Published in Mol Biol Cell on January 19, 2012
Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2. Proc Natl Acad Sci U S A (2013) 0.99
c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution. Am J Physiol Endocrinol Metab (2012) 0.96
Dynamics of ezrin and EBP50 in regulating microvilli on the apical aspect of epithelial cells. Biochem Soc Trans (2014) 0.90
Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration. Elife (2015) 0.89
Open conformation of ezrin bound to phosphatidylinositol 4,5-bisphosphate and to F-actin revealed by neutron scattering. J Biol Chem (2012) 0.87
Cordon Bleu serves as a platform at the basal region of microvilli, where it regulates microvillar length through its WH2 domains. Mol Biol Cell (2014) 0.86
A RhoA and Rnd3 cycle regulates actin reassembly during membrane blebbing. Proc Natl Acad Sci U S A (2016) 0.85
Isotropic actomyosin dynamics promote organization of the apical cell cortex in epithelial cells. J Cell Biol (2014) 0.84
Insights into the origin of metazoan filopodia and microvilli. Mol Biol Evol (2013) 0.84
Interactome analysis reveals ezrin can adopt multiple conformational states. J Biol Chem (2013) 0.83
Phosphatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assembles a specific CD44-Ezrin heterocomplex, as revealed by small angle neutron scattering. J Biol Chem (2015) 0.82
Physical model for the geometry of actin-based cellular protrusions. Biophys J (2014) 0.81
Phosphatidylinositol 4,5-bisphosphate alters the number of attachment sites between ezrin and actin filaments: a colloidal probe study. J Biol Chem (2014) 0.79
Eight proteins play critical roles in RCC with bone metastasis via mitochondrial dysfunction. Clin Exp Metastasis (2015) 0.79
Plasticity of the brush border - the yin and yang of intestinal homeostasis. Nat Rev Gastroenterol Hepatol (2016) 0.79
Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells. J Cell Sci (2014) 0.78
Microinjected antibodies against the cytoplasmic domain of vesicular stomatitis virus glycoprotein block its transport to the cell surface. EMBO J (1986) 5.60
Mechanism of filopodia initiation by reorganization of a dendritic network. J Cell Biol (2003) 5.47
Organizing the cell cortex: the role of ERM proteins. Nat Rev Mol Cell Biol (2010) 5.05
The many faces of actin: matching assembly factors with cellular structures. Nat Cell Biol (2007) 4.90
Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor. J Cell Biol (1989) 3.73
Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family. J Cell Biol (1994) 3.68
Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site. Mol Biol Cell (1995) 3.36
Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine. Dev Cell (2004) 3.33
Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin. J Cell Biol (2004) 3.03
EPS8 and E3B1 transduce signals from Ras to Rac. Nature (1999) 2.82
Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells. J Cell Biol (1997) 2.51
Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane. J Cell Biol (2000) 2.45
Eps8 controls actin-based motility by capping the barbed ends of actin filaments. Nat Cell Biol (2004) 2.40
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev Cell (2009) 2.40
The co-workers of actin filaments: from cell structures to signals. Nat Rev Mol Cell Biol (2004) 2.01
Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals. EMBO J (1993) 1.92
Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex. Nat Cell Biol (2006) 1.92
Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1. J Cell Biol (2003) 1.91
Direct involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the organization of microvilli in collaboration with activated ERM proteins. J Cell Biol (1999) 1.91
Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin. J Biol Chem (1992) 1.86
Ezrin has properties to self-associate at the plasma membrane. J Cell Sci (1994) 1.85
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans. Nat Cell Biol (2004) 1.82
Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF). PLoS Biol (2009) 1.78
The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation. Proc Natl Acad Sci U S A (2006) 1.72
Nucleated polymerization of actin from the membrane-associated ends of microvillar filaments in the intestinal brush border. J Cell Biol (1982) 1.65
A novel peptide-SH3 interaction. EMBO J (1999) 1.61
An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine. J Cell Biol (2001) 1.58
Emerging role for ERM proteins in cell adhesion and migration. Cell Adh Migr (2011) 1.58
Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8. Curr Biol (2011) 1.55
Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells. J Cell Biol (2005) 1.46
Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells. J Cell Sci (2006) 1.45
The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation. Oncogene (1993) 1.44
EPI64 regulates microvillar subdomains and structure. J Cell Biol (2006) 1.30
The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Mol Biol Cell (2003) 1.21
The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent manner. J Cell Biol (2010) 1.19
Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping. PLoS Biol (2010) 1.15
A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization. Mol Biol Cell (2010) 1.15
Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells. Mol Biol Cell (2007) 1.12
Src phosphorylates ezrin at tyrosine 477 and induces a phosphospecific association between ezrin and a kelch-repeat protein family member. J Biol Chem (2004) 1.03
Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering. EMBO J (2007) 1.01
In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure. Genomics (2003) 0.99
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. PLoS One (2010) 0.97
Regulation of actin cytoskeleton architecture by Eps8 and Abi1. BMC Cell Biol (2005) 0.94
Wizardry at the cell cortex. Curr Biol (1993) 0.80
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis (2004) 6.83
Notch signals control the fate of immature progenitor cells in the intestine. Nature (2005) 6.13
Protein interaction mapping: a Drosophila case study. Genome Res (2005) 4.15
Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol Cell Biol (2007) 3.06
Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin. J Cell Biol (2004) 3.03
Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia. J Cell Biol (2010) 2.62
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci U S A (2009) 2.34
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell (2011) 2.34
Overview of the matrisome--an inventory of extracellular matrix constituents and functions. Cold Spring Harb Perspect Biol (2012) 2.26
Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res (2007) 2.26
APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology (2006) 2.25
Ral GTPases regulate exocyst assembly through dual subunit interactions. J Biol Chem (2003) 2.23
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Mol Cell (2011) 2.13
The co-workers of actin filaments: from cell structures to signals. Nat Rev Mol Cell Biol (2004) 2.01
Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis. Nat Cell Biol (2011) 1.96
The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. EMBO J (2007) 1.92
A dual mechanism controlling the localization and function of exocytic v-SNAREs. Proc Natl Acad Sci U S A (2003) 1.86
ERM proteins in epithelial cell organization and functions. Biochim Biophys Acta (2006) 1.80
The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells. Breast Cancer Res (2005) 1.76
Molecular analysis of microscopic ezrin dynamics by two-photon FRAP. Proc Natl Acad Sci U S A (2002) 1.73
SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Mol Cell (2011) 1.70
Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation. Mol Biol Cell (2003) 1.67
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther (2009) 1.66
ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling. Curr Opin Cell Biol (2002) 1.61
Emerging role for ERM proteins in cell adhesion and migration. Cell Adh Migr (2011) 1.58
Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice. Gastroenterology (2002) 1.57
Different microtubule motors move early and late endocytic compartments. Traffic (2008) 1.50
hPOC5 is a centrin-binding protein required for assembly of full-length centrioles. J Cell Biol (2009) 1.49
An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. PLoS Biol (2009) 1.48
Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse. EMBO J (2010) 1.40
Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42. Mol Biol Cell (2007) 1.36
The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells. Mol Biol Cell (2002) 1.35
The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush border. Mol Biol Cell (2006) 1.34
PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. J Biol Chem (2003) 1.32
Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia. J Cell Biol (2013) 1.28
Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. PLoS One (2011) 1.24
Rab13 regulates PKA signaling during tight junction assembly. J Cell Biol (2004) 1.24
A molecular network for the transport of the TI-VAMP/VAMP7 vesicles from cell center to periphery. Dev Cell (2012) 1.22
Myosin 1b promotes the formation of post-Golgi carriers by regulating actin assembly and membrane remodelling at the trans-Golgi network. Nat Cell Biol (2011) 1.16
The multifunctional protein PEA-15 is involved in the control of apoptosis and cell cycle in astrocytes. Biochem Pharmacol (2003) 1.13
Myosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomes. J Cell Sci (2005) 1.13
Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells. Mol Biol Cell (2007) 1.12
Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors. Proc Natl Acad Sci U S A (2011) 1.12
Free Brick1 is a trimeric precursor in the assembly of a functional wave complex. PLoS One (2008) 1.09
Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium. Mol Biol Cell (2009) 1.06
Rab6 and the secretory pathway affect oocyte polarity in Drosophila. Development (2007) 1.05
Rab8 regulates the actin-based movement of melanosomes. Mol Biol Cell (2005) 1.03
Ectopic expression of syntaxin 1 in the ER redirects TI-VAMP- and cellubrevin-containing vesicles. J Cell Sci (2003) 1.03
Notch signaling in intestinal homeostasis across species: the cases of Drosophila, Zebrafish and the mouse. Exp Cell Res (2011) 1.03
Co-operative effect of c-Src and ezrin in deregulation of cell-cell contacts and scattering of mammary carcinoma cells. J Cell Biochem (2004) 1.03
Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells. Mol Biol Cell (2003) 1.02
The ERM proteins interact with the HOPS complex to regulate the maturation of endosomes. Mol Biol Cell (2010) 1.02
Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering. EMBO J (2007) 1.01
A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Mol Biol Cell (2011) 1.00
Enterocyte loss of polarity and gut wound healing rely upon the F-actin-severing function of villin. Proc Natl Acad Sci U S A (2013) 0.99
Mutant products of the NF2 tumor suppressor gene are degraded by the ubiquitin-proteasome pathway. J Biol Chem (2002) 0.98
Towards definition of an ECM parts list: an advance on GO categories. Matrix Biol (2012) 0.97
The epithelial cell cytoskeleton and intracellular trafficking. III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells? Am J Physiol Gastrointest Liver Physiol (2002) 0.96
Mouse models of K-ras-initiated carcinogenesis. Biochim Biophys Acta (2005) 0.96
Interaction between Polo and BicD proteins links oocyte determination and meiosis control in Drosophila. Development (2006) 0.93
Shigella flexneri infection is dependent on villin in the mouse intestine and in primary cultures of intestinal epithelial cells. Cell Microbiol (2005) 0.93
Cytoskeleton networks in basement membrane transmigration. Eur J Cell Biol (2010) 0.92
Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells. BMC Cancer (2012) 0.92
Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line. Oncogene (2004) 0.91
Do cancer cells have distinct adhesions in 3D collagen matrices and in vivo? Eur J Cell Biol (2012) 0.90
Villin severing activity enhances actin-based motility in vivo. Mol Biol Cell (2006) 0.89
Clathrin is required for Scar/Wave-mediated lamellipodium formation. J Cell Sci (2011) 0.88
APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. Gastroenterology (2007) 0.87
Epithelial morphogenesis and intestinal cancer: new insights in signaling mechanisms. Adv Cancer Res (2008) 0.87
Moesin/ezrin: a specific role in cell metastasis? Pigment Cell Melanoma Res (2009) 0.85
Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin. Mol Biol Cell (2013) 0.85
Isolation and characterization of an aggresome determinant in the NF2 tumor suppressor. J Biol Chem (2002) 0.84
Ezrin is a target for oncogenic Kit mutants in murine erythroleukemia. Blood (2008) 0.84
Myosin VI regulates actin dynamics and melanosome biogenesis. Traffic (2012) 0.83
Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity. PLoS One (2012) 0.83
Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate Moesin activity. J Cell Sci (2010) 0.82
In vivo tumor targeting using a novel intestinal pathogen-based delivery approach. Cancer Res (2006) 0.81
DLG1/SAP97 modulates transforming growth factor alpha bioavailability. Biochim Biophys Acta (2008) 0.80
Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation. J Cell Biol (2013) 0.79