Published in N Engl J Med on January 01, 2004
I3LTE4: Intensive Insulin Therapy and Production of LTE4 in Patients With Diabetes | NCT00324792
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TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects. Hum Genet (2006) 0.95
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Functional analysis of 5-lipoxygenase promoter repeat variants. Hum Mol Genet (2009) 0.94
Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk. Arterioscler Thromb Vasc Biol (2013) 0.94
Maresin 1 mitigates LPS-induced acute lung injury in mice. Br J Pharmacol (2014) 0.93
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Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. Hum Genet (2008) 0.93
Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4. Proc Natl Acad Sci U S A (2006) 0.92
Farp2 and Stk25 are candidate genes for the HDL cholesterol locus on mouse chromosome 1. Arterioscler Thromb Vasc Biol (2008) 0.92
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Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study. Mediators Inflamm (2010) 0.91
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The involvement of 5-lipoxygenase activating protein in anxiety-like behavior. J Psychiatr Res (2013) 0.89
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Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system. Am J Hypertens (2010) 0.88
Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation. Atherosclerosis (2009) 0.87
Genetics of stress response and stress-related disorders. Dialogues Clin Neurosci (2006) 0.86
Molecular pharmacological profile of the nonredox-type 5-lipoxygenase inhibitor CJ-13,610. Br J Pharmacol (2004) 0.85
5-Lipoxygenase facilitates healing after myocardial infarction. Basic Res Cardiol (2013) 0.85
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Feasibility study of erythrocyte long-chain omega-3 polyunsaturated fatty acid content and mortality risk in hemodialysis patients. J Ren Nutr (2008) 0.84
ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma. Clin Exp Allergy (2013) 0.84
15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness. Hum Genet (2008) 0.84
Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia. Genes Chromosomes Cancer (2013) 0.83
Quantifying diet for nutrigenomic studies. Annu Rev Nutr (2013) 0.83
ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. J Lipid Res (2011) 0.83
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Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans. J Nutr (2012) 0.82
Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease. PLoS One (2012) 0.81
Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression. Am J Physiol Heart Circ Physiol (2011) 0.81
The role of lipoxygenases in pathophysiology; new insights and future perspectives. Redox Biol (2015) 0.81
Fatty acid interactions with genetic polymorphisms for cardiovascular disease. Curr Opin Clin Nutr Metab Care (2010) 0.81
Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study. Pharmacogenet Genomics (2013) 0.81
Leukotriene A4 hydrolase haplotype, diet and atherosclerosis: a twin study. Atherosclerosis (2012) 0.80
Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers. Cancer Prev Res (Phila) (2013) 0.80
Higher Plasma Phospholipid n-3 PUFAs, but Lower n-6 PUFAs, Are Associated with Lower Pulse Wave Velocity among Older Adults. J Nutr (2015) 0.80
Functional characterization of genetic enzyme variations in human lipoxygenases. Redox Biol (2013) 0.79
Adipose tissue arachidonic acid content is associated with the expression of 5-lipoxygenase in atherosclerotic plaques. Lipids Health Dis (2013) 0.79
Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest. Heart Rhythm (2014) 0.79
The leukotriene receptor antagonist montelukast and its possible role in the cardiovascular field. Eur J Clin Pharmacol (2017) 0.78
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The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer Risk. J Cancer Epidemiol (2012) 0.78
Association of PLA2G4A with myocardial infarction is modulated by dietary PUFAs. Am J Clin Nutr (2012) 0.78
Genotyping the GGGCGG tandem repeat promoter polymorphism in the 5-lipoxygenase enzyme gene (ALOX5) by pyrosequencing assay. Genet Test Mol Biomarkers (2009) 0.78
Genetics of gene expression surveyed in maize, mouse and man. Nature (2003) 22.17
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med (2013) 9.44
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev (2011) 7.43
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82
Vegetarian dietary patterns and mortality in Adventist Health Study 2. JAMA Intern Med (2013) 4.27
Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A (2002) 4.23
The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet (2003) 3.96
A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res (2010) 3.81
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet (2005) 3.74
Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA (2008) 3.64
Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome (2007) 3.59
Genetics of atherosclerosis. Annu Rev Genomics Hum Genet (2004) 3.51
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology (2008) 3.38
Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res (2008) 3.26
Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genet (2011) 3.23
Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology (2011) 3.15
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science (2002) 3.13
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet (2011) 3.07
Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes (2008) 3.05
Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci U S A (2006) 3.03
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab (2013) 3.01
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler Thromb Vasc Biol (2006) 2.90
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet (2004) 2.86
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J Lipid Res (2004) 2.72
Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res (2002) 2.69
Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels. Genomics (2005) 2.61
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A (2013) 2.57
Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A (2002) 2.56
Using genetic markers to orient the edges in quantitative trait networks: the NEO software. BMC Syst Biol (2008) 2.51
Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology (2002) 2.45
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
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Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood (2009) 2.26
A treasure trove for lipoprotein biology. Nat Genet (2008) 2.25
Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest (2007) 2.24
Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab (2013) 2.17
Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Am J Clin Nutr (2012) 2.14
Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci U S A (2007) 2.13
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Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB J (2008) 2.09
Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res (2007) 2.07
The allelic structure of common disease. Hum Mol Genet (2002) 2.03
Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes. J Neurochem (2006) 2.00
Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation (2002) 1.96
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Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice. Circ Res (2007) 1.81
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Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS Microbiol Lett (2005) 1.81
Genomic analysis of metabolic pathway gene expression in mice. Genome Biol (2005) 1.79
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Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circ Res (2010) 1.75
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Predicting preschoolers' externalizing behaviors from toddler temperament, conflict, and maternal negativity. Dev Psychol (2003) 1.71
CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade. J Immunol (2009) 1.70
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Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. PLoS Genet (2011) 1.68
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Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. Am J Respir Crit Care Med (2005) 1.58
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Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell (2012) 1.57
Expression quantitative trait loci: replication, tissue- and sex-specificity in mice. Genetics (2010) 1.55
Understanding the sexome: measuring and reporting sex differences in gene systems. Endocrinology (2012) 1.55
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