Published in RNA on December 21, 2011
Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol (2013) 3.80
MicroRNA-like viral small RNA from Dengue virus 2 autoregulates its replication in mosquito cells. Proc Natl Acad Sci U S A (2014) 1.78
Discovery of hundreds of mirtrons in mouse and human small RNA data. Genome Res (2012) 1.63
Deep sequencing of small RNAs identifies canonical and non-canonical miRNA and endogenous siRNAs in mammalian somatic tissues. Nucleic Acids Res (2013) 1.12
Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals. Genes Dev (2013) 1.01
IsomiRage: From Functional Classification to Differential Expression of miRNA Isoforms. Front Bioeng Biotechnol (2014) 1.00
Wolbachia infection modifies the profile, shuttling and structure of microRNAs in a mosquito cell line. PLoS One (2014) 0.99
Beta cell 5'-shifted isomiRs are candidate regulatory hubs in type 2 diabetes. PLoS One (2013) 0.99
RNase III-independent microRNA biogenesis in mammalian cells. RNA (2012) 0.96
Regulation of microRNA biogenesis and turnover by animals and their viruses. Cell Mol Life Sci (2013) 0.95
Analysis of Nearly One Thousand Mammalian Mirtrons Reveals Novel Features of Dicer Substrates. PLoS Comput Biol (2015) 0.89
Impact of age-associated increase in 2'-O-methylation of miRNAs on aging and neurodegeneration in Drosophila. Genes Dev (2014) 0.88
The exonuclease Nibbler regulates age-associated traits and modulates piRNA length in Drosophila. Aging Cell (2015) 0.87
Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor. Mol Cell (2015) 0.86
Uridylation of RNA Hairpins by Tailor Confines the Emergence of MicroRNAs in Drosophila. Mol Cell (2015) 0.86
The human TUT1 nucleotidyl transferase as a global regulator of microRNA abundance. PLoS One (2013) 0.86
Comparison of Analysis Tools for miRNA High Throughput Sequencing Using Nerve Crush as a Model. Front Genet (2013) 0.85
Sequence features of Drosha and Dicer cleavage sites affect the complexity of isomiRs. Int J Mol Sci (2015) 0.84
The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNAs. BMC Genomics (2015) 0.84
MicroRNAs in HIV-1 infection: an integration of viral and cellular interaction at the genomic level. Front Microbiol (2012) 0.84
3' IsomiR species and DNA contamination influence reliable quantification of microRNAs by stem-loop quantitative PCR. PLoS One (2014) 0.81
Intertwined pathways for Argonaute-mediated microRNA biogenesis in Drosophila. Nucleic Acids Res (2013) 0.79
A micro-RNA expression signature for human NAFLD progression. J Gastroenterol (2016) 0.76
MicroRNAs and tRNA-derived fragments predict the transformation of myelodysplastic syndromes to acute myeloid leukemia. Leuk Lymphoma (2017) 0.76
Alternative splicing of a viral mirtron differentially affects the expression of other microRNAs from its cluster and of the host transcript. RNA Biol (2016) 0.75
Uridylation and adenylation of RNAs. Sci China Life Sci (2015) 0.75
Comprehensive evaluation of extracellular small RNA isolation methods from serum in high throughput sequencing. BMC Genomics (2017) 0.75
Prediction of mammalian microRNA targets. Cell (2003) 53.70
A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03
Principles of microRNA-target recognition. PLoS Biol (2005) 23.70
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Nat Genet (2002) 17.20
Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. Cell (2006) 15.12
Selective blockade of microRNA processing by Lin28. Science (2008) 14.39
A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila. Science (2007) 10.73
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res (2008) 10.18
Intronic microRNA precursors that bypass Drosha processing. Nature (2007) 9.65
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell (2008) 8.32
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell (2007) 7.70
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol (2008) 7.35
Methylation as a crucial step in plant microRNA biogenesis. Science (2005) 7.16
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev (2010) 7.14
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev (2008) 7.07
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA (2008) 6.86
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature (2010) 6.37
TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell (2009) 5.99
Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis. Curr Biol (2005) 5.99
A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science (2010) 5.84
Mammalian mirtron genes. Mol Cell (2007) 5.75
PIWI-interacting small RNAs: the vanguard of genome defence. Nat Rev Mol Cell Biol (2011) 5.59
miRNA profiling of naïve, effector and memory CD8 T cells. PLoS One (2007) 5.43
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol (2009) 4.41
Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies. Curr Biol (2008) 4.07
Target RNA-directed trimming and tailing of small silencing RNAs. Science (2010) 3.98
Formation, regulation and evolution of Caenorhabditis elegans 3'UTRs. Nature (2010) 3.87
A microRNA catalog of the developing chicken embryo identified by a deep sequencing approach. Genome Res (2008) 3.74
Selective stabilization of mammalian microRNAs by 3' adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Genes Dev (2009) 3.62
Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway. RNA (2009) 3.19
A comprehensive survey of 3' animal miRNA modification events and a possible role for 3' adenylation in modulating miRNA targeting effectiveness. Genome Res (2010) 2.87
Evolutionary flux of canonical microRNAs and mirtrons in Drosophila. Nat Genet (2010) 2.84
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nat Struct Mol Biol (2009) 2.79
Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell (2011) 2.73
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proc Natl Acad Sci U S A (2010) 2.67
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res (2010) 2.56
Dicer recognizes the 5' end of RNA for efficient and accurate processing. Nature (2011) 2.49
Dynamic isomiR regulation in Drosophila development. RNA (2010) 2.19
A distinct class of small RNAs arises from pre-miRNA-proximal regions in a simple chordate. Nat Struct Mol Biol (2009) 1.90
Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. BMC Biol (2010) 1.80
MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila. Mol Cell (2010) 1.78
Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. Cancer Res (2011) 1.70
Modifications of small RNAs and their associated proteins. Cell (2010) 1.69
The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Curr Biol (2011) 1.66
The exoribonuclease Nibbler controls 3' end processing of microRNAs in Drosophila. Curr Biol (2011) 1.56
Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans. Genome Res (2010) 1.31
Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage. Blood (2011) 1.12
R2D2 organizes small regulatory RNA pathways in Drosophila. Mol Cell Biol (2010) 1.04
Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39
Unlocking the secrets of the genome. Nature (2009) 11.80
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (2010) 9.78
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61
The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell (2007) 7.70
Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nat Rev Genet (2008) 5.83
Mammalian mirtron genes. Mol Cell (2007) 5.75
Endogenous RNA interference provides a somatic defense against Drosophila transposons. Curr Biol (2008) 5.22
The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs. Nature (2008) 5.05
The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution. Nat Struct Mol Biol (2008) 4.88
Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs. Proc Natl Acad Sci U S A (2010) 3.92
Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature (2010) 3.44
Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster. Nat Struct Mol Biol (2008) 3.40
Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites. EMBO J (2008) 3.40
miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proc Natl Acad Sci U S A (2011) 3.35
Distinct mechanisms for microRNA strand selection by Drosophila Argonautes. Mol Cell (2009) 3.02
Endogenous small interfering RNAs in animals. Nat Rev Mol Cell Biol (2008) 3.00
Widespread regulatory activity of vertebrate microRNA* species. RNA (2010) 2.97
Evolutionary flux of canonical microRNAs and mirtrons in Drosophila. Nat Genet (2010) 2.84
Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell (2011) 2.73
A broadly conserved pathway generates 3'UTR-directed primary piRNAs. Curr Biol (2009) 2.69
Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line. Genome Res (2009) 2.68
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proc Natl Acad Sci U S A (2010) 2.67
Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proc Natl Acad Sci U S A (2005) 2.62
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res (2010) 2.56
Diversity and dynamics of the Drosophila transcriptome. Nature (2014) 2.47
Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma. Science (2014) 2.42
Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci. Genes Dev (2008) 2.35
Vive la différence: biogenesis and evolution of microRNAs in plants and animals. Genome Biol (2011) 2.21
The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings. Genes Dev (2005) 2.04
Global patterns of tissue-specific alternative polyadenylation in Drosophila. Cell Rep (2012) 1.99
Adult-specific functions of animal microRNAs. Nat Rev Genet (2013) 1.89
VAMP: visualization and analysis of array-CGH, transcriptome and other molecular profiles. Bioinformatics (2006) 1.87
MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila. Mol Cell (2010) 1.78
Widespread and extensive lengthening of 3' UTRs in the mammalian brain. Genome Res (2013) 1.72
Discovery of hundreds of mirtrons in mouse and human small RNA data. Genome Res (2012) 1.63
Dicing of viral replication intermediates during silencing of latent Drosophila viruses. Proc Natl Acad Sci U S A (2009) 1.61
Evolution of mir-92a underlies natural morphological variation in Drosophila melanogaster. Curr Biol (2013) 1.56
Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proc Natl Acad Sci U S A (2007) 1.53
The evolution and functional diversification of animal microRNA genes. Cell Res (2008) 1.49
Homeostatic control of Argonaute stability by microRNA availability. Nat Struct Mol Biol (2013) 1.42
Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems. Science (2008) 1.41
The long and short of inverted repeat genes in animals: microRNAs, mirtrons and hairpin RNAs. Cell Cycle (2008) 1.38
microRNA control of cell-cell signaling during development and disease. Cell Cycle (2008) 1.32
Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans. Genome Res (2010) 1.31
Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Proc Natl Acad Sci U S A (2005) 1.28
miR-9a prevents apoptosis during wing development by repressing Drosophila LIM-only. Dev Biol (2009) 1.25
Mirtrons: microRNA biogenesis via splicing. Biochimie (2011) 1.24
Dicer-independent, Ago2-mediated microRNA biogenesis in vertebrates. Cell Cycle (2010) 1.21
Lessons from microRNA mutants in worms, flies and mice. Cell Cycle (2008) 1.20
A genome-wide transgenic resource for conditional expression of Drosophila microRNAs. Development (2012) 1.16
Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster. Nat Struct Mol Biol (2008) 1.13
A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways. Mol Cell Biol (2008) 1.13
MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway. Nat Cell Biol (2013) 1.11
Genome-wide expression profiling, in vivo DNA binding analysis, and probabilistic motif prediction reveal novel Abf1 target genes during fermentation, respiration, and sporulation in yeast. Mol Biol Cell (2008) 1.09
Functional parameters of Dicer-independent microRNA biogenesis. RNA (2012) 1.08
Frequent unanticipated alleles of lethal giant larvae in Drosophila second chromosome stocks. Genetics (2009) 1.05
Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Nature (2011) 1.05
R2D2 organizes small regulatory RNA pathways in Drosophila. Mol Cell Biol (2010) 1.04
The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction. Neuron (2010) 1.04
The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila. EMBO J (2010) 1.02
Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals. Genes Dev (2013) 1.01
The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors. Genes Dev (2013) 1.00
A view from Drosophila: multiple biological functions for individual microRNAs. Semin Cell Dev Biol (2010) 0.99
RNase III-independent microRNA biogenesis in mammalian cells. RNA (2012) 0.96
A Drosophila genetic screen yields allelic series of core microRNA biogenesis factors and reveals post-developmental roles for microRNAs. RNA (2011) 0.96
Transgenic inhibitors of RNA interference in Drosophila. Fly (Austin) (2007) 0.95
Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects. PLoS One (2010) 0.94
Drosophila piwi mutants exhibit germline stem cell tumors that are sustained by elevated Dpp signaling. Curr Biol (2013) 0.92
Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development. EMBO J (2011) 0.91
Control of microRNA biogenesis and transcription by cell signaling pathways. Curr Opin Genet Dev (2011) 0.91
BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Development (2013) 0.88
Inhibition of hyaluronan synthase-3 decreases subcutaneous colon cancer growth by increasing apoptosis. Anticancer Agents Med Chem (2011) 0.88
Neurophysiological defects and neuronal gene deregulation in Drosophila mir-124 mutants. PLoS Genet (2012) 0.87
Drosophila Argonaute 1 and its miRNA biogenesis partners are required for oocyte formation and germline cell division. Dev Biol (2012) 0.87
The impact of age, biogenesis, and genomic clustering on Drosophila microRNA evolution. RNA (2013) 0.85
The miR-310/13 cluster antagonizes β-catenin function in the regulation of germ and somatic cell differentiation in the Drosophila testis. Development (2013) 0.84
Alternative polyadenylation in the nervous system: to what lengths will 3' UTR extensions take us? Bioessays (2014) 0.82