PubRank

Timothy A Garrow

Author PubWeight™ 29.28‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem 2011 1.40
2 Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci U S A 2002 1.28
3 Betaine-homocysteine methyltransferase: zinc in a distorted barrel. Structure 2002 1.26
4 Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis 2003 1.17
5 Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. J Nutr 2006 1.07
6 Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida. Am J Med Genet A 2003 1.06
7 Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. J Biol Chem 2008 1.02
8 Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver. Am J Physiol Endocrinol Metab 2005 1.01
9 Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. Biochemistry 2004 1.00
10 Type I diabetes leads to tissue-specific DNA hypomethylation in male rats. J Nutr 2008 0.99
11 Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutr Res 2010 0.95
12 Oligomerization is required for betaine-homocysteine S-methyltransferase function. Arch Biochem Biophys 2004 0.94
13 High sodium chloride intake decreases betaine-homocysteine S-methyltransferase expression in guinea pig liver and kidney. Am J Physiol Regul Integr Comp Physiol 2004 0.92
14 Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. J Biol Chem 2004 0.90
15 Betaine can partially spare choline in chicks but only when added to diets containing a minimal level of choline. J Nutr 2007 0.86
16 Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats. Am J Physiol Endocrinol Metab 2006 0.85
17 Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc. Arch Biochem Biophys 2008 0.85
18 Combining combinatorial chemistry and affinity chromatography: highly selective inhibitors of human betaine: homocysteine S-methyltransferase. Chem Biol 2003 0.85
19 Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells. Am J Physiol Gastrointest Liver Physiol 2007 0.85
20 S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase. J Med Chem 2006 0.84
21 Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency. Metabolism 2004 0.83
22 Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats. J Nutr 2006 0.83
23 Dietary S-methylmethionine, a component of foods, has choline-sparing activity in chickens. J Nutr 2005 0.82
24 Random mutagenesis of the zinc-binding motif of betaine-homocysteine methyltransferase reveals that Gly 214 is essential. Arch Biochem Biophys 2002 0.81
25 Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro. Biochem J 2005 0.81
26 Analysis and characterization of phosphinic pseudopeptides by capillary zone electrophoresis. Electrophoresis 2002 0.78
27 Betaine homocysteine methyltransferase is active in the mouse blastocyst and promotes inner cell mass development. J Biol Chem 2012 0.78
28 Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes. Gene 2010 0.78
29 Determination of dissociation constant of phosphinate group in phosphinic pseudopeptides by capillary zone electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci 2002 0.78
30 The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase. Eur J Med Chem 2013 0.77
31 Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity. Nutr Res 2011 0.77
32 Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase. J Med Chem 2009 0.77
33 Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S-methyltransferase 2. J Med Chem 2012 0.75
34 Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase. Proteins 2014 0.75