PubRank

Brian T Chait

Author PubWeight™ 277.42‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 X-ray structure of a voltage-dependent K+ channel. Nature 2003 14.50
2 A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature 2006 10.73
3 Crystal structure and mechanism of a calcium-gated potassium channel. Nature 2002 10.03
4 X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity. Nature 2002 9.96
5 The open pore conformation of potassium channels. Nature 2002 9.09
6 Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science 2011 9.00
7 The molecular architecture of the nuclear pore complex. Nature 2007 6.93
8 Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol 2009 6.69
9 Proteomic analysis of the mammalian nuclear pore complex. J Cell Biol 2002 6.38
10 Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell 2005 6.12
11 Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol 2002 5.67
12 Determining the architectures of macromolecular assemblies. Nature 2007 4.94
13 The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol Cell 2002 3.99
14 Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A 2007 3.92
15 Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell 2006 3.87
16 Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell 2007 3.51
17 Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. EMBO J 2007 3.31
18 ABI5 acts downstream of ABI3 to execute an ABA-dependent growth arrest during germination. Plant J 2002 3.28
19 Induction of autophagy in axonal dystrophy and degeneration. J Neurosci 2006 3.28
20 POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev 2004 3.25
21 Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science 2013 3.02
22 Fluorescent proteins as proteomic probes. Mol Cell Proteomics 2005 2.98
23 Components of coated vesicles and nuclear pore complexes share a common molecular architecture. PLoS Biol 2004 2.90
24 Virtual gating and nuclear transport: the hole picture. Trends Cell Biol 2003 2.68
25 Comprehensive analysis of diverse ribonucleoprotein complexes. Nat Methods 2007 2.55
26 Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini. Proc Natl Acad Sci U S A 2007 2.43
27 TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem 2004 2.36
28 Simple fold composition and modular architecture of the nuclear pore complex. Proc Natl Acad Sci U S A 2006 2.35
29 A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics 2011 2.34
30 Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly. Dev Cell 2007 2.25
31 Chromatin-bound Xenopus Dppa2 shapes the nucleus by locally inhibiting microtubule assembly. Dev Cell 2013 2.09
32 Tracking and elucidating alphavirus-host protein interactions. J Biol Chem 2006 2.01
33 Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc Natl Acad Sci U S A 2005 1.97
34 Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci U S A 2006 1.95
35 Proteomic and genomic characterization of chromatin complexes at a boundary. J Cell Biol 2005 1.92
36 E protein silencing by the leukemogenic AML1-ETO fusion protein. Science 2004 1.89
37 Artificial nanopores that mimic the transport selectivity of the nuclear pore complex. Nature 2008 1.89
38 I-DIRT, a general method for distinguishing between specific and nonspecific protein interactions. J Proteome Res 2005 1.87
39 MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol Cell 2005 1.85
40 Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex. Cell Host Microbe 2008 1.85
41 A modular cross-linking approach for exploring protein interactions. J Am Chem Soc 2003 1.85
42 Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med 2008 1.78
43 Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. J Virol 2010 1.78
44 Simple kinetic relationships and nonspecific competition govern nuclear import rates in vivo. J Cell Biol 2006 1.78
45 Evidence for a shared nuclear pore complex architecture that is conserved from the last common eukaryotic ancestor. Mol Cell Proteomics 2009 1.74
46 Identification of SMARCAL1 as a component of the DNA damage response. J Biol Chem 2009 1.74
47 Long range allosteric control of cytoplasmic dynein ATPase activity by the stalk and C-terminal domains. J Biol Chem 2005 1.68
48 Ku80 removal from DNA through double strand break-induced ubiquitylation. J Cell Biol 2008 1.64
49 Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. Proc Natl Acad Sci U S A 2007 1.64
50 Detection of secreted peptides by using hypothesis-driven multistage mass spectrometry. Proc Natl Acad Sci U S A 2003 1.63
51 The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control. J Cell Biol 2005 1.59
52 Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. J Biol Chem 2005 1.57
53 Targeted proteomic study of the cyclin-Cdk module. Mol Cell 2004 1.56
54 Structure of microcin J25, a peptide inhibitor of bacterial RNA polymerase, is a lassoed tail. J Am Chem Soc 2003 1.56
55 Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates. Cell 2006 1.54
56 Analysis of protein phosphorylation by hypothesis-driven multiple-stage mass spectrometry. Anal Chem 2004 1.52
57 RNA ligase RtcB splices 3'-phosphate and 5'-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3')pp(5')G intermediates. Proc Natl Acad Sci U S A 2012 1.51
58 Carbon dioxide-induced anesthesia results in a rapid increase in plasma levels of vasopressin. Endocrinology 2009 1.49
59 Improved beta-elimination-based affinity purification strategy for enrichment of phosphopeptides. Anal Chem 2003 1.48
60 GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome. Mol Syst Biol 2010 1.45
61 Structure-function mapping of a heptameric module in the nuclear pore complex. J Cell Biol 2012 1.44
62 Escherichia coli condensin MukB stimulates topoisomerase IV activity by a direct physical interaction. Proc Natl Acad Sci U S A 2010 1.41
63 SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. J Biol Chem 2001 1.40
64 Efficiency, selectivity, and robustness of nucleocytoplasmic transport. PLoS Comput Biol 2007 1.39
65 Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replication. J Virol 2010 1.38
66 Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. PLoS One 2011 1.38
67 Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization. Genes Dev 2012 1.38
68 Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition. Cell 2013 1.34
69 The nuclear pore complex-associated protein, Mlp2p, binds to the yeast spindle pole body and promotes its efficient assembly. J Cell Biol 2005 1.33
70 On the nature of the chemical noise in MALDI mass spectra. J Am Soc Mass Spectrom 2002 1.30
71 Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates. Nat Struct Mol Biol 2009 1.28
72 Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence. Proc Natl Acad Sci U S A 2002 1.25
73 Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA. J Gen Physiol 2005 1.22
74 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma. Proc Natl Acad Sci U S A 2002 1.21
75 Genomic and proteomic analysis of phiEco32, a novel Escherichia coli bacteriophage. J Mol Biol 2008 1.21
76 Rapid sensitive analysis of cysteine rich peptide venom components. Proc Natl Acad Sci U S A 2009 1.21
77 Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases. Biochemistry 2008 1.20
78 Quantitative analysis of protein phosphorylation in mouse brain by hypothesis-driven multistage mass spectrometry. Anal Chem 2005 1.20
79 Multifunctional class I transcription in Trypanosoma brucei depends on a novel protein complex. EMBO J 2007 1.20
80 Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II. Mol Cell 2012 1.18
81 Characterization of karyopherin cargoes reveals unique mechanisms of Kap121p-mediated nuclear import. Mol Cell Biol 2004 1.18
82 Activation of DSB processing requires phosphorylation of CtIP by ATR. Mol Cell 2012 1.16
83 Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair. J Cell Biol 2011 1.16
84 Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. PLoS Pathog 2010 1.16
85 Improved methodology for the affinity isolation of human protein complexes expressed at near endogenous levels. Biotechniques 2012 1.15
86 Quantitative chemical proteomics approach to identify post-translational modification-mediated protein-protein interactions. J Am Chem Soc 2012 1.12
87 Proteomic studies of a single CNS synapse type: the parallel fiber/purkinje cell synapse. PLoS Biol 2009 1.11
88 Conjugation of magnetic beads for immunopurification of protein complexes. Cold Spring Harb Protoc 2011 1.10
89 Rrp17p is a eukaryotic exonuclease required for 5' end processing of Pre-60S ribosomal RNA. Mol Cell 2009 1.10
90 SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action. Cell 2013 1.10
91 Protease accessibility laddering: a proteomic tool for probing protein structure. Structure 2006 1.07
92 Prediction of cyclin-dependent kinase phosphorylation substrates. PLoS One 2007 1.07
93 Affinity purification of protein complexes. Cold Spring Harb Protoc 2011 1.06
94 The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome. Mol Biol Cell 2013 1.06
95 Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes. J Biol Chem 2010 1.04
96 Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit. Mol Biol Cell 2003 1.03
97 CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals. Genes Dev 2003 1.02
98 Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs. J Biol Chem 2011 1.00
99 Mass spectrometric analysis of the N terminus of translational initiation factor eIF4G-1 reveals novel isoforms. J Biol Chem 2002 0.98
100 Rapid isolation and identification of bacteriophage T4-encoded modifications of Escherichia coli RNA polymerase: a generic method to study bacteriophage/host interactions. J Proteome Res 2008 0.98
101 Human embryonic, fetal, and adult hemoglobins have different subunit interface strengths. Correlation with lifespan in the red cell. Protein Sci 2007 0.97
102 Constrained de novo sequencing of conotoxins. J Proteome Res 2012 0.95
103 Dynorphin A(1-17) biotransformation in striatum of freely moving rats using microdialysis and matrix-assisted laser desorption/ionization mass spectrometry. J Neurochem 2003 0.94
104 Affinity isolation and I-DIRT mass spectrometric analysis of the Escherichia coli O157:H7 Sakai RNA polymerase complex. J Bacteriol 2007 0.94
105 A method for the rapid and efficient elution of native affinity-purified protein A tagged complexes. J Proteome Res 2005 0.93
106 Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation. Mol Cell Biol 2010 0.92
107 The biochemical anatomy of cortical inhibitory synapses. PLoS One 2012 0.90
108 "De novo" peptide sequencing by MALDI-quadrupole-ion trap mass spectrometry: a preliminary study. J Am Soc Mass Spectrom 2003 0.90
109 Enhancement of transport selectivity through nano-channels by non-specific competition. PLoS Comput Biol 2010 0.90
110 Temporal regulation of gene expression of the Thermus thermophilus bacteriophage P23-45. J Mol Biol 2010 0.88
111 Examining post-translational modification-mediated protein-protein interactions using a chemical proteomics approach. Protein Sci 2013 0.88
112 MALDI sample preparation: the ultra thin layer method. J Vis Exp 2007 0.87
113 Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV gag p24 protein. PLoS One 2012 0.86
114 Domain-specific incorporation of noninvasive optical probes into recombinant proteins. J Am Chem Soc 2004 0.86
115 N-terminal acetylation and protonation of individual hemoglobin subunits: position-dependent effects on tetramer strength and cooperativity. Protein Sci 2005 0.85
116 Protein quantitation using mass spectrometry. Methods Mol Biol 2010 0.85
117 Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol. J Lipid Res 2003 0.84
118 Dual functions, clamp opening and primer-template recognition, define a key clamp loader subunit. J Mol Biol 2004 0.84
119 Linker chains of the gigantic hemoglobin of the earthworm Lumbricus terrestris: primary structures of linkers L2, L3, and L4 and analysis of the connectivity of the disulfide bonds in linker L1. Proteins 2006 0.83
120 Efficient identification of phosphorylation by mass spectrometric phosphopeptide fingerprinting. Anal Chem 2008 0.83
121 N-terminal contributions of the gamma-subunit of fetal hemoglobin to its tetramer strength: remote effects at subunit contacts. Protein Sci 2002 0.83
122 Supervillin binding to myosin II and synergism with anillin are required for cytokinesis. Mol Biol Cell 2013 0.83
123 Nuclear pore complex evolution: a trypanosome Mlp analogue functions in chromosomal segregation but lacks transcriptional barrier activity. Mol Biol Cell 2014 0.83
124 The yeast Snt2 protein coordinates the transcriptional response to hydrogen peroxide-mediated oxidative stress. Mol Cell Biol 2013 0.83
125 Limited effects of beta-endorphin compared to loperamide or fentanyl in a neuroendocrine biomarker assay in non-human primates. Psychoneuroendocrinology 2008 0.81
126 High-yield isolation and subcellular proteomic characterization of nuclear and subnuclear structures from trypanosomes. Methods Mol Biol 2008 0.80
127 Developmental expression of human hemoglobins mediated by maturation of their subunit interfaces. Protein Sci 2010 0.80
128 Intrinsic regulation of hemoglobin expression by variable subunit interface strengths. FEBS J 2011 0.79
129 Proteomics on the rims: insights into the biology of the nuclear envelope and flagellar pocket of trypanosomes. Parasitology 2012 0.79
130 Maximizing ion transmission from atmospheric pressure into the vacuum of mass spectrometers with a novel electrospray interface. J Am Soc Mass Spectrom 2015 0.79
131 Biophysical methods: doing more with less. Curr Opin Struct Biol 2003 0.76
132 Using genetic mouse models to study the biology and pathology of autophagy in the central nervous system. Methods Enzymol 2009 0.76
133 Optimizing electrospray interfaces using slowly diverging conical duct (ConDuct) electrodes. J Am Soc Mass Spectrom 2015 0.76
134 Touching from a distance. Nucleus 2014 0.75
135 Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function. J Neurochem 2015 0.75
136 A novel high-capacity ion trap-quadrupole tandem mass spectrometer. Int J Mass Spectrom 2007 0.75
137 High-Capacity Ion Trap Coupled to a Time-of-Flight Mass Spectrometer for Comprehensive Linked Scans with no Scanning Losses. Int J Mass Spectrom 2011 0.75