Published in J Biol Chem on September 01, 2011
DNA double strand break repair via non-homologous end-joining. Transl Cancer Res (2013) 1.61
Repair of double-strand breaks by end joining. Cold Spring Harb Perspect Biol (2013) 1.58
Non-homologous end joining often uses microhomology: implications for alternative end joining. DNA Repair (Amst) (2014) 1.24
APLF promotes the assembly and activity of non-homologous end joining protein complexes. EMBO J (2012) 1.09
XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair. Biochem Cell Biol (2013) 1.09
Nonhomologous end joining: a good solution for bad ends. DNA Repair (Amst) (2014) 1.08
A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy. Nucleic Acids Res (2014) 1.05
Non-homologous end joining: emerging themes and unanswered questions. DNA Repair (Amst) (2014) 1.05
Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time. DNA Repair (Amst) (2014) 1.03
Processing of damaged DNA ends for double-strand break repair in mammalian cells. ISRN Mol Biol (2012) 0.98
The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy. Oncogene (2014) 0.98
DNA repair pathways in trypanosomatids: from DNA repair to drug resistance. Microbiol Mol Biol Rev (2014) 0.86
Non-homologous DNA end joining and alternative pathways to double-strand break repair. Nat Rev Mol Cell Biol (2017) 0.85
An Intrinsically Disordered APLF Links Ku, DNA-PKcs and XRCC4-DNA Ligase IV in an Extended Flexible Non-Homologous End Joining Complex. J Biol Chem (2016) 0.78
TDP1 promotes assembly of non-homologous end joining protein complexes on DNA. DNA Repair (Amst) (2015) 0.77
Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease. Immunology (2015) 0.76
Resolution of complex ends by Nonhomologous end joining - better to be lucky than good? Genome Integr (2012) 0.76
Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency. J Biol Chem (2016) 0.75
Understanding the DNA damage response in order to achieve desired gene editing outcomes in mosquitoes. Chromosome Res (2015) 0.75
Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex. Nucleic Acids Res (2017) 0.75
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell (2002) 6.34
The mechanism of human nonhomologous DNA end joining. J Biol Chem (2007) 5.02
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J (2009) 3.89
DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J (2006) 2.48
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. EMBO J (2004) 2.24
DNA-PK: the means to justify the ends? Adv Immunol (2008) 2.14
The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis. J Biol Chem (2005) 1.84
The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. DNA Repair (Amst) (2005) 1.81
Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors. Oncogene (2011) 1.78
PARP-3 and APLF function together to accelerate nonhomologous end-joining. Mol Cell (2011) 1.77
APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Mol Cell Biol (2007) 1.71
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. EMBO J (2007) 1.65
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation. DNA Repair (Amst) (2008) 1.44
Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. J Biol Chem (2007) 1.38
Processing of DNA for nonhomologous end-joining is controlled by kinase activity and XRCC4/ligase IV. J Biol Chem (2007) 1.29
DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs. J Biol Chem (2006) 1.28
Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites. J Biol Chem (2008) 1.10
Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability. J Exp Med (2009) 1.07
DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis. DNA Repair (Amst) (2010) 1.07
Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair. DNA Repair (Amst) (2010) 0.88
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell (2002) 6.34
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol (2003) 4.81
KIF5B-RET fusions in lung adenocarcinoma. Nat Med (2012) 4.38
Bidirectional gene organization: a common architectural feature of the human genome. Cell (2002) 3.47
Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell (2008) 3.31
A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1. Cancer Res (2013) 3.08
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines. Hum Mutat (2008) 3.02
A biochemically defined system for mammalian nonhomologous DNA end joining. Mol Cell (2004) 3.01
A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature (2004) 2.92
The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proc Natl Acad Sci U S A (2002) 2.82
Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas. Cancer Res (2011) 2.81
Spatial and temporal cellular responses to single-strand breaks in human cells. Mol Cell Biol (2003) 2.70
In situ analysis of repair processes for oxidative DNA damage in mammalian cells. Proc Natl Acad Sci U S A (2004) 2.59
The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell (2009) 2.42
H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations. Mol Cell (2009) 2.40
Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors. Clin Cancer Res (2009) 2.27
Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol (2002) 2.27
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
Comprehensive histologic analysis of ALK-rearranged lung carcinomas. Am J Surg Pathol (2011) 2.21
DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine. J Biol Chem (2003) 2.16
Frequent EGFR mutations in brain metastases of lung adenocarcinoma. Int J Cancer (2006) 2.11
FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell (2008) 1.99
Surgical treatment of congenital coronary artery fistulas: 27 years' experience and a review of the literature. J Card Surg (2002) 1.96
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev Cell (2009) 1.96
Hiccups as an adverse reaction to cancer chemotherapy. J Natl Cancer Inst (2002) 1.90
A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. J Biol Chem (2002) 1.89
Effect of granulocyte-macrophage colony-stimulating factor inducer on left ventricular remodeling after acute myocardial infarction. J Am Coll Cardiol (2004) 1.87
MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1. Cancer Discov (2013) 1.85
The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis. J Biol Chem (2005) 1.84
The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. DNA Repair (Amst) (2005) 1.81
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps. EMBO J (2007) 1.80
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes. J Exp Med (2005) 1.80
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Mol Cell (2006) 1.79
Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution. Genes Chromosomes Cancer (2007) 1.77
Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells. Proc Natl Acad Sci U S A (2008) 1.73
In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product. J Biol Chem (2003) 1.73
Retrospective analysis of 45 consecutive patients with advanced gastric cancer treated with neoadjuvant chemotherapy using an S-1/CDDP combination. Gastric Cancer (2006) 1.70
Long-term outcomes of peripheral arm ports implanted in patients with colorectal cancer. Int J Clin Oncol (2008) 1.67
Length-dependent binding of human XLF to DNA and stimulation of XRCC4.DNA ligase IV activity. J Biol Chem (2007) 1.65
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. EMBO J (2007) 1.65
DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair. J Biol Chem (2005) 1.63
Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer. Genes Chromosomes Cancer (2005) 1.60
Accumulation of Werner protein at DNA double-strand breaks in human cells. J Cell Sci (2005) 1.59
The ACF1 complex is required for DNA double-strand break repair in human cells. Mol Cell (2010) 1.57
Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese. Carcinogenesis (2008) 1.57
Total endoscopic robotic atrial septal defect repair in a patient with dextrocardia and situs inversus totalis. Interact Cardiovasc Thorac Surg (2011) 1.57
Chest CT and serum vascular endothelial growth factor-C level to diagnose lymph node metastasis in patients with primary non-small cell lung cancer. Chest (2004) 1.57
The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions. DNA Repair (Amst) (2005) 1.57
Measurement of internal body time by blood metabolomics. Proc Natl Acad Sci U S A (2009) 1.56
Efficacy and safety of on-pump beating heart surgery for valvular disease. Ann Thorac Surg (2002) 1.56
Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice. Genes Dev (2002) 1.56
Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence. Nucleic Acids Res (2007) 1.56
Long term parathyroid function following total parathyroidectomy with autotransplantation in adult patients with MEN2A. Endocr J (2009) 1.54
Functional and biochemical dissection of the structure-specific nuclease ARTEMIS. EMBO J (2004) 1.54
Mechanism of R-loop formation at immunoglobulin class switch sequences. Mol Cell Biol (2007) 1.54
Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res (2003) 1.53
ROS1-rearranged lung cancer: a clinicopathologic and molecular study of 15 surgical cases. Am J Surg Pathol (2013) 1.52
Impact of DNA ligase IV on the fidelity of end joining in human cells. Nucleic Acids Res (2003) 1.52
Subzero 24-hr nonfreezing rat heart preservation: a novel preservation method in a variable magnetic field. Transplantation (2012) 1.52
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nat Genet (2012) 1.51
Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism. DNA Repair (Amst) (2003) 1.51
A novel technique to prevent intra-operative pneumothorax in awake coronary artery bypass grafting: biomaterial neo-pleura. Eur J Cardiothorac Surg (2008) 1.50
HMGB1 is a cofactor in mammalian base excision repair. Mol Cell (2007) 1.49
Prognostic significance of fascin overexpression in human esophageal squamous cell carcinoma. Clin Cancer Res (2005) 1.48
Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region. Mol Cell Biol (2007) 1.48
Omenn syndrome due to ARTEMIS mutations. Blood (2005) 1.47
Robot-assisted minimally invasive direct coronary artery bypass grafting. ThoraCAB. Circ J (2013) 1.47
A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell. Nucleic Acids Res (2008) 1.47
Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV. Eur J Immunol (2006) 1.45
G clustering is important for the initiation of transcription-induced R-loops in vitro, whereas high G density without clustering is sufficient thereafter. Mol Cell Biol (2009) 1.43
Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site. Mol Cell Biol (2010) 1.43
Differential effects of carvedilol and metoprolol on renal function in patients with heart failure. Circ J (2010) 1.42
Pathologic and biological assessment of lung tumors showing ground-glass opacity. Ann Thorac Surg (2006) 1.42
Diagnostic capacity of 64-slice multidetector computed tomography for acute coronary syndrome in patients presenting with acute chest pain. Cardiology (2008) 1.42
Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair. Nat Genet (2012) 1.42
The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst) (2002) 1.41
RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Mol Cell Biol (2007) 1.41
Lidocaine-magnesium blood cardioplegia was equivalent to potassium blood cardioplegia in left ventricular function of canine heart. Interact Cardiovasc Thorac Surg (2006) 1.40
Powerful skin cancer protection by a CPD-photolyase transgene. Curr Biol (2005) 1.39
Hybrid surgical angiogenesis: omentopexy can enhance myocardial angiogenesis induced by cell therapy. Ann Thorac Surg (2006) 1.39
Usefulness of fluorine-18 fluorodeoxyglucose-positron emission tomography in management strategy for thymic epithelial tumors. Ann Thorac Surg (2012) 1.39
Portable coronary active perfusion system for off-pump coronary artery bypass grafting. Ann Thorac Surg (2006) 1.38
Free pericardial fat pads can act as sealant for preventing alveolar air leaks. Ann Thorac Surg (2005) 1.38
Mechanisms of chromosomal rearrangement in the human genome. BMC Genomics (2010) 1.37
Long-term survival cases of lung cancer presented as solitary bone metastasis. Ann Thorac Cardiovasc Surg (2005) 1.37
Cryptochrome-deficient mice lack circadian electrical activity in the suprachiasmatic nuclei. Curr Biol (2002) 1.36
The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase. Clin Cancer Res (2003) 1.35
Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination. Proc Natl Acad Sci U S A (2006) 1.35
Mutations and deletions of the CBP gene in human lung cancer. Clin Cancer Res (2005) 1.34
The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells. Mol Cell (2011) 1.34
DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients. Proc Natl Acad Sci U S A (2009) 1.34
Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. Genet Epidemiol (2012) 1.34
A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene. Genes Chromosomes Cancer (2010) 1.33