Maintaining embryonic stem cell pluripotency with Wnt signaling.

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TCF/LEFs and Wnt signaling in the nucleus. Cold Spring Harb Perspect Biol (2012) 1.78

Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature (2013) 1.65

Mitotic and mitogenic Wnt signalling. EMBO J (2012) 1.62

Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling. Genes Dev (2014) 1.33

Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nat Commun (2013) 1.23

Role of EMT in Metastasis and Therapy Resistance. J Clin Med (2016) 1.20

The transcriptional regulation of pluripotency. Cell Res (2012) 1.15

A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation. PLoS Genet (2012) 1.05

Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One (2012) 1.01

Signaling networks in human pluripotent stem cells. Curr Opin Cell Biol (2012) 0.97

Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells. PLoS One (2012) 0.95

Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment. Nat Commun (2014) 0.95

Fibroblast growth factor receptor-mediated activation of AKT-β-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells. PLoS One (2012) 0.94

The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells. Proc Natl Acad Sci U S A (2014) 0.92

Physiological β-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma. BMC Cell Biol (2013) 0.92

Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage. Sci Rep (2013) 0.91

Multiple tumor suppressor microRNAs regulate telomerase and TCF7, an important transcriptional regulator of the Wnt pathway. PLoS One (2014) 0.89

Anti-inflammatory activity of Wnt signaling in enteric nervous system: in vitro preliminary evidences in rat primary cultures. J Neuroinflammation (2015) 0.88

Temporal perturbation of the Wnt signaling pathway in the control of cell reprogramming is modulated by TCF1. Stem Cell Reports (2014) 0.88

A simple and robust method for establishing homogeneous mouse epiblast stem cell lines by wnt inhibition. Stem Cell Reports (2015) 0.87

A modified EpiSC culture condition containing a GSK3 inhibitor can support germline-competent pluripotency in mice. PLoS One (2014) 0.86

Evidence for involvement of Wnt signalling in body polarities, cell proliferation, and the neuro-sensory system in an adult ctenophore. PLoS One (2013) 0.85

High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells. J Biol Chem (2014) 0.84

Craniofacial abnormalities and altered wnt and mmp mRNA expression in zebrafish embryos exposed to gasoline oxygenates ETBE and TAME. Aquat Toxicol (2012) 0.82

β-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells. PLoS One (2013) 0.81

Involvement of Wnt signaling pathways in the metamorphosis of the bryozoan Bugula neritina. PLoS One (2012) 0.81

p120-catenin regulates REST and CoREST, and modulates mouse embryonic stem cell differentiation. J Cell Sci (2014) 0.81

Alternative intronic promoters in development and disease. Protoplasma (2017) 0.81

Wnt3a-dependent and -independent protein interaction networks of chromatin-bound β-catenin in mouse embryonic stem cells. Mol Cell Proteomics (2013) 0.80

miRNA let-7e modulates the Wnt pathway and early nephrogenic markers in mouse embryonic stem cell differentiation. PLoS One (2013) 0.80

Inhibition of β-catenin-TCF1 interaction delays differentiation of mouse embryonic stem cells. J Cell Biol (2015) 0.79

Functional analysis of Tcl1 using Tcl1-deficient mouse embryonic stem cells. PLoS One (2013) 0.79

Animal development: an ancient β-catenin switch? Curr Biol (2013) 0.78

LTβR signalling preferentially accelerates oncogenic AKT-initiated liver tumours. Gut (2015) 0.77

Tcf7l1 proteins cell autonomously restrict cardiomyocyte and promote endothelial specification in zebrafish. Dev Biol (2013) 0.77

OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus during Human ES Cell Differentiation into Definitive Endoderm. Stem Cell Reports (2015) 0.77

Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation. PLoS One (2013) 0.77

The crossroads between cancer stem cells and aging. BMC Cancer (2015) 0.76

Echoes of the embryo: using the developmental biology toolkit to study cancer. Dis Model Mech (2016) 0.76

Can pluripotent stem cells be used in cell-based therapy? Cell Reprogram (2014) 0.76

STAT3 Potentiates SIAH-1 Mediated Proteasomal Degradation of β-Catenin in Human Embryonic Kidney Cells. Mol Cells (2016) 0.75

G-protein Coupled Receptor Signaling in Pluripotent Stem Cell-derived Cardiovascular Cells: Implications for Disease Modeling. Front Cell Dev Biol (2015) 0.75

Application Of Small Molecules Favoring Naïve Pluripotency during Human Embryonic Stem Cell Derivation. Cell Reprogram (2015) 0.75

Self-regulation of functional pathways by motifs inside the disordered tails of beta-catenin. BMC Genomics (2016) 0.75

Nanog down-regulates the Wnt signaling pathway via β-catenin phosphorylation during epidermal stem cell proliferation and differentiation. Cell Biosci (2015) 0.75

PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway. Oncotarget (2016) 0.75

Dual Function of Wnt Signaling during Neuronal Differentiation of Mouse Embryonic Stem Cells. Stem Cells Int (2015) 0.75

CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities. Stem Cells Dev (2016) 0.75

Icaritin enhances mESC self-renewal through upregulating core pluripotency transcription factors mediated by ERα. Sci Rep (2017) 0.75

Can recurrences be predicted in craniopharyngiomas? β-catenin coexisting with stem cells markers and p-ATM in a clinicopathologic study of 45cases. J Exp Clin Cancer Res (2017) 0.75

The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome. J Biol Chem (2017) 0.75

Ctbp2-mediated β-catenin regulation is required for exit from pluripotency. Exp Mol Med (2017) 0.75

MATCHER: manifold alignment reveals correspondence between single cell transcriptome and epigenome dynamics. Genome Biol (2017) 0.75

Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93

Establishment in culture of pluripotential cells from mouse embryos. Nature (1981) 30.49

Wnt/beta-catenin signaling in development and disease. Cell (2006) 30.09

Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet (2000) 21.52

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76

Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell (2003) 20.16

The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A (1981) 18.96

Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31

The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell (2003) 17.72

Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature (1988) 13.21

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med (2003) 12.94

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell (1996) 11.70

GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci (2003) 10.89

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet (1998) 10.51

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell (1997) 8.23

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature (1988) 7.61

Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell (1997) 6.10

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev (1994) 6.07

Towards an integrated view of Wnt signaling in development. Development (2009) 6.07

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature (1998) 5.16

Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell (2010) 5.13

An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell (2010) 5.00

Lack of beta-catenin affects mouse development at gastrulation. Development (1995) 4.95

Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev (2008) 4.77

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature (1990) 4.69

Requirement for Wnt3 in vertebrate axis formation. Nat Genet (1999) 4.68

Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature (1998) 4.50

Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature (2009) 4.49

Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell (2008) 4.43

Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev Cell (2007) 4.39

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38

Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol (2000) 4.36

Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell (1994) 4.24

Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science (1999) 4.08

Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proc Natl Acad Sci U S A (2007) 3.90

Tcf3 governs stem cell features and represses cell fate determination in skin. Cell (2006) 3.88

Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc Natl Acad Sci U S A (2006) 3.85

Convergent extension: the molecular control of polarized cell movement during embryonic development. Dev Cell (2002) 3.81

Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin. Mol Cell Biol (1998) 3.79

An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature (1995) 3.78

Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev (1994) 3.77

Formation and function of Spemann's organizer. Annu Rev Cell Dev Biol (1997) 3.62

Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex. Genes Dev (2005) 3.61

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling. Nat Genet (2002) 3.60

Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis. Proc Natl Acad Sci U S A (2006) 3.54

Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell (2011) 3.53

Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol (2005) 3.41

Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. Nature (2002) 3.31

Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat Cell Biol (2011) 3.25

Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development (2009) 3.25

Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity (2000) 3.19

pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila. Nature (1997) 3.15

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development (1994) 3.12

Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression. Mol Cell Biol (1999) 3.08

Molecular genetics of axis formation in zebrafish. Annu Rev Genet (2005) 3.06

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes Dev (1999) 2.94

GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci (2009) 2.87

Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo. Nat Rev Mol Cell Biol (2009) 2.86

Diversity of LEF/TCF action in development and disease. Oncogene (2006) 2.84

Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development (2006) 2.82

Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells. Stem Cells (2005) 2.81

Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells. Biochem Biophys Res Commun (2006) 2.76

Wnt signaling mediates self-organization and axis formation in embryoid bodies. Cell Stem Cell (2008) 2.64

Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol (2011) 2.64

Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat Biotechnol (2002) 2.64

Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal. Mol Cell Biol (2006) 2.63

WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells. Dev Biol (2005) 2.54

Repressor activity of Headless/Tcf3 is essential for vertebrate head formation. Nature (2000) 2.49

Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature (2010) 2.46

Wnt signaling and the polarity of the primary body axis. Cell (2009) 2.46

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development (2004) 2.45

T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells (2008) 2.43

Comparative aspects of animal regeneration. Annu Rev Cell Dev Biol (2008) 2.34

Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation. Nat Cell Biol (2011) 2.32

Tcf3: a transcriptional regulator of axis induction in the early embryo. Development (2003) 2.26

Wnt signalling: variety at the core. J Cell Sci (2007) 2.23

Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal. Stem Cells (2008) 2.20

Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. Stem Cells (2006) 2.18

Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A (2007) 2.15

Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol (2011) 2.13

Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet (2009) 2.07

β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism. Cell Stem Cell (2011) 2.07

Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev Biol (1997) 2.02

Wnt signaling and stem cell control. Cold Spring Harb Symp Quant Biol (2008) 1.95

Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development. Development (2008) 1.87

Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. Mol Cell Biol (1996) 1.84

Wnt signaling in stem and cancer stem cells. Semin Cell Dev Biol (2010) 1.79

Wnt signals from the neural tube block ectopic cardiogenesis. Genes Dev (2001) 1.79

Periodic activation of Wnt/beta-catenin signaling enhances somatic cell reprogramming mediated by cell fusion. Cell Stem Cell (2008) 1.78

Insertional mutagenesis by the Tol2 transposon-mediated enhancer trap approach generated mutations in two developmental genes: tcf7 and synembryn-like. Development (2008) 1.76

Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells. Stem Cells (2009) 1.72

Beta-catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cells. FEBS Lett (2007) 1.71

Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells. Biochem Biophys Res Commun (2006) 1.66

The origin and identity of embryonic stem cells. Development (2011) 1.60

wnt3a but not wnt11 supports self-renewal of embryonic stem cells. Biochem Biophys Res Commun (2006) 1.53

Generation of multipotential mesendodermal progenitors from mouse embryonic stem cells via sustained Wnt pathway activation. J Biol Chem (2007) 1.45

Wnt signaling through T-cell factor phosphorylation. Cell Res (2011) 0.87