Published in Nat Genet on April 11, 2004
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet (2007) 8.63
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med (2009) 7.53
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Am J Hum Genet (2005) 6.61
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet (2006) 5.10
European evidence based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis. Gut (2006) 3.57
Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell (2008) 3.43
IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology (2007) 2.97
Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation? Gut (2005) 2.17
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. Proc Natl Acad Sci U S A (2007) 1.95
Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays. PLoS Med (2005) 1.88
Systematic association mapping identifies NELL1 as a novel IBD disease gene. PLoS One (2007) 1.57
Family and twin studies in inflammatory bowel disease. World J Gastroenterol (2006) 1.54
Inflammatory bowel disease: review from the aspect of genetics. J Gastroenterol (2009) 1.51
Inflammatory bowel disease in Korea: epidemiological, genomic, clinical, and therapeutic characteristics. Gut Liver (2010) 1.51
Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics. Front Immunol (2013) 1.41
Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll" ? World J Gastroenterol (2006) 1.35
Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice. Dev Cell (2007) 1.33
Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease. Gut (2005) 1.30
Immunopathogenesis of inflammatory bowel disease. World J Gastroenterol (2008) 1.28
Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease. Clin Gastroenterol Hepatol (2007) 1.26
TNFSF15 is an ethnic-specific IBD gene. Inflamm Bowel Dis (2007) 1.24
Is Crohn's disease due to defective immunity? Gut (2007) 1.21
SAMP1/YitFc mouse strain: a spontaneous model of Crohn's disease-like ileitis. Inflamm Bowel Dis (2011) 1.17
A functional methylome map of ulcerative colitis. Genome Res (2012) 1.15
Evidence for association of OCTN genes and IBD5 with ulcerative colitis. Gut (2005) 1.14
DLG5 variants do not influence susceptibility to inflammatory bowel disease in the Scottish population. Gut (2005) 1.12
Inflammatory bowel disease: Moving toward a stem cell-based therapy. World J Gastroenterol (2008) 1.10
Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models. Mutat Res (2010) 1.06
Guanylate-binding protein-1 is expressed at tight junctions of intestinal epithelial cells in response to interferon-gamma and regulates barrier function through effects on apoptosis. Mucosal Immunol (2008) 1.05
Inflammatory bowel disease: genetic and epidemiologic considerations. World J Gastroenterol (2008) 1.03
Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy. World J Gastroenterol (2008) 1.01
Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. Ann Hum Genet (2010) 1.01
A general model for multilocus epistatic interactions in case-control studies. PLoS One (2010) 0.99
NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway. Infect Immun (2006) 0.99
Novel genetic markers in inflammatory bowel disease. World J Gastroenterol (2007) 0.99
Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men. Hum Genet (2006) 0.98
Genetic studies of Crohn's disease: past, present and future. Best Pract Res Clin Gastroenterol (2014) 0.94
Takusan: a large gene family that regulates synaptic activity. Neuron (2007) 0.94
Genotype/phenotype analyses for 53 Crohn's disease associated genetic polymorphisms. PLoS One (2012) 0.93
MAGI2 genetic variation and inflammatory bowel disease. Inflamm Bowel Dis (2009) 0.93
Role of discs large homolog 5. World J Gastroenterol (2006) 0.93
Lack of evidence for association of primary sclerosing cholangitis and primary biliary cirrhosis with risk alleles for Crohn's disease in Polish patients. BMC Med Genet (2008) 0.92
Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk. BMC Cancer (2008) 0.92
Associations between NOD2/CARD15 genotype and phenotype in Crohn's disease--Are we there yet? World J Gastroenterol (2006) 0.92
Selective effect of infliximab on the inflammatory component of a colonic stricture in Crohn's disease. Int J Colorectal Dis (2005) 0.91
PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites. PLoS One (2012) 0.89
Genetic factors associated with the development of inflammatory bowel disease. World J Gastroenterol (2007) 0.89
Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease. World J Gastroenterol (2005) 0.88
Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis. Dev Biol (2013) 0.88
Stem cells as potential therapeutic targets for inflammatory bowel disease. Front Biosci (Schol Ed) (2010) 0.87
Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease. Can J Gastroenterol (2010) 0.87
Nuclear factor-kappaB is a critical mediator of Ste20-like proline-/alanine-rich kinase regulation in intestinal inflammation. Am J Pathol (2008) 0.86
CARD15/NOD2 in a Tunisian population with Crohn's disease. Dig Dis Sci (2005) 0.85
Crohn's disease in a Saudi outpatient population: is it still rare? Saudi J Gastroenterol (2009) 0.84
Angiotensinogen and transforming growth factor beta1: novel genes in the pathogenesis of Crohn's disease. J Med Genet (2006) 0.84
Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort. PLoS One (2010) 0.84
Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population. Int J Colorectal Dis (2006) 0.83
Immunology of inflammatory bowel disease and molecular targets for biologics. Gastroenterol Clin North Am (2014) 0.82
Genetics of inflammatory bowel disease: current status and future directions. Can J Gastroenterol (2006) 0.82
Genetic variants associated with Crohn's disease. Appl Clin Genet (2013) 0.81
Novel susceptibility genes in inflammatory bowel disease. World J Gastroenterol (2006) 0.81
Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells. PLoS One (2012) 0.81
The promise and perils of interpreting genetic associations in Crohn's disease. Gut (2005) 0.80
A conditional synergy index to assess biological interaction. Eur J Epidemiol (2009) 0.80
Development and dynamics of cell polarity at a glance. J Cell Sci (2017) 0.79
Variant detection and runs of homozygosity in next generation sequencing data elucidate the genetic background of Lundehund syndrome. BMC Genomics (2016) 0.79
Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease. World J Gastroenterol (2005) 0.79
Genetic association of nonsynonymous variants of the IL23R with familial and sporadic inflammatory bowel disease in women. Dig Dis Sci (2009) 0.79
Intestinal DMBT1 expression is modulated by Crohn's disease-associated IL23R variants and by a DMBT1 variant which influences binding of the transcription factors CREB1 and ATF-2. PLoS One (2013) 0.79
Role of CARD15, DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases. World J Gastroenterol (2007) 0.79
Discs large 5, an Essential Gene in Drosophila, Regulates Egg Chamber Organization. G3 (Bethesda) (2015) 0.78
New IBD genes? Gut (2005) 0.78
Association of a vascular endothelial growth factor polymorphism with the development of bronchopulmonary dysplasia in Japanese premature newborns. Sci Rep (2014) 0.78
Aberrant methylation of PSD disturbs Rac1-mediated immune responses governing neutrophil chemotaxis and apoptosis in ulcerative colitis-associated carcinogenesis. Int J Oncol (2011) 0.77
Systematic meta-analyses and field synopsis of genetic and epigenetic studies in paediatric inflammatory bowel disease. Sci Rep (2016) 0.77
Expression of polarity genes in human cancer. Cancer Inform (2015) 0.77
The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease. BMC Med Genet (2010) 0.77
Ste20-related proline/alanine-rich kinase: a novel regulator of intestinal inflammation. World J Gastroenterol (2008) 0.77
Polymorphisms on SSC15q21-q26 Containing QTL for reproduction in Swine and its association with litter size. Genet Mol Biol (2009) 0.77
Expressing the differences between Crohn disease and ulcerative colitis. PLoS Med (2005) 0.76
Contribution of genetics to a new vision in the understanding of inflammatory bowel disease. World J Gastroenterol (2006) 0.76
Caenorhabditis elegans susceptibility to gut Enterococcus faecalis infection is associated with fat metabolism and epithelial junction integrity. BMC Microbiol (2016) 0.76
Inflammatory Bowel Disease: Updates on Molecular Targets for Biologics. Gut Liver (2017) 0.75
DLG5 variants and susceptibility to inflammatory bowel disease in the Scottish population. Gut (2006) 0.75
A Genome-Wide Methylation Approach Identifies a New Hypermethylated Gene Panel in Ulcerative Colitis. Int J Mol Sci (2016) 0.75
Investigation of association of the DLG5 gene with psoriatic arthritis. Ann Rheum Dis (2007) 0.75
Restorative procedures in colonic crohn disease. Clin Colon Rectal Surg (2013) 0.75
Meta-analysis of associations between DLG5 R30Q and P1371Q polymorphisms and susceptibility to inflammatory bowel disease. Sci Rep (2016) 0.75
Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut. Mediators Inflamm (2015) 0.75
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Genes Dev (2016) 0.75
Potentially functional SNPs (pfSNPs) as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients. PLoS One (2014) 0.75
Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease. World J Gastroenterol (2014) 0.75
Identification of microRNAs regulating Escherichia coli F18 infection in Meishan weaned piglets. Biol Direct (2016) 0.75
Identification of genetic loci for basal cell nevus syndrome and inflammatory bowel disease in a single large pedigree. Hum Genet (2006) 0.75
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Signatures of mutational processes in human cancer. Nature (2013) 21.63
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
ROCR: visualizing classifier performance in R. Bioinformatics (2005) 19.60
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet (2008) 15.51
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet (2006) 15.14
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Improved scoring of functional groups from gene expression data by decorrelating GO graph structure. Bioinformatics (2006) 11.33
Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34
Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol (2005) 10.16
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43
Mucosal flora in inflammatory bowel disease. Gastroenterology (2002) 8.42
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet (2008) 6.97
Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology (2006) 6.88
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet (2008) 6.75
Integrating biological data--the Distributed Annotation System. BMC Bioinformatics (2008) 6.56
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet (2008) 6.26
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy. Nat Genet (2009) 6.21
Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial. Gut (2011) 6.08
BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing. Bioinformatics (2005) 5.95
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat Genet (2010) 5.48
Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med (2005) 5.36
Computing topological parameters of biological networks. Bioinformatics (2007) 5.36
Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation (2008) 5.20
New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12
Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. Nat Genet (2006) 5.12
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet (2008) 5.05
Correlation between genetic and geographic structure in Europe. Curr Biol (2008) 5.02
PSICQUIC and PSISCORE: accessing and scoring molecular interactions. Nat Methods (2011) 5.01
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet (2008) 4.96
The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J. Nat Genet (2005) 4.92
A new measure for functional similarity of gene products based on Gene Ontology. BMC Bioinformatics (2006) 4.82
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships. Community Genet (2006) 4.72
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet (2009) 4.63
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet (2005) 4.57
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med (2012) 4.41
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet (2009) 4.38
Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease. Gastroenterology (2004) 4.26
Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Genet (2005) 4.23
The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology (2002) 4.20
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13
Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med (2007) 4.07
Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat Med (2003) 4.04
Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci U S A (2009) 4.02
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat Genet (2008) 3.99