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S D Emr

Author PubWeight™ 390.87‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Autophagy as a regulated pathway of cellular degradation. Science 2000 17.27
2 Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol Cell Biol 1988 13.27
3 A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast. J Cell Biol 1995 12.18
4 Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 2001 9.08
5 Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 1993 7.86
6 The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J 1998 7.68
7 The fungal vacuole: composition, function, and biogenesis. Microbiol Rev 1990 6.98
8 Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum. Cell 1994 6.57
9 Suppressor mutations that restore export of a protein with a defective signal sequence. Cell 1981 6.33
10 Mechanisms of protein localization. Microbiol Rev 1983 6.12
11 Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Cell 1998 6.07
12 Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease. Cell 1987 5.92
13 Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant. J Cell Biol 1991 5.76
14 Isolation of yeast mutants defective in protein targeting to the vacuole. Proc Natl Acad Sci U S A 1986 5.71
15 Intracellular sorting and processing of a yeast vacuolar hydrolase: proteinase A propeptide contains vacuolar targeting information. Mol Cell Biol 1988 5.42
16 Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol Cell Biol 1990 5.25
17 Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase. EMBO J 1989 5.12
18 The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell 1994 5.10
19 Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p. EMBO J 1997 5.05
20 Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sorting. J Cell Biol 1988 4.90
21 Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant. Mol Biol Cell 1996 4.71
22 Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast. Mol Biol Cell 1996 4.58
23 A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol 1998 4.41
24 Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Traffic 2000 4.17
25 A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole. J Cell Biol 1997 4.16
26 Phosphoinositides as regulators in membrane traffic. Science 1996 4.13
27 The amino terminus of the yeast F1-ATPase beta-subunit precursor functions as a mitochondrial import signal. J Cell Biol 1986 4.07
28 Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains. Mol Cell 1998 4.01
29 An MF alpha 1-SUC2 (alpha-factor-invertase) gene fusion for study of protein localization and gene expression in yeast. Proc Natl Acad Sci U S A 1983 3.95
30 Characterization of a component of the yeast secretion machinery: identification of the SEC18 gene product. Mol Cell Biol 1988 3.74
31 New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion. J Cell Biol 2000 3.69
32 Mutations affecting localization of an Escherichia coli outer membrane protein, the bacteriophage lambda receptor. J Mol Biol 1980 3.62
33 Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. J Cell Biol 1997 3.61
34 The role of phosphoinositides in membrane transport. Curr Opin Cell Biol 2001 3.57
35 The Saccharomyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex. J Cell Biol 1989 3.55
36 A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. EMBO J 1993 3.49
37 Sequence analysis of mutations that prevent export of lambda receptor, an Escherichia coli outer membrane protein. Nature 1980 3.36
38 Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast. J Cell Biol 1994 3.32
39 The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 1997 3.30
40 Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion. Mol Cell 2000 3.30
41 A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole. Mol Biol Cell 1997 3.27
42 Yeast vacuolar proenzymes are sorted in the late Golgi complex and transported to the vacuole via a prevacuolar endosome-like compartment. J Cell Biol 1993 3.25
43 Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. J Cell Biol 1998 3.24
44 Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J Cell Biol 1995 3.16
45 Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nat Cell Biol 2001 3.14
46 Intracellular targeting and import of an F1-ATPase beta-subunit-beta-galactosidase hybrid protein into yeast mitochondria. Proc Natl Acad Sci U S A 1984 3.02
47 Receptor-mediated protein sorting to the vacuole in yeast: roles for a protein kinase, a lipid kinase and GTP-binding proteins. Annu Rev Cell Dev Biol 1995 2.93
48 A mechanism of protein localization: the signal hypothesis and bacteria. J Cell Biol 1980 2.91
49 VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins. EMBO J 1994 2.90
50 Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics. Mol Biol Cell 2000 2.87
51 Localization and processing of outer membrane and periplasmic proteins in Escherichia coli strains harboring export-specific suppressor mutations. J Biol Chem 1982 2.85
52 A previously unidentified gene in the spc operon of Escherichia coli K12 specifies a component of the protein export machinery. Cell 1982 2.84
53 Vam7p, a SNAP-25-like molecule, and Vam3p, a syntaxin homolog, function together in yeast vacuolar protein trafficking. Mol Cell Biol 1998 2.80
54 Cytoplasm to vacuole trafficking of aminopeptidase I requires a t-SNARE-Sec1p complex composed of Tlg2p and Vps45p. EMBO J 1999 2.77
55 Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells. J Cell Biol 1995 2.74
56 Phosphoinositide signaling and the regulation of membrane trafficking in yeast. Trends Biochem Sci 2000 2.72
57 Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities. J Biol Chem 1994 2.66
58 Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast. Mol Biol Cell 1995 2.64
59 A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole. Cell 1991 2.64
60 A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. J Cell Biol 1996 2.62
61 Mutations in the VPS45 gene, a SEC1 homologue, result in vacuolar protein sorting defects and accumulation of membrane vesicles. J Cell Sci 1994 2.61
62 Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component. EMBO J 1997 2.60
63 The VPS16 gene product associates with a sedimentable protein complex and is essential for vacuolar protein sorting in yeast. J Biol Chem 1993 2.50
64 The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization. Mol Biol Cell 1995 2.50
65 Phosphoinositide signaling and turnover: PtdIns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities. EMBO J 1998 2.44
66 Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis. J Cell Biol 1998 2.43
67 A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation. Mol Cell Biol 1991 2.38
68 Mutations altering the cellular localization of the phage lambda receptor, an Escherichia coli outer membrane protein. Proc Natl Acad Sci U S A 1978 2.37
69 Characterization of yeast Vps33p, a protein required for vacuolar protein sorting and vacuole biogenesis. Mol Cell Biol 1990 2.32
70 ARF is required for maintenance of yeast Golgi and endosome structure and function. Mol Biol Cell 1998 2.32
71 Alternative pathways for the sorting of soluble vacuolar proteins in yeast: a vps35 null mutant missorts and secretes only a subset of vacuolar hydrolases. Mol Biol Cell 1992 2.32
72 GAL2 codes for a membrane-bound subunit of the galactose permease in Saccharomyces cerevisiae. J Bacteriol 1986 2.30
73 A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast. Mol Biol Cell 1997 2.24
74 Mutants of Saccharomyces cerevisiae that block intervacuole vesicular traffic and vacuole division and segregation. Proc Natl Acad Sci U S A 1990 2.18
75 Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 1999 2.18
76 COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants. J Cell Biol 1997 2.16
77 Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. Curr Biol 1999 2.15
78 A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor. Mol Biol Cell 1997 2.14
79 Protein traffic in the yeast endocytic and vacuolar protein sorting pathways. Curr Opin Cell Biol 1998 2.13
80 Location, location, location: membrane targeting directed by PX domains. Science 2001 2.09
81 Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Mol Biol Cell 2001 1.99
82 Importance of secondary structure in the signal sequence for protein secretion. Proc Natl Acad Sci U S A 1983 1.98
83 A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery. EMBO J 1991 1.93
84 The AP-3 complex: a coat of many colours. Trends Cell Biol 1998 1.92
85 Invertase beta-galactosidase hybrid proteins fail to be transported from the endoplasmic reticulum in Saccharomyces cerevisiae. Mol Cell Biol 1984 1.91
86 D-ribose metabolism in Escherichia coli K-12: genetics, regulation, and transport. J Bacteriol 1984 1.89
87 In vitro reconstitution of intercompartmental protein transport to the yeast vacuole. J Cell Biol 1990 1.85
88 Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery. Protein Sci 1999 1.84
89 Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways. J Biol Chem 1999 1.80
90 Clathrin-dependent localization of alpha 1,3 mannosyltransferase to the Golgi complex of Saccharomyces cerevisiae. J Cell Biol 1994 1.79
91 Phosphatidylinositol 3-phosphate recognition by the FYVE domain. Mol Cell 1999 1.76
92 The class C Vps complex functions at multiple stages of the vacuolar transport pathway. Traffic 2001 1.73
93 AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain. Proc Natl Acad Sci U S A 1994 1.72
94 Yeast Gga coat proteins function with clathrin in Golgi to endosome transport. Mol Biol Cell 2001 1.72
95 Formation of AP-3 transport intermediates requires Vps41 function. Nat Cell Biol 1999 1.69
96 Molecular components of the signal sequence that function in the initiation of protein export. J Cell Biol 1982 1.65
97 A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development. Mol Cell Biol 1995 1.64
98 Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway. EMBO J 1993 1.59
99 Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE. J Cell Biol 1998 1.58
100 The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases. J Biol Chem 1993 1.58
101 A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins. Mol Cell Biol 1996 1.56
102 Protein transport to the yeast vacuole. Curr Opin Cell Biol 1995 1.50
103 An essential role for a protein and lipid kinase complex in secretory protein sorting. Trends Cell Biol 1992 1.46
104 A novel RING finger protein, Vps8p, functionally interacts with the small GTPase, Vps21p, to facilitate soluble vacuolar protein localization. J Biol Chem 1996 1.39
105 A new class of lysosomal/vacuolar protein sorting signals. J Biol Chem 1990 1.38
106 COPI in ER/Golgi and intra-Golgi transport: do yeast COPI mutants point the way? Biochim Biophys Acta 1998 1.36
107 Heat-shock proteins can substitute for SecB function during protein export in Escherichia coli. EMBO J 1991 1.31
108 Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast. Proc Natl Acad Sci U S A 1997 1.28
109 Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology. J Cell Sci 1995 1.26
110 Receptor signalling and the regulation of endocytic membrane transport. Curr Opin Cell Biol 1996 1.25
111 Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains. Mol Biol Cell 2001 1.25
112 MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast. Mol Biol Cell 1999 1.18
113 The yeast F1-ATPase beta subunit precursor contains functionally redundant mitochondrial protein import information. Mol Cell Biol 1987 1.17
114 Invertase fusion proteins for analysis of protein trafficking in yeast. Methods Enzymol 2000 1.16
115 Genetic and biochemical studies of protein sorting to the yeast vacuole. Curr Opin Cell Biol 1993 1.15
116 Ligand recognition and domain structure of Vps10p, a vacuolar protein sorting receptor in Saccharomyces cerevisiae. Eur J Biochem 1999 1.14
117 Novel pathways, membrane coats and PI kinase regulation in yeast lysosomal trafficking. Semin Cell Dev Biol 1998 1.14
118 Multiple pathways for vacuolar sorting of yeast proteinase A. J Biol Chem 1996 1.12
119 The presence of both the signal sequence and a region of mature LamB protein is required for the interaction of LamB with the export factor SecB. J Biol Chem 1990 1.11
120 Isolation of subcellular fractions from the yeast Saccharomyces cerevisiae. Curr Protoc Cell Biol 2001 1.04
121 Characterization of a region in mature LamB protein that interacts with a component of the export machinery of Escherichia coli. J Biol Chem 1990 1.04
122 The genetics of protein secretion in Escherichia coli. Methods Cell Biol 1981 1.02
123 Sequence and structural requirements of a mitochondrial protein import signal defined by saturation cassette mutagenesis. Mol Cell Biol 1989 1.00
124 Mitochondrial protein import: isolation and characterization of the Saccharomyces cerevisiae MFT1 gene. Mol Gen Genet 1991 0.97
125 Molecular dissection of guanine nucleotide dissociation inhibitor function in vivo. Rab-independent binding to membranes and role of Rab recycling factors. J Biol Chem 1999 0.96
126 Genetic studies on mechanisms of protein localization in Escherichia coli K-12. J Supramol Struct 1980 0.85
127 Overview of subcellular fractionation procedures for the yeast Saccharomyces cerevisiae. Curr Protoc Cell Biol 2001 0.81
128 The signal hypothesis in bacteria. Prog Clin Biol Res 1982 0.80
129 Heterologous gene expression in yeast. Methods Enzymol 1990 0.75
130 Regulation of the Saccharomyces cerevisiae Vps34p phosphatidylinositol 3-kinase. Biochem Soc Trans 1997 0.75
131 Novel protein kinase/phosphatidylinositol 3-kinase complex essential for receptor-mediated protein sorting to the vacuole in yeast. Cold Spring Harb Symp Quant Biol 1995 0.75
132 Compartmentalized transport, modification, and sorting of yeast vacuolar hydrolases. Biomed Biochim Acta 1991 0.75