Published in PLoS One on May 01, 2012
c-Jun N-Terminal Kinases Mediate a Wide Range of Targets in the Metastatic Cascade. Genes Cancer (2013) 0.98
JNK3 is required for the cytoprotective effect of exendin 4. J Diabetes Res (2014) 0.82
JNK at the crossroad of obesity, insulin resistance, and cell stress response. Mol Metab (2016) 0.80
Proteasome inhibitors, including curcumin, improve pancreatic β-cell function and insulin sensitivity in diabetic mice. Nutr Diabetes (2016) 0.79
JNK1/2 regulates ER-mitochondrial Ca2+ cross-talk during IL-1β-mediated cell death in RINm5F and human primary β-cells. Mol Biol Cell (2013) 0.78
Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance. Mol Cell Biochem (2016) 0.76
Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States. PLoS One (2015) 0.75
JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression. J Diabetes Res (2016) 0.75
Regulation of the JNK3 signaling pathway during islet isolation: JNK3 and c-fos as new markers of islet quality for transplantation. PLoS One (2014) 0.75
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A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell (2002) 3.73
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PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit (2004) 1.47
Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes (2003) 1.46
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The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells. Diabetes (2000) 1.28
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IRS proteins and beta-cell function. Diabetes (2001) 1.26
The emerging role of FOXO transcription factors in pancreatic beta cells. J Endocrinol (2007) 1.19
Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice. Diabetologia (2010) 1.15
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci U S A (2005) 1.13
Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation. Diabetologia (2007) 1.11
Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice. Diabetologia (2007) 1.10
Exendin-4 protects oxidative stress-induced β-cell apoptosis through reduced JNK and GSK3β activity. J Korean Med Sci (2010) 0.95
JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis. Diabetologia (2009) 0.94
The c-Jun N-terminal kinase JNK participates in cytokine- and isolation stress-induced rat pancreatic islet apoptosis. Diabetologia (2007) 0.93
Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation. PLoS One (2011) 0.93
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A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat Med (2003) 3.45
Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure. Diabetes (2004) 1.55
D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia. Stroke (2004) 1.16
Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals. Mol Pharmacol (2006) 1.15
Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity. Hear Res (2006) 1.14
Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases. FASEB J (2008) 1.10
A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo. Am J Physiol Heart Circ Physiol (2006) 1.08
Induction of apoptosis in human corneal and HeLa cells by mutated BIGH3. Invest Ophthalmol Vis Sci (2003) 1.08
JNK inhibition and inflammation after cerebral ischemia. Brain Behav Immun (2009) 1.08
Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase. J Virol (2007) 1.01
The nNOS-p38MAPK pathway is mediated by NOS1AP during neuronal death. J Neurosci (2013) 1.01
Cell-permeable peptides induce dose- and length-dependent cytotoxic effects. Biochim Biophys Acta (2007) 1.00
A unique set of SH3-SH3 interactions controls IB1 homodimerization. EMBO J (2006) 0.95
Role of the c-Jun N-terminal kinase pathway in retinal excitotoxicity, and neuroprotection by its inhibition. J Neurochem (2010) 0.93
A RasGAP-derived cell permeable peptide potently enhances genotoxin-induced cytotoxicity in tumor cells. Oncogene (2004) 0.92
Use of cell-permeable peptides to prevent neuronal degeneration. Trends Mol Med (2004) 0.91
c-Jun N-terminal kinase pathway inhibition in intracerebral hemorrhage. Cerebrovasc Dis (2010) 0.90
The JNK inhibitor XG-102 protects from ischemic damage with delayed intravenous administration also in the presence of recombinant tissue plasminogen activator. Cerebrovasc Dis (2008) 0.89
D-TAT transporter as an ocular peptide delivery system. Clin Experiment Ophthalmol (2005) 0.88
c-Jun N-terminal kinase signaling pathway in excitotoxic cell death following kainic acid-induced status epilepticus. Eur J Neurosci (2010) 0.88
The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria. Mol Cell Neurosci (2011) 0.85
Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse. Mol Pain (2012) 0.83
Brief reoxygenation episodes during chronic hypoxia enhance posthypoxic recovery of LV function: role of mitogen-activated protein kinase signaling pathways. Basic Res Cardiol (2006) 0.83
D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma. Otol Neurotol (2006) 0.82
Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1. J Biol Chem (2003) 0.82
Homogeneous and nonradioactive high-throughput screening platform for the characterization of kinase inhibitors in cell lysates. J Biomol Screen (2006) 0.81
Antitumorigenic effect of proteasome inhibitors on insulinoma cells. Endocrinology (2004) 0.79
Profiling treatment-specific post-translational modifications in a complex proteome with subtractive substrate phage display. Proteomics (2004) 0.78
Crystallization and preliminary crystallographic characterization of an SH3 domain from the IB1 scaffold protein. Acta Crystallogr D Biol Crystallogr (2003) 0.77
Large Family With Maturity-Onset Diabetes of the Young and a Novel V121I Mutation in HNF4A. Hum Mutat (2002) 0.77
Modulation of the c-Jun N-terminal kinase activity in the embryonic heart in response to anoxia-reoxygenation: involvement of the Ca2+ and mitoKATP channels. Mol Cell Biochem (2008) 0.75