Published in PLoS One on February 29, 2012
Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes. Acta Crystallogr D Biol Crystallogr (2014) 0.98
Toward aldehyde and alkane production by removing aldehyde reductase activity in Escherichia coli. Metab Eng (2014) 0.87
Structure of NADP(+)-dependent glutamate dehydrogenase from Escherichia coli--reflections on the basis of coenzyme specificity in the family of glutamate dehydrogenases. FEBS J (2013) 0.84
Automated identification of elemental ions in macromolecular crystal structures. Acta Crystallogr D Biol Crystallogr (2014) 0.80
Crystallization of proteins from crude bovine rod outer segments. Methods Enzymol (2015) 0.79
GH1-family 6-P-β-glucosidases from human microbiome lactic acid bacteria. Acta Crystallogr D Biol Crystallogr (2013) 0.78
Multiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological Implications. Biology (Basel) (2016) 0.75
Evolution of aromatic β-glucoside utilization by successive mutational steps in Escherichia coli. J Bacteriol (2014) 0.75
Characterization of a novel metagenome-derived 6-phospho-β-glucosidase from black liquor sediment. Appl Environ Microbiol (2013) 0.75
The 3-D Structural Basis for the Pgi Genotypic Differences in the Performance of the Butterfly Melitaea cinxia at Different Temperatures. PLoS One (2016) 0.75
Proteins evolve on the edge of supramolecular self-assembly. Nature (2017) 0.75
In vitro and in silico characterization of metagenomic soil-derived cellulases capable of hydrolyzing oil palm empty fruit bunch. Biotechnol Rep (Amst) (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
The complete genome sequence of Escherichia coli K-12. Science (1997) 84.27
XDS. Acta Crystallogr D Biol Crystallogr (2010) 67.46
Inference of macromolecular assemblies from crystalline state. J Mol Biol (2007) 44.95
REFMAC5 for the refinement of macromolecular crystal structures. Acta Crystallogr D Biol Crystallogr (2011) 39.32
Automated protein model building combined with iterative structure refinement. Nat Struct Biol (1999) 27.52
Molecular replacement with MOLREP. Acta Crystallogr D Biol Crystallogr (2009) 26.26
Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science (2010) 11.37
BALBES: a molecular-replacement pipeline. Acta Crystallogr D Biol Crystallogr (2007) 9.29
Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res (2006) 7.93
Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard. Acta Crystallogr D Biol Crystallogr (2007) 7.72
High-resolution structure prediction and the crystallographic phase problem. Nature (2007) 7.67
Crystal structure of a monomeric retroviral protease solved by protein folding game players. Nat Struct Mol Biol (2011) 5.02
EcoCyc: a comprehensive database of Escherichia coli biology. Nucleic Acids Res (2010) 4.68
A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion. Proc Natl Acad Sci U S A (2002) 4.16
Automated protein crystal structure determination using ELVES. Proc Natl Acad Sci U S A (2004) 4.10
Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics (2008) 3.78
Exploration of uncharted regions of the protein universe. PLoS Biol (2009) 3.41
Comparative anatomy of the aldo-keto reductase superfamily. Biochem J (1997) 3.39
Improved molecular replacement by density- and energy-guided protein structure optimization. Nature (2011) 2.74
Modelling bound ligands in protein crystal structures. Acta Crystallogr D Biol Crystallogr (2004) 1.86
Protein oligomerization: how and why. Bioorg Med Chem (2005) 1.85
Improving radiation-damage substructures for RIP. Acta Crystallogr D Biol Crystallogr (2005) 1.80
The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr (2007) 1.75
Protein structure determination by exhaustive search of Protein Data Bank derived databases. Proc Natl Acad Sci U S A (2010) 1.66
A microfluidic device for kinetic optimization of protein crystallization and in situ structure determination. J Am Chem Soc (2006) 1.65
Glutamate dehydrogenase from Escherichia coli: purification and properties. J Bacteriol (1975) 1.51
Crystallographic ab initio protein structure solution below atomic resolution. Nat Methods (2009) 1.38
Structural genomics: from genes to structures with valuable materials and many questions in between. Nat Methods (2008) 1.33
Protein crystallization using microfluidic technologies based on valves, droplets, and SlipChip. Annu Rev Biophys (2010) 1.28
Prospects for de novo phasing with de novo protein models. Acta Crystallogr D Biol Crystallogr (2009) 1.22
Escherichia coli Hsp31 functions as a holding chaperone that cooperates with the DnaK-DnaJ-GrpE system in the management of protein misfolding under severe stress conditions. Mol Microbiol (2004) 1.09
Phasing in the presence of radiation damage. J Synchrotron Radiat (2005) 1.08
Predicting protein crystallization propensity from protein sequence. J Struct Funct Genomics (2010) 1.04
A relationship between mRNA expression levels and protein solubility in E. coli. J Mol Biol (2009) 1.01
The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening. J Mol Biol (2004) 0.99
A novel aldo-keto reductase from Escherichia coli can increase resistance to methylglyoxal toxicity. FEMS Microbiol Lett (2003) 0.94
Crystal structure of phosphoglucose isomerase from pig muscle and its complex with 5-phosphoarabinonate. Proteins (2002) 0.94
Fractionation of soluble proteins in Escherichia coli using DEAE-, SP-, and phenyl sepharose chromatographies. J Biomol Tech (2004) 0.88
Increasing incidence of necrotizing fasciitis in New Zealand: a nationwide study over the period 1990 to 2006. J Infect (2011) 0.87
Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4. Mol Cell Endocrinol (2008) 0.86
Capillary electrophoresis/tandem mass spectrometry for analysis of proteins from two-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis. Rapid Commun Mass Spectrom (1999) 0.77
Identification of proteins from two-dimensional gel electrophoresis of human erythroleukemia cells using capillary high performance liquid chromatography/electrospray-ion trap-reflectron time-of-flight mass spectrometry with two-dimensional topographic map analysis of in-gel tryptic digest products. Rapid Commun Mass Spectrom (1999) 0.77
High-efficiency capillary isoelectric focusing of protein complexes from Escherichia coli cytosolic extracts. J Chromatogr A (2001) 0.77
Eosinophilia-myalgia syndrome or fibromyalgia with eosinophilia? JAMA (1993) 0.77
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Towards automated crystallographic structure refinement with phenix.refine. Acta Crystallogr D Biol Crystallogr (2012) 11.31
Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci Transl Med (2012) 5.69
c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response. Science (2010) 5.31
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science (2014) 5.13
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell (2005) 4.83
Evolutionary relationships and structural mechanisms of AAA+ proteins. Annu Rev Biophys Biomol Struct (2006) 4.74
A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion. Proc Natl Acad Sci U S A (2002) 4.16
Automated protein crystal structure determination using ELVES. Proc Natl Acad Sci U S A (2004) 4.10
An integrated approach for finding overlooked genes in yeast. Nat Biotechnol (2002) 3.88
The Phenix software for automated determination of macromolecular structures. Methods (2011) 3.81
Global landscape of HIV-human protein complexes. Nature (2011) 3.70
Simultaneous femtosecond X-ray spectroscopy and diffraction of photosystem II at room temperature. Science (2013) 3.60
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology. Q Rev Biophys (2008) 3.50
Running in reverse: the structural basis for translocation polarity in hexameric helicases. Cell (2009) 3.38
Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases. Annu Rev Biophys Biomol Struct (2004) 3.37
Hidden alternative structures of proline isomerase essential for catalysis. Nature (2009) 3.28
Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals. Chem Biol (2009) 3.11
Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading. Cell (2003) 3.00
DNA replication initiation: mechanisms and regulation in bacteria. Nat Rev Microbiol (2007) 2.96
The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nat Struct Mol Biol (2011) 2.93
Accessing protein conformational ensembles using room-temperature X-ray crystallography. Proc Natl Acad Sci U S A (2011) 2.92
HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. Mol Cell (2010) 2.91
Molecular fossils in the human genome: identification and analysis of the pseudogenes in chromosomes 21 and 22. Genome Res (2002) 2.89
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol Cell (2008) 2.85
Structural basis for gate-DNA recognition and bending by type IIA topoisomerases. Nature (2007) 2.79
Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling. Nat Struct Mol Biol (2006) 2.73
Normal mode analysis of macromolecular motions in a database framework: developing mode concentration as a useful classifying statistic. Proteins (2002) 2.72
The protective antigen component of anthrax toxin forms functional octameric complexes. J Mol Biol (2009) 2.69
All tangled up: how cells direct, manage and exploit topoisomerase function. Nat Rev Mol Cell Biol (2011) 2.66
Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export. Nat Cell Biol (2006) 2.58
Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure (2005) 2.53
Saccharomyces cerevisiae septins: supramolecular organization of heterooligomers and the mechanism of filament assembly. Proc Natl Acad Sci U S A (2008) 2.46
Room temperature femtosecond X-ray diffraction of photosystem II microcrystals. Proc Natl Acad Sci U S A (2012) 2.43
Crystallization reports are the backbone of Acta Cryst. F, but do they have any spine? Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 2.43
Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nat Struct Biol (2002) 2.38
New Python-based methods for data processing. Acta Crystallogr D Biol Crystallogr (2013) 2.34
Nanoflow electrospinning serial femtosecond crystallography. Acta Crystallogr D Biol Crystallogr (2012) 2.32
The protein target list of the Northeast Structural Genomics Consortium. Proteins (2004) 2.31
Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases. Nat Struct Biol (2003) 2.27
Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis. Nat Struct Mol Biol (2004) 2.25
Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa. Proc Natl Acad Sci U S A (2009) 2.17
Automated electron-density sampling reveals widespread conformational polymorphism in proteins. Protein Sci (2010) 2.16
ISPyB: an information management system for synchrotron macromolecular crystallography. Bioinformatics (2011) 2.14
Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex. Science (2007) 2.10
The structural basis for substrate specificity in DNA topoisomerase IV. J Mol Biol (2005) 2.08
Structure and function of the conserved core of histone deposition protein Asf1. Curr Biol (2003) 2.02
Regulation of ubiquitin chain initiation to control the timing of substrate degradation. Mol Cell (2011) 2.01
An alternate conformation and a third metal in PstP/Ppp, the M. tuberculosis PP2C-Family Ser/Thr protein phosphatase. Structure (2004) 1.99
Organelle-targetable fluorescent probes for imaging hydrogen peroxide in living cells via SNAP-Tag protein labeling. J Am Chem Soc (2010) 1.99
The structure of bacterial DnaA: implications for general mechanisms underlying DNA replication initiation. EMBO J (2002) 1.98
Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A. J Virol (2005) 1.96
Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep (2013) 1.96
The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold. Proc Natl Acad Sci U S A (2004) 1.93
The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2. Genes Dev (2004) 1.90
The Database of Macromolecular Motions: new features added at the decade mark. Nucleic Acids Res (2006) 1.89
Molecular dissection of the Munc18c/syntaxin4 interaction: implications for regulation of membrane trafficking. Traffic (2006) 1.88
The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage. J Mol Biol (2012) 1.87
Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol (2006) 1.80
Structure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins. Proc Natl Acad Sci U S A (2007) 1.79
Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation. Mol Cell Biol (2002) 1.77
Suite of three protein crystallography beamlines with single superconducting bend magnet as the source. J Synchrotron Radiat (2004) 1.70
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export. Nature (2011) 1.70
ExpressYourself: A modular platform for processing and visualizing microarray data. Nucleic Acids Res (2003) 1.68
Characterization of phenylpropene O-methyltransferases from sweet basil: facile change of substrate specificity and convergent evolution within a plant O-methyltransferase family. Plant Cell (2002) 1.67
A microfluidic device for kinetic optimization of protein crystallization and in situ structure determination. J Am Chem Soc (2006) 1.65
Binding mechanism of metal⋅NTP substrates and stringent-response alarmones to bacterial DnaG-type primases. Structure (2012) 1.64
Use of knowledge-based restraints in phenix.refine to improve macromolecular refinement at low resolution. Acta Crystallogr D Biol Crystallogr (2012) 1.64
Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae. Mol Biol Cell (2004) 1.63
The energy landscape of adenylate kinase during catalysis. Nat Struct Mol Biol (2015) 1.62
A small reservoir of disabled ORFs in the yeast genome and its implications for the dynamics of proteome evolution. J Mol Biol (2002) 1.62
The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore. Mol Cell (2004) 1.59
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature (2010) 1.59
Structural insights into RNA-dependent ring closure and ATPase activation by the Rho termination factor. Cell (2006) 1.58
Crosstalk between primase subunits can act to regulate primer synthesis in trans. Mol Cell (2005) 1.57
Mining the structural genomics pipeline: identification of protein properties that affect high-throughput experimental analysis. J Mol Biol (2004) 1.57
Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin. Proc Natl Acad Sci U S A (2011) 1.56
DNA stretching by bacterial initiators promotes replication origin opening. Nature (2011) 1.55
Depletion of antibiotic targets has widely varying effects on growth. Proc Natl Acad Sci U S A (2011) 1.54
phenix.mr_rosetta: molecular replacement and model rebuilding with Phenix and Rosetta. J Struct Funct Genomics (2012) 1.53
Normal modes for predicting protein motions: a comprehensive database assessment and associated Web tool. Protein Sci (2005) 1.51
Structural synergy and molecular crosstalk between bacterial helicase loaders and replication initiators. Cell (2008) 1.51
Induction of lignocellulose-degrading enzymes in Neurospora crassa by cellodextrins. Proc Natl Acad Sci U S A (2012) 1.48
The use of workflows in the design and implementation of complex experiments in macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2012) 1.46
SPINE 2: a system for collaborative structural proteomics within a federated database framework. Nucleic Acids Res (2003) 1.46
Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc Natl Acad Sci U S A (2003) 1.44
The nuts and bolts of ring-translocase structure and mechanism. Curr Opin Struct Biol (2011) 1.44
Identification of a DNA primase template tracking site redefines the geometry of primer synthesis. Nat Struct Mol Biol (2008) 1.42
A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria. Sci Signal (2012) 1.41
Escherichia coli condensin MukB stimulates topoisomerase IV activity by a direct physical interaction. Proc Natl Acad Sci U S A (2010) 1.41
Function and structure of a prokaryotic formylglycine-generating enzyme. J Biol Chem (2008) 1.35
Structural analysis of specific metal chelating inhibitor binding to the endonuclease domain of influenza pH1N1 (2009) polymerase. PLoS Pathog (2012) 1.34
Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigenetics. BMC Struct Biol (2006) 1.34
Energy-dispersive X-ray emission spectroscopy using an X-ray free-electron laser in a shot-by-shot mode. Proc Natl Acad Sci U S A (2012) 1.33
Arabidopsis isochorismate synthase functional in pathogen-induced salicylate biosynthesis exhibits properties consistent with a role in diverse stress responses. J Biol Chem (2006) 1.32
Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D. J Biol Chem (2006) 1.31
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3). Proc Natl Acad Sci U S A (2011) 1.30