A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.

PubWeight™: 1.85‹?› | Rank: Top 3%

🔗 View Article (PMC 3358516)

Published in Nature on May 17, 2012

Authors

Johan W Jonker1, Jae Myoung Suh, Annette R Atkins, Maryam Ahmadian, Pingping Li, Jamie Whyte, Mingxiao He, Henry Juguilon, Yun-Qiang Yin, Colin T Phillips, Ruth T Yu, Jerrold M Olefsky, Robert R Henry, Michael Downes, Ronald M Evans

Author Affiliations

1: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

Articles citing this

What we talk about when we talk about fat. Cell (2014) 4.12

Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev (2013) 3.74

PPARγ signaling and metabolism: the good, the bad and the future. Nat Med (2013) 3.71

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature (2014) 3.57

Nuclear Receptors, RXR, and the Big Bang. Cell (2014) 2.22

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue. Mol Metab (2012) 1.90

Exploring mechanisms of FGF signalling through the lens of structural biology. Nat Rev Mol Cell Biol (2013) 1.90

The Fibroblast Growth Factor signaling pathway. Wiley Interdiscip Rev Dev Biol (2015) 1.82

Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes. Cell Metab (2014) 1.53

Biochemistry and pathophysiology of intravascular and intracellular lipolysis. Genes Dev (2013) 1.49

Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents. Nat Med (2016) 1.45

Integrated physiology and systems biology of PPARα. Mol Metab (2014) 1.12

Adipose tissue plasticity from WAT to BAT and in between. Biochim Biophys Acta (2013) 1.12

Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2. Hepatology (2013) 0.99

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nat Commun (2015) 0.99

The PPARγ-FGF1 axis: an unexpected mediator of adipose tissue homeostasis. Cell Res (2012) 0.99

Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor. J Biol Chem (2012) 0.96

Clinical implications of adipocytokines and newly emerging metabolic factors with relation to insulin resistance and cardiovascular health. Front Endocrinol (Lausanne) (2013) 0.94

Improved methodologies for the study of adipose biology: insights gained and opportunities ahead. J Lipid Res (2014) 0.92

The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J Immunol (2013) 0.92

Molecular mechanisms regulating vascular tone by peroxisome proliferator activated receptor gamma. Curr Opin Nephrol Hypertens (2015) 0.87

Macrophage-induced adipose tissue dysfunction and the preadipocyte: should I stay (and differentiate) or should I go? Adv Nutr (2013) 0.87

Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis. Semin Cell Dev Biol (2015) 0.86

Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice. Biol Sex Differ (2015) 0.85

Nuclear receptors and metabolism: from feast to famine. Diabetologia (2014) 0.84

Quantitative Genetics of Food Intake in Drosophila melanogaster. PLoS One (2015) 0.82

A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition. J Pediatr Surg Case Rep (2015) 0.81

Fibroblast Growth Factor Signaling in Metabolic Regulation. Front Endocrinol (Lausanne) (2016) 0.80

Hepatoprotective effect of resveratrol against ethanol-induced oxidative stress through induction of superoxide dismutase in vivo and in vitro. Exp Ther Med (2016) 0.79

Expression analysis of human adipose-derived stem cells during in vitro differentiation to an adipocyte lineage. BMC Med Genomics (2015) 0.78

Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development. Development (2015) 0.78

Novel aspects of brown adipose tissue biology. Endocrinol Metab Clin North Am (2012) 0.78

Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocr Rev (2016) 0.78

Nuclear receptors and AMPK: can exercise mimetics cure diabetes? J Mol Endocrinol (2016) 0.78

Dual-stage growth factor release within 3D protein-engineered hydrogel niches promotes adipogenesis. Biomater Sci (2014) 0.77

Transcriptional control and hormonal response of thermogenic fat. J Endocrinol (2015) 0.77

Biphasic effects of FGF2 on adipogenesis. PLoS One (2015) 0.77

FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation. Diabetes (2015) 0.77

Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders. Front Endocrinol (Lausanne) (2015) 0.77

Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity. Mol Ther (2017) 0.76

Nutrigenomic Functions of PPARs in Obesogenic Environments. PPAR Res (2016) 0.76

Get the fat out! Cancer Prev Res (Phila) (2013) 0.76

Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A (2016) 0.76

An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities. J Pharm Sci (2016) 0.75

ABCD2 identifies a subclass of peroxisomes in mouse adipose tissue. Biochem Biophys Res Commun (2014) 0.75

Distinct but complementary contributions of PPAR isotypes to energy homeostasis. J Clin Invest (2017) 0.75

Metabolism: Tick, tock, a high-fat clock. Nat Rev Endocrinol (2014) 0.75

Biodegradable Polymeric Microsphere-Based Drug Delivery for Inductive Browning of Fat. Front Endocrinol (Lausanne) (2015) 0.75

Is the Mouse a Good Model of Human PPARγ-Related Metabolic Diseases? Int J Mol Sci (2016) 0.75

Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes. Metabolism (2015) 0.75

Targeting adipose tissue angiogenesis to enhance insulin sensitivity. Diabetologia (2012) 0.75

Fgf signaling in adipocytes as a target for metabolic diseases. Mol Metab (2012) 0.75

Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose. Cell Death Dis (2016) 0.75

Starvation-Induced Stress Response Is Critically Impacted by Ceramide Levels in Caenorhabditis elegans. Genetics (2016) 0.75

Reply to "PPAR-γ regulates pharmacological but not physiological or pathological osteoclast formation". Nat Med (2016) 0.75

FGF1 - a new weapon to control type 2 diabetes mellitus. Nat Rev Endocrinol (2017) 0.75

Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets. PPAR Res (2017) 0.75

Articles cited by this

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest (2006) 12.32

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell (1995) 11.72

PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell (1999) 10.08

Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem (2008) 9.56

Developmental origin of fat: tracking obesity to its source. Cell (2007) 8.80

Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A (2003) 6.82

The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov (2009) 6.23

Adipose tissue remodeling and obesity. J Clin Invest (2011) 6.12

Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem (2006) 5.57

Muscle-specific Pparg deletion causes insulin resistance. Nat Med (2003) 3.93

PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest (2006) 3.17

Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. J Biochem (2010) 2.70

Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol Endocrinol (2010) 2.67

Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages. Mol Cell Biol (2010) 2.47

Functional evolutionary history of the mouse Fgf gene family. Dev Dyn (2008) 2.43

PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A (2009) 2.38

Fibroblast growth factor 21: from pharmacology to physiology. Am J Clin Nutr (2009) 2.35

Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response. Genes Dev (2010) 2.31

Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice. Mol Cell Biol (2000) 1.65

FGFs and metabolism. Curr Opin Pharmacol (2009) 1.51

SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci U S A (2008) 1.46

Adipose tissue remodeling in pathophysiology of obesity. Curr Opin Clin Nutr Metab Care (2010) 1.37

Neutrophil elastase: mediator of extracellular matrix destruction and accumulation. Proc Am Thorac Soc (2006) 1.35

Fibroblast growth factor 1: a key regulator of human adipogenesis. Diabetes (2004) 1.24

Physiology. Sister act. Science (2007) 1.17

Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A (2011) 1.16

Angiogenesis monitored by perfusion with a space-filling microbead suspension. Mol Ther (2000) 1.06

Gene structure and differential expression of acidic fibroblast growth factor mRNA: identification and distribution of four different transcripts. Oncogene (1993) 0.97

A putative role for endogenous FGF-2 in FGF-1 mediated differentiation of human preadipocytes. Mol Cell Endocrinol (2011) 0.89

[Studies of lipase-induced fat necrosis in rats (author's transl)]. Pathol Res Pract (1978) 0.81

Lipase and colipase in canine pancreatic juice as etiologic factors in fat necrosis. Surg Gynecol Obstet (1979) 0.80

Articles by these authors

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21

Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med (2006) 9.53

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell (2010) 8.69

Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A (2003) 6.82

Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care (2004) 6.64

Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest (2008) 6.60

A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem (2007) 6.58

Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell (2003) 6.53

White fat progenitor cells reside in the adipose vasculature. Science (2008) 6.49

AMPK and PPARdelta agonists are exercise mimetics. Cell (2008) 6.39

Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes Care (2007) 6.24

Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups. Am J Hum Genet (2002) 6.02

Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol (2004) 5.66

The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med (2012) 5.63

Nuclear receptor expression links the circadian clock to metabolism. Cell (2006) 5.43

Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem (2003) 5.40

JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab (2007) 5.38

Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab (2008) 5.10

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest (2007) 4.86

AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science (2009) 4.72

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell (2006) 4.64

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med (2004) 4.64

Pioglitazone for diabetes prevention in impaired glucose tolerance. N Engl J Med (2011) 4.28

SGLT2 inhibition--a novel strategy for diabetes treatment. Nat Rev Drug Discov (2010) 4.22

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15

A role for adult TLX-positive neural stem cells in learning and behaviour. Nature (2008) 4.14

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature (2008) 3.98

Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science (2003) 3.97

Muscle-specific Pparg deletion causes insulin resistance. Nat Med (2003) 3.93

Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology (2003) 3.83

PPARγ signaling and metabolism: the good, the bad and the future. Nat Med (2013) 3.71

Vitamin D receptor as an intestinal bile acid sensor. Science (2002) 3.64

Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell (2011) 3.64

PPAR-gamma regulates osteoclastogenesis in mice. Nat Med (2007) 3.59

Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A (2001) 3.58

Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology (2010) 3.52

Inflammation and insulin resistance. FEBS Lett (2007) 3.34

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature (2013) 3.33

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med (2012) 3.33

Adiponectin: more than just another fat cell hormone? Diabetes Care (2003) 3.30

PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A (2006) 3.29

TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science (2006) 3.26

Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature (2004) 3.25

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med (2012) 3.21

PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest (2006) 3.17

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med (2013) 3.15

Regulation of lipolysis in adipocytes. Annu Rev Nutr (2007) 3.15

The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes (2002) 3.15

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature (2016) 3.13

Inflamed fat: what starts the fire? J Clin Invest (2006) 3.11

Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab (2009) 3.10

Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell (2012) 3.07

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A (2006) 3.05

CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2016 EXECUTIVE SUMMARY. Endocr Pract (2016) 3.01

Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab (2007) 3.00

Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab (2012) 2.96

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell (2003) 2.85

Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature (2002) 2.78

JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem (2005) 2.76

NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell (2011) 2.75

Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med (2011) 2.74

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol (2008) 2.73

Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology (2013) 2.70

Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell (2002) 2.69

Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med (2004) 2.61