PubRank

Eugene R Bleecker

Author PubWeight™ 225.51‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cumulative association of five genetic variants with prostate cancer. N Engl J Med 2008 15.34
2 The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 2006 8.43
3 International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2013 8.39
4 Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2009 7.17
5 Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol 2007 6.33
6 Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med 2010 6.19
7 Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012 5.82
8 Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP. J Natl Cancer Inst 2007 4.85
9 Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA 2012 4.30
10 Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet 2011 3.68
11 Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. N Engl J Med 2002 3.68
12 Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol 2010 3.12
13 Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol (1985) 2007 2.83
14 Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. Nat Genet 2002 2.76
15 Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am J Hum Genet 2001 2.61
16 A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med 2009 2.56
17 Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol 2010 2.51
18 Safety and tolerability of the novel inhaled corticosteroid fluticasone furoate in combination with the β2 agonist vilanterol administered once daily for 52 weeks in patients >=12 years old with asthma: a randomised trial. Thorax 2013 2.44
19 Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial. Eur Urol 2012 2.34
20 Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol 2010 2.27
21 Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels. J Natl Cancer Inst 2003 2.26
22 Design and baseline characteristics of the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol 2004 2.22
23 Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol 2010 2.20
24 Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error? Hum Genet 2002 2.15
25 Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21. Am J Hum Genet 2004 2.03
26 Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein. Circulation 2002 1.85
27 An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. Am J Respir Crit Care Med 2012 1.85
28 Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy Clin Immunol 2013 1.80
29 Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med 2011 1.76
30 Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma. Am J Respir Crit Care Med 2005 1.72
31 Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways. Am J Respir Crit Care Med 2014 1.69
32 Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. J Allergy Clin Immunol 2003 1.69
33 Fluticasone furoate demonstrates efficacy in patients with asthma symptomatic on medium doses of inhaled corticosteroid therapy: an 8-week, randomised, placebo-controlled trial. Thorax 2011 1.69
34 Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulation. Am J Physiol Lung Cell Mol Physiol 2007 1.66
35 Obesity and asthma: an association modified by age of asthma onset. J Allergy Clin Immunol 2011 1.64
36 Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. Am J Respir Crit Care Med 2006 1.59
37 Importance of hedgehog interacting protein and other lung function genes in asthma. J Allergy Clin Immunol 2011 1.58
38 IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression. Am J Respir Crit Care Med 2006 1.57
39 Dose effect of once-daily fluticasone furoate in persistent asthma: a randomized trial. Respir Med 2012 1.57
40 Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol 2012 1.54
41 Genome-wide search for atopy susceptibility genes in Dutch families with asthma. J Allergy Clin Immunol 2002 1.50
42 Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12. Am J Hum Genet 2002 1.47
43 Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. Am J Respir Crit Care Med 2008 1.45
44 Severity assessment in asthma: An evolving concept. J Allergy Clin Immunol 2005 1.42
45 Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines. J Allergy Clin Immunol 2008 1.42
46 Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol 2009 1.38
47 24-h duration of the novel LABA vilanterol trifenatate in asthma patients treated with inhaled corticosteroids. Eur Respir J 2012 1.36
48 Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. Am J Respir Crit Care Med 2009 1.35
49 ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. Am J Respir Crit Care Med 2008 1.34
50 A genome-wide search for quantitative trait loci contributing to variation in seasonal pollen reactivity. J Allergy Clin Immunol 2006 1.32
51 Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure. J Allergy Clin Immunol 2003 1.27
52 Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. J Allergy Clin Immunol 2008 1.27
53 Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers. Respir Res 2009 1.25
54 Aspirin sensitivity and severity of asthma: evidence for irreversible airway obstruction in patients with severe or difficult-to-treat asthma. J Allergy Clin Immunol 2005 1.23
55 Do symptoms predict COPD in smokers? Chest 2010 1.22
56 The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. J Allergy Clin Immunol 2009 1.21
57 Once-daily fluticasone furoate alone or combined with vilanterol in persistent asthma. Eur Respir J 2013 1.20
58 Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure. J Allergy Clin Immunol 2005 1.19
59 Interleukin 13 and interleukin 4 receptor-α polymorphisms in rhinitis and asthma. Int Arch Allergy Immunol 2010 1.17
60 Associations between hOGG1 sequence variants and prostate cancer susceptibility. Cancer Res 2002 1.17
61 Assessing productivity loss and activity impairment in severe or difficult-to-treat asthma. Value Health 2008 1.16
62 Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol 2013 1.15
63 A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors. Pharmacogenet Genomics 2008 1.15
64 A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS study. Prostate 2006 1.15
65 Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol 2012 1.14
66 Efficacy and safety of fluticasone furoate/vilanterol compared with fluticasone propionate/salmeterol combination in adult and adolescent patients with persistent asthma: a randomized trial. Chest 2013 1.13
67 Genomewide screen for pulmonary function in 200 families ascertained for asthma. Am J Respir Crit Care Med 2005 1.12
68 IL13 promoter polymorphism 1112C/T modulates the adverse effect of tobacco smoking on lung function. Am J Respir Crit Care Med 2007 1.12
69 Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol 2012 1.11
70 A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects. J Allergy Clin Immunol 2004 1.10
71 Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panel. DNA Seq 2004 1.09
72 Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. PLoS Genet 2012 1.09
73 Once-daily fluticasone furoate (FF)/vilanterol reduces risk of severe exacerbations in asthma versus FF alone. Thorax 2013 1.08
74 Resequencing candidate genes implicates rare variants in asthma susceptibility. Am J Hum Genet 2012 1.08
75 A Roadmap to functional genomics. Physiol Genomics 2007 1.07
76 IL-4 receptor α polymorphisms are predictors of a pharmacogenetic response to a novel IL-4/IL-13 antagonist. J Allergy Clin Immunol 2010 1.06
77 Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk. Cancer Res 2002 1.06
78 Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. Am J Hum Genet 2002 1.05
79 Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma. Respir Res 2011 1.02
80 Association studies of serum prostate-specific antigen levels and the genetic polymorphisms at the androgen receptor and prostate-specific antigen genes. Cancer Epidemiol Biomarkers Prev 2002 1.02
81 Estrogen receptor 1 polymorphisms are associated with airway hyperresponsiveness and lung function decline, particularly in female subjects with asthma. J Allergy Clin Immunol 2006 1.02
82 Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28. J Allergy Clin Immunol 2002 1.02
83 A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. J Allergy Clin Immunol 2012 1.01
84 Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort. Curr Respir Care Rep 2012 1.01
85 Polymorphisms in SPINK5 are not associated with asthma in a Dutch population. J Allergy Clin Immunol 2005 1.00
86 Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility. Cancer Res 2002 1.00
87 The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma. J Allergy Clin Immunol 2012 0.98
88 COPD is associated with a macrophage scavenger receptor-1 gene sequence variation. Chest 2010 0.97
89 Detrimental effects of environmental tobacco smoke in relation to asthma severity. PLoS One 2011 0.97
90 IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist. J Allergy Clin Immunol 2012 0.96
91 Safety of investigative bronchoscopy in the Severe Asthma Research Program. J Allergy Clin Immunol 2011 0.95
92 Clinical consequences of ADRbeta2 polymorphisms. Pharmacogenomics 2008 0.95
93 Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial. Respir Res 2011 0.95
94 Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects. J Allergy Clin Immunol 2012 0.95
95 Therapeutic responses in asthma and COPD. Corticosteroids. Chest 2004 0.94
96 Polymorphic GGC repeats in the androgen receptor gene are associated with hereditary and sporadic prostate cancer risk. Hum Genet 2002 0.93
97 Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD 2011 0.93
98 Mutational analysis of PINX1 in hereditary prostate cancer. Prostate 2004 0.93
99 Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study. J Transl Med 2014 0.93
100 A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma. Hum Genet 2003 0.91
101 Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One 2013 0.91
102 Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk. Cancer Genet Cytogenet 2002 0.91
103 Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine. J Allergy Clin Immunol 2010 0.90
104 Subacute lack of asthma control and acute asthma exacerbation history as predictors of subsequent acute asthma exacerbations: evidence from managed care data. J Asthma 2010 0.90
105 Identification of coding polymorphisms in human circadian rhythm genes PER1, PER2, PER3, CLOCK, ARNTL, CRY1, CRY2 and TIMELESS in a multi-ethnic screening panel. DNA Seq 2008 0.89
106 Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. Am J Respir Crit Care Med 2010 0.88
107 Pharmacogenetics of asthma. Curr Opin Pharmacol 2010 0.86
108 Asthma and gender impact accumulation of T cell subtypes. Respir Res 2010 0.85
109 Differential desensitization of homozygous haplotypes of the beta2-adrenergic receptor in lymphocytes. Am J Respir Crit Care Med 2005 0.85
110 Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study. Mutat Res 2003 0.85
111 Clinical heterogeneity in the severe asthma research program. Ann Am Thorac Soc 2013 0.84
112 Disconnect between sputum neutrophils and other measures of airway inflammation in asthma. Eur Respir J 2013 0.84
113 Efficacy and safety of once-daily fluticasone furoate 50 mcg in adults with persistent asthma: a 12-week randomized trial. Respir Res 2014 0.83
114 Effect of β2-adrenergic receptor gene (ADRB2) 3' untranslated region polymorphisms on inhaled corticosteroid/long-acting β2-adrenergic agonist response. Respir Res 2012 0.82
115 Sequence variants in the human 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) gene are not associated with prostate cancer risk. Prostate 2002 0.82
116 Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk. Int J Cancer 2003 0.82
117 Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. BMC Med Genomics 2014 0.81
118 CLC-2 single nucleotide polymorphisms (SNPs) as potential modifiers of cystic fibrosis disease severity. BMC Med Genet 2004 0.81
119 Sequence analysis of HSPA1A and HSPA1B in a multi-ethnic study population. DNA Seq 2007 0.81
120 Exploring pleiotropy using principal components. BMC Genet 2003 0.81
121 The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients. J Allergy Clin Immunol 2011 0.81
122 Predictors of response to tiotropium versus salmeterol in asthmatic adults. J Allergy Clin Immunol 2013 0.80
123 Pharmacogenetics of the beta 2-adrenergic receptor gene. Immunol Allergy Clin North Am 2007 0.79
124 Evaluation of SRD5A2 sequence variants in susceptibility to hereditary and sporadic prostate cancer. Prostate 2003 0.79
125 Comparison of vilanterol, a novel long-acting beta2 agonist, with placebo and a salmeterol reference arm in asthma uncontrolled by inhaled corticosteroids. J Negat Results Biomed 2014 0.79
126 Efficacy and safety of budesonide/formoterol pressurized metered-dose inhaler: randomized controlled trial comparing once- and twice-daily dosing in patients with asthma. Allergy Asthma Proc 2010 0.78
127 Genetics of asthma susceptibility and severity. Clin Chest Med 2012 0.78
128 Effects of beta2-agonists on airway tone and bronchial responsiveness. J Allergy Clin Immunol 2002 0.78
129 Montelukast added to fluticasone propionate does not alter inflammation or outcomes. Respir Med 2010 0.76
130 Asthma pharmacogenomics. Immunol Allergy Clin North Am 2005 0.76
131 Mapping susceptibility genes for allergic diseases. Chest 2003 0.76
132 Meeting the obligation to balance bioethics and clinical trial design in asthma. Am J Respir Crit Care Med 2010 0.75
133 Association of polymorphisms in CASP10 and CASP8 with FEV(1)/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics. Clin Exp Allergy 2008 0.75
134 Asthma exacerbations and formoterol. Chest 2004 0.75
135 Pharmacogenetics of asthma: where are we now? Clin Chest Med 2006 0.75