Biol Chem (1997) 1.40
Mutation of the gene encoding protein kinase C 1 stimulates mitotic recombination in Saccharomyces cerevisiae. Mol Cell Biol (1994) 1.38
Functional interactions between Sae2 and the Mre11 complex. Genetics (2008) 1.20
Microhomology-dependent end joining and repair of transposon-induced DNA hairpins by host factors in Saccharomyces cerevisiae. Mol Cell Biol (2004) 1.16
Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants. J Biol Chem (1993) 1.07
Pulsed-field gel electrophoresis of budding yeast chromosomes. Methods Mol Biol (2006) 1.04
Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae. DNA Repair (Amst) (2008) 1.01
DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions. Cancer Res (2008) 0.97
Studies on the mode of Ku interaction with DNA. J Biol Chem (2002) 0.96
Mechanisms of DNA topoisomerase I-induced cell killing in the yeast Saccharomyces cerevisiae. Ann N Y Acad Sci (2000) 0.88
The MRE11 complex: starting from the ends. Nat Rev Mol Cell Biol (2011) 3.83
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature (2002) 3.48
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat Genet (2002) 2.97
The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. DNA Repair (Amst) (2004) 2.68
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet (2012) 2.63
DNA replication-dependent nuclear dynamics of the Mre11 complex. Mol Cancer Res (2003) 2.23
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol (2004) 2.23
The Rad50 hook domain is a critical determinant of Mre11 complex functions. Nat Struct Mol Biol (2005) 2.08
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell (2003) 2.08
A murine model of Nijmegen breakage syndrome. Curr Biol (2002) 1.96
Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO J (2008) 1.90
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst) (2009) 1.89
Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev (2002) 1.87
Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization. Mol Cell (2009) 1.73
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Mol Cell (2009) 1.70
Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Mol Cell Biol (2005) 1.69
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature (2007) 1.58
Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance. DNA Repair (Amst) (2002) 1.57
Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint. Mol Cell Biol (2008) 1.54
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev (2005) 1.37
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev (2009) 1.36
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell (2008) 1.30
The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr Biol (2007) 1.23
The mre11 complex and the response to dysfunctional telomeres. Mol Cell Biol (2009) 1.22
Functional interactions between Sae2 and the Mre11 complex. Genetics (2008) 1.20
ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over. PLoS Genet (2008) 1.18
The Rad50 coiled-coil domain is indispensable for Mre11 complex functions. Nat Struct Mol Biol (2011) 1.16
Methods for studying the cellular response to DNA damage: influence of the Mre11 complex on chromosome metabolism. Methods Enzymol (2006) 1.15
Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol Cell Biol (2008) 1.13
Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway. Cancer Res (2009) 1.10
A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome. PLoS Genet (2013) 1.05
An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63. Nat Cell Biol (2009) 1.05
Rad50S alleles of the Mre11 complex: questions answered and questions raised. Exp Cell Res (2006) 1.02
Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication. DNA Repair (Amst) (2007) 0.99
DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions. Cancer Res (2008) 0.97
The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53. Proc Natl Acad Sci U S A (2007) 0.97
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. PLoS Genet (2012) 0.92
Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability. Mol Cell Biol (2008) 0.92
The Mre11 complex suppresses oncogene-driven breast tumorigenesis and metastasis. Mol Cell (2013) 0.87
Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression. Proc Natl Acad Sci U S A (2012) 0.86
The Rad50 hook domain regulates DNA damage signaling and tumorigenesis. Genes Dev (2014) 0.83
Working together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression. Cell Cycle (2008) 0.83
Modeling disease in the mouse: lessons from DNA damage response and cell cycle control genes. J Cell Biochem (2006) 0.83
The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks. Cell Rep (2013) 0.82
Division of labor: DNA repair and the cell cycle specific functions of the Mre11 complex. Cell Cycle (2009) 0.80
At the end, remodeling leads to eviction. Nat Struct Mol Biol (2005) 0.79
NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication. DNA Repair (Amst) (2009) 0.78
TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding. Mol Cell (2016) 0.75