PubRank

Paul I W de Bakker

Author PubWeight™ 855.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007 209.92
2 A second generation human haplotype map of over 3.1 million SNPs. Nature 2007 85.39
3 Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 2007 75.09
4 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007 51.70
5 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008 35.06
6 Structure validation by Calpha geometry: phi,psi and Cbeta deviation. Proteins 2003 32.38
7 Integrating common and rare genetic variation in diverse human populations. Nature 2010 32.30
8 Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 2008 20.66
9 Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet 2008 19.55
10 Genome-wide detection and characterization of positive selection in human populations. Nature 2007 17.27
11 Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007 17.06
12 SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics 2008 15.77
13 Evaluating and improving power in whole-genome association studies using fixed marker sets. Nat Genet 2006 14.76
14 Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011 13.23
15 Pooled association tests for rare variants in exon-resequencing studies. Am J Hum Genet 2010 13.18
16 Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet 2012 12.10
17 Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet 2010 9.90
18 STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med 2007 9.80
19 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science 2010 9.61
20 Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet 2007 8.74
21 TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 2006 7.75
22 Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One 2008 7.16
23 Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 2009 7.16
24 Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet 2009 5.20
25 Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet 2012 5.11
26 Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet 2012 4.63
27 High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet 2012 4.46
28 Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat Genet 2012 4.41
29 Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes 2008 4.20
30 Exome sequencing and the genetic basis of complex traits. Nat Genet 2012 4.11
31 Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet 2010 3.97
32 Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol 2012 3.93
33 HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med 2011 3.93
34 Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genet 2011 3.68
35 Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet 2010 3.55
36 Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol 2011 3.52
37 Heterogeneity and inaccuracy in protein structures solved by X-ray crystallography. Structure 2004 3.32
38 Imputing amino acid polymorphisms in human leukocyte antigens. PLoS One 2013 3.07
39 Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study. Circulation 2007 2.82
40 Seventy-five genetic loci influencing the human red blood cell. Nature 2012 2.77
41 Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nat Genet 2005 2.71
42 Comprehensive association testing of common mitochondrial DNA variation in metabolic disease. Am J Hum Genet 2006 2.60
43 Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet 2012 2.53
44 Knowledge-based real-space explorations for low-resolution structure determination. Structure 2006 2.52
45 Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region. Diabetes 2004 2.52
46 Extremely low-coverage sequencing and imputation increases power for genome-wide association studies. Nat Genet 2012 2.50
47 Crystallographic refinement by knowledge-based exploration of complex energy landscapes. Structure 2005 2.42
48 The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A 2009 2.38
49 Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A 2009 2.31
50 Biases and reconciliation in estimates of linkage disequilibrium in the human genome. Am J Hum Genet 2006 2.26
51 Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis. Arthritis Rheum 2013 2.17
52 Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet 2010 2.15
53 Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. Diabetes 2010 2.02
54 Next-generation sequencing for HLA typing of class I loci. BMC Genomics 2011 1.99
55 Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. PLoS Genet 2012 1.97
56 Searching for signals of evolutionary selection in 168 genes related to immune function. Hum Genet 2005 1.97
57 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet 2012 1.96
58 An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol 2014 1.95
59 GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. PLoS Genet 2012 1.86
60 Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology 2014 1.85
61 Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes. Stroke 2013 1.80
62 Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet 2013 1.72
63 Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction. Atherosclerosis 2013 1.69
64 Pandit: a database of protein and associated nucleotide domains with inferred trees. Bioinformatics 2003 1.69
65 Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet 2010 1.67
66 Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms. PLoS One 2008 1.64
67 Evidence for an oligogenic basis of amyotrophic lateral sclerosis. Hum Mol Genet 2012 1.62
68 PANDIT: an evolution-centric database of protein and associated nucleotide domains with inferred trees. Nucleic Acids Res 2006 1.58
69 Ab initio construction of polypeptide fragments: efficient generation of accurate, representative ensembles. Proteins 2003 1.56
70 Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genet 2013 1.55
71 Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. Am J Hum Genet 2009 1.51
72 Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis. Ann Neurol 2011 1.45
73 Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls. PLoS Pathog 2013 1.33
74 Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. PLoS One 2009 1.28
75 Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet 2013 1.27
76 Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populations. Hum Mol Genet 2007 1.24
77 Multiethnic genetic association studies improve power for locus discovery. PLoS One 2010 1.23
78 Association of common variation in the HNF1alpha gene region with risk of type 2 diabetes. Diabetes 2005 1.22
79 Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08. Ann Neurol 2012 1.19
80 Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans. Hum Mol Genet 2012 1.14
81 Association testing of variants in the hepatocyte nuclear factor 4alpha gene with risk of type 2 diabetes in 7,883 people. Diabetes 2005 1.12
82 Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency. PLoS Genet 2013 1.10
83 The value of gene-based selection of tag SNPs in genome-wide association studies. Eur J Hum Genet 2006 1.04
84 Principal-component analysis for assessment of population stratification in mitochondrial medical genetics. Am J Hum Genet 2010 1.02
85 Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk. Am J Hum Genet 2013 1.00
86 Genetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program. PLoS Genet 2012 0.99
87 Many hypotheses but no replication for the association between PDE4D and stroke. Nat Genet 2006 0.98
88 Common mitochondrial sequence variants in ischemic stroke. Ann Neurol 2010 0.97
89 Infectious diseases not immune to genome-wide association. Nat Genet 2010 0.95
90 The impact of susceptibility loci for coronary artery disease on other vascular domains and recurrence risk. Eur Heart J 2013 0.94
91 The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression. Cell Host Microbe 2009 0.92
92 High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people. Diabetes 2006 0.91
93 IL28B alleles exert an additive dose effect when applied to HCV-HIV coinfected persons undergoing peginterferon and ribavirin therapy. PLoS One 2011 0.89
94 Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes. Diabetes 2006 0.85
95 Meta-analysis of genome-wide association studies. Cold Spring Harb Protoc 2010 0.84
96 Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols. Pharmacogenet Genomics 2015 0.84
97 Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Neurology 2014 0.84
98 C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis. Ann Neurol 2014 0.83
99 Impact of inherited genetic variants associated with lipid profile, hypertension, and coronary artery disease on the risk of intracranial and abdominal aortic aneurysms. Circ Cardiovasc Genet 2013 0.83
100 Towards a molecular systems model of coronary artery disease. Curr Cardiol Rep 2014 0.82
101 No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. Hum Mol Genet 2013 0.80
102 LDL-c-linked SNPs are associated with LDL-c and myocardial infarction despite lipid-lowering therapy in patients with established vascular disease. Eur J Clin Invest 2013 0.78
103 Fast pairwise IBD association testing in genome-wide association studies. Bioinformatics 2013 0.78
104 No association between CYP3A4*22 and statin effectiveness in reducing the risk for myocardial infarction. Pharmacogenomics 2014 0.76
105 Selection and evaluation of Tag-SNPs using Tagger and HapMap. Cold Spring Harb Protoc 2009 0.75
106 Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet 2016 0.75
107 In search of genes for stroke. Lancet Neurol 2007 0.75
108 [Genome-wide association studies: methodology and interpretation for clinicians]. Ned Tijdschr Geneeskd 2014 0.75
109 Negative selection in humans and fruit flies involves synergistic epistasis. Science 2017 0.75
110 Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nat Commun 2017 0.75
111 Reply: Poor Sensitivity and Specificity of Electrocardiographic Estimation of Myocardial Mass. J Am Coll Cardiol 2017 0.75