Published in Nat Methods on December 04, 2011
Biological insights from 108 schizophrenia-associated genetic loci. Nature (2014) 16.13
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet (2012) 11.29
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Improved whole-chromosome phasing for disease and population genetic studies. Nat Methods (2013) 5.43
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet (2012) 4.46
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet (2013) 3.17
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet (2015) 2.59
Phasing of many thousands of genotyped samples. Am J Hum Genet (2012) 2.47
A general approach for haplotype phasing across the full spectrum of relatedness. PLoS Genet (2014) 2.38
Imputation of the rare HOXB13 G84E mutation and cancer risk in a large population-based cohort. PLoS Genet (2015) 2.19
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet (2013) 1.86
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel. Nat Commun (2014) 1.85
Common variants associated with general and MMR vaccine-related febrile seizures. Nat Genet (2014) 1.81
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet (2013) 1.70
A thrifty variant in CREBRF strongly influences body mass index in Samoans. Nat Genet (2016) 1.62
Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci (2015) 1.60
An integrative variant analysis pipeline for accurate genotype/haplotype inference in population NGS data. Genome Res (2013) 1.56
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet (2015) 1.55
Imputation of high-density genotypes in the Fleckvieh cattle population. Genet Sel Evol (2013) 1.48
Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat Genet (2015) 1.47
Novel genetic predictors of venous thromboembolism risk in African Americans. Blood (2016) 1.43
Chimpanzee genomic diversity reveals ancient admixture with bonobos. Science (2016) 1.41
Strong Selection at MHC in Mexicans since Admixture. PLoS Genet (2016) 1.41
Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility. Nat Genet (2017) 1.40
Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis. Lancet Oncol (2016) 1.40
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism. Proc Natl Acad Sci U S A (2014) 1.40
ReMixT: clone-specific genomic structure estimation in cancer. Genome Biol (2017) 1.40
Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania. Nat Commun (2017) 1.38
Nicotine N-glucuronidation relative to N-oxidation and C-oxidation and UGT2B10 genotype in five ethnic/racial groups. Carcinogenesis (2014) 1.36
Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT). Mol Psychiatry (2013) 1.34
POPULATION GENETICS. Genomic evidence for the Pleistocene and recent population history of Native Americans. Science (2015) 1.33
Improved statistics for genome-wide interaction analysis. PLoS Genet (2012) 1.33
Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls. PLoS Pathog (2013) 1.33
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity. J Clin Invest (2014) 1.25
DIST: direct imputation of summary statistics for unmeasured SNPs. Bioinformatics (2013) 1.25
Genome-wide diversity in the levant reveals recent structuring by culture. PLoS Genet (2013) 1.20
Genotype imputation via matrix completion. Genome Res (2012) 1.18
New loci associated with chronic hepatitis B virus infection in Han Chinese. Nat Genet (2013) 1.18
Genomic reconstruction of the history of extant populations of India reveals five distinct ancestral components and a complex structure. Proc Natl Acad Sci U S A (2016) 1.17
Rare-variant extensions of the transmission disequilibrium test: application to autism exome sequence data. Am J Hum Genet (2013) 1.16
GIGI: an approach to effective imputation of dense genotypes on large pedigrees. Am J Hum Genet (2013) 1.15
Efficient haplotype matching and storage using the positional Burrows-Wheeler transform (PBWT). Bioinformatics (2014) 1.15
Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun (2015) 1.14
Biased allelic expression in human primary fibroblast single cells. Am J Hum Genet (2014) 1.13
Genetic evidence for two founding populations of the Americas. Nature (2015) 1.13
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet (2016) 1.08
Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types. Hum Mol Genet (2014) 1.08
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet (2016) 1.08
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways. Nat Commun (2015) 1.04
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. Nat Commun (2014) 1.04
Evidence for a Common Origin of Blacksmiths and Cultivators in the Ethiopian Ari within the Last 4500 Years: Lessons for Clustering-Based Inference. PLoS Genet (2015) 1.03
Population genetic differentiation of height and body mass index across Europe. Nat Genet (2015) 1.03
Amerindian-specific regions under positive selection harbour new lipid variants in Latinos. Nat Commun (2014) 1.02
Genome-wide analysis of cold adaptation in indigenous Siberian populations. PLoS One (2014) 1.02
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. Am J Hum Genet (2015) 1.01
Next-generation genotype imputation service and methods. Nat Genet (2016) 1.01
Polygenic scores predict alcohol problems in an independent sample and show moderation by the environment. Genes (Basel) (2014) 1.01
Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci. Nat Commun (2015) 1.01
Efficient haplotype block recognition of very long and dense genetic sequences. BMC Bioinformatics (2014) 1.01
Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer. Hum Mol Genet (2013) 1.00
Fast and accurate long-range phasing in a UK Biobank cohort. Nat Genet (2016) 1.00
Tracing the route of modern humans out of Africa by using 225 human genome sequences from Ethiopians and Egyptians. Am J Hum Genet (2015) 1.00
Reference-based phasing using the Haplotype Reference Consortium panel. Nat Genet (2016) 0.98
High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms. PLoS Genet (2014) 0.98
A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain. Eur J Pain (2015) 0.97
The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations. Cancer Epidemiol Biomarkers Prev (2014) 0.97
A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Cancer Discov (2015) 0.97
Genetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association Studies. J Mol Biol (2015) 0.96
Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations. Proc Natl Acad Sci U S A (2015) 0.95
Assessing the Causal Relationship of Maternal Height on Birth Size and Gestational Age at Birth: A Mendelian Randomization Analysis. PLoS Med (2015) 0.95
Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort. Genome Res (2015) 0.94
The Andean adaptive toolkit to counteract high altitude maladaptation: genome-wide and phenotypic analysis of the Collas. PLoS One (2014) 0.94
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. PLoS Genet (2013) 0.94
Genomic Insights into the Ancestry and Demographic History of South America. PLoS Genet (2015) 0.93
A genome-wide association study of bronchodilator response in Latinos implicates rare variants. J Allergy Clin Immunol (2013) 0.93
Identification of new susceptibility loci for IgA nephropathy in Han Chinese. Nat Commun (2015) 0.93
Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response. Clin Pharmacol Ther (2015) 0.93
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Sci Rep (2015) 0.92
Detecting structure of haplotypes and local ancestry. Genetics (2014) 0.92
Genomic modulators of gene expression in human neutrophils. Nat Commun (2015) 0.91
Poly-omic prediction of complex traits: OmicKriging. Genet Epidemiol (2014) 0.91
Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer. Cancer Discov (2015) 0.90
Unravelling the hidden ancestry of American admixed populations. Nat Commun (2015) 0.90
A Genome-wide Association Study Provides Evidence of Sex-specific Involvement of Chr1p35.1 (ZSCAN20-TLR12P) and Chr8p23.1 (HMGB1P46) With Diabetic Neuropathic Pain. EBioMedicine (2015) 0.90
Whole-genome haplotyping approaches and genomic medicine. Genome Med (2014) 0.90
Detection of recombination events, haplotype reconstruction and imputation of sires using half-sib SNP genotypes. Genet Sel Evol (2014) 0.90
Genome-wide patterns of identity-by-descent sharing in the French Canadian founder population. Eur J Hum Genet (2013) 0.90
CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus. Cancer Res (2015) 0.89
Using genome-wide measures of coancestry to maintain diversity and fitness in endangered and domestic pig populations. Genome Res (2015) 0.89
The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape. Curr Biol (2015) 0.89
Family-based approaches: design, imputation, analysis, and beyond. BMC Genet (2016) 0.89
fcGENE: a versatile tool for processing and transforming SNP datasets. PLoS One (2014) 0.89
A novel colorectal cancer risk locus at 4q32.2 identified from an international genome-wide association study. Carcinogenesis (2014) 0.89
Genetic risk factors in two Utah pedigrees at high risk for suicide. Transl Psychiatry (2013) 0.89
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells. Nat Commun (2015) 0.88
The industrial melanism mutation in British peppered moths is a transposable element. Nature (2016) 0.88
Identification of four new susceptibility loci for testicular germ cell tumour. Nat Commun (2015) 0.88
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. Pharmacogenomics J (2014) 0.87
First genome-wide association study in an Australian aboriginal population provides insights into genetic risk factors for body mass index and type 2 diabetes. PLoS One (2015) 0.87
Molecular validation of the schizophrenia spectrum. Schizophr Bull (2013) 0.87
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
A new statistical method for haplotype reconstruction from population data. Am J Hum Genet (2001) 59.30
A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet (2007) 52.68
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet (2009) 30.09
A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase. Am J Hum Genet (2006) 28.32
A fine-scale map of recombination rates and hotspots across the human genome. Science (2005) 26.82
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41
Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Am J Hum Genet (2007) 24.68
Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data. Genetics (2003) 17.73
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Genotype imputation for genome-wide association studies. Nat Rev Genet (2010) 14.59
A comparison of phasing algorithms for trios and unrelated individuals. Am J Hum Genet (2006) 12.45
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet (2009) 30.09
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet (2012) 11.29
Genotype imputation with thousands of genomes. G3 (Bethesda) (2011) 8.77
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet (2009) 6.61
Two-stage two-locus models in genome-wide association. PLoS Genet (2006) 5.60
Improved whole-chromosome phasing for disease and population genetic studies. Nat Methods (2013) 5.43
A robust statistical method for case-control association testing with copy number variation. Nat Genet (2008) 4.78
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
HAPGEN2: simulation of multiple disease SNPs. Bioinformatics (2011) 2.58
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). J Infect Dis (2009) 2.53
Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer. PLoS Genet (2011) 2.47
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med (2011) 2.07
The origin, evolution, and functional impact of short insertion-deletion variants identified in 179 human genomes. Genome Res (2013) 1.83
Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). J Infect Dis (2009) 1.57
Haplotype estimation using sequencing reads. Am J Hum Genet (2013) 1.56
Comparing algorithms for genotype imputation. Am J Hum Genet (2008) 1.54
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet (2012) 1.52
Genotype calling and phasing using next-generation sequencing reads and a haplotype scaffold. Bioinformatics (2012) 1.51
Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis. Arthritis Res Ther (2014) 1.50
Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls. PLoS Pathog (2013) 1.33
Multiway admixture deconvolution using phased or unphased ancestral panels. Genet Epidemiol (2012) 1.28
CD39/adenosine pathway is involved in AIDS progression. PLoS Pathog (2011) 1.26
Shape-IT: new rapid and accurate algorithm for haplotype inference. BMC Bioinformatics (2008) 1.17
Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS. J Infect Dis (2010) 1.16
Genome-wide association study implicates PARD3B-based AIDS restriction. J Infect Dis (2011) 1.15
Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Arch Gen Psychiatry (2012) 1.08
A model-based approach to capture genetic variation for future association studies. Genome Res (2006) 1.05
Exhaustive genotyping of the CEM15 (APOBEC3G) gene and absence of association with AIDS progression in a French cohort. J Infect Dis (2004) 1.04
The effect of genome-wide association scan quality control on imputation outcome for common variants. Eur J Hum Genet (2011) 1.04
Comparative evaluation of 3D virtual ligand screening methods: impact of the molecular alignment on enrichment. J Chem Inf Model (2010) 1.02
Associations of MHC ancestral haplotypes with resistance/susceptibility to AIDS disease development. J Immunol (2003) 1.01
Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression. J Acquir Immune Defic Syndr (2004) 0.98
Screening low-frequency SNPS from genome-wide association study reveals a new risk allele for progression to AIDS. J Acquir Immune Defic Syndr (2011) 0.98
Bayesian hierarchical mixture modeling to assign copy number from a targeted CNV array. Genet Epidemiol (2011) 0.93
Anti-cytokine therapeutics: history and update. Curr Pharm Des (2009) 0.92
T-cell and neuronal apoptosis in HIV infection: implications for therapeutic intervention. Int Rev Immunol (2003) 0.91
Multicohort genomewide association study reveals a new signal of protection against HIV-1 acquisition. J Infect Dis (2012) 0.89
Genome-wide association scan in HIV-1-infected individuals identifying variants influencing disease course. PLoS One (2011) 0.88
Intra-individual variation in resting metabolic rate during the menstrual cycle. Br J Nutr (2003) 0.88
Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. Genet Epidemiol (2013) 0.87
Active immunization against IL-23p19 improves experimental arthritis. Vaccine (2011) 0.87
Improvement of collagen-induced arthritis by active immunization against murine IL-1beta peptides designed by molecular modelling. Vaccine (2005) 0.87
Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages. PLoS One (2011) 0.87
Vaccination with cytokines in autoimmune diseases. Ann Med (2008) 0.86
Modeling interactions with known risk loci-a Bayesian model averaging approach. Ann Hum Genet (2010) 0.86
Computation of haplotypes on SNPs subsets: advantage of the "global method". BMC Genet (2006) 0.83
Persistent anti-gag, -Nef, and -Rev IgM levels as markers of the impaired functions of CD4+ T-helper lymphocytes during SIVmac251 infection of cynomolgus macaques. J Acquir Immune Defic Syndr (2005) 0.82
ISHAPE: new rapid and accurate software for haplotyping. BMC Bioinformatics (2007) 0.82
Multiple structures for virtual ligand screening: defining binding site properties-based criteria to optimize the selection of the query. J Chem Inf Model (2013) 0.81
Immunogenetics: Genome-Wide Association of Non-Progressive HIV and Viral Load Control: HLA Genes and Beyond. Front Immunol (2013) 0.81
Joint genotype calling with array and sequence data. Genet Epidemiol (2012) 0.81
Associations of the IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFN (gamma) R1 cytokine receptor genes with AIDS progression in a French AIDS cohort. Immunogenetics (2006) 0.81
Immunogenicity of HIV-1 IIIB and SHIV 89.6P Tat and Tat toxoids in rhesus macaques: induction of humoral and cellular immune responses. DNA Cell Biol (2002) 0.80
Identification of IL7RA risk alleles for rapid progression during HIV-1 infection: a comprehensive study in the GRIV cohort. Curr HIV Res (2012) 0.79
NRLiSt BDB, the manually curated nuclear receptors ligands and structures benchmarking database. J Med Chem (2014) 0.79
T-cell receptor excision circles (TREC) and maintenance of long-term non-progression status in HIV-1 infection. AIDS (2003) 0.79
Filtering redundancies for sequence similarity search programs. J Biomol Struct Dyn (2005) 0.79
Genomic approach of AIDS pathogenesis: exhaustive genotyping of the TNFR1 gene in a French AIDS cohort. Biomed Pharmacother (2005) 0.78
Exploration of associations between phospholipase A2 gene family polymorphisms and AIDS progression using the SNPlex method. Biomed Pharmacother (2007) 0.78
Analysis of IGG and IGG4 in HIV-1 seropositive patients and correlation with biological and genetic markers. Biomed Pharmacother (2005) 0.77
Importance of the pharmacological profile of the bound ligand in enrichment on nuclear receptors: toward the use of experimentally validated decoy ligands. J Chem Inf Model (2014) 0.77
Haplotype inference. Methods Mol Biol (2012) 0.77
Udock, the interactive docking entertainment system. Faraday Discuss (2014) 0.75
The interferon antagonist sarcolectin in the progress of HIV-1 infection and in AIDS. J Interferon Cytokine Res (2002) 0.75