Published in EMBO J on February 17, 2012
Stim and Orai proteins in neuronal Ca(2+) signaling and excitability. Front Cell Neurosci (2015) 0.99
Low hippocampal PI(4,5)P₂ contributes to reduced cognition in old mice as a result of loss of MARCKS. Nat Neurosci (2013) 0.94
Lipid dynamics at dendritic spines. Front Neuroanat (2014) 0.89
Cholesterol in brain disease: sometimes determinant and frequently implicated. EMBO Rep (2014) 0.88
STIM and ORAI proteins in the nervous system. Channels (Austin) (2015) 0.85
LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery. J Cell Biol (2015) 0.82
Targeting cholesterol homeostasis to fight hearing loss: a new perspective. Front Aging Neurosci (2015) 0.80
Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington's disease. Cell Death Differ (2014) 0.78
Inhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus. Eur J Neurosci (2015) 0.78
Brain Cholesterol Metabolism and Its Defects: Linkage to Neurodegenerative Diseases and Synaptic Dysfunction. Acta Naturae (2016) 0.77
Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk. Sci Rep (2016) 0.75
24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure. Sci Rep (2016) 0.75
Role of STIM2 in cell function and physiopathology. J Physiol (2017) 0.75
Cholesterol in the Pathogenesis of Alzheimer's, Parkinson's Diseases and Autism: Link to Synaptic Dysfunction. Acta Naturae (2017) 0.75
24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation. PLoS One (2017) 0.75
Apolipoprotein D Overexpression Protects Against Kainate-Induced Neurotoxicity in Mice. Mol Neurobiol (2016) 0.75
In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds. J Biol Chem (2017) 0.75
A rapid method of total lipid extraction and purification. Can J Biochem Physiol (1959) 173.74
Lipid rafts and signal transduction. Nat Rev Mol Cell Biol (2000) 25.87
Lipid rafts as a membrane-organizing principle. Science (2010) 13.48
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet (2003) 12.16
Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids (1970) 11.81
Culturing hippocampal neurons. Nat Protoc (2007) 8.34
Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane. J Cell Biol (2006) 6.88
Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell (1999) 5.16
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci (2008) 4.04
STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels. Cell (2007) 3.75
Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death. Trends Neurosci (2007) 3.55
Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res (2004) 3.30
The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell (2008) 3.10
Kainate, a double agent that generates seizures: two decades of progress. Trends Neurosci (2000) 2.78
Brain cholesterol: long secret life behind a barrier. Arterioscler Thromb Vasc Biol (2004) 2.57
Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res (2005) 2.38
Synaptic vesicles and exocytosis. Annu Rev Neurosci (1994) 2.24
Shrinking patches and slippery rafts: scales of domains in the plasma membrane. Trends Cell Biol (2001) 2.23
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci U S A (1999) 2.20
Intracellular cholesterol transport. Biochim Biophys Acta (1999) 2.17
A subfraction of the yeast endoplasmic reticulum associates with the plasma membrane and has a high capacity to synthesize lipids. Eur J Biochem (2001) 2.07
Lipid rafts in neuronal signaling and function. Trends Neurosci (2002) 2.06
Regulation of raft-dependent endocytosis. J Cell Mol Med (2007) 2.01
Dendritic spines as individual neuronal compartments for synaptic Ca2+ responses. Nature (1991) 1.98
From form to function: calcium compartmentalization in dendritic spines. Nat Neurosci (2000) 1.94
Interactions between the endoplasmic reticulum, mitochondria, plasma membrane and other subcellular organelles. Int J Biochem Cell Biol (2009) 1.64
The dichotomy of NMDA receptor signaling. Neuroscientist (2007) 1.61
Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annu Rev Biochem (2009) 1.61
Control of the postsynaptic membrane viscosity. J Neurosci (2009) 1.55
STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death. Sci Signal (2009) 1.54
Mass spectrometric detection of cholesterol oxidation in bovine sperm. Biol Reprod (2011) 1.50
Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain. J Comp Neurol (2008) 1.47
The integration of mitochondrial calcium transport and storage. J Bioenerg Biomembr (2004) 1.41
Suppression of the intrinsic apoptosis pathway by synaptic activity. J Neurosci (2010) 1.40
Disposition of intracellular cholesterol in human fibroblasts. J Lipid Res (1991) 1.39
Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior. EMBO J (2007) 1.38
Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture. J Neurochem (2000) 1.36
Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice. J Biol Chem (2002) 1.29
Use of thapsigargin to study Ca2+ homeostasis in cardiac cells. Biosci Rep (1995) 1.28
Localized recruitment and activation of RhoA underlies dendritic spine morphology in a glutamate receptor-dependent manner. J Cell Biol (2006) 1.24
Lipid distribution and transport across cellular membranes. Semin Cell Dev Biol (2001) 1.20
Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats. J Neurochem (2009) 1.15
Role of glia-derived cholesterol in synaptogenesis: new revelations in the synapse-glia affair. J Physiol Paris (2002) 1.14
The endoplasmic reticulum and neuronal calcium signalling. Cell Calcium (2003) 1.08
The cytoplasmic and N-terminal transmembrane domains of cytochrome P450 contain independent signals for retention in the endoplasmic reticulum. J Biol Chem (1995) 1.06
Endoplasmic reticulum Ca(2+) release through ryanodine and IP(3) receptors contributes to neuronal excitotoxicity. Cell Calcium (2009) 1.03
Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro. Mol Biol Cell (2008) 1.01
Cholesterol metabolism in the brain: importance of 24S-hydroxylation. Acta Neurol Scand Suppl (2006) 1.01
Cholesterol depletion inhibits synaptic transmission and synaptic plasticity in rat hippocampus. Exp Neurol (2008) 0.97
NMDA receptor stimulation induces reversible fission of the neuronal endoplasmic reticulum. PLoS One (2009) 0.95
Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice. Neuroscience (2009) 0.90
Cytochrome P450 proteins: retention and distribution from the endoplasmic reticulum. Curr Opin Drug Discov Devel (2010) 0.84
Vesicular transport of newly synthesized cytochromes P4501A to the outside of rat hepatocyte plasma membranes. J Pharmacol Exp Ther (2000) 0.83
Cholesterol depletion from the plasma membrane impairs proton and glutamate storage in synaptic vesicles of nerve terminals. J Mol Neurosci (2010) 0.82
Changes in brain cholesterol metabolome after excitotoxicity. Mol Neurobiol (2010) 0.80
Transient receptor potential cation channels in disease. Physiol Rev (2007) 6.91
Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med (2008) 4.55
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature (2003) 4.45
Identification of a candidate therapeutic autophagy-inducing peptide. Nature (2013) 3.76
Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med (2005) 3.59
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem (2002) 3.14
Centrosome localization determines neuronal polarity. Nature (2005) 3.06
Permeation and selectivity of TRP channels. Annu Rev Physiol (2006) 2.96
Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem (2002) 2.87
Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci (2007) 2.78
A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med (2002) 2.75
Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med (2006) 2.54
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature (2005) 2.52
Breaking the neuronal sphere: regulation of the actin cytoskeleton in neuritogenesis. Nat Rev Neurosci (2002) 2.51
A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med (2003) 2.49
TRPV4 calcium entry channel: a paradigm for gating diversity. Am J Physiol Cell Physiol (2004) 2.35
TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron (2011) 2.31
Gating of TRP channels: a voltage connection? J Physiol (2005) 2.30
Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem (2002) 2.24
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet (2008) 2.24
Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding. Circulation (2007) 2.23
The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. EMBO J (2006) 2.22
Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem (2003) 2.21
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest (2007) 2.19
Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation. Blood (2008) 2.18
Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation. Blood (2010) 2.17
Chronic administration of anticholinergics in rats induces a shift from muscarinic to purinergic transmission in the bladder wall. Eur Urol (2013) 2.15
CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis. Blood (2009) 2.15
TRPs in our senses. Curr Biol (2008) 2.12
Asymmetric membrane ganglioside sialidase activity specifies axonal fate. Nat Neurosci (2005) 2.12
The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ. J Neurosci (2004) 2.07
Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia. Am J Hum Genet (2009) 2.02
Cell adhesion mechanisms in platelets. Arterioscler Thromb Vasc Biol (2008) 1.98
Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A (2010) 1.96
CAPS1 regulates catecholamine loading of large dense-core vesicles. Neuron (2005) 1.94
Critical role for stromal interaction molecule 1 in cardiac hypertrophy. Circulation (2011) 1.91
Transient receptor potential channels meet phosphoinositides. EMBO J (2008) 1.89
Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood (2011) 1.88
Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. Sci Signal (2012) 1.86
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res (2012) 1.85
Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity (2003) 1.84
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem (2004) 1.82
TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. Cell Metab (2008) 1.79
G13 is an essential mediator of platelet activation in hemostasis and thrombosis. Nat Med (2003) 1.77
TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal (2009) 1.75
Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report. Arterioscler Thromb Vasc Biol (2010) 1.74
Only severe thrombocytopenia results in bleeding and defective thrombus formation in mice. Blood (2013) 1.74
The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction. J Exp Med (2008) 1.74
Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium (2005) 1.70
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain (2011) 1.70
Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice. Arterioscler Thromb Vasc Biol (2013) 1.68
Neuronal membrane cholesterol loss enhances amyloid peptide generation. J Cell Biol (2004) 1.66
Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. J Biol Chem (2002) 1.66
Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning. Nat Neurosci (2009) 1.66
Deficiency of von Willebrand factor protects mice from ischemic stroke. Blood (2009) 1.65
Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation. Blood (2012) 1.64
The TRPV4 channel: structure-function relationship and promiscuous gating behaviour. Pflugers Arch (2003) 1.64
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood (2012) 1.64
Neuronal TRP channels: thermometers, pathfinders and life-savers. Trends Neurosci (2008) 1.63
Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody. Cytometry (2002) 1.62
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature (2013) 1.61
Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G. J Cell Biol (2008) 1.60
Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics. EMBO J (2010) 1.58
Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases. Blood (2010) 1.56
The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Curr Biol (2011) 1.56
In vivo thrombus formation in murine models. Circ Res (2007) 1.54
TRP channels: a TR(I)P through a world of multifunctional cation channels. Pflugers Arch (2005) 1.54
STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death. Sci Signal (2009) 1.54
Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42. Blood (2013) 1.52
Mass spectrometric detection of cholesterol oxidation in bovine sperm. Biol Reprod (2011) 1.50
Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1. Sci Signal (2010) 1.49
Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets. Blood (2003) 1.49
A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3. Nat Immunol (2011) 1.48
The SNARE protein SNAP-25 is linked to fast calcium triggering of exocytosis. Proc Natl Acad Sci U S A (2002) 1.46
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Natl Acad Sci U S A (2010) 1.46
Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons. J Neurosci (2014) 1.45
Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci (2009) 1.44
Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment. Blood (2008) 1.44
Immunofluorescence in brain sections: simultaneous detection of presynaptic and postsynaptic proteins in identified neurons. Nat Protoc (2006) 1.44
Transient receptor potential channel modulators as pharmacological treatments for lower urinary tract symptoms (LUTS): myth or reality? BJU Int (2015) 1.40
Complex role of collybistin and gephyrin in GABAA receptor clustering. J Biol Chem (2010) 1.40
Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge. Blood (2008) 1.40
RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability. J Cell Biol (2003) 1.39
Functional characterization of transient receptor potential channels in mouse urothelial cells. Am J Physiol Renal Physiol (2009) 1.39
Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior. EMBO J (2007) 1.38
Transmitting on actin: synaptic control of dendritic architecture. J Cell Sci (2007) 1.37
Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina. Proc Natl Acad Sci U S A (2011) 1.37
Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. J Biol Chem (2007) 1.36