Published in J Biol Chem on November 04, 2002
Conservative Versus Conventional Oxygen Administration in Critically Ill Patients | NCT04198077
Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis. Mol Cell (2010) 5.33
Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol (2004) 5.29
Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death. Cell (2008) 4.47
Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli. Mol Syst Biol (2007) 3.98
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood (2005) 3.57
New strategies for fluorescent probe design in medical diagnostic imaging. Chem Rev (2010) 3.35
Cell death from antibiotics without the involvement of reactive oxygen species. Science (2013) 2.95
Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli. Mol Cell (2009) 2.74
One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes. Tetrahedron Lett (2007) 2.49
Antibiotics induce redox-related physiological alterations as part of their lethality. Proc Natl Acad Sci U S A (2014) 2.25
Boronate-based fluorescent probes for imaging cellular hydrogen peroxide. J Am Chem Soc (2005) 2.11
Dietary phosphorus acutely impairs endothelial function. J Am Soc Nephrol (2009) 2.09
A selective, cell-permeable optical probe for hydrogen peroxide in living cells. J Am Chem Soc (2004) 2.08
Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nat Chem Biol (2010) 2.06
Reaction-based small-molecule fluorescent probes for chemoselective bioimaging. Nat Chem (2012) 2.05
Silver enhances antibiotic activity against gram-negative bacteria. Sci Transl Med (2013) 1.97
NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1. Neuron (2006) 1.83
A palette of fluorescent probes with varying emission colors for imaging hydrogen peroxide signaling in living cells. J Am Chem Soc (2010) 1.79
Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation. J Biol Chem (2007) 1.73
Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death. J Antimicrob Chemother (2010) 1.69
Boronate oxidation as a bioorthogonal reaction approach for studying the chemistry of hydrogen peroxide in living systems. Acc Chem Res (2011) 1.63
Electrical stimulation of human embryonic stem cells: cardiac differentiation and the generation of reactive oxygen species. Exp Cell Res (2009) 1.49
Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype. Am J Pathol (2009) 1.44
DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae. Free Radic Biol Med (2008) 1.40
Antagonism of ionotropic glutamate receptors attenuates chemical ischemia-induced injury in rat primary cultured myenteric ganglia. PLoS One (2014) 1.38
Monitoring singlet oxygen and hydroxyl radical formation with fluorescent probes during photodynamic therapy. Photochem Photobiol (2009) 1.34
A central role for carbon-overflow pathways in the modulation of bacterial cell death. PLoS Pathog (2014) 1.30
Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications. Curr Pharm Des (2011) 1.29
The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease. J Neurosci (2011) 1.26
Silver coordination polymers for prevention of implant infection: thiol interaction, impact on respiratory chain enzymes, and hydroxyl radical induction. Antimicrob Agents Chemother (2010) 1.22
Measuring myeloperoxidase activity in biological samples. PLoS One (2013) 1.21
Type I and Type II mechanisms of antimicrobial photodynamic therapy: an in vitro study on gram-negative and gram-positive bacteria. Lasers Surg Med (2012) 1.11
Role of autofluorescence in flow cytometric analysis of Escherichia coli treated with bactericidal antibiotics. J Bacteriol (2013) 1.09
Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of Corti treated with gentamicin. Neuroscience (2009) 1.08
Comparison of bee products based on assays of antioxidant capacities. BMC Complement Altern Med (2009) 1.07
Cold atmospheric plasma jet-generated RONS and their selective effects on normal and carcinoma cells. Sci Rep (2016) 1.02
DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines. PLoS One (2012) 1.01
Comparison of fluorescence-based techniques for the quantification of particle-induced hydroxyl radicals. Part Fibre Toxicol (2008) 1.00
Imidazole metalloporphyrins as photosensitizers for photodynamic therapy: role of molecular charge, central metal and hydroxyl radical production. Cancer Lett (2009) 0.99
A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages. Chem Biol (2007) 0.99
The stringent response controls catalases in Pseudomonas aeruginosa and is required for hydrogen peroxide and antibiotic tolerance. J Bacteriol (2013) 0.99
Boronate-based fluorescent probes: imaging hydrogen peroxide in living systems. Methods Enzymol (2013) 0.98
Therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes. Oxid Med Cell Longev (2012) 0.98
Enhanced efficacy of photodynamic therapy via a sequential targeting protocol. Photochem Photobiol (2014) 0.97
EPR-Spin Trapping and Flow Cytometric Studies of Free Radicals Generated Using Cold Atmospheric Argon Plasma and X-Ray Irradiation in Aqueous Solutions and Intracellular Milieu. PLoS One (2015) 0.97
Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation. J Am Chem Soc (2009) 0.95
Hydroxyl radicals are involved in cell killing by the bacterial topoisomerase I cleavage complex. J Bacteriol (2009) 0.94
Mitochondrial reactive oxygen species accelerate gastric cancer cell invasion. J Clin Biochem Nutr (2013) 0.94
Bioimaging probes for reactive oxygen species and reactive nitrogen species. J Clin Biochem Nutr (2009) 0.94
The contribution of reactive oxygen species to the photobleaching of organic fluorophores. Photochem Photobiol (2013) 0.94
Adenine oxidation by pyrite-generated hydroxyl radicals. Geochem Trans (2010) 0.93
HIV-1 transforms the monocyte plasma membrane proteome. Cell Immunol (2009) 0.93
FoxO transcription factors support oxidative stress resistance in human chondrocytes. Arthritis Rheumatol (2014) 0.92
Mechanism of Honey Bacteriostatic Action Against MRSA and VRE Involves Hydroxyl Radicals Generated from Honey's Hydrogen Peroxide. Front Microbiol (2012) 0.92
Arginine deiminase in Staphylococcus epidermidis functions to augment biofilm maturation through pH homeostasis. J Bacteriol (2014) 0.92
Bactericidal antibiotics increase hydroxyphenyl fluorescein signal by altering cell morphology. PLoS One (2014) 0.91
Stable synthetic bacteriochlorins overcome the resistance of melanoma to photodynamic therapy. FASEB J (2010) 0.91
Role of pyrite in formation of hydroxyl radicals in coal: possible implications for human health. Part Fibre Toxicol (2006) 0.91
Ozone affects pollen viability and NAD(P)H oxidase release from Ambrosia artemisiifolia pollen. Environ Pollut (2011) 0.91
Modern reaction-based indicator systems. Chem Soc Rev (2009) 0.90
Transiently produced hypochlorite is responsible for the irreversible inhibition of chlorite dismutase. Biochemistry (2014) 0.90
Enhancement of neutrophil function by interleukin-18 therapy protects burn-injured mice from methicillin-resistant Staphylococcus aureus. Infect Immun (2011) 0.90
Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols. Coord Chem Rev (2012) 0.90
Synthesis and photodynamic effect of new highly photostable decacationically armed [60]- and [70]fullerene decaiodide monoadducts to target pathogenic bacteria and cancer cells. J Med Chem (2012) 0.90
Survival signaling by C-RAF: mitochondrial reactive oxygen species and Ca2+ are critical targets. Mol Cell Biol (2008) 0.90
Glutathione is a physiologic reservoir of neuronal glutamate. Biochem Biophys Res Commun (2011) 0.90
Increased nitric oxide production by neutrophils in early stage of Kawasaki disease. Eur J Pediatr (2008) 0.89
Nanoencapsulation method for high selectivity sensing of hydrogen peroxide inside live cells. Anal Chem (2010) 0.89
Preadaptation to cold stress in Salmonella enterica serovar Typhimurium increases survival during subsequent acid stress exposure. Appl Environ Microbiol (2013) 0.89
Effects of the oxygenation level on formation of different reactive oxygen species during photodynamic therapy. Photochem Photobiol (2013) 0.88
The antidote effect of quinone oxidoreductase 2 inhibitor against paraquat-induced toxicity in vitro and in vivo. Br J Pharmacol (2013) 0.88
Oxidative DNA damage is instrumental in hyperreplication stress-induced inviability of Escherichia coli. Nucleic Acids Res (2014) 0.87
Stable synthetic bacteriochlorins for photodynamic therapy: role of dicyano peripheral groups, central metal substitution (2H, Zn, Pd), and Cremophor EL delivery. ChemMedChem (2012) 0.87
Anatase titanium dioxide nanoparticles in mice: evidence for induced structural and functional sperm defects after short-, but not long-, term exposure. Asian J Androl (2015) 0.86
Thimerosal-Derived Ethylmercury Is a Mitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage of mtDNA. J Toxicol (2012) 0.86
Time to fatigue is increased in mouse muscle at 37 degrees C; the role of iron and reactive oxygen species. J Physiol (2009) 0.86
Photoinduced electron-transfer mechanisms for radical-enhanced photodynamic therapy mediated by water-soluble decacationic C₇₀ and C₈₄O₂ Fullerene Derivatives. Nanomedicine (2012) 0.85
Dual functionality of myeloperoxidase in rotenone-exposed brain-resident immune cells. Am J Pathol (2011) 0.85
Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2. Clin Exp Metastasis (2011) 0.85
Role of ER stress response in photodynamic therapy: ROS generated in different subcellular compartments trigger diverse cell death pathways. PLoS One (2012) 0.84
Cerium oxide nanoparticles accelerate the decay of peroxynitrite (ONOO(-)). Drug Deliv Transl Res (2013) 0.84
The fluorescein-derived dye aminophenyl fluorescein is a suitable tool to detect hypobromous acid (HOBr)-producing activity in eosinophils. J Biol Chem (2012) 0.84
Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea. PLoS One (2013) 0.84
On the use of fluorescence probes for detecting reactive oxygen and nitrogen species associated with photodynamic therapy. J Biomed Opt (2010) 0.83
Evaluating the use of 3'-(p-Aminophenyl) fluorescein for determining the formation of highly reactive oxygen species in particle suspensions. Geochem Trans (2009) 0.83
Pramipexole protects against H2O2-induced PC12 cell death. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.83
EGCG inhibit chemical reactivity of iron through forming an Ngal-EGCG-iron complex. Biometals (2013) 0.83
Absence of phagocyte NADPH oxidase 2 leads to severe inflammatory response in lungs of mice infected with Coccidioides. Microb Pathog (2011) 0.83
Sigma S-dependent antioxidant defense protects stationary-phase Escherichia coli against the bactericidal antibiotic gentamicin. Antimicrob Agents Chemother (2014) 0.82
Aconitase regulation of erythropoiesis correlates with a novel licensing function in erythropoietin-induced ERK signaling. PLoS One (2011) 0.82
Evaluation of diethyl-3-3'-(9,10-anthracenediyl)bis acrylate as a probe for singlet oxygen formation during photodynamic therapy. Photochem Photobiol (2012) 0.82
Inactivation of Escherichia coli by nanoparticulate zerovalent iron and ferrous ion. Appl Environ Microbiol (2010) 0.82
Development of fluorescent probes for bioimaging applications. Proc Jpn Acad Ser B Phys Biol Sci (2010) 0.82
Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia. Oncogene (2012) 0.82
Rab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cells. PLoS One (2014) 0.82
Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via the SIRT3-ROS pathway. Sci Rep (2015) 0.81
Identification of a hydrogen peroxide signalling pathway in the control of light-dependent germination in Arabidopsis. Planta (2013) 0.81
Synthesis of decacationic [60]fullerene decaiodides giving photoinduced production of superoxide radicals and effective PDT-mediation on antimicrobial photoinactivation. Eur J Med Chem (2013) 0.81
Antimicrobial photodynamic therapy with decacationic monoadducts and bisadducts of [70]fullerene: in vitro and in vivo studies. Nanomedicine (Lond) (2013) 0.81
Rapid cancer detection by topically spraying a γ-glutamyltranspeptidase-activated fluorescent probe. Sci Transl Med (2011) 4.72
New strategies for fluorescent probe design in medical diagnostic imaging. Chem Rev (2010) 3.35
Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes. Nat Med (2008) 3.15
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature (2013) 2.74
Simultaneous multicolor imaging of five different lymphatic basins using quantum dots. Nano Lett (2007) 2.46
Evolution of fluorescein as a platform for finely tunable fluorescence probes. J Am Chem Soc (2005) 2.35
Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore-rational design of potentially useful bioimaging fluorescence probe. J Am Chem Soc (2004) 2.12
In vivo diagnosis of epidermal growth factor receptor expression using molecular imaging with a cocktail of optically labeled monoclonal antibodies. Clin Cancer Res (2007) 2.01
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. J Biol Chem (2005) 1.95
Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2-* versus 1O2. J Am Chem Soc (2003) 1.87
Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion (2006) 1.86
AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation. Circulation (2004) 1.85
Zinc sensing for cellular application. Curr Opin Chem Biol (2004) 1.77
Spectral fluorescence molecular imaging of lung metastases targeting HER2/neu. Clin Cancer Res (2007) 1.76
Mechanistic background and clinical applications of indocyanine green fluorescence imaging of hepatocellular carcinoma. Ann Surg Oncol (2013) 1.76
Multimodal nanoprobes for radionuclide and five-color near-infrared optical lymphatic imaging. ACS Nano (2007) 1.70
A target cell-specific activatable fluorescence probe for in vivo molecular imaging of cancer based on a self-quenched avidin-rhodamine conjugate. Cancer Res (2007) 1.64
An enzymatically activated fluorescence probe for targeted tumor imaging. J Am Chem Soc (2007) 1.46
Improvement and biological applications of fluorescent probes for zinc, ZnAFs. J Am Chem Soc (2002) 1.43
Development of a highly selective fluorescence probe for hydrogen sulfide. J Am Chem Soc (2011) 1.43
Fluorophore-quencher based activatable targeted optical probes for detecting in vivo cancer metastases. Mol Pharm (2009) 1.42
Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs. J Am Chem Soc (2005) 1.41
Adipose-derived stem cells stimulate reendothelialization in stented rat abdominal aorta. Circ J (2014) 1.40
Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity. J Virol (2010) 1.40
Evolution of group 14 rhodamines as platforms for near-infrared fluorescence probes utilizing photoinduced electron transfer. ACS Chem Biol (2011) 1.38
A self-quenched galactosamine-serum albumin-rhodamineX conjugate: a "smart" fluorescent molecular imaging probe synthesized with clinically applicable material for detecting peritoneal ovarian cancer metastases. Clin Cancer Res (2007) 1.38
Activatable fluorescent molecular imaging of peritoneal metastases following pretargeting with a biotinylated monoclonal antibody. Cancer Res (2007) 1.37
Development of a ratiometric fluorescent zinc ion probe in near-infrared region, based on tricarbocyanine chromophore. J Am Chem Soc (2006) 1.36
Fluorescent probes for sensing and imaging. Nat Methods (2011) 1.32
D-galactose receptor-targeted in vivo spectral fluorescence imaging of peritoneal metastasis using galactosamin-conjugated serum albumin-rhodamine green. J Biomed Opt (2007) 1.29
A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity. J Am Chem Soc (2010) 1.29
Rational principles for modulating fluorescence properties of fluorescein. J Am Chem Soc (2004) 1.26
Highly efficient and photostable photosensitizer based on BODIPY chromophore. J Am Chem Soc (2005) 1.25
Design and synthesis of a novel magnetic resonance imaging contrast agent for selective sensing of zinc ion. Chem Biol (2002) 1.23
Simultaneous two-color spectral fluorescence lymphangiography with near infrared quantum dots to map two lymphatic flows from the breast and the upper extremity. Breast Cancer Res Treat (2006) 1.23
Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits. J Cell Biol (2002) 1.23
Two-color lymphatic mapping using Ig-conjugated near infrared optical probes. J Invest Dermatol (2007) 1.22
Rational design principle for modulating fluorescence properties of fluorescein-based probes by photoinduced electron transfer. J Am Chem Soc (2003) 1.22
A comparison of the emission efficiency of four common green fluorescence dyes after internalization into cancer cells. Bioconjug Chem (2006) 1.20
Angiotensin II and tumor necrosis factor-alpha synergistically promote monocyte chemoattractant protein-1 expression: roles of NF-kappaB, p38, and reactive oxygen species. Am J Physiol Heart Circ Physiol (2008) 1.19
Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes. J Am Chem Soc (2010) 1.18
Fluorescent probes for bioimaging applications. Curr Opin Chem Biol (2008) 1.18
Mechanism-based molecular design of highly selective fluorescence probes for nitrative stress. J Am Chem Soc (2006) 1.18
Development of a highly specific rhodamine-based fluorescence probe for hypochlorous acid and its application to real-time imaging of phagocytosis. J Am Chem Soc (2007) 1.16
Multicolor imaging of lymphatic function with two nanomaterials: quantum dot-labeled cancer cells and dendrimer-based optical agents. Nanomedicine (Lond) (2009) 1.15
Selective zinc sensor molecules with various affinities for Zn2+, revealing dynamics and regional distribution of synaptically released Zn2+ in hippocampal slices. J Am Chem Soc (2005) 1.15
Design and synthesis of fluorescent probes for selective detection of highly reactive oxygen species in mitochondria of living cells. J Am Chem Soc (2007) 1.14
Development of an iminocoumarin-based zinc sensor suitable for ratiometric fluorescence imaging of neuronal zinc. J Am Chem Soc (2007) 1.14
Highly activatable and rapidly releasable caged fluorescein derivatives. J Am Chem Soc (2007) 1.12
Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia. J Am Chem Soc (2010) 1.10
Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol (2012) 1.09
Design and synthesis of a library of BODIPY-based environmental polarity sensors utilizing photoinduced electron-transfer-controlled fluorescence ON/OFF switching. J Am Chem Soc (2007) 1.08
Red fluorescent probe for monitoring the dynamics of cytoplasmic calcium ions. Angew Chem Int Ed Engl (2013) 1.08
Fluorescence endoscopic detection of murine colitis-associated colon cancer by topically applied enzymatically rapid-activatable probe. Gut (2012) 1.07
Tunable design strategy for fluorescence probes based on 4-substituted BODIPY chromophore: improvement of highly sensitive fluorescence probe for nitric oxide. Anal Bioanal Chem (2006) 1.07
Development of a far-red to near-infrared fluorescence probe for calcium ion and its application to multicolor neuronal imaging. J Am Chem Soc (2011) 1.06
Targeted optical imaging of cancer cells using lectin-binding BODIPY conjugated avidin. Biochem Biophys Res Commun (2006) 1.05
Adipose tissue-derived stem cells inhibit neointimal formation in a paracrine fashion in rat femoral artery. Am J Physiol Heart Circ Physiol (2009) 1.05
A novel, cell-permeable, fluorescent probe for ratiometric imaging of zinc ion. J Am Chem Soc (2002) 1.04
In vivo spectral fluorescence imaging of submillimeter peritoneal cancer implants using a lectin-targeted optical agent. Neoplasia (2006) 1.04
Time-resolved long-lived luminescence imaging method employing luminescent lanthanide probes with a new microscopy system. J Am Chem Soc (2007) 1.03
A simple and effective strategy to increase the sensitivity of fluorescence probes in living cells. J Am Chem Soc (2009) 1.03
Development of an Si-rhodamine-based far-red to near-infrared fluorescence probe selective for hypochlorous acid and its applications for biological imaging. J Am Chem Soc (2011) 1.03
Rational design and development of near-infrared-emitting firefly luciferins available in vivo. Angew Chem Int Ed Engl (2012) 1.02
Iron hydroxide nanoparticles coated with poly(ethylene glycol)-poly(aspartic acid) block copolymer as novel magnetic resonance contrast agents for in vivo cancer imaging. Colloids Surf B Biointerfaces (2007) 1.01
Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production. Eur J Neurosci (2003) 1.01
Development of NIR fluorescent dyes based on Si-rhodamine for in vivo imaging. J Am Chem Soc (2012) 1.00
Development of luciferin analogues bearing an amino group and their application as BRET donors. Chem Asian J (2010) 0.99
Rational design of ratiometric near-infrared fluorescent pH probes with various pKa values, based on aminocyanine. J Am Chem Soc (2011) 0.97
Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method. J Am Chem Soc (2011) 0.97
Modulation of luminescence intensity of lanthanide complexes by photoinduced electron transfer and its application to a long-lived protease probe. J Am Chem Soc (2006) 0.95
Development of a highly sensitive fluorescence probe for hydrogen peroxide. J Am Chem Soc (2011) 0.95