Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells.

PubWeight™: 0.81‹?›

🔗 View Article (PMC 3335148)

Published in PLoS One on April 23, 2012

Authors

Takuhito Sezaki1, Kohki Inada, Takayuki Sogabe, Kumiyo Kakuda, Lucia Tomiyama, Yohsuke Matsuno, Takafumi Ichikawa, Michinori Matsuo, Kazumitsu Ueda, Noriyuki Kioka

Author Affiliations

1: Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto, Japan.

Articles cited by this

Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer (2002) 34.99

The basics of epithelial-mesenchymal transition. J Clin Invest (2009) 32.82

Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol (2006) 23.04

Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature (2003) 20.48

Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest (2003) 12.56

Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest (2002) 12.22

The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol (2006) 11.16

Biomarkers for epithelial-mesenchymal transitions. J Clin Invest (2009) 8.76

Mechanism of activation of the TGF-beta receptor. Nature (1994) 8.10

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature (1997) 7.69

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med (1996) 6.73

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest (2009) 6.70

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell (2000) 6.69

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell (1997) 6.34

Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol (2004) 5.43

Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition. Curr Opin Cell Biol (2009) 3.94

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat Cell Biol (2008) 3.31

Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet (2004) 3.19

TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. Mol Cell (2008) 3.04

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J Clin Invest (2001) 2.73

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance. J Exp Med (1996) 2.68

Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. Am J Physiol Renal Physiol (2002) 2.36

The genetics of Crohn's disease. Annu Rev Genomics Hum Genet (2009) 2.07

Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease. Am J Gastroenterol (2009) 1.80

Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection. Oncogene (2004) 1.77

Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization. J Cell Biol (1999) 1.65

The PDZ domains of zonula occludens-1 induce an epithelial to mesenchymal transition of Madin-Darby canine kidney I cells. Evidence for a role of beta-catenin/Tcf/Lef signaling. J Biol Chem (2000) 1.65

Transforming growth factor-β2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling. Biochem J (2011) 1.65

Discs large 5 is required for polarization of citron kinase in mitotic neural precursors. Cell Cycle (2010) 1.51

Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction. Cell Struct Funct (2002) 1.35

MST1-JNK promotes apoptosis via caspase-dependent and independent pathways. Genes Cells (2001) 1.34

Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice. Dev Cell (2007) 1.33

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer. Nat Commun (2011) 1.28

Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology. Mol Biol Cell (2000) 1.25

Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell. Cancer Res (2005) 1.24

A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration. Genes Dev (2010) 1.21

The role of the p38 MAPK signaling pathway in high glucose-induced epithelial-mesenchymal transition of cultured human renal tubular epithelial cells. PLoS One (2011) 1.20

Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity. Mol Biol Cell (2008) 1.18

Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis. Gastroenterology (2006) 1.17

Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact. J Biol Chem (2003) 1.06

Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55. FEBS Lett (1998) 0.94

DLG5 R30Q variant is a female-specific protective factor in pediatric onset Crohn's disease. Am J Gastroenterol (2006) 0.91

Activation of c-Jun amino-terminal kinase is required for retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells. FEBS Lett (2001) 0.91

UV irradiation induces Snail expression by AP-1 dependent mechanism in human skin keratinocytes. J Dermatol Sci (2010) 0.89

Long-term clinical results of ileocecal resection for Crohn's disease. Inflamm Bowel Dis (2007) 0.87

Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts. J Med Genet (2007) 0.85

Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface. Genes Cells (2006) 0.82

Erythropoietin suppresses epithelial to mesenchymal transition and intercepts Smad signal transduction through a MEK-dependent mechanism in pig kidney (LLC-PK1) cell lines. Exp Cell Res (2010) 0.82

Genetic association of DLG5 R30Q with familial and sporadic inflammatory bowel disease in men. Dis Markers (2009) 0.81

WAVE2 forms a complex with PKA and is involved in PKA enhancement of membrane protrusions. J Biol Chem (2010) 0.80

The Crohn's disease susceptibility gene DLG5 as a member of the CARD interaction network. J Mol Med (Berl) (2008) 0.79

v-Src-mediated transformation suppresses the expression of focal adhesion protein vinexin. Cancer Lett (2009) 0.77

c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes. J Transplant (2011) 0.77

Articles by these authors

Spatial distribution and functional significance of activated vinculin in living cells. J Cell Biol (2005) 1.77

Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner. Arterioscler Thromb Vasc Biol (2005) 1.64

Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. J Lipid Res (2006) 1.52

Involvement of CjMDR1, a plant multidrug-resistance-type ATP-binding cassette protein, in alkaloid transport in Coptis japonica. Proc Natl Acad Sci U S A (2003) 1.45

Early gastric cancer with Krukenberg tumor and review of cases of intramucosal gastric cancers with Krukenberg tumor. J Gastroenterol (2003) 1.36

Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction. Cell Struct Funct (2002) 1.35

Glutamate and amyloid beta-protein rapidly inhibit fast axonal transport in cultured rat hippocampal neurons by different mechanisms. J Neurosci (2003) 1.35

Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis. J Biol Chem (2002) 1.25

SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. J Biol Chem (2003) 1.22

Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency. J Biol Chem (2006) 1.20

Human ABCA3, a product of a responsible gene for abca3 for fatal surfactant deficiency in newborns, exhibits unique ATP hydrolysis activity and generates intracellular multilamellar vesicles. Biochem Biophys Res Commun (2004) 1.20

Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog. Proc Natl Acad Sci U S A (2014) 1.14

Purification and ATPase activity of human ABCA1. J Biol Chem (2006) 1.14

Alpha1-syntrophin modulates turnover of ABCA1. J Biol Chem (2004) 1.13

Mechanism of multidrug recognition by MDR1/ABCB1. Cancer Sci (2007) 1.13

LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. PLoS One (2012) 1.10

The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression. Mol Biol Cell (2010) 1.10

Retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation. Genes Cells (2008) 1.07

Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein. J Biol Chem (2003) 1.06

Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact. J Biol Chem (2003) 1.06

Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7. J Lipid Res (2005) 1.03

Lipid outward translocation by ABC proteins. FEBS Lett (2010) 1.02

ABC proteins: key molecules for lipid homeostasis. Med Mol Morphol (2005) 1.02

Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release. Biochem Biophys Res Commun (2003) 1.02

Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4. Hepatology (2007) 1.01

Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J (2007) 1.00

Direct interaction of nuclear liver X receptor-beta with ABCA1 modulates cholesterol efflux. J Biol Chem (2008) 1.00

Enhanced apoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient Chinese hamster ovary cells. J Biol Chem (2007) 0.99

Direct interaction of Cucurbitacin E isolated from Alsomitra macrocarpa to actin filament. Cytotechnology (2007) 0.99

Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation. J Lipid Res (2009) 0.98

KATP channel interaction with adenine nucleotides. J Mol Cell Cardiol (2005) 0.98

Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1. J Lipid Res (2007) 0.97

ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1). J Biol Chem (2002) 0.96

Enzymatic measurement of phosphatidic acid in cultured cells. J Lipid Res (2009) 0.96

ABCA1 dimer-monomer interconversion during HDL generation revealed by single-molecule imaging. Proc Natl Acad Sci U S A (2013) 0.95

Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner. J Lipid Res (2006) 0.95

Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. Proc Natl Acad Sci U S A (2013) 0.94

Liver X receptor beta (LXRbeta) interacts directly with ATP-binding cassette A1 (ABCA1) to promote high density lipoprotein formation during acute cholesterol accumulation. J Biol Chem (2011) 0.94

Microanalysis for MDR1 ATPase by high-performance liquid chromatography with a titanium dioxide column. Anal Biochem (2004) 0.94

Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. Biochem Biophys Res Commun (2003) 0.93

Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein. J Exp Bot (2002) 0.93

Functional role of the linker region in purified human P-glycoprotein. FEBS J (2009) 0.92

Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists. Mol Cancer Ther (2003) 0.92

Cloning of ABCA17, a novel rodent sperm-specific ABC (ATP-binding cassette) transporter that regulates intracellular lipid metabolism. Biochem J (2005) 0.92

Function and regulation of ABCA1--membrane meso-domain organization and reorganization. FEBS J (2011) 0.92

Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins. Biochim Biophys Acta (2010) 0.91

Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. Arterioscler Thromb Vasc Biol (2004) 0.91

Role of interaction with vinculin in recruitment of vinexins to focal adhesions. Biochem Biophys Res Commun (2005) 0.91

Successful utilization of coronary covered stents to treat a common hepatic artery pseudoaneurysm secondary to pancreatic fistula after Whipple's procedure: report of a case. Surg Today (2009) 0.91

Formation of two intramolecular disulfide bonds is necessary for ApoA-I-dependent cholesterol efflux mediated by ABCA1. J Biol Chem (2009) 0.90

ATP-binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion. J Nutr Biochem (2009) 0.90

Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome. Hepatology (2002) 0.90

Changes in the mucus barrier of the rat during 5-fluorouracil-induced gastrointestinal mucositis. Scand J Gastroenterol (2008) 0.90

ABCA7, a molecule with unknown function. FEBS Lett (2005) 0.89

Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin. J Biol Chem (2004) 0.89

A monoclonal antibody, PGM34, against 6-sulfated blood-group H type 2 antigen, on the carbohydrate moiety of mucin. FEBS J (2007) 0.89

ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding. J Lipid Res (2011) 0.88

Involvement of phosphatases in the anchorage-dependent regulation of ERK2 activation. Exp Cell Res (2007) 0.88

Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands. Biochem Biophys Res Commun (2002) 0.88

Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo. Exp Cell Res (2010) 0.88

The ABCA1 Q597R mutant undergoes trafficking from the ER upon ER stress. Biochem Biophys Res Commun (2008) 0.88

Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding. EMBO J (2002) 0.87