Published in Cell Metab on December 07, 2011
Dual functions of TAF7L in adipocyte differentiation. Elife (2013) 1.03
Transcriptional coregulators: fine-tuning metabolism. Cell Metab (2014) 0.93
The prolonged survival of fibroblasts with forced lipid catabolism in visceral fat following encapsulation in alginate-poly-L-lysine. Biomaterials (2012) 0.84
Hkat, a novel nutritionally regulated transmembrane protein in adipose tissues. Sci Rep (2012) 0.80
Elevation of transcription factor Islet-1 levels in vivo increases β-cell function but not β-cell mass. Islets (2012) 0.79
Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene. PLoS One (2012) 0.76
RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet (2009) 58.77
Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell (1987) 22.17
The mammalian epigenome. Cell (2007) 18.13
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell (1994) 17.58
Widespread transcription at neuronal activity-regulated enhancers. Nature (2010) 16.52
High-resolution mapping and characterization of open chromatin across the genome. Cell (2008) 15.93
Direct multiplexed measurement of gene expression with color-coded probe pairs. Nat Biotechnol (2008) 15.90
Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13
Global mapping of protein-DNA interactions in vivo by digital genomic footprinting. Nat Methods (2009) 10.17
Pax7 is required for the specification of myogenic satellite cells. Cell (2000) 9.88
Discovery and characterization of chromatin states for systematic annotation of the human genome. Nat Biotechnol (2010) 9.84
RNA sequencing: advances, challenges and opportunities. Nat Rev Genet (2010) 8.96
Protein sensors for membrane sterols. Cell (2006) 8.62
FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin. Genome Res (2006) 7.72
Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding. Science (2010) 7.41
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. Nature (2010) 6.87
Transcriptional control of brown fat determination by PRDM16. Cell Metab (2007) 6.79
A map of open chromatin in human pancreatic islets. Nat Genet (2010) 6.75
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature (2011) 6.10
Insights from genomic profiling of transcription factors. Nat Rev Genet (2009) 5.57
Accurate inference of transcription factor binding from DNA sequence and chromatin accessibility data. Genome Res (2010) 5.40
Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis. Genes Dev (2008) 4.93
PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev (2008) 4.83
High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells. Genome Res (2010) 4.69
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell (2006) 4.64
Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (2004) 4.55
Genome-wide approaches to studying chromatin modifications. Nat Rev Genet (2008) 4.28
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med (2008) 4.25
A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell (2007) 4.13
Comparative epigenomic analysis of murine and human adipogenesis. Cell (2010) 4.08
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J (2004) 3.92
Transcriptional control of preadipocyte determination by Zfp423. Nature (2010) 3.55
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell (2005) 3.52
Hybridization interactions between probesets in short oligo microarrays lead to spurious correlations. BMC Bioinformatics (2006) 3.44
Locating mammalian transcription factor binding sites: a survey of computational and experimental techniques. Genome Res (2006) 2.82
A survey of DNA motif finding algorithms. BMC Bioinformatics (2007) 2.79
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell (2010) 2.68
Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis. EMBO J (2011) 2.66
Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages. Mol Cell Biol (2010) 2.47
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. Diabetes (2009) 2.34
Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metab (2005) 2.29
Propagation of adipogenic signals through an epigenomic transition state. Genes Dev (2010) 2.23
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab (2010) 2.21
Rfx6 directs islet formation and insulin production in mice and humans. Nature (2010) 2.15
Histone methyl transferases and demethylases; can they link metabolism and transcription? Cell Metab (2010) 2.04
PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A (2010) 1.71
Systematic gene expression mapping clusters nuclear receptors according to their function in the brain. Cell (2007) 1.58
Interferon regulatory factors are transcriptional regulators of adipogenesis. Cell Metab (2008) 1.55
Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression. J Cell Biochem (1992) 1.54
Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites. BMC Genomics (2011) 1.52
Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development (2010) 1.43
A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development (2006) 1.32
A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci (2009) 1.27
Species-specific strategies underlying conserved functions of metabolic transcription factors. Mol Endocrinol (2011) 1.25
Understanding "active" chromatin: a historical perspective of chromatin remodeling. Crit Rev Eukaryot Gene Expr (2000) 1.05
Fasting of 3-day-old chicks leads to changes in histone H3 methylation status. Physiol Behav (2011) 0.79
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature (2012) 14.67
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature (2002) 14.37
PRDM16 controls a brown fat/skeletal muscle switch. Nature (2008) 13.08
Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab (2005) 11.66
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell (2012) 11.03
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell (2006) 10.18
Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature (2006) 10.07
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev (2003) 9.93
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature (2003) 9.77
Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem (2008) 9.56
Adipocytes as regulators of energy balance and glucose homeostasis. Nature (2006) 9.52
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell (2004) 8.58
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A (2007) 8.23
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest (2010) 6.96
Transcriptional control of brown fat determination by PRDM16. Cell Metab (2007) 6.79
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev (2006) 6.68
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A (2004) 6.53
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev (2002) 6.46
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature (2008) 5.85
Charting a dynamic DNA methylation landscape of the human genome. Nature (2013) 5.80
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 5.71
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56
The role of exercise and PGC1alpha in inflammation and chronic disease. Nature (2008) 5.31
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A (2006) 5.28
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab (2006) 5.01
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature (2010) 5.01
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature (2009) 4.98
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab (2005) 4.65
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem (2007) 4.58
Retracted Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A (2009) 4.37
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci U S A (2003) 4.34
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci U S A (2003) 4.31
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature (2011) 4.23
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem (2001) 4.20
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem (2003) 4.12
Comparative epigenomic analysis of murine and human adipogenesis. Cell (2010) 4.08
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell (2005) 4.04
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev (2008) 3.90
Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev (2013) 3.74
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell (2013) 3.71
Molecular mechanisms of cancer development in obesity. Nat Rev Cancer (2011) 3.65
Transcriptional control of preadipocyte determination by Zfp423. Nature (2010) 3.55
Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. J Appl Physiol (1985) (2008) 3.54
Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell (2005) 3.54
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev (2006) 3.48
The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes (2007) 3.42
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature (2002) 3.42
PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab (2012) 3.09
The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab (2007) 3.05
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest (2007) 3.02
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol (2004) 3.00
Transcriptional control of brown fat development. Cell Metab (2010) 2.97
Transcriptional control of adipose lipid handling by IRF4. Cell Metab (2011) 2.95
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest (2003) 2.87
Retracted Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metab (2008) 2.80
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes Dev (2007) 2.79
Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc Natl Acad Sci U S A (2006) 2.71
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell (2010) 2.68
Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes Dev (2009) 2.66
Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci U S A (2008) 2.49
Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab (2012) 2.41
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev (2004) 2.39
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab (2006) 2.37
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell (2012) 2.35
Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol Cell (2003) 2.31
Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metab (2005) 2.29
PGC-1beta in the regulation of hepatic glucose and energy metabolism. J Biol Chem (2003) 2.20
Irisin ERKs the fat. Diabetes (2014) 2.05
Lessons on conditional gene targeting in mouse adipose tissue. Diabetes (2013) 2.04
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab (2011) 2.02
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology (2011) 2.00
Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab (2012) 1.92
APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A (2002) 1.89
Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J Biol Chem (2002) 1.87
Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade. Mol Cell Biol (2006) 1.86
Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes Dev (2006) 1.85
A novel therapeutic approach to treating obesity through modulation of TGFβ signaling. Endocrinology (2012) 1.83
A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proc Natl Acad Sci U S A (2007) 1.79
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metab (2013) 1.76
Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev (2005) 1.73
PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A (2010) 1.71
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell (2003) 1.71
PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proc Natl Acad Sci U S A (2009) 1.67
The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis. Proc Natl Acad Sci U S A (2008) 1.67
Fat cells directly sense temperature to activate thermogenesis. Proc Natl Acad Sci U S A (2013) 1.64
Development of insulin resistance in mice lacking PGC-1α in adipose tissues. Proc Natl Acad Sci U S A (2012) 1.61
Synergy between PPARgamma ligands and platinum-based drugs in cancer. Cancer Cell (2007) 1.60
Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study. Breast Cancer Res Treat (2003) 1.60
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol (2003) 1.60
FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc Natl Acad Sci U S A (2007) 1.55
Interferon regulatory factors are transcriptional regulators of adipogenesis. Cell Metab (2008) 1.55
Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation. Proc Natl Acad Sci U S A (2008) 1.45
A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. Cancer J (2002) 1.33
Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. Diabetes (2009) 1.31
Regulation of early adipose commitment by Zfp521. PLoS Biol (2012) 1.30
A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis. J Biol Chem (2008) 1.16